Drosophila melanogaster

39 known processes

Sply (Dmel_CG8946)

Sphingosine-1-phosphate lyase

(Aliases: l(2)05091,spl,anon-WO0142479.5,SPL,sply,Spl,CG8946,Dmel\CG8946)

Sply biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ion transport GO:0006811 145 0.268
single organism behavior GO:0044708 391 0.238
organic substance transport GO:0071702 257 0.178
anion transport GO:0006820 41 0.119
homeostatic process GO:0042592 199 0.119
regionalization GO:0003002 416 0.117
imaginal disc derived appendage development GO:0048737 399 0.106
cation transport GO:0006812 110 0.100
embryo development ending in birth or egg hatching GO:0009792 152 0.098
embryonic development via the syncytial blastoderm GO:0001700 148 0.079
cell cell signaling involved in cell fate commitment GO:0045168 210 0.073
chemical homeostasis GO:0048878 92 0.068
adult somatic muscle development GO:0007527 14 0.065
organic acid transport GO:0015849 18 0.053
positive regulation of multicellular organismal process GO:0051240 143 0.053
amino acid transport GO:0006865 12 0.052
multicellular organism growth GO:0035264 46 0.050
Mouse
vesicle mediated transport GO:0016192 381 0.049
embryonic morphogenesis GO:0048598 206 0.045
immune system process GO:0002376 347 0.044
Mouse
regulation of cell death GO:0010941 173 0.044
neuron recognition GO:0008038 101 0.043
positive regulation of growth GO:0045927 75 0.043
epithelial cell differentiation GO:0030855 322 0.041
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.041
positive regulation of developmental growth GO:0048639 62 0.040
organic anion transport GO:0015711 28 0.039
positive regulation of protein secretion GO:0050714 9 0.038
digestive tract morphogenesis GO:0048546 127 0.037
gastrulation GO:0007369 70 0.037
imaginal disc derived wing morphogenesis GO:0007476 337 0.037
eye development GO:0001654 323 0.037
nitrogen compound transport GO:0071705 85 0.037
protein localization GO:0008104 284 0.037
lateral inhibition GO:0046331 206 0.035
negative regulation of cellular metabolic process GO:0031324 382 0.034
positive regulation of cell motility GO:2000147 3 0.033
intracellular transport GO:0046907 228 0.032
regulation of reproductive process GO:2000241 54 0.032
digestive system development GO:0055123 149 0.032
detection of light stimulus GO:0009583 58 0.031
epithelial tube morphogenesis GO:0060562 88 0.030
chemosensory behavior GO:0007635 106 0.030
regulation of multicellular organismal development GO:2000026 414 0.029
muscle structure development GO:0061061 224 0.029
actin cytoskeleton organization GO:0030036 206 0.029
positive regulation of protein transport GO:0051222 37 0.029
negative regulation of biosynthetic process GO:0009890 277 0.028
digestive tract development GO:0048565 149 0.028
regulation of multi organism process GO:0043900 131 0.028
endocytosis GO:0006897 310 0.027
programmed cell death GO:0012501 257 0.027
tube morphogenesis GO:0035239 191 0.027
dorsal appendage formation GO:0046843 47 0.026
ion homeostasis GO:0050801 55 0.025
metal ion transport GO:0030001 74 0.025
response to abiotic stimulus GO:0009628 341 0.025
single organism biosynthetic process GO:0044711 206 0.024
tube development GO:0035295 244 0.024
phosphatidic acid metabolic process GO:0046473 1 0.024
cellular cation homeostasis GO:0030003 38 0.023
wing disc morphogenesis GO:0007472 344 0.023
cell death GO:0008219 279 0.023
positive regulation of developmental process GO:0051094 143 0.023
establishment of localization in cell GO:0051649 402 0.023
response to wounding GO:0009611 94 0.022
positive regulation of cell migration GO:0030335 2 0.022
regulation of cellular localization GO:0060341 136 0.021
positive regulation of phosphate metabolic process GO:0045937 139 0.021
cytoplasmic transport GO:0016482 130 0.021
regulation of cellular component biogenesis GO:0044087 201 0.021
positive regulation of transport GO:0051050 92 0.021
regulation of growth GO:0040008 233 0.020
Mouse
neutral lipid metabolic process GO:0006638 12 0.020
adult behavior GO:0030534 137 0.020
phosphate ion transport GO:0006817 4 0.020
disaccharide metabolic process GO:0005984 4 0.020
morphogenesis of an epithelium GO:0002009 276 0.020
death GO:0016265 284 0.020
developmental growth GO:0048589 280 0.020
Mouse
wnt signaling pathway GO:0016055 98 0.019
protein complex assembly GO:0006461 200 0.019
regulation of metal ion transport GO:0010959 15 0.019
protein transport GO:0015031 155 0.019
tissue morphogenesis GO:0048729 297 0.019
negative regulation of cellular biosynthetic process GO:0031327 277 0.019
segmentation GO:0035282 207 0.018
growth GO:0040007 359 0.018
Mouse
glycosyl compound metabolic process GO:1901657 127 0.018
phagocytosis GO:0006909 215 0.018
single organism intracellular transport GO:1902582 207 0.017
imaginal disc derived appendage morphogenesis GO:0035114 395 0.017
intracellular protein transport GO:0006886 104 0.017
notch signaling pathway GO:0007219 120 0.017
establishment of protein localization GO:0045184 163 0.017
organonitrogen compound catabolic process GO:1901565 128 0.017
respiratory system development GO:0060541 213 0.017
positive regulation of multicellular organism growth GO:0040018 21 0.016
post embryonic appendage morphogenesis GO:0035120 385 0.016
connective tissue development GO:0061448 3 0.016
leg disc development GO:0035218 92 0.016
regulation of protein localization GO:0032880 76 0.016
positive regulation of cell communication GO:0010647 250 0.015
nucleoside phosphate metabolic process GO:0006753 162 0.015
response to hexose GO:0009746 3 0.015
response to oxygen levels GO:0070482 59 0.015
columnar cuboidal epithelial cell development GO:0002066 249 0.015
carboxylic acid transport GO:0046942 18 0.015
cellular protein modification process GO:0006464 438 0.015
macromolecular complex assembly GO:0065003 256 0.015
signal transduction by phosphorylation GO:0023014 107 0.015
protein secretion GO:0009306 45 0.015
nucleoside metabolic process GO:0009116 127 0.015
nucleobase containing small molecule metabolic process GO:0055086 174 0.015
negative regulation of rna biosynthetic process GO:1902679 240 0.015
positive regulation of signaling GO:0023056 243 0.014
secretion GO:0046903 109 0.014
purine ribonucleoside metabolic process GO:0046128 127 0.014
developmental programmed cell death GO:0010623 138 0.014
response to metal ion GO:0010038 23 0.014
cellular homeostasis GO:0019725 80 0.014
gland development GO:0048732 191 0.014
organelle assembly GO:0070925 198 0.014
regulation of intracellular transport GO:0032386 64 0.014
autophagy GO:0006914 108 0.014
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.014
gastrulation involving germ band extension GO:0010004 36 0.014
camera type eye development GO:0043010 4 0.013
protein complex biogenesis GO:0070271 201 0.013
positive regulation of cellular component organization GO:0051130 156 0.013
response to hypoxia GO:0001666 53 0.013
cellular component assembly involved in morphogenesis GO:0010927 151 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.013
cellular macromolecule localization GO:0070727 220 0.013
striated muscle myosin thick filament assembly GO:0071688 3 0.013
regulation of cell cycle GO:0051726 291 0.013
actin filament based process GO:0030029 220 0.013
cellular macromolecular complex assembly GO:0034622 153 0.013
oxoacid metabolic process GO:0043436 103 0.013
morphogenesis of a branching epithelium GO:0061138 45 0.013
germ band shortening GO:0007390 19 0.012
regulation of transport GO:0051049 181 0.012
response to lipopolysaccharide GO:0032496 4 0.012
cellular catabolic process GO:0044248 372 0.012
cellular protein localization GO:0034613 160 0.012
epithelial cell development GO:0002064 274 0.012
generation of precursor metabolites and energy GO:0006091 42 0.012
gonad development GO:0008406 50 0.012
Mouse
regulation of catabolic process GO:0009894 170 0.011
detection of abiotic stimulus GO:0009582 66 0.011
regulation of notch signaling pathway GO:0008593 100 0.011
positive regulation of reproductive process GO:2000243 7 0.011
mitochondrion organization GO:0007005 65 0.011
response to glucose GO:0009749 2 0.011
organic acid metabolic process GO:0006082 103 0.011
regulation of cell development GO:0060284 215 0.011
regulation of molecular function GO:0065009 217 0.011
cellular response to hexose stimulus GO:0071331 1 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
positive regulation of nfat protein import into nucleus GO:0051533 16 0.011
protein localization to organelle GO:0033365 82 0.011
appendage development GO:0048736 401 0.011
mesenchymal cell development GO:0014031 1 0.010
response to copper ion GO:0046688 4 0.010
endomembrane system organization GO:0010256 119 0.010
transcription from rna polymerase ii promoter GO:0006366 368 0.010
phosphatidylinositol mediated signaling GO:0048015 4 0.010
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 4 0.010
maintenance of location GO:0051235 73 0.010
ras protein signal transduction GO:0007265 88 0.010
catabolic process GO:0009056 409 0.010
purine nucleoside metabolic process GO:0042278 127 0.010

Sply disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.028
disease of metabolism DOID:0014667 0 0.021
musculoskeletal system disease DOID:17 0 0.014
inherited metabolic disorder DOID:655 0 0.012