Drosophila melanogaster

42 known processes

Spp (Dmel_CG11840)

Signal peptide protease

(Aliases: SPP,spp,Dmel\CG11840,CG11840)

Spp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule localization GO:0070727 220 0.264
protein localization GO:0008104 284 0.234
carbohydrate derivative biosynthetic process GO:1901137 85 0.232
cellular protein localization GO:0034613 160 0.214
glycoprotein metabolic process GO:0009100 41 0.187
carbohydrate derivative metabolic process GO:1901135 217 0.154
protein glycosylation GO:0006486 32 0.150
single organism intracellular transport GO:1902582 207 0.135
cuticle development GO:0042335 86 0.126
vesicle mediated transport GO:0016192 381 0.121
central nervous system development GO:0007417 201 0.121
cellular protein modification process GO:0006464 438 0.120
intracellular transport GO:0046907 228 0.113
response to topologically incorrect protein GO:0035966 10 0.103
response to unfolded protein GO:0006986 9 0.095
open tracheal system development GO:0007424 204 0.094
protein catabolic process GO:0030163 101 0.088
cytoplasmic transport GO:0016482 130 0.087
cellular macromolecule catabolic process GO:0044265 136 0.086
organonitrogen compound metabolic process GO:1901564 318 0.086
immune system process GO:0002376 347 0.083
glycoprotein biosynthetic process GO:0009101 41 0.082
multi organism behavior GO:0051705 175 0.075
intracellular protein transport GO:0006886 104 0.074
response to bacterium GO:0009617 198 0.073
brain development GO:0007420 120 0.072
regulation of multi organism process GO:0043900 131 0.071
response to other organism GO:0051707 293 0.070
establishment of localization in cell GO:0051649 402 0.069
peptidyl amino acid modification GO:0018193 105 0.065
maintenance of location GO:0051235 73 0.063
organic substance transport GO:0071702 257 0.062
defense response to other organism GO:0098542 225 0.058
regionalization GO:0003002 416 0.056
forebrain development GO:0030900 2 0.056
protein transport GO:0015031 155 0.055
intracellular signal transduction GO:0035556 300 0.054
multicellular organismal aging GO:0010259 140 0.054
protein modification process GO:0036211 438 0.053
catabolic process GO:0009056 409 0.053
neuron projection guidance GO:0097485 241 0.053
nucleotide metabolic process GO:0009117 161 0.052
establishment of protein localization GO:0045184 163 0.048
morphogenesis of an epithelium GO:0002009 276 0.048
dendrite development GO:0016358 204 0.047
carbohydrate metabolic process GO:0005975 82 0.047
endocytosis GO:0006897 310 0.046
response to external biotic stimulus GO:0043207 293 0.044
regulation of cell death GO:0010941 173 0.042
wing disc morphogenesis GO:0007472 344 0.042
head development GO:0060322 135 0.041
cell migration GO:0016477 238 0.040
aging GO:0007568 143 0.039
small molecule metabolic process GO:0044281 305 0.039
phagocytosis GO:0006909 215 0.039
cell motility GO:0048870 251 0.039
embryo development ending in birth or egg hatching GO:0009792 152 0.038
developmental programmed cell death GO:0010623 138 0.036
defense response to gram negative bacterium GO:0050829 94 0.036
defense response to bacterium GO:0042742 178 0.036
regulation of reproductive process GO:2000241 54 0.035
response to biotic stimulus GO:0009607 294 0.034
ribonucleotide catabolic process GO:0009261 109 0.033
regulation of localization GO:0032879 275 0.033
positive regulation of biosynthetic process GO:0009891 316 0.033
tube morphogenesis GO:0035239 191 0.032
gland development GO:0048732 191 0.032
peptidyl proline hydroxylation GO:0019511 1 0.032
purine nucleotide metabolic process GO:0006163 146 0.031
body morphogenesis GO:0010171 2 0.030
single organism carbohydrate metabolic process GO:0044723 72 0.030
macromolecule catabolic process GO:0009057 161 0.030
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.029
regulation of transport GO:0051049 181 0.029
positive regulation of cellular biosynthetic process GO:0031328 316 0.029
morphogenesis of embryonic epithelium GO:0016331 94 0.029
immune response GO:0006955 246 0.029
multi multicellular organism process GO:0044706 123 0.028
positive regulation of cellular component organization GO:0051130 156 0.028
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.028
embryonic development via the syncytial blastoderm GO:0001700 148 0.027
positive regulation of response to stimulus GO:0048584 323 0.027
defense response GO:0006952 300 0.027
anatomical structure homeostasis GO:0060249 97 0.027
transcription from rna polymerase ii promoter GO:0006366 368 0.027
lateral inhibition GO:0046331 206 0.027
macromolecule glycosylation GO:0043413 32 0.025
regulation of immune system process GO:0002682 176 0.025
regulation of intracellular signal transduction GO:1902531 236 0.025
proteolysis GO:0006508 192 0.025
embryonic morphogenesis GO:0048598 206 0.025
imaginal disc derived wing morphogenesis GO:0007476 337 0.024
single organism cellular localization GO:1902580 180 0.024
ovarian nurse cell to oocyte transport GO:0007300 27 0.024
carbohydrate derivative catabolic process GO:1901136 118 0.023
lipid storage GO:0019915 38 0.023
protein hydroxylation GO:0018126 1 0.023
regulation of cell cycle GO:0051726 291 0.023
entry into cell of other organism involved in symbiotic interaction GO:0051806 3 0.023
tube development GO:0035295 244 0.022
regulation of multicellular organismal development GO:2000026 414 0.022
protein n linked glycosylation GO:0006487 9 0.022
male gamete generation GO:0048232 201 0.022
multicellular organismal reproductive behavior GO:0033057 110 0.022
oocyte differentiation GO:0009994 145 0.022
cellular protein catabolic process GO:0044257 83 0.021
cell cell signaling involved in cell fate commitment GO:0045168 210 0.021
ribose phosphate metabolic process GO:0019693 145 0.021
protein localization to organelle GO:0033365 82 0.021
protein complex biogenesis GO:0070271 201 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.021
single organism behavior GO:0044708 391 0.020
positive regulation of transcription dna templated GO:0045893 266 0.020
dendrite morphogenesis GO:0048813 199 0.020
positive regulation of cell communication GO:0010647 250 0.020
cellular catabolic process GO:0044248 372 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
cell death GO:0008219 279 0.019
dorsal ventral pattern formation GO:0009953 133 0.019
imaginal disc derived appendage development GO:0048737 399 0.019
maintenance of protein location in cell GO:0032507 26 0.019
digestive tract morphogenesis GO:0048546 127 0.018
regulation of synapse organization GO:0050807 110 0.018
multi organism reproductive behavior GO:0044705 121 0.018
axonogenesis GO:0007409 290 0.017
morphogenesis of follicular epithelium GO:0016333 36 0.017
positive regulation of rna biosynthetic process GO:1902680 266 0.017
positive regulation of developmental process GO:0051094 143 0.017
negative regulation of cell communication GO:0010648 223 0.017
mitotic cytokinesis GO:0000281 50 0.017
nucleoside triphosphate metabolic process GO:0009141 120 0.017
regulation of protein transport GO:0051223 57 0.017
nucleobase containing small molecule metabolic process GO:0055086 174 0.017
branching involved in open tracheal system development GO:0060446 45 0.017
chitin based cuticle development GO:0040003 49 0.017
organic substance catabolic process GO:1901575 308 0.016
localization of cell GO:0051674 257 0.016
tissue morphogenesis GO:0048729 297 0.016
macromolecular complex assembly GO:0065003 256 0.016
exocrine system development GO:0035272 162 0.016
positive regulation of transport GO:0051050 92 0.016
regulation of cell differentiation GO:0045595 302 0.016
death GO:0016265 284 0.016
terminal branching open tracheal system GO:0007430 17 0.016
intracellular protein transmembrane transport GO:0065002 4 0.016
ribonucleotide metabolic process GO:0009259 145 0.016
digestive tract development GO:0048565 149 0.015
single organism membrane organization GO:0044802 93 0.015
protein complex assembly GO:0006461 200 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.015
respiratory system development GO:0060541 213 0.015
camera type eye development GO:0043010 4 0.015
regulation of epithelial cell migration open tracheal system GO:2000274 11 0.015
cytoskeleton dependent cytokinesis GO:0061640 81 0.015
monocarboxylic acid metabolic process GO:0032787 29 0.015
nucleoside catabolic process GO:0009164 112 0.015
endomembrane system organization GO:0010256 119 0.015
golgi organization GO:0007030 66 0.014
axon development GO:0061564 297 0.014
positive regulation of signal transduction GO:0009967 223 0.014
purine ribonucleoside metabolic process GO:0046128 127 0.014
regulation of molecular function GO:0065009 217 0.014
meiotic cell cycle process GO:1903046 132 0.014
purine ribonucleotide catabolic process GO:0009154 109 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
negative regulation of response to stimulus GO:0048585 258 0.014
negative regulation of cellular metabolic process GO:0031324 382 0.014
urogenital system development GO:0001655 72 0.014
response to virus GO:0009615 28 0.014
response to abiotic stimulus GO:0009628 341 0.014
telencephalon development GO:0021537 2 0.014
chromatin organization GO:0006325 207 0.014
nucleoside phosphate metabolic process GO:0006753 162 0.014
glycosylation GO:0070085 36 0.013
regulation of embryonic development GO:0045995 68 0.013
dorsal closure GO:0007391 79 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.013
organic acid metabolic process GO:0006082 103 0.013
nucleotide catabolic process GO:0009166 109 0.013
salivary gland development GO:0007431 162 0.013
protein localization to endoplasmic reticulum GO:0070972 2 0.013
organonitrogen compound biosynthetic process GO:1901566 117 0.013
regulation of tube architecture open tracheal system GO:0035152 68 0.012
axon guidance GO:0007411 233 0.012
taxis GO:0042330 304 0.012
spermatogenesis GO:0007283 200 0.012
modification dependent macromolecule catabolic process GO:0043632 79 0.012
regulation of protein localization GO:0032880 76 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
reproductive behavior GO:0019098 122 0.012
developmental maturation GO:0021700 172 0.012
regulation of catalytic activity GO:0050790 185 0.012
programmed cell death GO:0012501 257 0.012
purine nucleoside metabolic process GO:0042278 127 0.012
heart development GO:0007507 82 0.012
movement in environment of other organism involved in symbiotic interaction GO:0052192 3 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
salivary gland morphogenesis GO:0007435 145 0.012
nucleoside triphosphate catabolic process GO:0009143 108 0.011
secretion GO:0046903 109 0.011
tissue migration GO:0090130 155 0.011
positive regulation of hydrolase activity GO:0051345 78 0.011
regulation of intracellular transport GO:0032386 64 0.011
purine containing compound metabolic process GO:0072521 155 0.011
appendage morphogenesis GO:0035107 397 0.011
regulation of female receptivity GO:0045924 24 0.011
regulation of response to stress GO:0080134 200 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
negative regulation of signaling GO:0023057 219 0.011
regulation of protein import into nucleus GO:0042306 28 0.011
nucleoside phosphate catabolic process GO:1901292 110 0.011
immune effector process GO:0002252 98 0.011
microtubule polymerization or depolymerization GO:0031109 39 0.010
negative regulation of cell differentiation GO:0045596 143 0.010
response to endoplasmic reticulum stress GO:0034976 28 0.010
protein import GO:0017038 55 0.010
positive regulation of signaling GO:0023056 243 0.010
mesenchymal cell development GO:0014031 1 0.010
mesoderm morphogenesis GO:0048332 22 0.010
chemotaxis GO:0006935 249 0.010
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.010
gland morphogenesis GO:0022612 145 0.010

Spp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
disease of anatomical entity DOID:7 0 0.011
cardiovascular system disease DOID:1287 0 0.011
disease of metabolism DOID:0014667 0 0.011
musculoskeletal system disease DOID:17 0 0.011