Drosophila melanogaster

52 known processes

l(2)efl (Dmel_CG4533)

lethal (2) essential for life

(Aliases: Dmel\CG4533,el(2)13-1,CG4533,l(2)59Fa,l(2)13-1,l(2)Efl,L(2)efl)

l(2)efl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 143 0.748
multicellular organismal aging GO:0010259 140 0.227
determination of adult lifespan GO:0008340 137 0.139
catabolic process GO:0009056 409 0.094
Fly
cellular response to radiation GO:0071478 52 0.091
intracellular signal transduction GO:0035556 300 0.091
striated muscle cell differentiation GO:0051146 90 0.087
innate immune response activating signal transduction GO:0002758 2 0.086
macromolecule catabolic process GO:0009057 161 0.084
regulation of intracellular signal transduction GO:1902531 236 0.082
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.081
phosphorylation GO:0016310 294 0.074
organonitrogen compound metabolic process GO:1901564 318 0.067
kidney development GO:0001822 3 0.056
immune response activating signal transduction GO:0002757 2 0.055
immune response regulating signaling pathway GO:0002764 2 0.054
small molecule metabolic process GO:0044281 305 0.052
organonitrogen compound catabolic process GO:1901565 128 0.051
signal transduction by phosphorylation GO:0023014 107 0.050
organic substance catabolic process GO:1901575 308 0.050
humoral immune response GO:0006959 117 0.050
muscle structure development GO:0061061 224 0.046
response to abiotic stimulus GO:0009628 341 0.046
actin filament based process GO:0030029 220 0.044
actin cytoskeleton organization GO:0030036 206 0.042
regulation of phosphate metabolic process GO:0019220 210 0.041
cellular catabolic process GO:0044248 372 0.041
Fly
nucleobase containing compound catabolic process GO:0034655 165 0.041
response to organic substance GO:0010033 284 0.040
Fly
mapk cascade GO:0000165 107 0.039
cell aging GO:0007569 2 0.039
biological adhesion GO:0022610 138 0.039
positive regulation of response to stimulus GO:0048584 323 0.038
negative regulation of response to stimulus GO:0048585 258 0.038
muscle cell differentiation GO:0042692 103 0.038
appendage morphogenesis GO:0035107 397 0.038
regulation of phosphorus metabolic process GO:0051174 210 0.038
single organism catabolic process GO:0044712 228 0.037
negative regulation of cellular metabolic process GO:0031324 382 0.036
positive regulation of transcription dna templated GO:0045893 266 0.036
response to external biotic stimulus GO:0043207 293 0.036
activation of innate immune response GO:0002218 4 0.035
defense response GO:0006952 300 0.035
carbohydrate derivative metabolic process GO:1901135 217 0.034
carbohydrate derivative catabolic process GO:1901136 118 0.033
negative regulation of cell communication GO:0010648 223 0.033
response to biotic stimulus GO:0009607 294 0.033
cellular response to chemical stimulus GO:0070887 199 0.032
homeostatic process GO:0042592 199 0.031
defense response to bacterium GO:0042742 178 0.031
oxoacid metabolic process GO:0043436 103 0.031
endocytosis GO:0006897 310 0.030
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.030
vesicle mediated transport GO:0016192 381 0.030
open tracheal system development GO:0007424 204 0.030
positive regulation of immune system process GO:0002684 68 0.030
pattern recognition receptor signaling pathway GO:0002221 2 0.029
response to oxygen containing compound GO:1901700 200 0.028
Fly
tube morphogenesis GO:0035239 191 0.028
embryonic development via the syncytial blastoderm GO:0001700 148 0.028
defense response to other organism GO:0098542 225 0.027
response to endogenous stimulus GO:0009719 119 0.027
Fly
immune system development GO:0002520 57 0.027
positive regulation of cell communication GO:0010647 250 0.026
cellular component assembly involved in morphogenesis GO:0010927 151 0.026
organic acid metabolic process GO:0006082 103 0.025
single organism behavior GO:0044708 391 0.025
regulation of cell differentiation GO:0045595 302 0.025
morphogenesis of an epithelium GO:0002009 276 0.025
positive regulation of phosphorus metabolic process GO:0010562 139 0.025
organophosphate metabolic process GO:0019637 195 0.025
single organism biosynthetic process GO:0044711 206 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.024
actin filament organization GO:0007015 126 0.024
cellular nitrogen compound catabolic process GO:0044270 165 0.024
cell adhesion GO:0007155 136 0.024
immune system process GO:0002376 347 0.024
macromolecular complex assembly GO:0065003 256 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.023
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.023
wing disc morphogenesis GO:0007472 344 0.023
positive regulation of phosphate metabolic process GO:0045937 139 0.023
response to other organism GO:0051707 293 0.022
chromosome organization GO:0051276 360 0.022
positive regulation of signal transduction GO:0009967 223 0.022
response to high light intensity GO:0009644 1 0.022
cellular protein modification process GO:0006464 438 0.022
cellular amino acid metabolic process GO:0006520 61 0.022
glycosyl compound metabolic process GO:1901657 127 0.022
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
regulation of innate immune response GO:0045088 71 0.022
response to lipopolysaccharide GO:0032496 4 0.022
cellular response to abiotic stimulus GO:0071214 58 0.022
body morphogenesis GO:0010171 2 0.021
regulation of cell shape GO:0008360 113 0.021
regulation of cellular amine metabolic process GO:0033238 3 0.021
transcription from rna polymerase ii promoter GO:0006366 368 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.021
negative regulation of cell differentiation GO:0045596 143 0.021
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.020
cellular response to organic substance GO:0071310 132 0.020
regulation of phosphorylation GO:0042325 147 0.020
organelle fission GO:0048285 340 0.020
regulation of mapk cascade GO:0043408 92 0.020
imaginal disc derived appendage development GO:0048737 399 0.020
stress activated protein kinase signaling cascade GO:0031098 55 0.020
organic cyclic compound catabolic process GO:1901361 168 0.020
regulation of protein metabolic process GO:0051246 256 0.020
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.020
regulation of molecular function GO:0065009 217 0.019
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.019
regulation of catabolic process GO:0009894 170 0.019
Fly
syncytium formation by plasma membrane fusion GO:0000768 43 0.019
nucleoside phosphate catabolic process GO:1901292 110 0.019
cellular amine metabolic process GO:0044106 12 0.019
posttranscriptional regulation of gene expression GO:0010608 145 0.019
positive regulation of hydrolase activity GO:0051345 78 0.019
positive regulation of cellular amine metabolic process GO:0033240 0 0.019
regulation of anatomical structure morphogenesis GO:0022603 242 0.018
appendage development GO:0048736 401 0.018
regulation of immune system process GO:0002682 176 0.018
positive regulation of intracellular signal transduction GO:1902533 116 0.018
jnk cascade GO:0007254 50 0.018
tube development GO:0035295 244 0.018
positive regulation of signaling GO:0023056 243 0.018
peptidyl amino acid modification GO:0018193 105 0.018
myotube differentiation GO:0014902 46 0.018
regulation of cellular catabolic process GO:0031329 157 0.018
Fly
nucleoside metabolic process GO:0009116 127 0.018
small gtpase mediated signal transduction GO:0007264 88 0.018
digestive system development GO:0055123 149 0.018
cellular response to molecule of bacterial origin GO:0071219 3 0.017
immune response GO:0006955 246 0.017
regulation of multicellular organismal development GO:2000026 414 0.017
regulation of cellular ketone metabolic process GO:0010565 3 0.017
cellular response to lipopolysaccharide GO:0071222 3 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
regulation of immune response GO:0050776 118 0.017
regulation of cellular component biogenesis GO:0044087 201 0.017
imaginal disc derived wing morphogenesis GO:0007476 337 0.017
nucleoside phosphate metabolic process GO:0006753 162 0.017
negative regulation of signal transduction GO:0009968 206 0.017
purine ribonucleoside metabolic process GO:0046128 127 0.016
stem cell differentiation GO:0048863 117 0.016
syncytium formation GO:0006949 43 0.016
heterocycle catabolic process GO:0046700 166 0.016
protein catabolic process GO:0030163 101 0.016
myoblast fusion GO:0007520 43 0.016
organelle assembly GO:0070925 198 0.016
regulation of catalytic activity GO:0050790 185 0.016
purine nucleoside metabolic process GO:0042278 127 0.016
cellular response to light stimulus GO:0071482 37 0.016
nucleoside triphosphate metabolic process GO:0009141 120 0.016
stress activated mapk cascade GO:0051403 52 0.016
protein phosphorylation GO:0006468 169 0.016
growth GO:0040007 359 0.016
regulation of growth GO:0040008 233 0.016
regulation of cellular response to stress GO:0080135 89 0.016
positive regulation of nucleotide metabolic process GO:0045981 55 0.016
single organism carbohydrate metabolic process GO:0044723 72 0.016
hematopoietic progenitor cell differentiation GO:0002244 1 0.015
regulation of organelle organization GO:0033043 196 0.015
establishment of localization in cell GO:0051649 402 0.015
response to virus GO:0009615 28 0.015
nucleobase containing small molecule metabolic process GO:0055086 174 0.015
cellular ketone metabolic process GO:0042180 24 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
nucleotide metabolic process GO:0009117 161 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
antimicrobial humoral response GO:0019730 99 0.015
defense response to gram negative bacterium GO:0050829 94 0.015
purine nucleoside triphosphate catabolic process GO:0009146 108 0.015
mesoderm development GO:0007498 78 0.015
cell motility GO:0048870 251 0.014
compound eye development GO:0048749 307 0.014
negative regulation of cell cycle phase transition GO:1901988 103 0.014
dendrite morphogenesis GO:0048813 199 0.014
negative regulation of cellular biosynthetic process GO:0031327 277 0.014
ribonucleoside triphosphate metabolic process GO:0009199 119 0.014
regulation of cell death GO:0010941 173 0.014
response to bacterium GO:0009617 198 0.014
post embryonic appendage morphogenesis GO:0035120 385 0.014
positive regulation of catalytic activity GO:0043085 118 0.014
regulation of ras protein signal transduction GO:0046578 93 0.014
regionalization GO:0003002 416 0.014
defense response to virus GO:0051607 23 0.014
positive regulation of cell migration GO:0030335 2 0.014
protein localization GO:0008104 284 0.014
negative regulation of intracellular signal transduction GO:1902532 57 0.014
protein complex biogenesis GO:0070271 201 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
protein modification process GO:0036211 438 0.014
regulation of muscle cell differentiation GO:0051147 8 0.014
aminoglycan metabolic process GO:0006022 18 0.014
response to organonitrogen compound GO:0010243 75 0.014
Fly
dna metabolic process GO:0006259 227 0.013
cellular response to biotic stimulus GO:0071216 4 0.013
eye morphogenesis GO:0048592 260 0.013
cellular response to light intensity GO:0071484 1 0.013
purine ribonucleotide metabolic process GO:0009150 145 0.013
regulation of response to stress GO:0080134 200 0.013
purine nucleotide metabolic process GO:0006163 146 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
purine containing compound metabolic process GO:0072521 155 0.013
cell death GO:0008219 279 0.013
positive regulation of rna biosynthetic process GO:1902680 266 0.013
localization of cell GO:0051674 257 0.013
regulation of cellular localization GO:0060341 136 0.013
regulation of antimicrobial humoral response GO:0002759 50 0.013
imaginal disc derived appendage morphogenesis GO:0035114 395 0.013
embryo development ending in birth or egg hatching GO:0009792 152 0.013
anatomical structure homeostasis GO:0060249 97 0.013
cellular homeostasis GO:0019725 80 0.013
negative regulation of signaling GO:0023057 219 0.013
adult behavior GO:0030534 137 0.013
nuclear division GO:0000280 332 0.013
phagocytosis GO:0006909 215 0.013
respiratory system development GO:0060541 213 0.012
positive regulation of molecular function GO:0044093 136 0.012
cellular macromolecule catabolic process GO:0044265 136 0.012
regulation of circadian sleep wake cycle sleep GO:0045187 21 0.012
negative regulation of immune system process GO:0002683 50 0.012
microtubule polymerization or depolymerization GO:0031109 39 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
purine ribonucleoside catabolic process GO:0046130 112 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
protein complex assembly GO:0006461 200 0.012
mitotic g2 dna damage checkpoint GO:0007095 69 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
negative regulation of developmental process GO:0051093 201 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
ion homeostasis GO:0050801 55 0.012
cellular response to ionizing radiation GO:0071479 15 0.012
negative regulation of multicellular organismal process GO:0051241 142 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
purine containing compound catabolic process GO:0072523 112 0.012
positive regulation of phosphorylation GO:0042327 87 0.012
mitochondrion organization GO:0007005 65 0.012
response to radiation GO:0009314 155 0.011
embryonic morphogenesis GO:0048598 206 0.011
regulation of jnk cascade GO:0046328 40 0.011
ras protein signal transduction GO:0007265 88 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.011
antibacterial peptide production GO:0002778 22 0.011
negative regulation of phosphate metabolic process GO:0045936 45 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.011
aromatic compound catabolic process GO:0019439 166 0.011
cellular macromolecule localization GO:0070727 220 0.011
positive regulation of catabolic process GO:0009896 105 0.011
forebrain development GO:0030900 2 0.011
death GO:0016265 284 0.011
positive regulation of antibacterial peptide biosynthetic process GO:0006963 20 0.011
hematopoietic or lymphoid organ development GO:0048534 57 0.011
notch signaling pathway GO:0007219 120 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
sarcomere organization GO:0045214 26 0.011
mitotic nuclear division GO:0007067 213 0.011
regulation of apoptotic process GO:0042981 130 0.011
locomotory behavior GO:0007626 176 0.011
ribonucleoside catabolic process GO:0042454 112 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
regulation of multi organism process GO:0043900 131 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
regulation of stress activated mapk cascade GO:0032872 41 0.010
establishment of protein localization GO:0045184 163 0.010
regulation of purine nucleotide catabolic process GO:0033121 48 0.010
amine metabolic process GO:0009308 12 0.010
mitotic cell cycle checkpoint GO:0007093 88 0.010
regulation of purine nucleotide metabolic process GO:1900542 62 0.010
negative regulation of catabolic process GO:0009895 36 0.010
detection of external biotic stimulus GO:0098581 2 0.010
regulation of cell cycle GO:0051726 291 0.010
positive regulation of transport GO:0051050 92 0.010
regulation of protein phosphorylation GO:0001932 64 0.010
translation GO:0006412 69 0.010
wnt signaling pathway GO:0016055 98 0.010
chemical homeostasis GO:0048878 92 0.010
developmental growth GO:0048589 280 0.010
negative regulation of rna metabolic process GO:0051253 251 0.010
single organism cellular localization GO:1902580 180 0.010
actin filament based movement GO:0030048 26 0.010

l(2)efl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
cardiovascular system disease DOID:1287 0 0.040
musculoskeletal system disease DOID:17 0 0.016
muscle tissue disease DOID:66 0 0.016
muscular disease DOID:0080000 0 0.016
nervous system disease DOID:863 0 0.013
sensory system disease DOID:0050155 0 0.012
artery disease DOID:0050828 0 0.012
hypertension DOID:10763 0 0.012
vascular disease DOID:178 0 0.012
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011