Drosophila melanogaster

83 known processes

Buffy (Dmel_CG8238)

CG8238 gene product from transcript CG8238-RA

(Aliases: Buffy/Borg2,Drob2,dBorg-2,CG8238,buffy,dBORG-2/BUFFY,Dmel\CG8238,BUFFY,Bcl-2-48AE,Dbx,Buffy/dBorg-2,Buffy/DBorg-2,dbuffy,dBorg2)

Buffy biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
developmental programmed cell death GO:0010623 138 0.148
programmed cell death GO:0012501 257 0.126
response to other organism GO:0051707 293 0.103
protein modification process GO:0036211 438 0.090
positive regulation of response to stimulus GO:0048584 323 0.072
response to abiotic stimulus GO:0009628 341 0.070
Fly
lipid metabolic process GO:0006629 121 0.067
multicellular organismal aging GO:0010259 140 0.060
response to external biotic stimulus GO:0043207 293 0.060
positive regulation of signal transduction GO:0009967 223 0.059
response to organic substance GO:0010033 284 0.058
columnar cuboidal epithelial cell development GO:0002066 249 0.057
small molecule metabolic process GO:0044281 305 0.056
organonitrogen compound metabolic process GO:1901564 318 0.056
positive regulation of macromolecule metabolic process GO:0010604 405 0.056
Human
regulation of programmed cell death GO:0043067 152 0.055
carboxylic acid metabolic process GO:0019752 92 0.053
death GO:0016265 284 0.052
positive regulation of signaling GO:0023056 243 0.051
imaginal disc derived appendage morphogenesis GO:0035114 395 0.050
immune response GO:0006955 246 0.050
cellular catabolic process GO:0044248 372 0.048
morphogenesis of embryonic epithelium GO:0016331 94 0.048
cellular protein modification process GO:0006464 438 0.048
regulation of response to stress GO:0080134 200 0.047
cell death GO:0008219 279 0.046
autophagy GO:0006914 108 0.046
tissue morphogenesis GO:0048729 297 0.045
defense response to other organism GO:0098542 225 0.045
positive regulation of cell communication GO:0010647 250 0.044
defense response GO:0006952 300 0.043
establishment of localization in cell GO:0051649 402 0.043
organic hydroxy compound metabolic process GO:1901615 83 0.043
phosphorylation GO:0016310 294 0.043
aging GO:0007568 143 0.043
regulation of cellular protein metabolic process GO:0032268 243 0.041
Human
response to oxygen containing compound GO:1901700 200 0.040
regulation of protein metabolic process GO:0051246 256 0.039
Human
chemical homeostasis GO:0048878 92 0.039
open tracheal system development GO:0007424 204 0.039
organelle fission GO:0048285 340 0.038
cell division GO:0051301 248 0.038
oxoacid metabolic process GO:0043436 103 0.038
protein ubiquitination GO:0016567 70 0.037
detection of stimulus GO:0051606 156 0.037
forebrain development GO:0030900 2 0.037
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.036
regulation of apoptotic process GO:0042981 130 0.036
cellular response to dna damage stimulus GO:0006974 223 0.036
Fly
catabolic process GO:0009056 409 0.035
immune system process GO:0002376 347 0.035
regulation of immune system process GO:0002682 176 0.035
cellular amino acid metabolic process GO:0006520 61 0.035
regulation of intracellular signal transduction GO:1902531 236 0.035
response to bacterium GO:0009617 198 0.035
regulation of synaptic transmission GO:0050804 69 0.035
proteolysis GO:0006508 192 0.034
Human
immune response regulating signaling pathway GO:0002764 2 0.034
immune effector process GO:0002252 98 0.034
endocytosis GO:0006897 310 0.034
regulation of cell death GO:0010941 173 0.034
apoptotic process GO:0006915 159 0.034
epithelial cell differentiation GO:0030855 322 0.033
response to biotic stimulus GO:0009607 294 0.033
cellular macromolecule catabolic process GO:0044265 136 0.033
vesicle mediated transport GO:0016192 381 0.032
ovarian follicle cell migration GO:0007297 121 0.032
protein modification by small protein conjugation GO:0032446 79 0.032
neurological system process GO:0050877 358 0.031
posttranscriptional regulation of gene expression GO:0010608 145 0.031
organic substance transport GO:0071702 257 0.031
gland morphogenesis GO:0022612 145 0.031
negative regulation of developmental process GO:0051093 201 0.031
defense response to bacterium GO:0042742 178 0.031
single organism biosynthetic process GO:0044711 206 0.030
organic substance catabolic process GO:1901575 308 0.030
imaginal disc derived appendage development GO:0048737 399 0.030
tube morphogenesis GO:0035239 191 0.030
immune response activating signal transduction GO:0002757 2 0.030
intracellular signal transduction GO:0035556 300 0.030
Human Fly
cellular response to chemical stimulus GO:0070887 199 0.029
gliogenesis GO:0042063 80 0.029
Rat
apoptotic process involved in development GO:1902742 20 0.029
Fly
response to radiation GO:0009314 155 0.029
Fly
regulation of catalytic activity GO:0050790 185 0.029
Human
body morphogenesis GO:0010171 2 0.028
chromatin modification GO:0016568 147 0.028
nuclear division GO:0000280 332 0.028
response to endogenous stimulus GO:0009719 119 0.028
salivary gland morphogenesis GO:0007435 145 0.028
regulation of catabolic process GO:0009894 170 0.027
response to starvation GO:0042594 97 0.027
embryonic pattern specification GO:0009880 174 0.027
cell proliferation GO:0008283 299 0.027
Human
morphogenesis of an epithelium GO:0002009 276 0.027
glial cell differentiation GO:0010001 35 0.027
Rat
regulation of multi organism process GO:0043900 131 0.027
regulation of cellular catabolic process GO:0031329 157 0.027
single organism catabolic process GO:0044712 228 0.027
organic acid metabolic process GO:0006082 103 0.027
regulation of multicellular organismal development GO:2000026 414 0.027
response to organic cyclic compound GO:0014070 89 0.027
homeostatic process GO:0042592 199 0.027
Fly
exocrine system development GO:0035272 162 0.026
response to glucose GO:0009749 2 0.026
positive regulation of rna metabolic process GO:0051254 271 0.026
regulation of cellular amino acid metabolic process GO:0006521 0 0.026
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.025
amine metabolic process GO:0009308 12 0.025
segmentation GO:0035282 207 0.025
cellular amine metabolic process GO:0044106 12 0.025
synaptic transmission GO:0007268 288 0.025
compound eye development GO:0048749 307 0.025
protein modification by small protein conjugation or removal GO:0070647 106 0.024
macroautophagy GO:0016236 42 0.024
regulation of defense response GO:0031347 102 0.024
negative regulation of multicellular organismal process GO:0051241 142 0.024
positive regulation of cell death GO:0010942 69 0.024
morphogenesis of a polarized epithelium GO:0001738 93 0.024
post embryonic appendage morphogenesis GO:0035120 385 0.024
dna damage checkpoint GO:0000077 78 0.024
response to hexose GO:0009746 3 0.024
regulation of immune response GO:0050776 118 0.023
hormone metabolic process GO:0042445 33 0.023
regulation of proteolysis GO:0030162 87 0.023
Human
chromosome segregation GO:0007059 157 0.023
positive regulation of immune response GO:0050778 63 0.023
chaeta development GO:0022416 97 0.023
appendage morphogenesis GO:0035107 397 0.023
protein maturation GO:0051604 71 0.023
Human
regulation of cell cycle process GO:0010564 181 0.023
stem cell differentiation GO:0048863 117 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.022
salivary gland development GO:0007431 162 0.022
ion transport GO:0006811 145 0.022
positive regulation of hydrolase activity GO:0051345 78 0.022
Human
response to monosaccharide GO:0034284 4 0.022
regulation of cell cycle GO:0051726 291 0.022
histolysis GO:0007559 102 0.022
cellular ketone metabolic process GO:0042180 24 0.022
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.022
organic cyclic compound catabolic process GO:1901361 168 0.022
negative regulation of nervous system development GO:0051961 92 0.022
positive regulation of peptidase activity GO:0010952 29 0.022
Human
cellular response to hexose stimulus GO:0071331 1 0.021
mrna metabolic process GO:0016071 124 0.021
regulation of response to external stimulus GO:0032101 115 0.021
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.021
Human
regulation of phosphorus metabolic process GO:0051174 210 0.021
regulation of response to biotic stimulus GO:0002831 63 0.021
epithelial cell development GO:0002064 274 0.021
appendage development GO:0048736 401 0.021
single organism cellular localization GO:1902580 180 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.020
establishment of protein localization GO:0045184 163 0.020
cellular amide metabolic process GO:0043603 80 0.020
protein phosphorylation GO:0006468 169 0.020
salivary gland cell autophagic cell death GO:0035071 83 0.020
positive regulation of transport GO:0051050 92 0.020
positive regulation of macroautophagy GO:0016239 8 0.020
nitrogen compound transport GO:0071705 85 0.020
protein localization GO:0008104 284 0.020
phagocytosis GO:0006909 215 0.019
intracellular transport GO:0046907 228 0.019
tissue death GO:0016271 102 0.019
positive regulation of gene expression GO:0010628 290 0.019
establishment or maintenance of cell polarity GO:0007163 167 0.019
pigment metabolic process GO:0042440 84 0.019
dorsal ventral pattern formation GO:0009953 133 0.019
g protein coupled receptor signaling pathway GO:0007186 136 0.019
steroid catabolic process GO:0006706 1 0.019
cellular response to organic substance GO:0071310 132 0.019
negative regulation of programmed cell death GO:0043069 72 0.019
cellular response to abiotic stimulus GO:0071214 58 0.019
mesenchymal cell differentiation GO:0048762 1 0.019
wing disc morphogenesis GO:0007472 344 0.019
mitotic dna integrity checkpoint GO:0044774 75 0.018
central nervous system development GO:0007417 201 0.018
Rat
camera type eye development GO:0043010 4 0.018
developmental maturation GO:0021700 172 0.018
mitotic nuclear division GO:0007067 213 0.018
negative regulation of cell death GO:0060548 81 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.018
humoral immune response GO:0006959 117 0.018
regulation of cellular amine metabolic process GO:0033238 3 0.018
locomotory behavior GO:0007626 176 0.018
synapse organization GO:0050808 196 0.018
multicellular organismal reproductive behavior GO:0033057 110 0.018
regulation of mitotic cell cycle phase transition GO:1901990 130 0.018
ovarian follicle cell development GO:0030707 248 0.017
regulation of transport GO:0051049 181 0.017
mapk cascade GO:0000165 107 0.017
molting cycle process GO:0022404 29 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
positive regulation of transcription dna templated GO:0045893 266 0.017
actin cytoskeleton organization GO:0030036 206 0.017
regulation of execution phase of apoptosis GO:1900117 5 0.017
Human
acylglycerol biosynthetic process GO:0046463 2 0.017
developmental growth GO:0048589 280 0.017
urogenital system development GO:0001655 72 0.017
positive regulation of protein metabolic process GO:0051247 128 0.017
Human
multi organism reproductive behavior GO:0044705 121 0.017
regulation of cellular ketone metabolic process GO:0010565 3 0.017
determination of adult lifespan GO:0008340 137 0.017
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.017
Human
positive regulation of cellular protein metabolic process GO:0032270 118 0.017
Human
cellular response to ionizing radiation GO:0071479 15 0.017
peptidyl amino acid modification GO:0018193 105 0.017
neuropeptide signaling pathway GO:0007218 45 0.016
regulation of molecular function GO:0065009 217 0.016
Human
macromolecule catabolic process GO:0009057 161 0.016
apoptotic process involved in morphogenesis GO:0060561 3 0.016
Fly
positive regulation of catalytic activity GO:0043085 118 0.016
Human
response to nitrogen compound GO:1901698 90 0.016
cytoplasmic transport GO:0016482 130 0.016
positive regulation of intracellular signal transduction GO:1902533 116 0.016
negative regulation of cellular metabolic process GO:0031324 382 0.016
organelle localization GO:0051640 148 0.016
transcription from rna polymerase ii promoter GO:0006366 368 0.016
negative regulation of mitotic cell cycle GO:0045930 109 0.016
male mating behavior GO:0060179 70 0.016
cell type specific apoptotic process GO:0097285 38 0.016
Mouse Fly
protein processing GO:0016485 68 0.016
Human
salivary gland histolysis GO:0035070 88 0.016
signal transduction in response to dna damage GO:0042770 3 0.016
glial cell migration GO:0008347 31 0.016
retina development in camera type eye GO:0060041 4 0.016
negative regulation of gene expression GO:0010629 387 0.016
developmental pigmentation GO:0048066 68 0.016
positive regulation of defense response GO:0031349 59 0.016
multi multicellular organism process GO:0044706 123 0.015
response to lipopolysaccharide GO:0032496 4 0.015
innate immune response activating signal transduction GO:0002758 2 0.015
regulation of innate immune response GO:0045088 71 0.015
extracellular structure organization GO:0043062 46 0.015
chromosome organization GO:0051276 360 0.015
positive regulation of programmed cell death GO:0043068 62 0.015
kidney development GO:0001822 3 0.015
innate immune response GO:0045087 144 0.015
regulation of cellular amide metabolic process GO:0034248 39 0.015
molting cycle GO:0042303 56 0.015
stem cell development GO:0048864 79 0.015
organic hydroxy compound biosynthetic process GO:1901617 21 0.015
mitotic cell cycle phase transition GO:0044772 138 0.015
dendrite development GO:0016358 204 0.015
sterol homeostasis GO:0055092 4 0.015
telencephalon development GO:0021537 2 0.015
secondary metabolic process GO:0019748 75 0.015
dna integrity checkpoint GO:0031570 81 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
positive regulation of cellular biosynthetic process GO:0031328 316 0.015
cellular protein catabolic process GO:0044257 83 0.015
regulation of wnt signaling pathway GO:0030111 68 0.015
positive regulation of phosphate metabolic process GO:0045937 139 0.015
tube development GO:0035295 244 0.015
negative regulation of response to stimulus GO:0048585 258 0.015
axis specification GO:0009798 167 0.015
autophagic cell death GO:0048102 83 0.015
anion homeostasis GO:0055081 3 0.014
cell cycle checkpoint GO:0000075 95 0.014
hematopoietic progenitor cell differentiation GO:0002244 1 0.014
localization of cell GO:0051674 257 0.014
sex differentiation GO:0007548 81 0.014
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.014
meiotic cell cycle GO:0051321 171 0.014
defense response to gram negative bacterium GO:0050829 94 0.014
regulation of translation GO:0006417 56 0.014
negative regulation of cell cycle process GO:0010948 109 0.014
neutral lipid biosynthetic process GO:0046460 2 0.014
regulation of humoral immune response GO:0002920 51 0.014
positive regulation of immune system process GO:0002684 68 0.014
regionalization GO:0003002 416 0.014
cell cycle phase transition GO:0044770 140 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.014
sensory perception of smell GO:0007608 80 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.014
establishment of vesicle localization GO:0051650 51 0.014
regulation of cysteine type endopeptidase activity GO:2000116 27 0.014
Human
positive regulation of biosynthetic process GO:0009891 316 0.014
cellular homeostasis GO:0019725 80 0.014
Fly
rna localization GO:0006403 115 0.014
sensory organ morphogenesis GO:0090596 260 0.013
eye morphogenesis GO:0048592 260 0.013
regulation of localization GO:0032879 275 0.013
cell migration GO:0016477 238 0.013
antimicrobial humoral response GO:0019730 99 0.013
hormone catabolic process GO:0042447 3 0.013
gland development GO:0048732 191 0.013
stress activated mapk cascade GO:0051403 52 0.013
cellular response to extracellular stimulus GO:0031668 64 0.013
positive regulation of apoptotic process GO:0043065 47 0.013
Human Rat
protein catabolic process GO:0030163 101 0.013
positive regulation of molecular function GO:0044093 136 0.013
Human
eye development GO:0001654 323 0.013
protein transport GO:0015031 155 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
regulation of intracellular transport GO:0032386 64 0.013
cuticle development GO:0042335 86 0.013
signal transduction by phosphorylation GO:0023014 107 0.013
hindgut development GO:0061525 58 0.013
nuclear transport GO:0051169 72 0.013
meiotic chromosome segregation GO:0045132 59 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
connective tissue development GO:0061448 3 0.013
regulation of protein modification process GO:0031399 112 0.013
regulation of cellular localization GO:0060341 136 0.013
hindgut morphogenesis GO:0007442 58 0.013
molting cycle chitin based cuticle GO:0007591 56 0.013
regulation of mitotic cell cycle GO:0007346 190 0.013
digestive tract development GO:0048565 149 0.013
ameboidal type cell migration GO:0001667 151 0.013
positive regulation of endopeptidase activity GO:0010950 26 0.013
Human
cell cycle arrest GO:0007050 4 0.013
amide biosynthetic process GO:0043604 42 0.012
extrinsic apoptotic signaling pathway GO:0097191 1 0.012
regulation of cellular response to stress GO:0080135 89 0.012
translation GO:0006412 69 0.012
adult behavior GO:0030534 137 0.012
activation of innate immune response GO:0002218 4 0.012
positive regulation of response to biotic stimulus GO:0002833 31 0.012
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.012
heterocycle catabolic process GO:0046700 166 0.012
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
regulation of protein localization GO:0032880 76 0.012
negative regulation of signaling GO:0023057 219 0.012
regulation of phosphorylation GO:0042325 147 0.012
pattern recognition receptor signaling pathway GO:0002221 2 0.012
small gtpase mediated signal transduction GO:0007264 88 0.012
imaginal disc pattern formation GO:0007447 91 0.012
regulation of immune effector process GO:0002697 52 0.012
tissue migration GO:0090130 155 0.012
outflow tract morphogenesis GO:0003151 4 0.012
response to ethanol GO:0045471 59 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
cellular protein localization GO:0034613 160 0.012
cellular response to monosaccharide stimulus GO:0071326 2 0.012
cellular response to nutrient levels GO:0031669 62 0.012
cellular response to radiation GO:0071478 52 0.012
kidney morphogenesis GO:0060993 3 0.012
triglyceride biosynthetic process GO:0019432 2 0.012
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.012
single organism membrane organization GO:0044802 93 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
positive regulation of cell motility GO:2000147 3 0.012
cell motility GO:0048870 251 0.012
positive regulation of wnt signaling pathway GO:0030177 25 0.012
regulation of mapk cascade GO:0043408 92 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.012
nucleobase containing compound catabolic process GO:0034655 165 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.011
response to ionizing radiation GO:0010212 32 0.011
Fly
positive regulation of cellular catabolic process GO:0031331 95 0.011
female meiosis chromosome segregation GO:0016321 33 0.011
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.011
mitotic cell cycle checkpoint GO:0007093 88 0.011
growth GO:0040007 359 0.011
cellular response to mechanical stimulus GO:0071260 2 0.011
nucleocytoplasmic transport GO:0006913 72 0.011
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.011
muscle organ development GO:0007517 127 0.011
negative regulation of protein metabolic process GO:0051248 85 0.011
positive regulation of catabolic process GO:0009896 105 0.011
mesoderm development GO:0007498 78 0.011
leg disc morphogenesis GO:0007478 80 0.011
carbohydrate metabolic process GO:0005975 82 0.011
aromatic compound catabolic process GO:0019439 166 0.011
peripheral nervous system development GO:0007422 52 0.011
regulation of protein transport GO:0051223 57 0.011
embryonic morphogenesis GO:0048598 206 0.011
hindbrain development GO:0030902 2 0.011
antimicrobial peptide production GO:0002775 46 0.011
limb morphogenesis GO:0035108 1 0.011
single organism intracellular transport GO:1902582 207 0.011
androgen metabolic process GO:0008209 1 0.011
regulation of nervous system development GO:0051960 248 0.011
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.011
embryonic development via the syncytial blastoderm GO:0001700 148 0.011
chromatin organization GO:0006325 207 0.011
hippo signaling GO:0035329 20 0.010
positive regulation of retinal cell programmed cell death GO:0046670 9 0.010
phosphate ion transport GO:0006817 4 0.010
ras protein signal transduction GO:0007265 88 0.010
mrna processing GO:0006397 104 0.010
photoreceptor cell fate commitment GO:0046552 41 0.010
wnt signaling pathway GO:0016055 98 0.010
instar larval development GO:0002168 55 0.010
positive regulation of rna biosynthetic process GO:1902680 266 0.010
sensory perception GO:0007600 196 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.010
positive regulation of canonical wnt signaling pathway GO:0090263 7 0.010
stress activated protein kinase signaling cascade GO:0031098 55 0.010
regulation of protein ubiquitination GO:0031396 22 0.010
cholesterol homeostasis GO:0042632 3 0.010
negative regulation of neurogenesis GO:0050768 53 0.010
secretion GO:0046903 109 0.010
mesenchymal cell development GO:0014031 1 0.010
regulation of endopeptidase activity GO:0052548 36 0.010
Human
reproductive behavior GO:0019098 122 0.010
digestive system development GO:0055123 149 0.010
production of molecular mediator of immune response GO:0002440 46 0.010
regulation of hydrolase activity GO:0051336 97 0.010
Human
limb development GO:0060173 1 0.010
peptidyl lysine acetylation GO:0018394 39 0.010
rna processing GO:0006396 147 0.010

Buffy disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.031
urinary system disease DOID:18 0 0.016
nervous system disease DOID:863 0 0.016
sensory system disease DOID:0050155 0 0.011
disease of metabolism DOID:0014667 0 0.011
inherited metabolic disorder DOID:655 0 0.010