Drosophila melanogaster

17 known processes

Uch (Dmel_CG4265)

Ubiquitin carboxy-terminal hydrolase

(Aliases: Dmel\CG4265,UCH-D,uch-D,UBL,CG4265,uch,UCH-D19,UCH)

Uch biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis GO:0006508 192 0.175
cell death GO:0008219 279 0.169
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.156
death GO:0016265 284 0.149
protein ubiquitination GO:0016567 70 0.148
modification dependent macromolecule catabolic process GO:0043632 79 0.142
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.138
transcription from rna polymerase ii promoter GO:0006366 368 0.131
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.124
regulation of apoptotic process GO:0042981 130 0.122
cellular protein catabolic process GO:0044257 83 0.101
protein localization GO:0008104 284 0.092
apoptotic process GO:0006915 159 0.090
positive regulation of macromolecule metabolic process GO:0010604 405 0.085
cellular protein modification process GO:0006464 438 0.077
microtubule organizing center organization GO:0031023 168 0.072
protein modification process GO:0036211 438 0.069
cellular response to xenobiotic stimulus GO:0071466 5 0.068
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.068
modification dependent protein catabolic process GO:0019941 78 0.067
positive regulation of cellular biosynthetic process GO:0031328 316 0.059
catabolic process GO:0009056 409 0.058
cellular catabolic process GO:0044248 372 0.058
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.057
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.055
dna metabolic process GO:0006259 227 0.052
regulation of cell death GO:0010941 173 0.050
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.050
programmed cell death GO:0012501 257 0.050
ubiquitin dependent protein catabolic process GO:0006511 78 0.050
protein modification by small protein conjugation GO:0032446 79 0.046
regulation of localization GO:0032879 275 0.045
negative regulation of programmed cell death GO:0043069 72 0.044
regulation of transport GO:0051049 181 0.044
positive regulation of rna biosynthetic process GO:1902680 266 0.043
proteasomal protein catabolic process GO:0010498 59 0.041
positive regulation of nucleic acid templated transcription GO:1903508 266 0.039
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.039
organic substance catabolic process GO:1901575 308 0.038
protein modification by small protein conjugation or removal GO:0070647 106 0.037
pigment metabolic process GO:0042440 84 0.036
organonitrogen compound metabolic process GO:1901564 318 0.035
regulation of programmed cell death GO:0043067 152 0.035
response to external biotic stimulus GO:0043207 293 0.034
negative regulation of transcription dna templated GO:0045892 237 0.034
growth GO:0040007 359 0.034
cytoplasmic transport GO:0016482 130 0.032
positive regulation of cell death GO:0010942 69 0.032
positive regulation of protein metabolic process GO:0051247 128 0.031
protein targeting GO:0006605 64 0.031
cellular modified amino acid metabolic process GO:0006575 45 0.030
cellular macromolecule catabolic process GO:0044265 136 0.030
positive regulation of proteolysis GO:0045862 52 0.030
negative regulation of cell death GO:0060548 81 0.030
compound eye morphogenesis GO:0001745 249 0.030
single organism membrane organization GO:0044802 93 0.030
regulation of proteolysis GO:0030162 87 0.029
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.029
intracellular signal transduction GO:0035556 300 0.027
establishment of localization in cell GO:0051649 402 0.027
cellular response to chemical stimulus GO:0070887 199 0.027
establishment of protein localization GO:0045184 163 0.026
regulation of protein metabolic process GO:0051246 256 0.026
regulation of cellular localization GO:0060341 136 0.025
sulfur compound metabolic process GO:0006790 59 0.025
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.025
regulation of cellular protein metabolic process GO:0032268 243 0.024
membrane organization GO:0061024 112 0.024
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.024
positive regulation of transcription dna templated GO:0045893 266 0.023
single organism intracellular transport GO:1902582 207 0.023
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.022
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.022
negative regulation of cellular metabolic process GO:0031324 382 0.022
regulation of response to stress GO:0080134 200 0.022
single organism biosynthetic process GO:0044711 206 0.022
eye morphogenesis GO:0048592 260 0.022
negative regulation of cell proliferation GO:0008285 69 0.021
brain development GO:0007420 120 0.021
sensory organ morphogenesis GO:0090596 260 0.021
positive regulation of biosynthetic process GO:0009891 316 0.021
protein catabolic process GO:0030163 101 0.020
intracellular transport GO:0046907 228 0.020
peptide metabolic process GO:0006518 80 0.020
protein transport GO:0015031 155 0.019
positive regulation of gene expression GO:0010628 290 0.019
signal transduction in response to dna damage GO:0042770 3 0.018
regulation of molecular function GO:0065009 217 0.018
small molecule metabolic process GO:0044281 305 0.018
protein complex biogenesis GO:0070271 201 0.018
negative regulation of gene expression GO:0010629 387 0.018
positive regulation of apoptotic process GO:0043065 47 0.018
protein complex assembly GO:0006461 200 0.018
response to xenobiotic stimulus GO:0009410 5 0.018
eye development GO:0001654 323 0.018
oxidation reduction process GO:0055114 123 0.017
cellular response to organic substance GO:0071310 132 0.017
camera type eye development GO:0043010 4 0.017
regulation of multicellular organismal development GO:2000026 414 0.017
macromolecule catabolic process GO:0009057 161 0.017
establishment of protein localization to organelle GO:0072594 62 0.017
establishment or maintenance of cell polarity GO:0007163 167 0.017
regulation of cellular protein catabolic process GO:1903362 44 0.017
regulation of cell proliferation GO:0042127 163 0.016
regulation of cell morphogenesis GO:0022604 163 0.016
positive regulation of cellular protein metabolic process GO:0032270 118 0.016
multicellular organismal aging GO:0010259 140 0.016
maintenance of location GO:0051235 73 0.016
determination of adult lifespan GO:0008340 137 0.016
organonitrogen compound biosynthetic process GO:1901566 117 0.016
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.016
vesicle mediated transport GO:0016192 381 0.016
immune system process GO:0002376 347 0.016
macromolecular complex assembly GO:0065003 256 0.016
negative regulation of rna biosynthetic process GO:1902679 240 0.016
posttranscriptional regulation of gene expression GO:0010608 145 0.015
organic substance transport GO:0071702 257 0.015
positive regulation of programmed cell death GO:0043068 62 0.015
spermatogenesis GO:0007283 200 0.015
salivary gland morphogenesis GO:0007435 145 0.015
positive regulation of response to stimulus GO:0048584 323 0.015
wing disc morphogenesis GO:0007472 344 0.015
organelle assembly GO:0070925 198 0.015
carboxylic acid metabolic process GO:0019752 92 0.015
regulation of protein catabolic process GO:0042176 55 0.014
positive regulation of rna metabolic process GO:0051254 271 0.014
regulation of proteasomal protein catabolic process GO:0061136 39 0.014
regulation of immune system process GO:0002682 176 0.014
developmental programmed cell death GO:0010623 138 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.014
response to other organism GO:0051707 293 0.014
negative regulation of cellular biosynthetic process GO:0031327 277 0.014
positive regulation of cellular protein catabolic process GO:1903364 24 0.014
appendage development GO:0048736 401 0.013
response to organic substance GO:0010033 284 0.013
regulation of hydrolase activity GO:0051336 97 0.013
response to biotic stimulus GO:0009607 294 0.013
endocytosis GO:0006897 310 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.013
cullin deneddylation GO:0010388 3 0.013
pigment biosynthetic process GO:0046148 36 0.013
positive regulation of catabolic process GO:0009896 105 0.012
forebrain development GO:0030900 2 0.012
small gtpase mediated signal transduction GO:0007264 88 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.012
developmental growth GO:0048589 280 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
larval development GO:0002164 104 0.012
cellular response to extracellular stimulus GO:0031668 64 0.011
oxoacid metabolic process GO:0043436 103 0.011
telencephalon development GO:0021537 2 0.011
positive regulation of cellular component organization GO:0051130 156 0.011
secretion by cell GO:0032940 101 0.011
cytokinesis GO:0000910 90 0.011
positive regulation of cell communication GO:0010647 250 0.011
response to alcohol GO:0097305 95 0.011
negative regulation of molecular function GO:0044092 51 0.011
cytoskeleton dependent cytokinesis GO:0061640 81 0.011
regulation of phosphorus metabolic process GO:0051174 210 0.011
appendage morphogenesis GO:0035107 397 0.011
regulation of protein modification process GO:0031399 112 0.011
response to calcium ion GO:0051592 1 0.011
positive regulation of protein catabolic process GO:0045732 34 0.011
compound eye development GO:0048749 307 0.011
regulation of cell shape GO:0008360 113 0.011
intracellular protein transport GO:0006886 104 0.011
positive regulation of signal transduction GO:0009967 223 0.010
negative regulation of biosynthetic process GO:0009890 277 0.010
organic acid metabolic process GO:0006082 103 0.010
regulation of mitotic cell cycle GO:0007346 190 0.010
imaginal disc derived wing morphogenesis GO:0007476 337 0.010
stem cell differentiation GO:0048863 117 0.010
regulation of cell development GO:0060284 215 0.010
regulation of intracellular transport GO:0032386 64 0.010

Uch disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
neurodegenerative disease DOID:1289 0 0.014
motor neuron disease DOID:231 0 0.014
disease of anatomical entity DOID:7 0 0.014
central nervous system disease DOID:331 0 0.014
nervous system disease DOID:863 0 0.014