Drosophila melanogaster

4 known processes

Keap1 (Dmel_CG3962)

CG3962 gene product from transcript CG3962-RC

(Aliases: keap1,Dmel\CG3962,KEAP1,CG3962,dKEAP1,dKeap1)

Keap1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular biosynthetic process GO:0031327 277 0.578
positive regulation of rna biosynthetic process GO:1902680 266 0.311
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.287
negative regulation of transcription dna templated GO:0045892 237 0.281
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.261
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.255
negative regulation of cellular metabolic process GO:0031324 382 0.185
single organism biosynthetic process GO:0044711 206 0.171
negative regulation of nucleic acid templated transcription GO:1903507 240 0.167
negative regulation of biosynthetic process GO:0009890 277 0.150
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.147
negative regulation of rna biosynthetic process GO:1902679 240 0.145
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.143
tissue morphogenesis GO:0048729 297 0.139
positive regulation of nucleic acid templated transcription GO:1903508 266 0.135
negative regulation of rna metabolic process GO:0051253 251 0.131
catabolic process GO:0009056 409 0.131
lipid metabolic process GO:0006629 121 0.127
regulation of growth GO:0040008 233 0.124
developmental growth GO:0048589 280 0.123
negative regulation of gene expression GO:0010629 387 0.116
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.111
positive regulation of cellular biosynthetic process GO:0031328 316 0.100
negative regulation of response to stimulus GO:0048585 258 0.097
organophosphate metabolic process GO:0019637 195 0.094
actin cytoskeleton organization GO:0030036 206 0.092
organonitrogen compound biosynthetic process GO:1901566 117 0.089
positive regulation of transcription dna templated GO:0045893 266 0.088
positive regulation of gene expression GO:0010628 290 0.087
positive regulation of protein metabolic process GO:0051247 128 0.086
Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.086
establishment of localization in cell GO:0051649 402 0.082
positive regulation of rna metabolic process GO:0051254 271 0.082
cellular response to dna damage stimulus GO:0006974 223 0.076
negative regulation of multicellular organismal process GO:0051241 142 0.075
positive regulation of macromolecule metabolic process GO:0010604 405 0.075
Fly
response to other organism GO:0051707 293 0.074
homeostatic process GO:0042592 199 0.074
negative regulation of cell communication GO:0010648 223 0.073
chromosome organization GO:0051276 360 0.072
regulation of developmental growth GO:0048638 174 0.071
cellular response to chemical stimulus GO:0070887 199 0.070
imaginal disc derived appendage development GO:0048737 399 0.069
response to organic substance GO:0010033 284 0.069
cellular modified amino acid metabolic process GO:0006575 45 0.066
autophagy GO:0006914 108 0.066
growth GO:0040007 359 0.065
Fly
regulation of protein metabolic process GO:0051246 256 0.063
Fly
establishment or maintenance of cell polarity GO:0007163 167 0.062
positive regulation of biosynthetic process GO:0009891 316 0.061
negative regulation of signal transduction GO:0009968 206 0.061
cation transmembrane transport GO:0098655 88 0.059
organic hydroxy compound metabolic process GO:1901615 83 0.058
single organism behavior GO:0044708 391 0.058
small molecule metabolic process GO:0044281 305 0.058
regulation of intracellular signal transduction GO:1902531 236 0.057
cellular response to organic substance GO:0071310 132 0.055
regulation of immune response GO:0050776 118 0.053
regulation of anatomical structure morphogenesis GO:0022603 242 0.053
embryo development ending in birth or egg hatching GO:0009792 152 0.052
organophosphate biosynthetic process GO:0090407 46 0.051
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.051
cellular amine metabolic process GO:0044106 12 0.050
regulation of response to stress GO:0080134 200 0.050
protein modification process GO:0036211 438 0.050
Fly
phosphorylation GO:0016310 294 0.050
digestive tract development GO:0048565 149 0.049
regulation of multicellular organism growth GO:0040014 40 0.049
photoreceptor cell differentiation GO:0046530 170 0.049
negative regulation of developmental process GO:0051093 201 0.048
cellular amino acid metabolic process GO:0006520 61 0.048
pigment metabolic process GO:0042440 84 0.047
axis specification GO:0009798 167 0.047
negative regulation of cell cycle process GO:0010948 109 0.047
regulation of catabolic process GO:0009894 170 0.046
embryonic morphogenesis GO:0048598 206 0.046
organic hydroxy compound biosynthetic process GO:1901617 21 0.045
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.045
organelle fission GO:0048285 340 0.045
proteolysis GO:0006508 192 0.044
Fly
single organism catabolic process GO:0044712 228 0.044
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.044
cellular catabolic process GO:0044248 372 0.044
response to abiotic stimulus GO:0009628 341 0.043
regulation of localization GO:0032879 275 0.043
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.043
enzyme linked receptor protein signaling pathway GO:0007167 179 0.042
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.041
transmembrane transport GO:0055085 139 0.041
macromolecule catabolic process GO:0009057 161 0.040
negative regulation of cell cycle GO:0045786 116 0.040
immune response GO:0006955 246 0.040
salivary gland development GO:0007431 162 0.039
salivary gland morphogenesis GO:0007435 145 0.039
developmental maturation GO:0021700 172 0.038
cellular lipid metabolic process GO:0044255 83 0.038
response to external biotic stimulus GO:0043207 293 0.038
purine nucleoside metabolic process GO:0042278 127 0.038
inorganic cation transmembrane transport GO:0098662 61 0.037
adult behavior GO:0030534 137 0.037
cell death GO:0008219 279 0.037
Fly
epithelium migration GO:0090132 148 0.037
chromosome segregation GO:0007059 157 0.037
endocytosis GO:0006897 310 0.036
transcription from rna polymerase ii promoter GO:0006366 368 0.035
lipid modification GO:0030258 24 0.035
negative regulation of cell cycle phase transition GO:1901988 103 0.035
cell motility GO:0048870 251 0.035
vesicle mediated transport GO:0016192 381 0.034
appendage development GO:0048736 401 0.034
intracellular signal transduction GO:0035556 300 0.034
organonitrogen compound metabolic process GO:1901564 318 0.034
regulation of phosphorylation GO:0042325 147 0.034
organelle assembly GO:0070925 198 0.033
locomotory behavior GO:0007626 176 0.033
macromolecular complex assembly GO:0065003 256 0.033
gland morphogenesis GO:0022612 145 0.033
regulation of phosphorus metabolic process GO:0051174 210 0.033
erbb signaling pathway GO:0038127 58 0.032
epidermal growth factor receptor signaling pathway GO:0007173 58 0.032
regulation of cell cycle GO:0051726 291 0.032
Fly
organic acid metabolic process GO:0006082 103 0.032
inorganic ion transmembrane transport GO:0098660 73 0.032
cellular macromolecular complex assembly GO:0034622 153 0.031
regionalization GO:0003002 416 0.031
embryonic pattern specification GO:0009880 174 0.031
organic substance catabolic process GO:1901575 308 0.031
digestive tract morphogenesis GO:0048546 127 0.031
glycerophospholipid metabolic process GO:0006650 23 0.031
negative regulation of signaling GO:0023057 219 0.031
programmed cell death GO:0012501 257 0.031
Fly
amine metabolic process GO:0009308 12 0.030
negative regulation of mitotic cell cycle GO:0045930 109 0.030
nucleobase containing small molecule metabolic process GO:0055086 174 0.029
positive regulation of immune response GO:0050778 63 0.029
nucleoside phosphate metabolic process GO:0006753 162 0.028
polyol biosynthetic process GO:0046173 3 0.028
cell proliferation GO:0008283 299 0.028
actin filament based process GO:0030029 220 0.027
brain development GO:0007420 120 0.027
g protein coupled receptor signaling pathway GO:0007186 136 0.027
protein complex assembly GO:0006461 200 0.027
developmental programmed cell death GO:0010623 138 0.026
negative regulation of cellular component organization GO:0051129 108 0.026
chemical homeostasis GO:0048878 92 0.026
defense response GO:0006952 300 0.026
single organism cellular localization GO:1902580 180 0.026
tube development GO:0035295 244 0.026
glycerolipid metabolic process GO:0046486 34 0.026
negative regulation of growth GO:0045926 84 0.026
body morphogenesis GO:0010171 2 0.025
cellular macromolecule catabolic process GO:0044265 136 0.025
cell migration GO:0016477 238 0.025
response to biotic stimulus GO:0009607 294 0.025
oxoacid metabolic process GO:0043436 103 0.025
epithelial cell differentiation GO:0030855 322 0.025
cellular component assembly involved in morphogenesis GO:0010927 151 0.025
lipid biosynthetic process GO:0008610 46 0.025
defense response to bacterium GO:0042742 178 0.025
regulation of transport GO:0051049 181 0.025
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.024
peptidyl amino acid modification GO:0018193 105 0.024
multicellular organism growth GO:0035264 46 0.024
positive regulation of response to stimulus GO:0048584 323 0.024
chemotaxis GO:0006935 249 0.024
exocrine system development GO:0035272 162 0.023
regulation of cell cycle phase transition GO:1901987 130 0.023
lipid localization GO:0010876 54 0.023
regulation of notch signaling pathway GO:0008593 100 0.023
positive regulation of multicellular organismal process GO:0051240 143 0.023
carboxylic acid metabolic process GO:0019752 92 0.023
centrosome cycle GO:0007098 137 0.023
regulation of molecular function GO:0065009 217 0.023
Fly
spermatogenesis GO:0007283 200 0.022
Fly
protein complex biogenesis GO:0070271 201 0.022
regulation of multi organism process GO:0043900 131 0.022
medium chain fatty acid metabolic process GO:0051791 1 0.022
post embryonic appendage morphogenesis GO:0035120 385 0.022
morphogenesis of an epithelium GO:0002009 276 0.022
regulation of phosphate metabolic process GO:0019220 210 0.022
posttranscriptional regulation of gene expression GO:0010608 145 0.022
forebrain development GO:0030900 2 0.021
response to endogenous stimulus GO:0009719 119 0.021
multi organism behavior GO:0051705 175 0.021
embryonic development via the syncytial blastoderm GO:0001700 148 0.021
regulation of cellular response to stress GO:0080135 89 0.021
regulation of cellular localization GO:0060341 136 0.021
chemosensory behavior GO:0007635 106 0.021
regulation of cell cycle process GO:0010564 181 0.020
meiotic cell cycle GO:0051321 171 0.020
positive regulation of signaling GO:0023056 243 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.020
peptidyl lysine modification GO:0018205 57 0.020
nucleotide metabolic process GO:0009117 161 0.020
small molecule biosynthetic process GO:0044283 37 0.020
organic substance transport GO:0071702 257 0.020
ras protein signal transduction GO:0007265 88 0.020
cellular nitrogen compound catabolic process GO:0044270 165 0.020
regulation of mitotic cell cycle phase transition GO:1901990 130 0.020
cell growth GO:0016049 108 0.020
Fly
cell cycle checkpoint GO:0000075 95 0.020
amide biosynthetic process GO:0043604 42 0.020
localization of cell GO:0051674 257 0.019
immune response regulating signaling pathway GO:0002764 2 0.019
purine containing compound metabolic process GO:0072521 155 0.019
cellular response to lipopolysaccharide GO:0071222 3 0.019
imaginal disc derived wing morphogenesis GO:0007476 337 0.019
regulation of cell differentiation GO:0045595 302 0.019
nuclear division GO:0000280 332 0.019
negative regulation of cell death GO:0060548 81 0.019
regulation of cellular component biogenesis GO:0044087 201 0.019
signal transduction by phosphorylation GO:0023014 107 0.019
cellular macromolecule localization GO:0070727 220 0.019
negative regulation of organelle organization GO:0010639 56 0.019
regulation of response to external stimulus GO:0032101 115 0.019
regulation of cellular amine metabolic process GO:0033238 3 0.018
digestive system development GO:0055123 149 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.018
response to organophosphorus GO:0046683 2 0.018
gastrulation GO:0007369 70 0.018
notch signaling pathway GO:0007219 120 0.018
wing disc morphogenesis GO:0007472 344 0.018
mating GO:0007618 120 0.018
response to bacterium GO:0009617 198 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.018
eye development GO:0001654 323 0.017
cell cell signaling involved in cell fate commitment GO:0045168 210 0.017
protein phosphorylation GO:0006468 169 0.017
protein catabolic process GO:0030163 101 0.017
epithelial cell migration GO:0010631 148 0.017
positive regulation of signal transduction GO:0009967 223 0.017
compound eye morphogenesis GO:0001745 249 0.017
peptide metabolic process GO:0006518 80 0.017
response to hormone GO:0009725 45 0.017
response to oxygen containing compound GO:1901700 200 0.017
regulation of cell death GO:0010941 173 0.017
Fly
cellular response to endogenous stimulus GO:0071495 80 0.017
purine containing compound catabolic process GO:0072523 112 0.017
mitotic cell cycle checkpoint GO:0007093 88 0.017
dendrite development GO:0016358 204 0.017
larval development GO:0002164 104 0.017
regulation of cellular catabolic process GO:0031329 157 0.017
death GO:0016265 284 0.017
Fly
positive regulation of developmental process GO:0051094 143 0.017
nitrogen compound transport GO:0071705 85 0.016
regulation of organelle organization GO:0033043 196 0.016
salivary gland histolysis GO:0035070 88 0.016
cell maturation GO:0048469 144 0.016
cellular ketone metabolic process GO:0042180 24 0.016
spindle organization GO:0007051 253 0.016
segmentation GO:0035282 207 0.016
dna metabolic process GO:0006259 227 0.016
cellular protein modification process GO:0006464 438 0.016
Fly
multi organism reproductive behavior GO:0044705 121 0.016
sulfur compound metabolic process GO:0006790 59 0.016
positive regulation of cell motility GO:2000147 3 0.016
regulation of cellular protein metabolic process GO:0032268 243 0.015
Fly
negative regulation of programmed cell death GO:0043069 72 0.015
ribose phosphate metabolic process GO:0019693 145 0.015
regulation of multicellular organismal development GO:2000026 414 0.015
mitotic spindle organization GO:0007052 220 0.015
rna localization GO:0006403 115 0.015
nucleoside triphosphate metabolic process GO:0009141 120 0.015
mesenchymal cell development GO:0014031 1 0.015
epithelial tube morphogenesis GO:0060562 88 0.015
phosphatidylinositol mediated signaling GO:0048015 4 0.015
peptide biosynthetic process GO:0043043 42 0.015
immune system process GO:0002376 347 0.015
multicellular organismal aging GO:0010259 140 0.015
proteasomal protein catabolic process GO:0010498 59 0.015
tube morphogenesis GO:0035239 191 0.015
multi multicellular organism process GO:0044706 123 0.015
mapk cascade GO:0000165 107 0.015
mitotic cell cycle phase transition GO:0044772 138 0.014
epithelial cell development GO:0002064 274 0.014
renal tubule morphogenesis GO:0061333 44 0.014
head development GO:0060322 135 0.014
cellularization GO:0007349 90 0.014
Fly
positive regulation of cell migration GO:0030335 2 0.014
cell adhesion GO:0007155 136 0.014
appendage morphogenesis GO:0035107 397 0.014
phosphatidylinositol phosphorylation GO:0046854 10 0.014
ubiquitin dependent protein catabolic process GO:0006511 78 0.014
intracellular transport GO:0046907 228 0.014
ribonucleoside metabolic process GO:0009119 127 0.014
lipid homeostasis GO:0055088 33 0.014
cytoplasmic transport GO:0016482 130 0.014
nephron tubule development GO:0072080 3 0.014
olfactory behavior GO:0042048 97 0.014
columnar cuboidal epithelial cell development GO:0002066 249 0.014
chromatin organization GO:0006325 207 0.014
negative regulation of cell differentiation GO:0045596 143 0.014
mesenchymal cell differentiation GO:0048762 1 0.014
maintenance of location GO:0051235 73 0.014
secretion by cell GO:0032940 101 0.013
response to oxidative stress GO:0006979 86 0.013
single organism intracellular transport GO:1902582 207 0.013
purine ribonucleotide metabolic process GO:0009150 145 0.013
regulation of programmed cell death GO:0043067 152 0.013
Fly
cellular amide metabolic process GO:0043603 80 0.013
positive regulation of lipid metabolic process GO:0045834 4 0.013
response to temperature stimulus GO:0009266 106 0.013
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.013
alcohol metabolic process GO:0006066 25 0.013
phospholipid metabolic process GO:0006644 23 0.013
regulation of immune system process GO:0002682 176 0.013
chaeta development GO:0022416 97 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
connective tissue development GO:0061448 3 0.013
defense response to gram negative bacterium GO:0050829 94 0.013
phenol containing compound metabolic process GO:0018958 57 0.013
multicellular organismal reproductive behavior GO:0033057 110 0.013
ovarian follicle cell development GO:0030707 248 0.013
nucleobase containing compound catabolic process GO:0034655 165 0.013
organophosphate catabolic process GO:0046434 112 0.013
muscle structure development GO:0061061 224 0.013
cholesterol homeostasis GO:0042632 3 0.013
response to lipid GO:0033993 38 0.013
phagocytosis GO:0006909 215 0.013
response to organic cyclic compound GO:0014070 89 0.013
cell fate determination GO:0001709 91 0.013
regulation of steroid metabolic process GO:0019218 2 0.013
negative regulation of phosphorus metabolic process GO:0010563 45 0.013
cellular response to mechanical stimulus GO:0071260 2 0.013
membrane organization GO:0061024 112 0.013
histone modification GO:0016570 106 0.013
negative regulation of apoptotic process GO:0043066 63 0.013
mitochondrion organization GO:0007005 65 0.013
central nervous system development GO:0007417 201 0.013
positive regulation of immune effector process GO:0002699 28 0.012
single organism membrane organization GO:0044802 93 0.012
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.012
endomembrane system organization GO:0010256 119 0.012
regulation of protein modification process GO:0031399 112 0.012
compound eye development GO:0048749 307 0.012
ion transmembrane transport GO:0034220 122 0.012
lateral inhibition GO:0046331 206 0.012
camera type eye development GO:0043010 4 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
metal ion transport GO:0030001 74 0.012
gland development GO:0048732 191 0.012
response to lipopolysaccharide GO:0032496 4 0.012
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.012
positive regulation of developmental growth GO:0048639 62 0.012
meiotic nuclear division GO:0007126 151 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
positive regulation of growth GO:0045927 75 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
meiotic cell cycle process GO:1903046 132 0.012
gene silencing GO:0016458 138 0.012
cellular response to nutrient levels GO:0031669 62 0.011
regulation of gene expression epigenetic GO:0040029 128 0.011
kidney development GO:0001822 3 0.011
negative regulation of notch signaling pathway GO:0045746 41 0.011
kidney epithelium development GO:0072073 3 0.011
cell type specific apoptotic process GO:0097285 38 0.011
regulation of catalytic activity GO:0050790 185 0.011
Fly
regulation of cell development GO:0060284 215 0.011
regulation of mitotic cell cycle GO:0007346 190 0.011
cellular chemical homeostasis GO:0055082 40 0.011
regulation of anatomical structure size GO:0090066 163 0.011
histolysis GO:0007559 102 0.011
aromatic compound catabolic process GO:0019439 166 0.011
male gamete generation GO:0048232 201 0.011
Fly
ameboidal type cell migration GO:0001667 151 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
renal tubule development GO:0061326 64 0.011
protein targeting to nucleus GO:0044744 51 0.011
positive regulation of cell communication GO:0010647 250 0.011
fat soluble vitamin biosynthetic process GO:0042362 1 0.011
sterol homeostasis GO:0055092 4 0.011
negative regulation of phosphate metabolic process GO:0045936 45 0.011
protein transport GO:0015031 155 0.011
antimicrobial humoral response GO:0019730 99 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
cellular protein localization GO:0034613 160 0.011
nephron development GO:0072006 3 0.011
cell division GO:0051301 248 0.011
embryonic hindgut morphogenesis GO:0048619 48 0.011
modification dependent protein catabolic process GO:0019941 78 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
protein localization GO:0008104 284 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
centrosome organization GO:0051297 163 0.011
cellular response to hormone stimulus GO:0032870 44 0.011
wound healing GO:0042060 75 0.011
response to inorganic substance GO:0010035 44 0.011
ribonucleotide metabolic process GO:0009259 145 0.010
inositol lipid mediated signaling GO:0048017 4 0.010
nucleoside triphosphate catabolic process GO:0009143 108 0.010
development of primary sexual characteristics GO:0045137 50 0.010
regulation of cell morphogenesis GO:0022604 163 0.010
positive regulation of intracellular signal transduction GO:1902533 116 0.010
actin filament organization GO:0007015 126 0.010
somatic muscle development GO:0007525 66 0.010
ribonucleoside triphosphate metabolic process GO:0009199 119 0.010
cation transport GO:0006812 110 0.010
positive regulation of phosphorus metabolic process GO:0010562 139 0.010
cellular metal ion homeostasis GO:0006875 31 0.010
positive regulation of catabolic process GO:0009896 105 0.010
mitotic nuclear division GO:0007067 213 0.010
macroautophagy GO:0016236 42 0.010
protein import GO:0017038 55 0.010
heterocycle catabolic process GO:0046700 166 0.010
pigment biosynthetic process GO:0046148 36 0.010
cellular response to oxygen containing compound GO:1901701 79 0.010
regulation of mapk cascade GO:0043408 92 0.010

Keap1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
vascular disease DOID:178 0 0.052
cardiovascular system disease DOID:1287 0 0.052
nervous system disease DOID:863 0 0.018
disease of metabolism DOID:0014667 0 0.012
inherited metabolic disorder DOID:655 0 0.012