Drosophila melanogaster

37 known processes

PR2 (Dmel_CG3969)

Fak-like tyrosine kinase

(Aliases: Rp2,DPR2,DRODPR2,dACK,Dmel\CG3969,PR2/ACK,DmHD-11,HD-11,CG3969)

PR2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification process GO:0036211 438 0.095
Fly
cellular protein modification process GO:0006464 438 0.068
Fly
positive regulation of signal transduction GO:0009967 223 0.065
protein modification by small protein conjugation or removal GO:0070647 106 0.065
sensory organ morphogenesis GO:0090596 260 0.062
regulation of multicellular organismal development GO:2000026 414 0.061
positive regulation of signaling GO:0023056 243 0.057
positive regulation of response to stimulus GO:0048584 323 0.053
positive regulation of cell communication GO:0010647 250 0.050
male gamete generation GO:0048232 201 0.046
Fly
organic substance catabolic process GO:1901575 308 0.045
regulation of hydrolase activity GO:0051336 97 0.042
respiratory system development GO:0060541 213 0.042
dna metabolic process GO:0006259 227 0.041
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.040
appendage development GO:0048736 401 0.040
regulation of catabolic process GO:0009894 170 0.039
chromosome organization GO:0051276 360 0.039
cell motility GO:0048870 251 0.037
cell migration GO:0016477 238 0.036
homeostatic process GO:0042592 199 0.036
imaginal disc derived appendage development GO:0048737 399 0.036
catabolic process GO:0009056 409 0.036
regulation of catalytic activity GO:0050790 185 0.036
ras protein signal transduction GO:0007265 88 0.035
proteolysis GO:0006508 192 0.035
regulation of phosphate metabolic process GO:0019220 210 0.035
purine nucleotide metabolic process GO:0006163 146 0.034
response to abiotic stimulus GO:0009628 341 0.034
positive regulation of macromolecule metabolic process GO:0010604 405 0.034
regulation of cellular catabolic process GO:0031329 157 0.033
organonitrogen compound metabolic process GO:1901564 318 0.033
eye morphogenesis GO:0048592 260 0.032
cell cell signaling involved in cell fate commitment GO:0045168 210 0.032
small molecule metabolic process GO:0044281 305 0.032
nuclear division GO:0000280 332 0.032
cellular catabolic process GO:0044248 372 0.032
organelle fission GO:0048285 340 0.031
negative regulation of biosynthetic process GO:0009890 277 0.031
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.031
mitotic nuclear division GO:0007067 213 0.031
positive regulation of hydrolase activity GO:0051345 78 0.031
positive regulation of developmental process GO:0051094 143 0.031
heterocycle catabolic process GO:0046700 166 0.030
aromatic compound catabolic process GO:0019439 166 0.030
protein ubiquitination GO:0016567 70 0.030
positive regulation of catalytic activity GO:0043085 118 0.030
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.030
lateral inhibition GO:0046331 206 0.029
intracellular signal transduction GO:0035556 300 0.029
regulation of molecular function GO:0065009 217 0.029
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.029
positive regulation of catabolic process GO:0009896 105 0.029
compound eye morphogenesis GO:0001745 249 0.028
positive regulation of cellular biosynthetic process GO:0031328 316 0.028
protein processing GO:0016485 68 0.028
regulation of cellular protein metabolic process GO:0032268 243 0.028
appendage morphogenesis GO:0035107 397 0.027
photoreceptor cell differentiation GO:0046530 170 0.027
death GO:0016265 284 0.027
regulation of immune system process GO:0002682 176 0.027
epithelial cell development GO:0002064 274 0.026
cellular response to dna damage stimulus GO:0006974 223 0.026
regulation of protein metabolic process GO:0051246 256 0.026
embryonic morphogenesis GO:0048598 206 0.026
Fly
regulation of cell morphogenesis GO:0022604 163 0.026
eye development GO:0001654 323 0.026
regulation of intracellular signal transduction GO:1902531 236 0.025
regulation of cellular component biogenesis GO:0044087 201 0.025
gtp catabolic process GO:0006184 72 0.025
regulation of anatomical structure morphogenesis GO:0022603 242 0.025
developmental growth GO:0048589 280 0.025
chemotaxis GO:0006935 249 0.024
organic cyclic compound catabolic process GO:1901361 168 0.024
nucleoside catabolic process GO:0009164 112 0.024
modification dependent macromolecule catabolic process GO:0043632 79 0.024
immune system process GO:0002376 347 0.024
mitotic spindle organization GO:0007052 220 0.024
spermatogenesis GO:0007283 200 0.023
Fly
post embryonic appendage morphogenesis GO:0035120 385 0.023
negative regulation of developmental process GO:0051093 201 0.023
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.023
ribose phosphate metabolic process GO:0019693 145 0.023
negative regulation of response to stimulus GO:0048585 258 0.023
single organism catabolic process GO:0044712 228 0.023
small gtpase mediated signal transduction GO:0007264 88 0.023
imaginal disc derived wing morphogenesis GO:0007476 337 0.023
localization of cell GO:0051674 257 0.023
ribonucleotide metabolic process GO:0009259 145 0.023
negative regulation of cellular metabolic process GO:0031324 382 0.022
regulation of gene expression epigenetic GO:0040029 128 0.022
macromolecule catabolic process GO:0009057 161 0.022
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.022
wing disc morphogenesis GO:0007472 344 0.022
compound eye development GO:0048749 307 0.022
purine ribonucleoside metabolic process GO:0046128 127 0.021
guanosine containing compound metabolic process GO:1901068 74 0.021
regulation of cellular ketone metabolic process GO:0010565 3 0.021
regulation of cellular amine metabolic process GO:0033238 3 0.021
cellular amino acid metabolic process GO:0006520 61 0.021
purine ribonucleotide metabolic process GO:0009150 145 0.021
kidney development GO:0001822 3 0.021
regulation of apoptotic process GO:0042981 130 0.021
Fly
imaginal disc derived appendage morphogenesis GO:0035114 395 0.020
neurological system process GO:0050877 358 0.020
negative regulation of transcription dna templated GO:0045892 237 0.020
nucleoside metabolic process GO:0009116 127 0.020
regulation of localization GO:0032879 275 0.020
transcription from rna polymerase ii promoter GO:0006366 368 0.020
chromatin organization GO:0006325 207 0.020
positive regulation of gene expression GO:0010628 290 0.020
positive regulation of nucleoside metabolic process GO:0045979 47 0.020
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.020
positive regulation of molecular function GO:0044093 136 0.020
glycosyl compound metabolic process GO:1901657 127 0.020
cellular macromolecule catabolic process GO:0044265 136 0.020
positive regulation of gtpase activity GO:0043547 43 0.020
body morphogenesis GO:0010171 2 0.020
ubiquitin dependent protein catabolic process GO:0006511 78 0.020
guanosine containing compound catabolic process GO:1901069 74 0.019
axon guidance GO:0007411 233 0.019
response to organic substance GO:0010033 284 0.019
purine containing compound metabolic process GO:0072521 155 0.019
regulation of programmed cell death GO:0043067 152 0.019
Fly
regulation of cell differentiation GO:0045595 302 0.019
protein catabolic process GO:0030163 101 0.019
tissue morphogenesis GO:0048729 297 0.019
Fly
protein maturation GO:0051604 71 0.019
tube development GO:0035295 244 0.019
regulation of cell development GO:0060284 215 0.019
protein localization GO:0008104 284 0.018
Fly
axis specification GO:0009798 167 0.018
oxoacid metabolic process GO:0043436 103 0.018
developmental maturation GO:0021700 172 0.018
axonogenesis GO:0007409 290 0.018
nucleobase containing compound catabolic process GO:0034655 165 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.018
axon development GO:0061564 297 0.018
regulation of phosphorus metabolic process GO:0051174 210 0.018
negative regulation of cellular biosynthetic process GO:0031327 277 0.018
negative regulation of multicellular organismal process GO:0051241 142 0.018
carboxylic acid metabolic process GO:0019752 92 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.018
compound eye photoreceptor cell differentiation GO:0001751 140 0.018
carbohydrate derivative metabolic process GO:1901135 217 0.018
positive regulation of ras gtpase activity GO:0032320 36 0.018
taxis GO:0042330 304 0.018
ribonucleoside catabolic process GO:0042454 112 0.017
organic acid metabolic process GO:0006082 103 0.017
phagocytosis GO:0006909 215 0.017
wnt signaling pathway GO:0016055 98 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.017
single organism behavior GO:0044708 391 0.017
protein modification by small protein conjugation GO:0032446 79 0.017
ribonucleoside metabolic process GO:0009119 127 0.017
response to external biotic stimulus GO:0043207 293 0.017
organonitrogen compound catabolic process GO:1901565 128 0.017
positive regulation of rna biosynthetic process GO:1902680 266 0.017
anterior posterior pattern specification GO:0009952 136 0.017
sister chromatid segregation GO:0000819 92 0.017
head development GO:0060322 135 0.017
positive regulation of gtp catabolic process GO:0033126 43 0.017
gland development GO:0048732 191 0.017
positive regulation of biosynthetic process GO:0009891 316 0.016
nucleoside phosphate metabolic process GO:0006753 162 0.016
regulation of cell death GO:0010941 173 0.016
Fly
purine nucleoside triphosphate metabolic process GO:0009144 119 0.016
positive regulation of phosphorus metabolic process GO:0010562 139 0.016
carbohydrate derivative catabolic process GO:1901136 118 0.016
segmentation GO:0035282 207 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
gtp metabolic process GO:0046039 72 0.016
regionalization GO:0003002 416 0.016
spindle organization GO:0007051 253 0.016
cell death GO:0008219 279 0.016
single organism cellular localization GO:1902580 180 0.016
protein transport GO:0015031 155 0.016
cell projection assembly GO:0030031 94 0.016
nucleotide metabolic process GO:0009117 161 0.016
golgi organization GO:0007030 66 0.016
negative regulation of nucleic acid templated transcription GO:1903507 240 0.016
regulation of gtp catabolic process GO:0033124 44 0.015
exocrine system development GO:0035272 162 0.015
purine containing compound catabolic process GO:0072523 112 0.015
salivary gland morphogenesis GO:0007435 145 0.015
regulation of response to stress GO:0080134 200 0.015
morphogenesis of an epithelium GO:0002009 276 0.015
Fly
neuron projection guidance GO:0097485 241 0.015
positive regulation of intracellular signal transduction GO:1902533 116 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
ribonucleotide catabolic process GO:0009261 109 0.015
ribonucleoside triphosphate catabolic process GO:0009203 108 0.015
ribonucleoside triphosphate metabolic process GO:0009199 119 0.015
response to endogenous stimulus GO:0009719 119 0.015
positive regulation of cellular catabolic process GO:0031331 95 0.015
negative regulation of rna biosynthetic process GO:1902679 240 0.015
cell division GO:0051301 248 0.015
cellular nitrogen compound catabolic process GO:0044270 165 0.015
nucleoside triphosphate catabolic process GO:0009143 108 0.015
gene silencing GO:0016458 138 0.015
purine ribonucleotide catabolic process GO:0009154 109 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.015
posttranscriptional regulation of gene expression GO:0010608 145 0.015
response to lipopolysaccharide GO:0032496 4 0.015
negative regulation of signal transduction GO:0009968 206 0.015
synapse organization GO:0050808 196 0.015
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
protein phosphorylation GO:0006468 169 0.014
Fly
organophosphate metabolic process GO:0019637 195 0.014
regulation of notch signaling pathway GO:0008593 100 0.014
regulation of developmental growth GO:0048638 174 0.014
establishment of localization in cell GO:0051649 402 0.014
cellular amine metabolic process GO:0044106 12 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.014
anatomical structure homeostasis GO:0060249 97 0.014
tissue death GO:0016271 102 0.014
jak stat cascade GO:0007259 49 0.014
negative regulation of immune system process GO:0002683 50 0.014
endomembrane system organization GO:0010256 119 0.014
regulation of cell cycle process GO:0010564 181 0.014
regulation of cell proliferation GO:0042127 163 0.014
negative regulation of gene expression GO:0010629 387 0.014
developmental programmed cell death GO:0010623 138 0.014
regulation of purine nucleotide catabolic process GO:0033121 48 0.014
epithelial cell differentiation GO:0030855 322 0.014
regulation of small gtpase mediated signal transduction GO:0051056 93 0.014
positive regulation of nucleic acid templated transcription GO:1903508 266 0.014
cellular protein localization GO:0034613 160 0.014
Fly
chromosome segregation GO:0007059 157 0.014
regulation of nucleotide metabolic process GO:0006140 62 0.014
immune response GO:0006955 246 0.014
programmed cell death GO:0012501 257 0.014
macromolecular complex assembly GO:0065003 256 0.014
cytoskeleton dependent cytokinesis GO:0061640 81 0.014
response to organophosphorus GO:0046683 2 0.013
negative regulation of signaling GO:0023057 219 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
nucleoside triphosphate metabolic process GO:0009141 120 0.013
wound healing GO:0042060 75 0.013
nucleoside phosphate catabolic process GO:1901292 110 0.013
response to wounding GO:0009611 94 0.013
positive regulation of phosphate metabolic process GO:0045937 139 0.013
enzyme linked receptor protein signaling pathway GO:0007167 179 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.013
autophagic cell death GO:0048102 83 0.013
mating GO:0007618 120 0.013
photoreceptor cell development GO:0042461 96 0.013
regulation of defense response GO:0031347 102 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
glycosyl compound catabolic process GO:1901658 112 0.013
regulation of ras protein signal transduction GO:0046578 93 0.013
defense response to other organism GO:0098542 225 0.013
camera type eye morphogenesis GO:0048593 2 0.013
negative regulation of rna metabolic process GO:0051253 251 0.013
eye photoreceptor cell differentiation GO:0001754 145 0.013
regulation of synapse organization GO:0050807 110 0.013
regulation of immune response GO:0050776 118 0.013
mushroom body development GO:0016319 70 0.013
establishment of protein localization GO:0045184 163 0.013
response to bacterium GO:0009617 198 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
amine metabolic process GO:0009308 12 0.012
purine nucleoside triphosphate catabolic process GO:0009146 108 0.012
determination of adult lifespan GO:0008340 137 0.012
modification dependent protein catabolic process GO:0019941 78 0.012
regulation of purine nucleotide metabolic process GO:1900542 62 0.012
innate immune response GO:0045087 144 0.012
mitotic sister chromatid segregation GO:0000070 87 0.012
cell proliferation GO:0008283 299 0.012
cellular protein catabolic process GO:0044257 83 0.012
instar larval development GO:0002168 55 0.012
embryonic pattern specification GO:0009880 174 0.012
centrosome cycle GO:0007098 137 0.012
positive regulation of endopeptidase activity GO:0010950 26 0.012
connective tissue development GO:0061448 3 0.012
synapse assembly GO:0007416 143 0.012
endocytosis GO:0006897 310 0.012
actin filament organization GO:0007015 126 0.012
negative regulation of cell communication GO:0010648 223 0.012
cellular ketone metabolic process GO:0042180 24 0.012
covalent chromatin modification GO:0016569 106 0.012
positive regulation of cell migration GO:0030335 2 0.012
protein complex biogenesis GO:0070271 201 0.012
open tracheal system development GO:0007424 204 0.012
methylation GO:0032259 47 0.012
tube morphogenesis GO:0035239 191 0.011
telencephalon development GO:0021537 2 0.011
spermatid differentiation GO:0048515 114 0.011
Fly
gland morphogenesis GO:0022612 145 0.011
protein complex assembly GO:0006461 200 0.011
imaginal disc derived leg morphogenesis GO:0007480 80 0.011
growth GO:0040007 359 0.011
positive regulation of multicellular organismal process GO:0051240 143 0.011
defense response to bacterium GO:0042742 178 0.011
negative regulation of protein metabolic process GO:0051248 85 0.011
peptidyl amino acid modification GO:0018193 105 0.011
Fly
response to biotic stimulus GO:0009607 294 0.011
columnar cuboidal epithelial cell development GO:0002066 249 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
single organism intracellular transport GO:1902582 207 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
regulation of cell shape GO:0008360 113 0.011
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.011
positive regulation of nucleotide metabolic process GO:0045981 55 0.011
regulation of wnt signaling pathway GO:0030111 68 0.011
regulation of nucleoside metabolic process GO:0009118 50 0.011
organic substance transport GO:0071702 257 0.011
regulation of mapk cascade GO:0043408 92 0.011
positive regulation of cell death GO:0010942 69 0.011
organophosphate catabolic process GO:0046434 112 0.011
vesicle mediated transport GO:0016192 381 0.011
response to oxygen containing compound GO:1901700 200 0.011
regulation of nucleotide catabolic process GO:0030811 48 0.011
chromosome separation GO:0051304 42 0.011
positive regulation of cell motility GO:2000147 3 0.011
regulation of synapse structure and activity GO:0050803 128 0.011
positive regulation of nucleotide catabolic process GO:0030813 46 0.011
nucleotide catabolic process GO:0009166 109 0.011
microtubule organizing center organization GO:0031023 168 0.011
regulation of protein modification process GO:0031399 112 0.011
response to other organism GO:0051707 293 0.011
salivary gland cell autophagic cell death GO:0035071 83 0.011
regulation of gtpase activity GO:0043087 44 0.010
regulation of organelle organization GO:0033043 196 0.010
cell maturation GO:0048469 144 0.010
organonitrogen compound biosynthetic process GO:1901566 117 0.010
intracellular protein transport GO:0006886 104 0.010
dendrite morphogenesis GO:0048813 199 0.010
regulation of protein catabolic process GO:0042176 55 0.010
peptidyl threonine modification GO:0018210 3 0.010
regulation of embryonic development GO:0045995 68 0.010
single organism biosynthetic process GO:0044711 206 0.010
purine nucleotide catabolic process GO:0006195 109 0.010
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.010
histone modification GO:0016570 106 0.010
response to organic cyclic compound GO:0014070 89 0.010
positive regulation of transcription dna templated GO:0045893 266 0.010
maternal determination of anterior posterior axis embryo GO:0008358 74 0.010
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.010
negative regulation of cell cycle process GO:0010948 109 0.010
tripartite regional subdivision GO:0007351 103 0.010

PR2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.033
nervous system disease DOID:863 0 0.016
cancer DOID:162 0 0.010
disease of cellular proliferation DOID:14566 0 0.010
organ system cancer DOID:0050686 0 0.010