Drosophila melanogaster

174 known processes

Doa (Dmel_CG42320)

Darkener of apricot

(Aliases: Dmel\CG42320,Dmel_CG33204,Dmel_CG33553,CG33204,Msu,DOA,CG42320,doa,CG33553,CG31049,DOA/CLK2,l(3)01705,CG1658)

Doa biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
wing disc morphogenesis GO:0007472 344 0.766
negative regulation of cell cycle GO:0045786 116 0.542
imaginal disc derived wing morphogenesis GO:0007476 337 0.471
death GO:0016265 284 0.406
imaginal disc derived appendage morphogenesis GO:0035114 395 0.355
positive regulation of developmental process GO:0051094 143 0.291
modification dependent protein catabolic process GO:0019941 78 0.216
negative regulation of meiotic cell cycle GO:0051447 2 0.204
cell death GO:0008219 279 0.200
ubiquitin dependent protein catabolic process GO:0006511 78 0.186
modification dependent macromolecule catabolic process GO:0043632 79 0.172
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.156
negative regulation of rna metabolic process GO:0051253 251 0.154
taxis GO:0042330 304 0.148
ion transport GO:0006811 145 0.148
regulation of cellular protein catabolic process GO:1903362 44 0.143
immune system process GO:0002376 347 0.143
appendage development GO:0048736 401 0.141
heart process GO:0003015 37 0.134
apoptotic process GO:0006915 159 0.132
regulation of phosphate metabolic process GO:0019220 210 0.132
bmp signaling pathway GO:0030509 27 0.126
imaginal disc pattern formation GO:0007447 91 0.121
regulation of cell cycle GO:0051726 291 0.118
regulation of cellular catabolic process GO:0031329 157 0.118
programmed cell death GO:0012501 257 0.116
cell recognition GO:0008037 102 0.111
meiotic cell cycle process GO:1903046 132 0.109
negative regulation of cell proliferation GO:0008285 69 0.108
negative regulation of response to stimulus GO:0048585 258 0.106
organic substance transport GO:0071702 257 0.102
negative regulation of gene expression GO:0010629 387 0.097
negative regulation of protein metabolic process GO:0051248 85 0.092
regulation of programmed cell death GO:0043067 152 0.090
oocyte axis specification GO:0007309 108 0.089
regulation of protein catabolic process GO:0042176 55 0.089
regulation of phosphorus metabolic process GO:0051174 210 0.082
regulation of cell proliferation GO:0042127 163 0.081
peptidyl amino acid modification GO:0018193 105 0.079
kidney development GO:0001822 3 0.078
cellular catabolic process GO:0044248 372 0.078
regulation of protein metabolic process GO:0051246 256 0.076
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.076
regulation of catabolic process GO:0009894 170 0.076
regulation of molecular function GO:0065009 217 0.074
cellular response to organic substance GO:0071310 132 0.074
negative regulation of cellular protein metabolic process GO:0032269 85 0.073
protein maturation GO:0051604 71 0.072
appendage morphogenesis GO:0035107 397 0.072
negative regulation of transcription dna templated GO:0045892 237 0.072
negative regulation of cellular metabolic process GO:0031324 382 0.069
response to bacterium GO:0009617 198 0.069
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.066
enzyme linked receptor protein signaling pathway GO:0007167 179 0.063
protein complex biogenesis GO:0070271 201 0.060
sex differentiation GO:0007548 81 0.060
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.059
protein modification by small protein conjugation GO:0032446 79 0.056
vesicle mediated transport GO:0016192 381 0.054
oocyte development GO:0048599 124 0.051
regulation of transferase activity GO:0051338 58 0.051
post embryonic appendage morphogenesis GO:0035120 385 0.050
macromolecule catabolic process GO:0009057 161 0.049
regulation of catalytic activity GO:0050790 185 0.049
regulation of growth GO:0040008 233 0.049
defense response GO:0006952 300 0.049
ectodermal placode morphogenesis GO:0071697 4 0.049
regulation of proteolysis GO:0030162 87 0.048
regulation of anatomical structure size GO:0090066 163 0.048
organelle fusion GO:0048284 46 0.046
negative regulation of cellular catabolic process GO:0031330 34 0.046
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.046
regulation of cell death GO:0010941 173 0.046
growth GO:0040007 359 0.046
cell maturation GO:0048469 144 0.046
negative regulation of signal transduction GO:0009968 206 0.045
regulation of response to stress GO:0080134 200 0.045
positive regulation of multicellular organismal process GO:0051240 143 0.044
regionalization GO:0003002 416 0.043
positive regulation of programmed cell death GO:0043068 62 0.043
determination of dorsal ventral asymmetry GO:0048262 3 0.042
chemical homeostasis GO:0048878 92 0.041
negative regulation of cell communication GO:0010648 223 0.039
endocytosis GO:0006897 310 0.037
imaginal disc derived wing vein specification GO:0007474 48 0.037
regulation of apoptotic process GO:0042981 130 0.037
oocyte differentiation GO:0009994 145 0.036
cytokinesis GO:0000910 90 0.036
negative regulation of cellular biosynthetic process GO:0031327 277 0.034
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.033
cellular macromolecule catabolic process GO:0044265 136 0.033
small molecule metabolic process GO:0044281 305 0.032
sensory organ morphogenesis GO:0090596 260 0.032
protein processing GO:0016485 68 0.031
cellular response to abiotic stimulus GO:0071214 58 0.030
protein modification by small protein conjugation or removal GO:0070647 106 0.029
regulation of cellular protein metabolic process GO:0032268 243 0.029
ectodermal placode development GO:0071696 4 0.029
regulation of cellular component movement GO:0051270 42 0.028
sex determination GO:0007530 18 0.028
secretion by cell GO:0032940 101 0.028
neuron projection guidance GO:0097485 241 0.027
regulation of immune response GO:0050776 118 0.027
regulation of transport GO:0051049 181 0.027
amine metabolic process GO:0009308 12 0.026
cellular protein modification process GO:0006464 438 0.026
negative regulation of molecular function GO:0044092 51 0.026
protein secretion GO:0009306 45 0.026
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 17 0.025
positive regulation of phosphorus metabolic process GO:0010562 139 0.025
regulation of kinase activity GO:0043549 53 0.024
larval midgut histolysis GO:0035069 22 0.023
positive regulation of cell differentiation GO:0045597 64 0.023
negative regulation of biosynthetic process GO:0009890 277 0.022
lipid localization GO:0010876 54 0.022
regulation of proteasomal protein catabolic process GO:0061136 39 0.022
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
single organism membrane fusion GO:0044801 42 0.021
male gamete generation GO:0048232 201 0.021
organic substance catabolic process GO:1901575 308 0.021
segmentation GO:0035282 207 0.021
sperm individualization GO:0007291 48 0.021
determination of ventral identity GO:0048264 1 0.021
cellular response to gamma radiation GO:0071480 10 0.021
positive regulation of nervous system development GO:0051962 69 0.020
multicellular organismal aging GO:0010259 140 0.020
response to alcohol GO:0097305 95 0.020
regulation of protein modification process GO:0031399 112 0.020
muscle system process GO:0003012 21 0.020
ommochrome biosynthetic process GO:0006727 19 0.019
positive regulation of execution phase of apoptosis GO:1900119 4 0.019
transition metal ion homeostasis GO:0055076 17 0.019
cell division GO:0051301 248 0.019
epithelial cell development GO:0002064 274 0.019
cellular macromolecule localization GO:0070727 220 0.018
determination of adult lifespan GO:0008340 137 0.018
tripartite regional subdivision GO:0007351 103 0.018
protein phosphorylation GO:0006468 169 0.018
activation of cysteine type endopeptidase activity GO:0097202 17 0.018
protein heterooligomerization GO:0051291 4 0.018
cellular protein catabolic process GO:0044257 83 0.018
leg disc development GO:0035218 92 0.018
cellular response to mechanical stimulus GO:0071260 2 0.018
response to biotic stimulus GO:0009607 294 0.017
positive regulation of signal transduction GO:0009967 223 0.017
larval development GO:0002164 104 0.017
cell proliferation GO:0008283 299 0.017
regulation of localization GO:0032879 275 0.017
regulation of autophagy GO:0010506 62 0.017
negative regulation of cell differentiation GO:0045596 143 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.016
ectodermal placode formation GO:0060788 4 0.016
cellular amine metabolic process GO:0044106 12 0.016
stress activated protein kinase signaling cascade GO:0031098 55 0.016
positive regulation of biosynthetic process GO:0009891 316 0.015
oocyte construction GO:0007308 112 0.015
maintenance of location GO:0051235 73 0.015
anterior posterior axis specification embryo GO:0008595 103 0.015
regulation of nuclear division GO:0051783 58 0.015
jnk cascade GO:0007254 50 0.015
proteolysis GO:0006508 192 0.014
regulation of cell division GO:0051302 72 0.014
signal release GO:0023061 49 0.014
homeostatic process GO:0042592 199 0.014
regulation of endopeptidase activity GO:0052548 36 0.013
negative regulation of catalytic activity GO:0043086 42 0.013
response to other organism GO:0051707 293 0.013
regulation of mitosis GO:0007088 56 0.013
regulation of cell differentiation GO:0045595 302 0.013
covalent chromatin modification GO:0016569 106 0.013
negative regulation of immune system process GO:0002683 50 0.013
positive regulation of protein metabolic process GO:0051247 128 0.013
response to decreased oxygen levels GO:0036293 58 0.013
positive regulation of transcription dna templated GO:0045893 266 0.013
axon development GO:0061564 297 0.012
compound eye morphogenesis GO:0001745 249 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.012
regulation of phosphatase activity GO:0010921 3 0.012
regulation of protein maturation GO:1903317 32 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.012
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.012
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.012
negative regulation of intracellular signal transduction GO:1902532 57 0.011
spermatogenesis GO:0007283 200 0.011
regulation of erbb signaling pathway GO:1901184 42 0.011
developmental maturation GO:0021700 172 0.011
connective tissue development GO:0061448 3 0.011
reproductive structure development GO:0048608 74 0.011
immune response GO:0006955 246 0.011
centrosome duplication GO:0051298 121 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
regulation of secretion by cell GO:1903530 39 0.011
positive regulation of apoptotic process GO:0043065 47 0.011
regulation of phosphorylation GO:0042325 147 0.010
regulation of cellular response to stress GO:0080135 89 0.010
transcription from rna polymerase ii promoter GO:0006366 368 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.010
spermatid differentiation GO:0048515 114 0.010
positive regulation of catabolic process GO:0009896 105 0.010
negative regulation of catabolic process GO:0009895 36 0.010

Doa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
renal tubular transport disease DOID:447 0 0.153
bartter disease DOID:445 0 0.153
kidney disease DOID:557 0 0.153
disease of anatomical entity DOID:7 0 0.153
urinary system disease DOID:18 0 0.153
cancer DOID:162 0 0.021
disease of cellular proliferation DOID:14566 0 0.021
auditory system disease DOID:2742 0 0.019
sensory system disease DOID:0050155 0 0.019
nervous system disease DOID:863 0 0.019
organ system cancer DOID:0050686 0 0.013
central nervous system disease DOID:331 0 0.013