Drosophila melanogaster

86 known processes

Npc2a (Dmel_CG7291)

Niemann-Pick type C-2a

(Aliases: BcDNA:GH22047,DmML3,CT22505,NPC2,dnpc2a,CG7291,BEST:GH08376,Dmel\CG7291,npc2a,BcDNA:RH53228)

Npc2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
pigment metabolic process involved in pigmentation GO:0043474 33 0.100
neurological system process GO:0050877 358 0.092
establishment of localization in cell GO:0051649 402 0.080
single organism intracellular transport GO:1902582 207 0.078
ion transport GO:0006811 145 0.071
intracellular transport GO:0046907 228 0.068
post embryonic appendage morphogenesis GO:0035120 385 0.066
organonitrogen compound metabolic process GO:1901564 318 0.065
appendage development GO:0048736 401 0.064
pigmentation GO:0043473 75 0.062
organonitrogen compound biosynthetic process GO:1901566 117 0.062
developmental pigmentation GO:0048066 68 0.062
response to abiotic stimulus GO:0009628 341 0.059
wing disc morphogenesis GO:0007472 344 0.057
small molecule metabolic process GO:0044281 305 0.054
imaginal disc derived appendage development GO:0048737 399 0.052
catabolic process GO:0009056 409 0.052
response to organic substance GO:0010033 284 0.051
eye pigment biosynthetic process GO:0006726 32 0.049
imaginal disc derived appendage morphogenesis GO:0035114 395 0.049
appendage morphogenesis GO:0035107 397 0.047
vesicle mediated transport GO:0016192 381 0.046
single organism catabolic process GO:0044712 228 0.046
single organism biosynthetic process GO:0044711 206 0.045
pigment metabolic process involved in developmental pigmentation GO:0043324 33 0.043
oxoacid metabolic process GO:0043436 103 0.041
imaginal disc derived wing morphogenesis GO:0007476 337 0.040
regulation of catabolic process GO:0009894 170 0.039
exocrine system development GO:0035272 162 0.039
homeostatic process GO:0042592 199 0.038
cellular catabolic process GO:0044248 372 0.038
pigment metabolic process GO:0042440 84 0.038
organic substance transport GO:0071702 257 0.037
tube morphogenesis GO:0035239 191 0.037
eye pigment metabolic process GO:0042441 33 0.037
tissue death GO:0016271 102 0.036
eye pigmentation GO:0048069 43 0.036
macromolecular complex assembly GO:0065003 256 0.035
regulation of protein metabolic process GO:0051246 256 0.035
determination of adult lifespan GO:0008340 137 0.034
peptide metabolic process GO:0006518 80 0.034
regulation of localization GO:0032879 275 0.034
cellular homeostasis GO:0019725 80 0.034
organic acid metabolic process GO:0006082 103 0.033
salivary gland development GO:0007431 162 0.033
carboxylic acid metabolic process GO:0019752 92 0.032
cytoplasmic transport GO:0016482 130 0.032
histolysis GO:0007559 102 0.032
organic substance catabolic process GO:1901575 308 0.031
organelle fission GO:0048285 340 0.031
protein complex assembly GO:0006461 200 0.031
organophosphate metabolic process GO:0019637 195 0.030
cell migration GO:0016477 238 0.029
death GO:0016265 284 0.029
single organism behavior GO:0044708 391 0.029
response to biotic stimulus GO:0009607 294 0.027
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.027
cellular amino acid metabolic process GO:0006520 61 0.027
cation homeostasis GO:0055080 51 0.027
regulation of multicellular organismal development GO:2000026 414 0.027
developmental maturation GO:0021700 172 0.027
gland morphogenesis GO:0022612 145 0.026
salivary gland histolysis GO:0035070 88 0.026
embryonic morphogenesis GO:0048598 206 0.026
regulation of cellular protein metabolic process GO:0032268 243 0.026
multicellular organismal aging GO:0010259 140 0.026
glycosyl compound metabolic process GO:1901657 127 0.026
proteolysis GO:0006508 192 0.026
epithelial cell development GO:0002064 274 0.026
negative regulation of gene expression GO:0010629 387 0.026
protein localization GO:0008104 284 0.026
synaptic transmission GO:0007268 288 0.026
cognition GO:0050890 141 0.025
digestive tract morphogenesis GO:0048546 127 0.024
developmental programmed cell death GO:0010623 138 0.024
programmed cell death GO:0012501 257 0.024
autophagic cell death GO:0048102 83 0.024
epithelial cell differentiation GO:0030855 322 0.024
regulation of anatomical structure morphogenesis GO:0022603 242 0.024
pigment biosynthetic process GO:0046148 36 0.024
morphogenesis of an epithelium GO:0002009 276 0.024
salivary gland cell autophagic cell death GO:0035071 83 0.024
cell death GO:0008219 279 0.023
response to light stimulus GO:0009416 124 0.023
membrane organization GO:0061024 112 0.023
gland development GO:0048732 191 0.023
camera type eye development GO:0043010 4 0.023
endocytosis GO:0006897 310 0.023
regulation of cell morphogenesis GO:0022604 163 0.022
columnar cuboidal epithelial cell development GO:0002066 249 0.022
cell adhesion GO:0007155 136 0.022
regulation of cellular localization GO:0060341 136 0.022
positive regulation of response to stimulus GO:0048584 323 0.021
sulfur compound metabolic process GO:0006790 59 0.021
purine ribonucleoside metabolic process GO:0046128 127 0.021
regulation of cellular catabolic process GO:0031329 157 0.021
tissue morphogenesis GO:0048729 297 0.021
response to oxygen containing compound GO:1901700 200 0.021
ras protein signal transduction GO:0007265 88 0.021
protein transport GO:0015031 155 0.020
aging GO:0007568 143 0.020
response to other organism GO:0051707 293 0.020
single organism cellular localization GO:1902580 180 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
amine metabolic process GO:0009308 12 0.020
response to endogenous stimulus GO:0009719 119 0.020
developmental growth GO:0048589 280 0.019
regulation of cell cycle GO:0051726 291 0.019
small gtpase mediated signal transduction GO:0007264 88 0.019
positive regulation of signal transduction GO:0009967 223 0.019
positive regulation of biosynthetic process GO:0009891 316 0.019
endomembrane system organization GO:0010256 119 0.019
glutathione metabolic process GO:0006749 37 0.019
positive regulation of signaling GO:0023056 243 0.019
cellular amine metabolic process GO:0044106 12 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.018
male gamete generation GO:0048232 201 0.018
protein modification process GO:0036211 438 0.018
localization of cell GO:0051674 257 0.018
organic hydroxy compound metabolic process GO:1901615 83 0.018
signal transduction by phosphorylation GO:0023014 107 0.017
purine nucleoside triphosphate catabolic process GO:0009146 108 0.017
defense response GO:0006952 300 0.017
intracellular signal transduction GO:0035556 300 0.017
cellular macromolecular complex assembly GO:0034622 153 0.017
regulation of hydrolase activity GO:0051336 97 0.017
cellular macromolecule localization GO:0070727 220 0.017
ribonucleoside metabolic process GO:0009119 127 0.017
sensory perception GO:0007600 196 0.017
cellular protein complex assembly GO:0043623 71 0.017
autophagy GO:0006914 108 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.017
regulation of catalytic activity GO:0050790 185 0.017
response to organic cyclic compound GO:0014070 89 0.017
positive regulation of macromolecule metabolic process GO:0010604 405 0.017
ameboidal type cell migration GO:0001667 151 0.017
phagocytosis GO:0006909 215 0.016
transmembrane transport GO:0055085 139 0.016
cellular amide metabolic process GO:0043603 80 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.016
response to external biotic stimulus GO:0043207 293 0.016
cellular response to nutrient levels GO:0031669 62 0.016
nuclear division GO:0000280 332 0.016
positive regulation of transport GO:0051050 92 0.016
embryo development ending in birth or egg hatching GO:0009792 152 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
spermatogenesis GO:0007283 200 0.015
regulation of intracellular transport GO:0032386 64 0.015
ovarian follicle cell development GO:0030707 248 0.015
heterocycle catabolic process GO:0046700 166 0.015
regulation of intracellular signal transduction GO:1902531 236 0.015
regulation of cell shape GO:0008360 113 0.015
cellular response to dna damage stimulus GO:0006974 223 0.015
positive regulation of cell communication GO:0010647 250 0.015
salivary gland morphogenesis GO:0007435 145 0.015
positive regulation of molecular function GO:0044093 136 0.015
regulation of nervous system development GO:0051960 248 0.015
organophosphate biosynthetic process GO:0090407 46 0.015
regulation of anatomical structure size GO:0090066 163 0.015
digestive system development GO:0055123 149 0.015
regulation of transport GO:0051049 181 0.015
cellular ketone metabolic process GO:0042180 24 0.015
intracellular protein transport GO:0006886 104 0.014
tube development GO:0035295 244 0.014
cellular component assembly involved in morphogenesis GO:0010927 151 0.014
single organism membrane organization GO:0044802 93 0.014
response to lipopolysaccharide GO:0032496 4 0.014
response to starvation GO:0042594 97 0.014
nucleobase containing compound catabolic process GO:0034655 165 0.014
ion transmembrane transport GO:0034220 122 0.014
negative regulation of protein metabolic process GO:0051248 85 0.014
long term memory GO:0007616 62 0.014
enzyme linked receptor protein signaling pathway GO:0007167 179 0.014
defense response to other organism GO:0098542 225 0.014
regulation of response to external stimulus GO:0032101 115 0.014
meiotic cell cycle GO:0051321 171 0.014
chemotaxis GO:0006935 249 0.014
response to radiation GO:0009314 155 0.014
cation transport GO:0006812 110 0.014
positive regulation of phosphorus metabolic process GO:0010562 139 0.014
endosomal transport GO:0016197 44 0.014
embryonic hindgut morphogenesis GO:0048619 48 0.014
regulation of molecular function GO:0065009 217 0.014
carbohydrate derivative metabolic process GO:1901135 217 0.014
guanosine containing compound catabolic process GO:1901069 74 0.014
regulation of cell differentiation GO:0045595 302 0.013
nucleobase containing small molecule metabolic process GO:0055086 174 0.013
forebrain development GO:0030900 2 0.013
cell proliferation GO:0008283 299 0.013
alcohol metabolic process GO:0006066 25 0.013
regulation of notch signaling pathway GO:0008593 100 0.013
biological adhesion GO:0022610 138 0.013
digestive tract development GO:0048565 149 0.013
body morphogenesis GO:0010171 2 0.013
protein complex biogenesis GO:0070271 201 0.013
response to organophosphorus GO:0046683 2 0.013
cellular response to chemical stimulus GO:0070887 199 0.013
ribonucleoside triphosphate metabolic process GO:0009199 119 0.013
negative regulation of rna metabolic process GO:0051253 251 0.013
divalent inorganic cation homeostasis GO:0072507 29 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
positive regulation of gene expression GO:0010628 290 0.013
regulation of cellular component size GO:0032535 98 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
immune system process GO:0002376 347 0.012
Fly
regulation of protein localization GO:0032880 76 0.012
cellular protein localization GO:0034613 160 0.012
regulation of cell development GO:0060284 215 0.012
macromolecule catabolic process GO:0009057 161 0.012
single organismal cell cell adhesion GO:0016337 45 0.012
ion homeostasis GO:0050801 55 0.012
locomotory behavior GO:0007626 176 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
vesicle organization GO:0016050 44 0.012
molting cycle chitin based cuticle GO:0007591 56 0.012
phosphorylation GO:0016310 294 0.012
nucleotide metabolic process GO:0009117 161 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
regulation of immune system process GO:0002682 176 0.012
response to nitrogen compound GO:1901698 90 0.012
ethanolamine containing compound metabolic process GO:0042439 4 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
cellular nitrogen compound catabolic process GO:0044270 165 0.012
positive regulation of cellular biosynthetic process GO:0031328 316 0.011
response to temperature stimulus GO:0009266 106 0.011
negative regulation of cellular metabolic process GO:0031324 382 0.011
transcription from rna polymerase ii promoter GO:0006366 368 0.011
negative regulation of signaling GO:0023057 219 0.011
cellular protein modification process GO:0006464 438 0.011
aromatic compound catabolic process GO:0019439 166 0.011
organic hydroxy compound catabolic process GO:1901616 4 0.011
ommochrome biosynthetic process GO:0006727 19 0.011
cellular ion homeostasis GO:0006873 39 0.011
regulation of cellular ketone metabolic process GO:0010565 3 0.011
response to nutrient levels GO:0031667 114 0.011
cellular chemical homeostasis GO:0055082 40 0.011
negative regulation of response to stimulus GO:0048585 258 0.011
meiotic cell cycle process GO:1903046 132 0.011
mushroom body development GO:0016319 70 0.011
learning or memory GO:0007611 141 0.011
gtp metabolic process GO:0046039 72 0.011
open tracheal system development GO:0007424 204 0.011
learning GO:0007612 75 0.011
mesenchymal cell development GO:0014031 1 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
response to organonitrogen compound GO:0010243 75 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
regulation of small gtpase mediated signal transduction GO:0051056 93 0.011
humoral immune response GO:0006959 117 0.011
Fly
establishment of protein localization GO:0045184 163 0.011
chromosome segregation GO:0007059 157 0.011
cellular response to starvation GO:0009267 61 0.010
cellular macromolecule catabolic process GO:0044265 136 0.010
cellular response to organic substance GO:0071310 132 0.010
response to heat GO:0009408 63 0.010
regulation of phosphate metabolic process GO:0019220 210 0.010
regulation of cellular component biogenesis GO:0044087 201 0.010
positive regulation of nucleic acid templated transcription GO:1903508 266 0.010
growth GO:0040007 359 0.010
associative learning GO:0008306 65 0.010
regulation of cell death GO:0010941 173 0.010
purine nucleotide metabolic process GO:0006163 146 0.010
epidermal growth factor receptor signaling pathway GO:0007173 58 0.010
regulation of establishment of protein localization GO:0070201 61 0.010
hindgut morphogenesis GO:0007442 58 0.010
positive regulation of cell migration GO:0030335 2 0.010
chemical homeostasis GO:0048878 92 0.010
olfactory learning GO:0008355 56 0.010
nucleotide catabolic process GO:0009166 109 0.010
renal tubule morphogenesis GO:0061333 44 0.010
synapse assembly GO:0007416 143 0.010
secretion GO:0046903 109 0.010
regulation of cell proliferation GO:0042127 163 0.010

Npc2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
nervous system disease DOID:863 0 0.015