Drosophila melanogaster

81 known processes

Gclm (Dmel_CG4919)

Glutamate-cysteine ligase modifier subunit

(Aliases: box,GCLm,Dmel\CG4919,4919,DmGCLM,DmGCSl,CG4919,GCSl,Gcsl)

Gclm biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cognition GO:0050890 141 0.247
learning or memory GO:0007611 141 0.235
neurological system process GO:0050877 358 0.223
memory GO:0007613 94 0.123
single organism behavior GO:0044708 391 0.115
carboxylic acid metabolic process GO:0019752 92 0.088
positive regulation of macromolecule metabolic process GO:0010604 405 0.080
learning GO:0007612 75 0.072
organic acid metabolic process GO:0006082 103 0.062
imaginal disc derived appendage morphogenesis GO:0035114 395 0.061
small molecule metabolic process GO:0044281 305 0.058
protein modification process GO:0036211 438 0.056
vesicle mediated transport GO:0016192 381 0.053
associative learning GO:0008306 65 0.048
cellular modified amino acid metabolic process GO:0006575 45 0.047
long term memory GO:0007616 62 0.047
regulation of catalytic activity GO:0050790 185 0.046
organic substance transport GO:0071702 257 0.045
negative regulation of cellular metabolic process GO:0031324 382 0.043
imaginal disc derived appendage development GO:0048737 399 0.042
post embryonic appendage morphogenesis GO:0035120 385 0.040
cell death GO:0008219 279 0.040
wing disc morphogenesis GO:0007472 344 0.040
single organism biosynthetic process GO:0044711 206 0.039
protein transport GO:0015031 155 0.039
olfactory learning GO:0008355 56 0.039
organonitrogen compound metabolic process GO:1901564 318 0.038
imaginal disc derived wing morphogenesis GO:0007476 337 0.038
cellular catabolic process GO:0044248 372 0.037
response to abiotic stimulus GO:0009628 341 0.037
organic substance catabolic process GO:1901575 308 0.036
regulation of protein metabolic process GO:0051246 256 0.034
appendage morphogenesis GO:0035107 397 0.034
olfactory behavior GO:0042048 97 0.034
organophosphate metabolic process GO:0019637 195 0.033
cellular protein localization GO:0034613 160 0.032
regulation of cellular protein metabolic process GO:0032268 243 0.031
cellular response to dna damage stimulus GO:0006974 223 0.031
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.030
programmed cell death GO:0012501 257 0.030
regulation of localization GO:0032879 275 0.029
eye development GO:0001654 323 0.029
regulation of phosphorus metabolic process GO:0051174 210 0.029
chromosome organization GO:0051276 360 0.029
carbohydrate derivative metabolic process GO:1901135 217 0.028
single organism catabolic process GO:0044712 228 0.028
nuclear division GO:0000280 332 0.028
regulation of molecular function GO:0065009 217 0.028
response to oxygen containing compound GO:1901700 200 0.027
localization of cell GO:0051674 257 0.027
appendage development GO:0048736 401 0.027
negative regulation of gene expression GO:0010629 387 0.027
ribose phosphate metabolic process GO:0019693 145 0.027
cellular response to chemical stimulus GO:0070887 199 0.026
cellular protein modification process GO:0006464 438 0.026
sulfur compound metabolic process GO:0006790 59 0.026
adult behavior GO:0030534 137 0.026
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.026
forebrain development GO:0030900 2 0.026
positive regulation of cell migration GO:0030335 2 0.025
cell proliferation GO:0008283 299 0.025
response to nutrient levels GO:0031667 114 0.025
regulation of cellular amine metabolic process GO:0033238 3 0.025
camera type eye development GO:0043010 4 0.024
body morphogenesis GO:0010171 2 0.024
organelle fission GO:0048285 340 0.024
positive regulation of response to stimulus GO:0048584 323 0.023
amine metabolic process GO:0009308 12 0.023
intracellular transport GO:0046907 228 0.023
chemosensory behavior GO:0007635 106 0.023
regulation of phosphate metabolic process GO:0019220 210 0.023
establishment of protein localization GO:0045184 163 0.022
regulation of cell death GO:0010941 173 0.022
taxis GO:0042330 304 0.022
embryo development ending in birth or egg hatching GO:0009792 152 0.022
establishment of localization in cell GO:0051649 402 0.022
negative regulation of response to stimulus GO:0048585 258 0.022
response to organic substance GO:0010033 284 0.022
epithelial cell differentiation GO:0030855 322 0.022
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
regulation of cellular catabolic process GO:0031329 157 0.022
tissue morphogenesis GO:0048729 297 0.022
wound healing GO:0042060 75 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
regulation of cell cycle GO:0051726 291 0.022
cytoplasmic transport GO:0016482 130 0.022
positive regulation of programmed cell death GO:0043068 62 0.021
pattern recognition receptor signaling pathway GO:0002221 2 0.021
glutathione metabolic process GO:0006749 37 0.021
cell cell signaling involved in cell fate commitment GO:0045168 210 0.021
oxoacid metabolic process GO:0043436 103 0.021
regulation of cellular ketone metabolic process GO:0010565 3 0.021
catabolic process GO:0009056 409 0.021
purine containing compound metabolic process GO:0072521 155 0.021
organonitrogen compound biosynthetic process GO:1901566 117 0.021
protein complex assembly GO:0006461 200 0.021
negative regulation of nucleic acid templated transcription GO:1903507 240 0.020
cellular amino acid metabolic process GO:0006520 61 0.020
cellular macromolecule localization GO:0070727 220 0.020
cellular amine metabolic process GO:0044106 12 0.020
regulation of apoptotic process GO:0042981 130 0.020
peptide metabolic process GO:0006518 80 0.020
response to external biotic stimulus GO:0043207 293 0.020
positive regulation of protein transport GO:0051222 37 0.020
positive regulation of cell death GO:0010942 69 0.020
response to lipopolysaccharide GO:0032496 4 0.019
regulation of protein modification process GO:0031399 112 0.019
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.019
protein localization GO:0008104 284 0.019
immune response regulating signaling pathway GO:0002764 2 0.019
ion transport GO:0006811 145 0.019
negative regulation of rna metabolic process GO:0051253 251 0.018
ras protein signal transduction GO:0007265 88 0.018
regulation of programmed cell death GO:0043067 152 0.018
endocytosis GO:0006897 310 0.018
retina development in camera type eye GO:0060041 4 0.018
proteolysis GO:0006508 192 0.018
rna processing GO:0006396 147 0.018
phosphorylation GO:0016310 294 0.018
behavioral response to ethanol GO:0048149 49 0.018
cellular protein catabolic process GO:0044257 83 0.018
apoptotic process GO:0006915 159 0.018
positive regulation of cell motility GO:2000147 3 0.018
positive regulation of cell communication GO:0010647 250 0.018
nucleoside triphosphate catabolic process GO:0009143 108 0.018
zymogen activation GO:0031638 20 0.018
negative regulation of cell communication GO:0010648 223 0.017
establishment or maintenance of cell polarity GO:0007163 167 0.017
nucleotide metabolic process GO:0009117 161 0.017
positive regulation of signaling GO:0023056 243 0.017
growth GO:0040007 359 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.017
cellular ketone metabolic process GO:0042180 24 0.017
phagocytosis GO:0006909 215 0.017
salivary gland development GO:0007431 162 0.017
protein modification by small protein conjugation GO:0032446 79 0.017
cell migration GO:0016477 238 0.017
regulation of phosphorylation GO:0042325 147 0.017
regionalization GO:0003002 416 0.017
protein modification by small protein conjugation or removal GO:0070647 106 0.017
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.017
developmental maturation GO:0021700 172 0.017
positive regulation of cellular protein metabolic process GO:0032270 118 0.016
cellular response to extracellular stimulus GO:0031668 64 0.016
response to biotic stimulus GO:0009607 294 0.016
gland development GO:0048732 191 0.016
intracellular signal transduction GO:0035556 300 0.016
positive regulation of defense response GO:0031349 59 0.016
response to glucose GO:0009749 2 0.016
positive regulation of catalytic activity GO:0043085 118 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.016
cellular macromolecule catabolic process GO:0044265 136 0.016
negative regulation of signal transduction GO:0009968 206 0.016
cellular response to molecule of bacterial origin GO:0071219 3 0.016
positive regulation of molecular function GO:0044093 136 0.016
steroid catabolic process GO:0006706 1 0.016
macromolecule catabolic process GO:0009057 161 0.016
regulation of response to stress GO:0080134 200 0.016
synapse organization GO:0050808 196 0.016
purine ribonucleotide metabolic process GO:0009150 145 0.016
regulation of cellular localization GO:0060341 136 0.015
gtp catabolic process GO:0006184 72 0.015
response to hexose GO:0009746 3 0.015
nucleoside phosphate metabolic process GO:0006753 162 0.015
nucleocytoplasmic transport GO:0006913 72 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
organophosphate catabolic process GO:0046434 112 0.015
centrosome duplication GO:0051298 121 0.015
regulation of proteolysis GO:0030162 87 0.015
ribonucleotide metabolic process GO:0009259 145 0.015
protein ubiquitination GO:0016567 70 0.015
mitotic nuclear division GO:0007067 213 0.015
response to organophosphorus GO:0046683 2 0.015
cellular response to organic substance GO:0071310 132 0.015
death GO:0016265 284 0.015
ubiquitin dependent protein catabolic process GO:0006511 78 0.015
telencephalon development GO:0021537 2 0.015
regulation of multicellular organismal development GO:2000026 414 0.015
positive regulation of signal transduction GO:0009967 223 0.015
macromolecular complex assembly GO:0065003 256 0.015
purine nucleoside triphosphate metabolic process GO:0009144 119 0.015
dna metabolic process GO:0006259 227 0.015
autophagy GO:0006914 108 0.015
activation of cysteine type endopeptidase activity GO:0097202 17 0.015
immune response activating signal transduction GO:0002757 2 0.014
gland morphogenesis GO:0022612 145 0.014
positive regulation of protein metabolic process GO:0051247 128 0.014
regulation of transport GO:0051049 181 0.014
regulation of mapk cascade GO:0043408 92 0.014
intracellular protein transport GO:0006886 104 0.014
metal ion homeostasis GO:0055065 44 0.014
regulation of cell differentiation GO:0045595 302 0.014
myotube cell development GO:0014904 3 0.014
positive regulation of apoptotic signaling pathway GO:2001235 4 0.014
protein maturation GO:0051604 71 0.014
meiotic cell cycle GO:0051321 171 0.014
membrane organization GO:0061024 112 0.014
response to bacterium GO:0009617 198 0.014
nucleoside triphosphate metabolic process GO:0009141 120 0.014
cellular response to mechanical stimulus GO:0071260 2 0.014
chromatin organization GO:0006325 207 0.014
negative regulation of biosynthetic process GO:0009890 277 0.014
synaptic transmission GO:0007268 288 0.014
aromatic compound catabolic process GO:0019439 166 0.013
response to ethanol GO:0045471 59 0.013
negative regulation of cell death GO:0060548 81 0.013
ameboidal type cell migration GO:0001667 151 0.013
response to other organism GO:0051707 293 0.013
proteasomal protein catabolic process GO:0010498 59 0.013
nuclear transport GO:0051169 72 0.013
nucleobase containing small molecule metabolic process GO:0055086 174 0.013
sex differentiation GO:0007548 81 0.013
nucleoside metabolic process GO:0009116 127 0.013
regulation of catabolic process GO:0009894 170 0.013
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
dephosphorylation GO:0016311 51 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
mesenchymal cell differentiation GO:0048762 1 0.013
cell division GO:0051301 248 0.013
meiotic nuclear division GO:0007126 151 0.013
response to alcohol GO:0097305 95 0.013
regulation of small gtpase mediated signal transduction GO:0051056 93 0.013
negative regulation of transcription dna templated GO:0045892 237 0.013
negative regulation of organelle organization GO:0010639 56 0.013
negative regulation of small gtpase mediated signal transduction GO:0051058 13 0.013
protein processing GO:0016485 68 0.013
organic cyclic compound catabolic process GO:1901361 168 0.012
posttranscriptional regulation of gene expression GO:0010608 145 0.012
secretion by cell GO:0032940 101 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.012
response to endogenous stimulus GO:0009719 119 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
response to radiation GO:0009314 155 0.012
mapk cascade GO:0000165 107 0.012
positive regulation of immune response GO:0050778 63 0.012
positive regulation of rna biosynthetic process GO:1902680 266 0.012
positive regulation of apoptotic process GO:0043065 47 0.012
regulation of anatomical structure morphogenesis GO:0022603 242 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
regulation of hydrolase activity GO:0051336 97 0.012
notch signaling pathway GO:0007219 120 0.012
negative regulation of multicellular organismal process GO:0051241 142 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.012
cellular response to starvation GO:0009267 61 0.012
modification dependent protein catabolic process GO:0019941 78 0.012
defense response GO:0006952 300 0.012
cellular response to biotic stimulus GO:0071216 4 0.012
carbohydrate derivative biosynthetic process GO:1901137 85 0.012
positive regulation of gene expression GO:0010628 290 0.012
positive regulation of transport GO:0051050 92 0.012
purine nucleotide metabolic process GO:0006163 146 0.012
response to wounding GO:0009611 94 0.012
activation of innate immune response GO:0002218 4 0.012
embryonic morphogenesis GO:0048598 206 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
spermatogenesis GO:0007283 200 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
reproductive structure development GO:0048608 74 0.011
amide biosynthetic process GO:0043604 42 0.011
compound eye development GO:0048749 307 0.011
regulation of establishment of protein localization GO:0070201 61 0.011
secretion GO:0046903 109 0.011
cell growth GO:0016049 108 0.011
ovarian follicle cell development GO:0030707 248 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.011
locomotory behavior GO:0007626 176 0.011
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.011
epidermis development GO:0008544 65 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
sensory organ morphogenesis GO:0090596 260 0.011
lateral inhibition GO:0046331 206 0.011
axis specification GO:0009798 167 0.011
single organism cellular localization GO:1902580 180 0.011
chemical homeostasis GO:0048878 92 0.011
male gamete generation GO:0048232 201 0.011
transmembrane transport GO:0055085 139 0.011
protein phosphorylation GO:0006468 169 0.011
regulation of innate immune response GO:0045088 71 0.011
salivary gland cell autophagic cell death GO:0035071 83 0.011
spermatid differentiation GO:0048515 114 0.011
cell motility GO:0048870 251 0.011
regulation of autophagy GO:0010506 62 0.011
cation homeostasis GO:0055080 51 0.011
regulation of protein localization GO:0032880 76 0.011
signal transduction by phosphorylation GO:0023014 107 0.011
response to organic cyclic compound GO:0014070 89 0.011
positive regulation of phosphorus metabolic process GO:0010562 139 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.011
purine nucleoside catabolic process GO:0006152 112 0.010
neural precursor cell proliferation GO:0061351 75 0.010
golgi organization GO:0007030 66 0.010
regulation of wnt signaling pathway GO:0030111 68 0.010
organonitrogen compound catabolic process GO:1901565 128 0.010
homeostatic process GO:0042592 199 0.010
protein localization to organelle GO:0033365 82 0.010
salivary gland morphogenesis GO:0007435 145 0.010
cellular response to external stimulus GO:0071496 66 0.010
mrna processing GO:0006397 104 0.010
response to monosaccharide GO:0034284 4 0.010
exocrine system development GO:0035272 162 0.010
positive regulation of biosynthetic process GO:0009891 316 0.010
developmental programmed cell death GO:0010623 138 0.010
gene silencing GO:0016458 138 0.010
epithelium migration GO:0090132 148 0.010

Gclm disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
nervous system disease DOID:863 0 0.024
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
central nervous system disease DOID:331 0 0.011