Drosophila melanogaster

4 known processes

Spn7 (Dmel_CG6717)

Serine protease inhibitor 7

(Aliases: CG6717,Dmel\CG6717,Spn28B)

Spn7 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
insemination GO:0007320 22 0.361
protein hydroxylation GO:0018126 1 0.299
sperm competition GO:0046692 21 0.216
peptidyl proline hydroxylation GO:0019511 1 0.128
peptidyl proline modification GO:0018208 3 0.120
cell cell signaling involved in cell fate commitment GO:0045168 210 0.101
sperm storage GO:0046693 10 0.087
lateral inhibition GO:0046331 206 0.087
salivary gland morphogenesis GO:0007435 145 0.076
salivary gland development GO:0007431 162 0.074
exocrine system development GO:0035272 162 0.071
sterol homeostasis GO:0055092 4 0.070
cellular protein modification process GO:0006464 438 0.068
negative regulation of gene expression GO:0010629 387 0.064
Rat Fly
protein modification process GO:0036211 438 0.063
cholesterol homeostasis GO:0042632 3 0.052
mating GO:0007618 120 0.050
gland morphogenesis GO:0022612 145 0.048
vesicle mediated transport GO:0016192 381 0.047
endocytosis GO:0006897 310 0.046
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.046
negative regulation of cellular metabolic process GO:0031324 382 0.046
Rat Fly
single organism behavior GO:0044708 391 0.044
multi multicellular organism process GO:0044706 123 0.044
gland development GO:0048732 191 0.042
positive regulation of response to stimulus GO:0048584 323 0.038
multicellular organismal reproductive behavior GO:0033057 110 0.036
small molecule metabolic process GO:0044281 305 0.035
organic acid metabolic process GO:0006082 103 0.035
neurological system process GO:0050877 358 0.035
oxoacid metabolic process GO:0043436 103 0.035
regulation of localization GO:0032879 275 0.034
appendage development GO:0048736 401 0.034
imaginal disc derived appendage development GO:0048737 399 0.034
carboxylic acid metabolic process GO:0019752 92 0.032
sensory perception GO:0007600 196 0.032
detection of stimulus involved in sensory perception GO:0050906 92 0.031
imaginal disc derived appendage morphogenesis GO:0035114 395 0.031
response to other organism GO:0051707 293 0.031
Fly
body morphogenesis GO:0010171 2 0.031
growth GO:0040007 359 0.030
Rat
organonitrogen compound metabolic process GO:1901564 318 0.030
Fly
negative regulation of rna metabolic process GO:0051253 251 0.029
response to abiotic stimulus GO:0009628 341 0.029
defense response to other organism GO:0098542 225 0.029
Fly
phagocytosis GO:0006909 215 0.029
response to external biotic stimulus GO:0043207 293 0.029
Fly
appendage morphogenesis GO:0035107 397 0.028
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.027
Fly
organic substance catabolic process GO:1901575 308 0.027
peptidyl amino acid modification GO:0018193 105 0.027
lipid metabolic process GO:0006629 121 0.026
rhythmic process GO:0048511 106 0.026
positive regulation of signal transduction GO:0009967 223 0.026
negative regulation of rna biosynthetic process GO:1902679 240 0.026
cellular lipid metabolic process GO:0044255 83 0.026
homeostatic process GO:0042592 199 0.026
positive regulation of cell communication GO:0010647 250 0.026
chromosome organization GO:0051276 360 0.026
regulation of multicellular organismal development GO:2000026 414 0.026
cell division GO:0051301 248 0.025
respiratory system development GO:0060541 213 0.025
organic substance transport GO:0071702 257 0.025
detection of chemical stimulus GO:0009593 93 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.025
regionalization GO:0003002 416 0.024
carbohydrate derivative metabolic process GO:1901135 217 0.024
catabolic process GO:0009056 409 0.024
single organism biosynthetic process GO:0044711 206 0.023
protein maturation GO:0051604 71 0.023
Fly
positive regulation of signaling GO:0023056 243 0.023
regulation of female receptivity GO:0045924 24 0.023
developmental growth GO:0048589 280 0.023
Rat
regulation of molecular function GO:0065009 217 0.023
Rat Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.023
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
wing disc morphogenesis GO:0007472 344 0.022
regulation of cellular amine metabolic process GO:0033238 3 0.022
regulation of catalytic activity GO:0050790 185 0.022
Rat Fly
response to biotic stimulus GO:0009607 294 0.022
Fly
negative regulation of cellular biosynthetic process GO:0031327 277 0.021
defense response to bacterium GO:0042742 178 0.021
Fly
amine metabolic process GO:0009308 12 0.021
negative regulation of nucleic acid templated transcription GO:1903507 240 0.021
locomotory behavior GO:0007626 176 0.021
establishment of localization in cell GO:0051649 402 0.021
defense response GO:0006952 300 0.021
Rat Fly
copulation GO:0007620 26 0.021
ethanolamine containing compound metabolic process GO:0042439 4 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.021
Rat Fly
sensory perception of chemical stimulus GO:0007606 116 0.021
multi organism reproductive behavior GO:0044705 121 0.021
regulation of transport GO:0051049 181 0.021
macromolecular complex assembly GO:0065003 256 0.021
cellular amine metabolic process GO:0044106 12 0.021
regulation of phosphorus metabolic process GO:0051174 210 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.020
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.020
negative regulation of biosynthetic process GO:0009890 277 0.020
forebrain development GO:0030900 2 0.020
cellular amino acid metabolic process GO:0006520 61 0.020
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.020
cellular catabolic process GO:0044248 372 0.020
female mating behavior GO:0060180 30 0.020
chemical homeostasis GO:0048878 92 0.020
protein localization GO:0008104 284 0.020
negative regulation of developmental process GO:0051093 201 0.020
cellular ketone metabolic process GO:0042180 24 0.019
organophosphate metabolic process GO:0019637 195 0.019
protein complex assembly GO:0006461 200 0.019
positive regulation of biosynthetic process GO:0009891 316 0.019
adult behavior GO:0030534 137 0.019
organic hydroxy compound metabolic process GO:1901615 83 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
regulation of cell differentiation GO:0045595 302 0.019
imaginal disc derived wing morphogenesis GO:0007476 337 0.018
eye development GO:0001654 323 0.018
axon development GO:0061564 297 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.018
compound eye development GO:0048749 307 0.018
regulation of immune system process GO:0002682 176 0.018
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.018
positive regulation of macromolecule metabolic process GO:0010604 405 0.017
negative regulation of response to stimulus GO:0048585 258 0.017
Rat Fly
positive regulation of rna metabolic process GO:0051254 271 0.017
cell proliferation GO:0008283 299 0.017
post embryonic appendage morphogenesis GO:0035120 385 0.017
regulation of proteolysis GO:0030162 87 0.017
Rat Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.017
regulation of mitotic cell cycle GO:0007346 190 0.017
taxis GO:0042330 304 0.017
cell migration GO:0016477 238 0.017
intracellular transport GO:0046907 228 0.017
single organism catabolic process GO:0044712 228 0.017
proteolysis GO:0006508 192 0.017
Rat Fly
camera type eye development GO:0043010 4 0.017
muscle structure development GO:0061061 224 0.017
kidney development GO:0001822 3 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
Rat Fly
immune system process GO:0002376 347 0.017
Fly
regulation of response to stress GO:0080134 200 0.017
Rat
triglyceride catabolic process GO:0019433 3 0.017
multi organism behavior GO:0051705 175 0.017
regulation of cell development GO:0060284 215 0.017
oxidation reduction process GO:0055114 123 0.017
positive regulation of rna biosynthetic process GO:1902680 266 0.016
response to radiation GO:0009314 155 0.016
negative regulation of transcription dna templated GO:0045892 237 0.016
organelle fission GO:0048285 340 0.016
death GO:0016265 284 0.016
notch signaling pathway GO:0007219 120 0.016
regulation of multi organism process GO:0043900 131 0.016
Fly
regulation of gene expression epigenetic GO:0040029 128 0.016
protein complex biogenesis GO:0070271 201 0.016
eye morphogenesis GO:0048592 260 0.016
regulation of organelle organization GO:0033043 196 0.016
open tracheal system development GO:0007424 204 0.016
cellular macromolecule localization GO:0070727 220 0.016
regulation of developmental growth GO:0048638 174 0.016
dna metabolic process GO:0006259 227 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
response to organic substance GO:0010033 284 0.015
regulation of nervous system development GO:0051960 248 0.015
localization of cell GO:0051674 257 0.015
nuclear division GO:0000280 332 0.015
muscle organ development GO:0007517 127 0.015
positive regulation of transcription dna templated GO:0045893 266 0.015
actin cytoskeleton organization GO:0030036 206 0.015
developmental maturation GO:0021700 172 0.015
regulation of growth GO:0040008 233 0.015
axonogenesis GO:0007409 290 0.015
neuron projection guidance GO:0097485 241 0.015
circadian rhythm GO:0007623 105 0.015
enzyme linked receptor protein signaling pathway GO:0007167 179 0.015
heterocycle catabolic process GO:0046700 166 0.015
response to oxygen containing compound GO:1901700 200 0.015
intracellular signal transduction GO:0035556 300 0.015
regulation of intracellular signal transduction GO:1902531 236 0.015
chaeta development GO:0022416 97 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
regulation of notch signaling pathway GO:0008593 100 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
epithelial cell differentiation GO:0030855 322 0.015
negative regulation of female receptivity GO:0007621 14 0.015
segmentation GO:0035282 207 0.015
positive regulation of lipid storage GO:0010884 4 0.015
carbohydrate derivative biosynthetic process GO:1901137 85 0.015
regulation of female receptivity post mating GO:0046008 17 0.015
phosphorylation GO:0016310 294 0.014
regulation of catabolic process GO:0009894 170 0.014
reproductive behavior GO:0019098 122 0.014
gene silencing GO:0016458 138 0.014
dendrite development GO:0016358 204 0.014
detection of stimulus GO:0051606 156 0.014
negative regulation of cell communication GO:0010648 223 0.014
Fly
response to lipopolysaccharide GO:0032496 4 0.014
telencephalon development GO:0021537 2 0.014
chromatin modification GO:0016568 147 0.014
anion homeostasis GO:0055081 3 0.014
response to monosaccharide GO:0034284 4 0.014
regulation of immune response GO:0050776 118 0.014
Fly
sensory perception of smell GO:0007608 80 0.014
regulation of cell cycle GO:0051726 291 0.014
regulation of anatomical structure morphogenesis GO:0022603 242 0.014
cell motility GO:0048870 251 0.014
compound eye morphogenesis GO:0001745 249 0.014
ameboidal type cell migration GO:0001667 151 0.013
rna processing GO:0006396 147 0.013
negative regulation of multicellular organismal process GO:0051241 142 0.013
actin filament based process GO:0030029 220 0.013
synaptic transmission GO:0007268 288 0.013
negative regulation of gene expression epigenetic GO:0045814 77 0.013
regulation of mitotic cell cycle phase transition GO:1901990 130 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
embryonic pattern specification GO:0009880 174 0.013
response to nutrient levels GO:0031667 114 0.013
Rat
rrna processing GO:0006364 3 0.013
regulation of protein metabolic process GO:0051246 256 0.013
Rat Fly
mitotic cell cycle phase transition GO:0044772 138 0.013
mitotic nuclear division GO:0007067 213 0.013
nucleotide metabolic process GO:0009117 161 0.013
negative regulation of growth GO:0045926 84 0.013
chromosome segregation GO:0007059 157 0.013
axon guidance GO:0007411 233 0.013
chromatin organization GO:0006325 207 0.013
mating behavior GO:0007617 106 0.013
negative regulation of signal transduction GO:0009968 206 0.013
Fly
chemotaxis GO:0006935 249 0.013
tube development GO:0035295 244 0.013
response to bacterium GO:0009617 198 0.013
Fly
nucleoside phosphate metabolic process GO:0006753 162 0.013
organic cyclic compound catabolic process GO:1901361 168 0.013
dendrite morphogenesis GO:0048813 199 0.013
tube morphogenesis GO:0035239 191 0.013
regulation of anatomical structure size GO:0090066 163 0.012
mitotic cell cycle checkpoint GO:0007093 88 0.012
regulation of cell cycle process GO:0010564 181 0.012
cation transmembrane transport GO:0098655 88 0.012
ion transport GO:0006811 145 0.012
single organism cellular localization GO:1902580 180 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
embryo development ending in birth or egg hatching GO:0009792 152 0.012
nucleobase containing small molecule metabolic process GO:0055086 174 0.012
epithelial cell development GO:0002064 274 0.012
ras protein signal transduction GO:0007265 88 0.012
positive regulation of multicellular organismal process GO:0051240 143 0.012
eye photoreceptor cell differentiation GO:0001754 145 0.012
protein heterooligomerization GO:0051291 4 0.012
acylglycerol catabolic process GO:0046464 3 0.012
positive regulation of transport GO:0051050 92 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
male courtship behavior GO:0008049 63 0.012
blastoderm segmentation GO:0007350 159 0.012
columnar cuboidal epithelial cell development GO:0002066 249 0.012
regulation of endopeptidase activity GO:0052548 36 0.012
Rat Fly
negative regulation of cellular protein metabolic process GO:0032269 85 0.012
Rat Fly
chemosensory behavior GO:0007635 106 0.012
negative regulation of mitotic cell cycle GO:0045930 109 0.012
regulation of cellular catabolic process GO:0031329 157 0.012
phosphatidylethanolamine metabolic process GO:0046337 1 0.012
macromolecule catabolic process GO:0009057 161 0.012
sensory organ morphogenesis GO:0090596 260 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
single organism intracellular transport GO:1902582 207 0.012
organelle localization GO:0051640 148 0.012
ribonucleotide metabolic process GO:0009259 145 0.012
programmed cell death GO:0012501 257 0.012
pigment metabolic process GO:0042440 84 0.012
positive regulation of cellular component organization GO:0051130 156 0.011
protein processing GO:0016485 68 0.011
Fly
compound eye photoreceptor cell differentiation GO:0001751 140 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
g protein coupled receptor signaling pathway GO:0007186 136 0.011
retina development in camera type eye GO:0060041 4 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
organophosphate catabolic process GO:0046434 112 0.011
single organism carbohydrate metabolic process GO:0044723 72 0.011
regulation of synapse structure and activity GO:0050803 128 0.011
detection of chemical stimulus involved in sensory perception of smell GO:0050911 50 0.011
response to light stimulus GO:0009416 124 0.011
regulation of epithelial cell differentiation GO:0030856 4 0.011
response to organophosphorus GO:0046683 2 0.011
establishment of protein localization GO:0045184 163 0.011
positive regulation of cell motility GO:2000147 3 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
negative regulation of signaling GO:0023057 219 0.011
Fly
regulation of peptidase activity GO:0052547 39 0.011
Rat Fly
ribose phosphate metabolic process GO:0019693 145 0.011
response to hexose GO:0009746 3 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.011
regulation of cell cycle phase transition GO:1901987 130 0.011
developmental programmed cell death GO:0010623 138 0.011
lipid homeostasis GO:0055088 33 0.011
rna localization GO:0006403 115 0.011
organelle assembly GO:0070925 198 0.011
tripartite regional subdivision GO:0007351 103 0.011
camera type eye morphogenesis GO:0048593 2 0.011
aromatic compound catabolic process GO:0019439 166 0.011
cellular macromolecule catabolic process GO:0044265 136 0.011
transmembrane transport GO:0055085 139 0.011
cholesterol transport GO:0030301 2 0.011
meiotic cell cycle GO:0051321 171 0.011
endomembrane system organization GO:0010256 119 0.011
mesenchymal cell development GO:0014031 1 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
response to copper ion GO:0046688 4 0.011
very long chain fatty acid metabolic process GO:0000038 4 0.011
ovarian follicle cell development GO:0030707 248 0.011
histone modification GO:0016570 106 0.011
wnt signaling pathway GO:0016055 98 0.011
regulation of behavior GO:0050795 75 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
carbohydrate metabolic process GO:0005975 82 0.011
purine ribonucleotide metabolic process GO:0009150 145 0.011
axis specification GO:0009798 167 0.011
regulation of cellular localization GO:0060341 136 0.010
monocarboxylic acid transport GO:0015718 3 0.010
male mating behavior GO:0060179 70 0.010
striated muscle cell differentiation GO:0051146 90 0.010
response to extracellular stimulus GO:0009991 116 0.010
Rat
organonitrogen compound biosynthetic process GO:1901566 117 0.010
regulation of hydrolase activity GO:0051336 97 0.010
Rat Fly
regulation of cell proliferation GO:0042127 163 0.010
ion homeostasis GO:0050801 55 0.010
triglyceride biosynthetic process GO:0019432 2 0.010
anterior posterior pattern specification GO:0009952 136 0.010
salivary gland cell autophagic cell death GO:0035071 83 0.010
tissue morphogenesis GO:0048729 297 0.010
cell maturation GO:0048469 144 0.010
morphogenesis of an epithelium GO:0002009 276 0.010
antimicrobial humoral response GO:0019730 99 0.010
Fly
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.010
hindbrain development GO:0030902 2 0.010
chromatin silencing GO:0006342 76 0.010
neutral lipid biosynthetic process GO:0046460 2 0.010
purine containing compound metabolic process GO:0072521 155 0.010
triglyceride homeostasis GO:0070328 18 0.010

Spn7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.038
nervous system disease DOID:863 0 0.020
diabetes mellitus DOID:9351 0 0.017
type 2 diabetes mellitus DOID:9352 0 0.017
disease of metabolism DOID:0014667 0 0.017
carbohydrate metabolism disease DOID:0050013 0 0.017
glucose metabolism disease DOID:4194 0 0.017
acquired metabolic disease DOID:0060158 0 0.017
inherited metabolic disorder DOID:655 0 0.014