Drosophila melanogaster

159 known processes

spi (Dmel_CG10334)

spitz

(Aliases: EP(2)2378,anon-WO0118547.158,CT29014,Dmel\CG10334,l(2)01068,l(2)37Fa,l(2)s3547,Spi,Spitz,CG10334,s-spi)

spi biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
ameboidal type cell migration GO:0001667 151 1.000
learning GO:0007612 75 0.998
brain development GO:0007420 120 0.994
epithelial cell migration GO:0010631 148 0.994
axon development GO:0061564 297 0.990
regulation of neurogenesis GO:0050767 158 0.988
border follicle cell migration GO:0007298 113 0.988
eye photoreceptor cell fate commitment GO:0042706 37 0.985
central nervous system development GO:0007417 201 0.984
regulation of r7 cell differentiation GO:0045676 15 0.984
axonogenesis GO:0007409 290 0.978
r7 cell differentiation GO:0045466 43 0.974
cell motility GO:0048870 251 0.973
dna metabolic process GO:0006259 227 0.973
stem cell fate commitment GO:0048865 25 0.972
cell migration GO:0016477 238 0.970
photoreceptor cell fate commitment GO:0046552 41 0.964
tissue migration GO:0090130 155 0.964
glial cell migration GO:0008347 31 0.963
positive regulation of r7 cell differentiation GO:0045678 7 0.956
positive regulation of nervous system development GO:0051962 69 0.951
regulation of epithelial cell proliferation GO:0050678 4 0.951
nuclear division GO:0000280 332 0.948
malpighian tubule development GO:0072002 64 0.948
positive regulation of neurogenesis GO:0050769 41 0.947
appendage development GO:0048736 401 0.935
cognition GO:0050890 141 0.930
olfactory learning GO:0008355 56 0.929
neurological system process GO:0050877 358 0.924
appendage morphogenesis GO:0035107 397 0.922
forebrain development GO:0030900 2 0.913
open tracheal system development GO:0007424 204 0.913
epithelium migration GO:0090132 148 0.910
morphogenesis of an epithelium GO:0002009 276 0.903
compound eye photoreceptor fate commitment GO:0001752 36 0.898
chorion containing eggshell formation GO:0007304 105 0.878
gliogenesis GO:0042063 80 0.866
establishment of localization in cell GO:0051649 402 0.858
single organism behavior GO:0044708 391 0.840
regulation of photoreceptor cell differentiation GO:0046532 34 0.838
positive regulation of transcription dna templated GO:0045893 266 0.838
mapk cascade GO:0000165 107 0.837
Fly
response to ethanol GO:0045471 59 0.836
germ cell migration GO:0008354 43 0.835
exocrine system development GO:0035272 162 0.812
positive regulation of photoreceptor cell differentiation GO:0046534 12 0.810
transcription from rna polymerase ii promoter GO:0006366 368 0.807
r3 r4 cell differentiation GO:0048056 12 0.789
ovarian follicle cell migration GO:0007297 121 0.788
stem cell differentiation GO:0048863 117 0.788
digestive tract development GO:0048565 149 0.780
heart process GO:0003015 37 0.776
cellular protein modification process GO:0006464 438 0.773
Fly
enzyme linked receptor protein signaling pathway GO:0007167 179 0.768
Fly
eye antennal disc development GO:0035214 60 0.766
telencephalon development GO:0021537 2 0.757
positive regulation of rna biosynthetic process GO:1902680 266 0.755
circulatory system development GO:0072359 82 0.752
oocyte differentiation GO:0009994 145 0.744
eye morphogenesis GO:0048592 260 0.743
Fly
cardiovascular system development GO:0072358 82 0.733
actin filament based process GO:0030029 220 0.730
regulation of epithelial cell migration GO:0010632 12 0.724
digestive tract morphogenesis GO:0048546 127 0.720
response to external biotic stimulus GO:0043207 293 0.715
cell adhesion GO:0007155 136 0.708
imaginal disc derived wing morphogenesis GO:0007476 337 0.708
columnar cuboidal epithelial cell development GO:0002066 249 0.706
r3 r4 cell fate commitment GO:0007464 10 0.706
learning or memory GO:0007611 141 0.691
gland morphogenesis GO:0022612 145 0.688
axon guidance GO:0007411 233 0.672
regulation of cardioblast differentiation GO:0051890 9 0.671
head development GO:0060322 135 0.663
haltere disc development GO:0035216 10 0.663
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.662
immune system process GO:0002376 347 0.658
gland development GO:0048732 191 0.656
negative regulation of neurogenesis GO:0050768 53 0.639
positive regulation of cell development GO:0010720 61 0.635
regulation of neuron differentiation GO:0045664 103 0.631
immune response GO:0006955 246 0.629
protein localization GO:0008104 284 0.627
regulation of cell morphogenesis GO:0022604 163 0.612
tube development GO:0035295 244 0.600
epithelial cell migration open tracheal system GO:0007427 32 0.599
embryonic organ development GO:0048568 50 0.580
germarium derived egg chamber formation GO:0007293 101 0.569
adult behavior GO:0030534 137 0.569
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.565
Fly
regulation of multicellular organismal development GO:2000026 414 0.563
imaginal disc derived appendage morphogenesis GO:0035114 395 0.561
oocyte axis specification GO:0007309 108 0.558
morphogenesis of a branching epithelium GO:0061138 45 0.556
positive regulation of rna metabolic process GO:0051254 271 0.548
single organismal cell cell adhesion GO:0016337 45 0.546
synaptic growth at neuromuscular junction GO:0051124 119 0.545
cell proliferation GO:0008283 299 0.542
germarium derived female germ line cyst formation GO:0030727 42 0.542
embryonic morphogenesis GO:0048598 206 0.542
response to biotic stimulus GO:0009607 294 0.533
negative regulation of cardiac cell fate specification GO:2000044 7 0.529
neuron fate commitment GO:0048663 50 0.526
eye antennal disc morphogenesis GO:0007455 34 0.515
positive regulation of macromolecule metabolic process GO:0010604 405 0.512
Fly
meiotic cell cycle GO:0051321 171 0.508
dendrite morphogenesis GO:0048813 199 0.507
homeostatic process GO:0042592 199 0.507
malpighian tubule morphogenesis GO:0007443 44 0.504
negative regulation of autophagy GO:0010507 16 0.504
growth GO:0040007 359 0.500
positive regulation of neuron differentiation GO:0045666 26 0.494
epithelial cell development GO:0002064 274 0.491
compound eye cone cell fate commitment GO:0042676 5 0.486
defense response GO:0006952 300 0.485
actin cytoskeleton organization GO:0030036 206 0.484
negative regulation of heart induction GO:1901320 3 0.482
defense response to other organism GO:0098542 225 0.477
tube morphogenesis GO:0035239 191 0.474
regulation of neuron projection development GO:0010975 69 0.473
positive regulation of signal transduction GO:0009967 223 0.472
Fly
negative regulation of cellular protein metabolic process GO:0032269 85 0.471
positive regulation of cell migration GO:0030335 2 0.469
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.469
sensory organ morphogenesis GO:0090596 260 0.465
Fly
tissue morphogenesis GO:0048729 297 0.464
response to oxygen containing compound GO:1901700 200 0.452
locomotory behavior GO:0007626 176 0.446
olfactory behavior GO:0042048 97 0.442
single organism intracellular transport GO:1902582 207 0.434
regionalization GO:0003002 416 0.430
glial cell differentiation GO:0010001 35 0.428
salivary gland morphogenesis GO:0007435 145 0.421
neuron projection guidance GO:0097485 241 0.421
imaginal disc derived appendage development GO:0048737 399 0.415
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.410
hemocyte differentiation GO:0042386 38 0.404
determination of genital disc primordium GO:0035225 10 0.400
organelle fission GO:0048285 340 0.396
respiratory system development GO:0060541 213 0.393
biological adhesion GO:0022610 138 0.391
signal transduction by phosphorylation GO:0023014 107 0.388
Fly
positive regulation of cell proliferation GO:0008284 47 0.387
negative regulation of signal transduction GO:0009968 206 0.384
negative regulation of neural precursor cell proliferation GO:2000178 27 0.381
dorsal closure spreading of leading edge cells GO:0007395 4 0.380
negative regulation of nervous system development GO:0051961 92 0.375
regulation of cell proliferation GO:0042127 163 0.370
positive regulation of nucleic acid templated transcription GO:1903508 266 0.369
response to growth factor GO:0070848 31 0.364
regulation of protein metabolic process GO:0051246 256 0.363
Fly
negative regulation of epithelial cell proliferation GO:0050680 4 0.360
wound healing GO:0042060 75 0.359
epithelial cell differentiation GO:0030855 322 0.351
protein transport GO:0015031 155 0.344
cell type specific apoptotic process GO:0097285 38 0.344
axon midline choice point recognition GO:0016199 26 0.336
regulation of anatomical structure morphogenesis GO:0022603 242 0.335
eggshell chorion assembly GO:0007306 66 0.333
chemotaxis GO:0006935 249 0.330
epithelial cell proliferation GO:0050673 15 0.330
positive regulation of gene expression GO:0010628 290 0.328
neuron death GO:0070997 27 0.325
positive regulation of locomotion GO:0040017 8 0.323
positive regulation of signaling GO:0023056 243 0.323
Fly
formation of anatomical boundary GO:0048859 37 0.323
torc1 signaling GO:0038202 12 0.321
regulation of neuroblast proliferation GO:1902692 34 0.319
negative regulation of cell development GO:0010721 62 0.315
chemical homeostasis GO:0048878 92 0.307
digestive system development GO:0055123 149 0.307
regulation of cell migration GO:0030334 22 0.305
regulation of cell development GO:0060284 215 0.303
regulation of response to wounding GO:1903034 19 0.302
negative regulation of protein phosphorylation GO:0001933 17 0.301
establishment or maintenance of cell polarity GO:0007163 167 0.297
Fly
compound eye photoreceptor cell differentiation GO:0001751 140 0.297
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.297
regulation of cell differentiation GO:0045595 302 0.295
renal system development GO:0072001 72 0.295
dendrite development GO:0016358 204 0.293
regulation of erbb signaling pathway GO:1901184 42 0.292
Fly
second mitotic wave involved in compound eye morphogenesis GO:0016330 7 0.292
cellular response to peptide GO:1901653 28 0.290
cardioblast cell fate specification GO:0042685 9 0.286
post embryonic appendage morphogenesis GO:0035120 385 0.285
regulation of cell motility GO:2000145 23 0.285
motor neuron axon guidance GO:0008045 58 0.281
regulation of locomotion GO:0040012 42 0.280
circadian rhythm GO:0007623 105 0.276
eye photoreceptor cell differentiation GO:0001754 145 0.273
regulation of cell fate commitment GO:0010453 29 0.272
meiotic nuclear division GO:0007126 151 0.269
phosphorylation GO:0016310 294 0.268
Fly
negative regulation of photoreceptor cell differentiation GO:0046533 8 0.265
positive regulation of protein kinase activity GO:0045860 25 0.265
Fly
regulation of response to stress GO:0080134 200 0.264
organic substance transport GO:0071702 257 0.263
chorion containing eggshell pattern formation GO:0030381 11 0.262
defense response to bacterium GO:0042742 178 0.261
regulation of protein modification process GO:0031399 112 0.261
Fly
negative regulation of phosphorylation GO:0042326 35 0.259
axonal fasciculation GO:0007413 12 0.259
response to other organism GO:0051707 293 0.252
developmental growth GO:0048589 280 0.252
germ line stem cell maintenance GO:0030718 50 0.251
response to insulin GO:0032868 29 0.251
regulation of neuron death GO:1901214 26 0.247
positive regulation of response to stimulus GO:0048584 323 0.244
Fly
positive regulation of developmental process GO:0051094 143 0.242
r7 cell fate commitment GO:0007465 12 0.241
mitochondrial fission GO:0000266 8 0.240
positive regulation of cell cycle GO:0045787 43 0.235
embryonic hindgut morphogenesis GO:0048619 48 0.235
regulation of cell adhesion GO:0030155 27 0.234
heart development GO:0007507 82 0.231
germ line cyst formation GO:0048134 44 0.231
cellular response to organonitrogen compound GO:0071417 36 0.228
cell division GO:0051301 248 0.228
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.227
bmp signaling pathway GO:0030509 27 0.226
gastrulation GO:0007369 70 0.222
axon extension GO:0048675 32 0.218
positive regulation of protein import into nucleus GO:0042307 21 0.217
synaptic vesicle localization GO:0097479 53 0.216
response to bacterium GO:0009617 198 0.214
localization of cell GO:0051674 257 0.213
neural precursor cell proliferation GO:0061351 75 0.209
synapse assembly GO:0007416 143 0.208
ion transport GO:0006811 145 0.206
regulation of immune system process GO:0002682 176 0.204
morphogenesis of a polarized epithelium GO:0001738 93 0.203
Fly
regulation of nervous system development GO:0051960 248 0.202
cellular response to growth factor stimulus GO:0071363 30 0.196
regulation of tube size GO:0035150 46 0.194
larval development GO:0002164 104 0.194
embryonic pattern specification GO:0009880 174 0.193
protein phosphorylation GO:0006468 169 0.193
Fly
establishment of organelle localization GO:0051656 122 0.193
regulation of transferase activity GO:0051338 58 0.192
Fly
regulation of cell cell adhesion GO:0022407 21 0.192
stem cell development GO:0048864 79 0.190
neuron recognition GO:0008038 101 0.188
specification of organ identity GO:0010092 3 0.187
negative regulation of phosphorus metabolic process GO:0010563 45 0.187
actin filament organization GO:0007015 126 0.187
negative regulation of gene expression GO:0010629 387 0.186
renal tubule development GO:0061326 64 0.184
regulation of mapk cascade GO:0043408 92 0.183
response to alcohol GO:0097305 95 0.183
regulation of cellular component movement GO:0051270 42 0.181
skeletal muscle organ development GO:0060538 48 0.180
microtubule based transport GO:0010970 42 0.180
negative regulation of immune system process GO:0002683 50 0.180
glial cell fate determination GO:0007403 3 0.179
muscle fiber development GO:0048747 12 0.178
morphogenesis of a branching structure GO:0001763 45 0.172
endomembrane system organization GO:0010256 119 0.171
response to hormone GO:0009725 45 0.171
cell recognition GO:0008037 102 0.171
cellular lipid metabolic process GO:0044255 83 0.163
positive regulation of protein secretion GO:0050714 9 0.163
delamination GO:0060232 8 0.162
response to organic substance GO:0010033 284 0.160
single organism cell adhesion GO:0098602 47 0.157
oxoacid metabolic process GO:0043436 103 0.157
compound eye development GO:0048749 307 0.156
Fly
cellular response to insulin stimulus GO:0032869 28 0.153
taxis GO:0042330 304 0.152
synaptic transmission GO:0007268 288 0.152
hindbrain development GO:0030902 2 0.152
cellular macromolecular complex assembly GO:0034622 153 0.150
negative regulation of compound eye retinal cell programmed cell death GO:0046673 7 0.150
establishment of protein localization GO:0045184 163 0.149
negative regulation of developmental process GO:0051093 201 0.145
negative regulation of catalytic activity GO:0043086 42 0.145
lateral inhibition GO:0046331 206 0.144
macroautophagy GO:0016236 42 0.143
positive regulation of cellular component organization GO:0051130 156 0.143
positive regulation of protein transport GO:0051222 37 0.143
regulation of actin filament based process GO:0032970 42 0.141
regulation of secretion by cell GO:1903530 39 0.141
regulation of glial cell differentiation GO:0045685 1 0.141
ovarian follicle cell development GO:0030707 248 0.140
response to radiation GO:0009314 155 0.140
response to inorganic substance GO:0010035 44 0.140
cell fate determination GO:0001709 91 0.137
epithelial cell proliferation involved in malpighian tubule morphogenesis GO:0061331 11 0.137
mesenchymal cell differentiation GO:0048762 1 0.136
spindle organization GO:0007051 253 0.134
negative regulation of protein metabolic process GO:0051248 85 0.133
positive regulation of cellular biosynthetic process GO:0031328 316 0.132
actomyosin structure organization GO:0031032 56 0.132
regulation of map kinase activity GO:0043405 17 0.132
regulation of defense response GO:0031347 102 0.130
cell fate specification GO:0001708 71 0.129
compound eye cone cell differentiation GO:0042675 13 0.127
establishment of planar polarity GO:0001736 87 0.126
Fly
axon choice point recognition GO:0016198 26 0.125
regulation of phosphorylation GO:0042325 147 0.125
Fly
positive regulation of gliogenesis GO:0014015 5 0.125
cation transport GO:0006812 110 0.123
establishment of tissue polarity GO:0007164 87 0.123
Fly
positive regulation of ras protein signal transduction GO:0046579 43 0.122
wing cell fate specification GO:0035311 3 0.121
negative regulation of epithelial cell migration GO:0010633 1 0.121
developmental maturation GO:0021700 172 0.119
regulation of cellular response to growth factor stimulus GO:0090287 13 0.119
response to extracellular stimulus GO:0009991 116 0.119
chromosome organization GO:0051276 360 0.118
positive regulation of cell cycle process GO:0090068 28 0.118
positive regulation of nitric oxide biosynthetic process GO:0045429 1 0.117
heart morphogenesis GO:0003007 32 0.116
epidermis morphogenesis GO:0048730 5 0.115
regulation of cell cycle GO:0051726 291 0.115
positive regulation of mitotic cell cycle GO:0045931 34 0.115
rhythmic process GO:0048511 106 0.114
regulation of organ morphogenesis GO:2000027 78 0.114
convergent extension GO:0060026 2 0.114
neuron maturation GO:0042551 31 0.113
developmental programmed cell death GO:0010623 138 0.113
cellular response to chemical stimulus GO:0070887 199 0.113
apoptotic signaling pathway GO:0097190 27 0.112
response to drug GO:0042493 17 0.112
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.111
juvenile hormone mediated signaling pathway GO:0035626 3 0.110
regulation of phosphorus metabolic process GO:0051174 210 0.109
Fly
oocyte construction GO:0007308 112 0.107
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.105
histolysis GO:0007559 102 0.104
developmental induction GO:0031128 3 0.103
response to wounding GO:0009611 94 0.102
genital disc development GO:0035215 44 0.102
negative regulation of phosphate metabolic process GO:0045936 45 0.101
heart induction GO:0003129 3 0.101
hematopoietic or lymphoid organ development GO:0048534 57 0.100
protein maturation GO:0051604 71 0.100
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.100
eggshell formation GO:0030703 105 0.099
regulation of proteasomal protein catabolic process GO:0061136 39 0.098
regulation of synaptic transmission GO:0050804 69 0.098
phosphatidylinositol mediated signaling GO:0048015 4 0.096
regulation of cell fate specification GO:0042659 27 0.096
positive regulation of intracellular signal transduction GO:1902533 116 0.096
endocytosis GO:0006897 310 0.095
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.095
photoreceptor cell differentiation GO:0046530 170 0.094
negative regulation of neuron death GO:1901215 18 0.094
secretion by cell GO:0032940 101 0.094
humoral immune response GO:0006959 117 0.093
protein modification by small protein conjugation GO:0032446 79 0.093
regulation of cytoplasmic transport GO:1903649 47 0.092
positive regulation of kinase activity GO:0033674 25 0.092
Fly
negative regulation of neuron apoptotic process GO:0043524 14 0.091
positive regulation of mapk cascade GO:0043410 63 0.090
negative regulation of cell communication GO:0010648 223 0.089
canonical wnt signaling pathway involved in heart development GO:0061316 3 0.089
cell maturation GO:0048469 144 0.088
positive regulation of epithelial cell differentiation GO:0030858 1 0.088
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.087
protein localization to nucleus GO:0034504 55 0.086
skeletal muscle fiber development GO:0048741 3 0.086
organ induction GO:0001759 3 0.086
embryonic hemopoiesis GO:0035162 26 0.085
positive regulation of cell adhesion GO:0045785 10 0.085
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.084
positive regulation of cell growth GO:0030307 19 0.082
rhythmic behavior GO:0007622 76 0.082
negative regulation of apoptotic signaling pathway GO:2001234 5 0.082
negative regulation of cardioblast differentiation GO:0051892 7 0.082
tor signaling GO:0031929 32 0.082
regulation of protein localization GO:0032880 76 0.082
negative regulation of protein modification process GO:0031400 29 0.081
inositol lipid mediated signaling GO:0048017 4 0.080
posttranscriptional regulation of gene expression GO:0010608 145 0.080
regulation of axonogenesis GO:0050770 32 0.078
regulation of dna metabolic process GO:0051052 34 0.077
regulation of meiotic cell cycle GO:0051445 9 0.077
regulation of protein kinase activity GO:0045859 51 0.077
Fly
regulation of stem cell differentiation GO:2000736 14 0.077
protein kinase b signaling GO:0043491 1 0.077
substrate dependent cell migration GO:0006929 3 0.077
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.076
anterior posterior axis specification GO:0009948 109 0.076
regulation of cellular component biogenesis GO:0044087 201 0.076
dna conformation change GO:0071103 105 0.075
salivary gland development GO:0007431 162 0.075
regulation of protein phosphorylation GO:0001932 64 0.075
Fly
peptidyl amino acid modification GO:0018193 105 0.074
Fly
negative regulation of kinase activity GO:0033673 16 0.074
body morphogenesis GO:0010171 2 0.074
central nervous system projection neuron axonogenesis GO:0021952 6 0.074
ras protein signal transduction GO:0007265 88 0.074
nuclear transport GO:0051169 72 0.074
proteolysis GO:0006508 192 0.073
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.073
anatomical structure homeostasis GO:0060249 97 0.073
regulation of synapse structure and activity GO:0050803 128 0.073
axis specification GO:0009798 167 0.072
female germ line cyst formation GO:0048135 42 0.072
cellular response to oxidative stress GO:0034599 28 0.072
response to endogenous stimulus GO:0009719 119 0.071
secretion GO:0046903 109 0.070
cellular response to abiotic stimulus GO:0071214 58 0.070
golgi organization GO:0007030 66 0.070
activation of protein kinase activity GO:0032147 12 0.070
neuroblast fate commitment GO:0014017 19 0.070
wing disc morphogenesis GO:0007472 344 0.067
regulation of cytoskeleton organization GO:0051493 89 0.067
positive regulation of cell motility GO:2000147 3 0.067
epithelial structure maintenance GO:0010669 17 0.066
positive regulation of phosphorylation GO:0042327 87 0.066
Fly
response to ketone GO:1901654 34 0.066
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 4 0.066
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.066
response to peptide GO:1901652 29 0.065
regulation of wound healing GO:0061041 13 0.065
gonad development GO:0008406 50 0.065
erbb signaling pathway GO:0038127 58 0.065
Fly
hindgut morphogenesis GO:0007442 58 0.065
dna packaging GO:0006323 91 0.064
positive regulation of transferase activity GO:0051347 26 0.064
Fly
mitotic nuclear division GO:0007067 213 0.063
regulation of protein serine threonine kinase activity GO:0071900 25 0.063
positive regulation of biosynthetic process GO:0009891 316 0.063
nucleoside metabolic process GO:0009116 127 0.063
extrinsic apoptotic signaling pathway GO:0097191 1 0.062
cell growth GO:0016049 108 0.061
wnt signaling pathway involved in heart development GO:0003306 3 0.061
neuronal action potential GO:0019228 10 0.061
negative regulation of response to stimulus GO:0048585 258 0.061
startle response GO:0001964 16 0.060
positive regulation of cell communication GO:0010647 250 0.060
Fly
aging GO:0007568 143 0.060
positive regulation of cell morphogenesis involved in differentiation GO:0010770 12 0.059
regulation of catalytic activity GO:0050790 185 0.058
Fly
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.058
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.058
Fly
negative regulation of retinal cell programmed cell death GO:0046671 7 0.057
ribonucleoprotein complex disassembly GO:0032988 1 0.055
regulation of establishment of protein localization GO:0070201 61 0.055
protein secretion GO:0009306 45 0.055
insulin receptor signaling pathway GO:0008286 25 0.054
positive regulation of multicellular organismal process GO:0051240 143 0.054
peptidyl tyrosine modification GO:0018212 24 0.054
Fly
positive regulation of reactive oxygen species biosynthetic process GO:1903428 0 0.053
positive regulation of protein metabolic process GO:0051247 128 0.052
Fly
protein targeting to nucleus GO:0044744 51 0.052
negative regulation of neuron differentiation GO:0045665 16 0.051
regulation of phosphate metabolic process GO:0019220 210 0.051
Fly
regulation of cell cycle phase transition GO:1901987 130 0.051
dorsal vessel heart proper cell fate commitment GO:0035053 2 0.051
hindgut development GO:0061525 58 0.050
eye development GO:0001654 323 0.050
Fly
memory GO:0007613 94 0.050
cytokinesis GO:0000910 90 0.050
regulation of dendrite development GO:0050773 37 0.050
head involution GO:0008258 35 0.049
genitalia development GO:0048806 26 0.048
determination of dorsal ventral asymmetry GO:0048262 3 0.048
lipid localization GO:0010876 54 0.048
lipid metabolic process GO:0006629 121 0.047
single organism nuclear import GO:1902593 51 0.047
tube formation GO:0035148 21 0.046
chemosensory behavior GO:0007635 106 0.046
regulation of ras protein signal transduction GO:0046578 93 0.046
oocyte development GO:0048599 124 0.046
nucleus localization GO:0051647 34 0.045
negative regulation of neuroblast proliferation GO:0007406 27 0.045
regulation of localization GO:0032879 275 0.045
regulation of anatomical structure size GO:0090066 163 0.045
cell cell signaling involved in cell fate commitment GO:0045168 210 0.044
ensheathment of neurons GO:0007272 10 0.044
regulation of meiosis GO:0040020 3 0.044
multicellular organismal reproductive behavior GO:0033057 110 0.044
regulation of small gtpase mediated signal transduction GO:0051056 93 0.044
response to nitrogen compound GO:1901698 90 0.044
neuron projection extension GO:1990138 32 0.043
retina development in camera type eye GO:0060041 4 0.043
organonitrogen compound metabolic process GO:1901564 318 0.043
brain morphogenesis GO:0048854 16 0.043
negative regulation of macroautophagy GO:0016242 6 0.042
regulation of kinase activity GO:0043549 53 0.042
Fly
regulation of transport GO:0051049 181 0.042
sensory perception GO:0007600 196 0.042
positive regulation of cell differentiation GO:0045597 64 0.042
male meiosis GO:0007140 52 0.042
positive regulation of stem cell differentiation GO:2000738 3 0.042

spi disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.069
musculoskeletal system disease DOID:17 0 0.069
disease of cellular proliferation DOID:14566 0 0.066
cancer DOID:162 0 0.063
muscular disease DOID:0080000 0 0.061
muscle tissue disease DOID:66 0 0.061
myopathy DOID:423 0 0.043
large intestine cancer DOID:5672 0 0.042
gastrointestinal system cancer DOID:3119 0 0.042
intestinal cancer DOID:10155 0 0.042
organ system cancer DOID:0050686 0 0.042