Drosophila melanogaster

58 known processes

eIF4E-3 (Dmel_CG8023)

CG8023 gene product from transcript CG8023-RA

(Aliases: eIF4E,Dmel\CG8023,anon-WO0140519.227,CG8023)

eIF4E-3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
spermatid differentiation GO:0048515 114 0.814
spermatogenesis GO:0007283 200 0.644
sperm individualization GO:0007291 48 0.542
nuclear division GO:0000280 332 0.495
negative regulation of cellular metabolic process GO:0031324 382 0.253
cellularization GO:0007349 90 0.153
posttranscriptional regulation of gene expression GO:0010608 145 0.140
meiotic cell cycle GO:0051321 171 0.139
organelle assembly GO:0070925 198 0.137
organelle fission GO:0048285 340 0.118
male gamete generation GO:0048232 201 0.118
cilium assembly GO:0042384 38 0.113
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.105
spermatid development GO:0007286 98 0.102
chromosome organization GO:0051276 360 0.100
regulation of protein metabolic process GO:0051246 256 0.099
rna interference GO:0016246 27 0.095
positive regulation of macromolecule metabolic process GO:0010604 405 0.095
regulation of chromatin silencing GO:0031935 36 0.094
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.093
oxoacid metabolic process GO:0043436 103 0.087
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.086
positive regulation of cellular biosynthetic process GO:0031328 316 0.071
cell projection assembly GO:0030031 94 0.070
chromatin silencing GO:0006342 76 0.070
activation of cysteine type endopeptidase activity GO:0097202 17 0.067
organelle fusion GO:0048284 46 0.067
positive regulation of nucleic acid templated transcription GO:1903508 266 0.065
cell division GO:0051301 248 0.064
developmental growth GO:0048589 280 0.064
single organism membrane fusion GO:0044801 42 0.060
organic acid metabolic process GO:0006082 103 0.060
negative regulation of gene expression epigenetic GO:0045814 77 0.059
spindle assembly GO:0051225 80 0.057
positive regulation of rna biosynthetic process GO:1902680 266 0.055
sperm motility GO:0030317 12 0.055
negative regulation of transcription dna templated GO:0045892 237 0.054
negative regulation of rna biosynthetic process GO:1902679 240 0.054
negative regulation of gene expression GO:0010629 387 0.053
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.053
regulation of mitochondrial fusion GO:0010635 5 0.053
germarium derived egg chamber formation GO:0007293 101 0.052
mitochondrial fusion GO:0008053 7 0.049
cellular protein modification process GO:0006464 438 0.049
cilium morphogenesis GO:0060271 39 0.048
posttranscriptional gene silencing by rna GO:0035194 45 0.048
neurological system process GO:0050877 358 0.048
positive regulation of gene expression GO:0010628 290 0.044
positive regulation of cellular protein metabolic process GO:0032270 118 0.044
regulation of anatomical structure morphogenesis GO:0022603 242 0.044
posttranscriptional gene silencing GO:0016441 46 0.044
negative regulation of nucleic acid templated transcription GO:1903507 240 0.043
negative regulation of rna metabolic process GO:0051253 251 0.043
microtubule based transport GO:0010970 42 0.042
negative regulation of cellular biosynthetic process GO:0031327 277 0.041
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.041
sperm mitochondrion organization GO:0030382 7 0.040
positive regulation of protein metabolic process GO:0051247 128 0.040
gland development GO:0048732 191 0.039
Fly
carboxylic acid metabolic process GO:0019752 92 0.039
membrane fusion GO:0061025 42 0.038
growth GO:0040007 359 0.038
sensory perception of sound GO:0007605 56 0.037
gene silencing by rna GO:0031047 57 0.037
small molecule metabolic process GO:0044281 305 0.035
regulation of cellular protein metabolic process GO:0032268 243 0.035
positive regulation of proteolysis GO:0045862 52 0.034
catabolic process GO:0009056 409 0.034
defense response GO:0006952 300 0.034
regulation of gene expression epigenetic GO:0040029 128 0.033
vesicle mediated transport GO:0016192 381 0.033
sperm axoneme assembly GO:0007288 13 0.033
histolysis GO:0007559 102 0.033
Fly
protein modification process GO:0036211 438 0.033
regulation of microtubule based process GO:0032886 49 0.033
gland morphogenesis GO:0022612 145 0.031
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.031
intercellular bridge organization GO:0043063 14 0.031
regulation of organelle organization GO:0033043 196 0.031
endocytosis GO:0006897 310 0.031
compound eye development GO:0048749 307 0.031
regulation of molecular function GO:0065009 217 0.030
autophagy GO:0006914 108 0.030
respiratory system development GO:0060541 213 0.030
Rat
cellular protein catabolic process GO:0044257 83 0.030
negative regulation of biosynthetic process GO:0009890 277 0.029
female germline ring canal formation GO:0007301 9 0.028
fatty acid elongation GO:0030497 3 0.028
regulation of intracellular signal transduction GO:1902531 236 0.027
positive regulation of transcription dna templated GO:0045893 266 0.026
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.026
apoptotic process GO:0006915 159 0.026
positive regulation of peptidase activity GO:0010952 29 0.026
cell proliferation GO:0008283 299 0.026
negative regulation of cellular response to oxidative stress GO:1900408 1 0.025
open tracheal system development GO:0007424 204 0.025
positive regulation of endopeptidase activity GO:0010950 26 0.025
response to glucose GO:0009749 2 0.025
positive regulation of rna metabolic process GO:0051254 271 0.025
cellular response to dna damage stimulus GO:0006974 223 0.024
immune system process GO:0002376 347 0.024
epithelial cell differentiation GO:0030855 322 0.024
regulation of localization GO:0032879 275 0.024
positive regulation of cellular amine metabolic process GO:0033240 0 0.024
phagocytosis GO:0006909 215 0.024
regulation of autophagy GO:0010506 62 0.024
positive regulation of molecular function GO:0044093 136 0.023
cilium organization GO:0044782 41 0.023
neuroblast proliferation GO:0007405 74 0.022
negative regulation of cell communication GO:0010648 223 0.022
programmed cell death GO:0012501 257 0.022
Fly
exocrine system development GO:0035272 162 0.022
Fly
cellular component assembly involved in morphogenesis GO:0010927 151 0.022
synapse organization GO:0050808 196 0.021
death GO:0016265 284 0.021
Fly
ubiquitin dependent protein catabolic process GO:0006511 78 0.020
regulation of cellular ketone metabolic process GO:0010565 3 0.020
salivary gland development GO:0007431 162 0.020
Fly
actomyosin structure organization GO:0031032 56 0.020
autophagic cell death GO:0048102 83 0.019
Fly
synaptic transmission GO:0007268 288 0.019
body morphogenesis GO:0010171 2 0.019
salivary gland morphogenesis GO:0007435 145 0.019
Fly
wing disc morphogenesis GO:0007472 344 0.019
response to nitrogen compound GO:1901698 90 0.019
cell motility GO:0048870 251 0.018
protein complex assembly GO:0006461 200 0.018
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.018
macromolecular complex assembly GO:0065003 256 0.018
positive regulation of signaling GO:0023056 243 0.018
response to other organism GO:0051707 293 0.018
negative regulation of cellular component organization GO:0051129 108 0.018
eye photoreceptor cell differentiation GO:0001754 145 0.018
salivary gland histolysis GO:0035070 88 0.017
Fly
regulation of cytoskeleton organization GO:0051493 89 0.017
immune response GO:0006955 246 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.017
positive regulation of programmed cell death GO:0043068 62 0.017
regulation of cellular component biogenesis GO:0044087 201 0.016
localization of cell GO:0051674 257 0.016
regulation of gene silencing GO:0060968 63 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
protein localization GO:0008104 284 0.016
single organism biosynthetic process GO:0044711 206 0.016
regulation of programmed cell death GO:0043067 152 0.016
multi organism behavior GO:0051705 175 0.015
neuromuscular junction development GO:0007528 149 0.015
negative regulation of peptide secretion GO:0002792 1 0.015
regulation of cellular localization GO:0060341 136 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
cellular catabolic process GO:0044248 372 0.015
myotube cell development GO:0014904 3 0.015
tube development GO:0035295 244 0.015
Rat
cell cycle g1 s phase transition GO:0044843 31 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
regulation of catalytic activity GO:0050790 185 0.014
organic substance transport GO:0071702 257 0.014
circadian sleep wake cycle GO:0042745 28 0.014
macroautophagy GO:0016236 42 0.014
embryo development ending in birth or egg hatching GO:0009792 152 0.014
segmentation GO:0035282 207 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.014
organonitrogen compound metabolic process GO:1901564 318 0.014
response to organic substance GO:0010033 284 0.014
translation GO:0006412 69 0.014
regulation of response to stress GO:0080134 200 0.014
erbb signaling pathway GO:0038127 58 0.014
regulation of microtubule cytoskeleton organization GO:0070507 41 0.014
ovarian follicle cell development GO:0030707 248 0.014
regulation of developmental growth GO:0048638 174 0.014
negative regulation of signaling GO:0023057 219 0.014
regulation of translation GO:0006417 56 0.013
negative regulation of growth GO:0045926 84 0.013
regulation of cell cycle GO:0051726 291 0.013
response to oxygen containing compound GO:1901700 200 0.013
embryonic development via the syncytial blastoderm GO:0001700 148 0.013
actin filament organization GO:0007015 126 0.013
sensory organ morphogenesis GO:0090596 260 0.013
positive regulation of catalytic activity GO:0043085 118 0.013
regulation of proteolysis GO:0030162 87 0.013
organic substance catabolic process GO:1901575 308 0.013
blastoderm segmentation GO:0007350 159 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.013
response to starvation GO:0042594 97 0.013
signal transduction by phosphorylation GO:0023014 107 0.013
photoreceptor cell differentiation GO:0046530 170 0.013
eye development GO:0001654 323 0.013
regulation of phosphorylation GO:0042325 147 0.013
appendage development GO:0048736 401 0.013
negative regulation of signal transduction GO:0009968 206 0.012
embryonic pattern specification GO:0009880 174 0.012
ras protein signal transduction GO:0007265 88 0.012
anterior posterior axis specification embryo GO:0008595 103 0.012
salivary gland cell autophagic cell death GO:0035071 83 0.012
Fly
stem cell proliferation GO:0072089 88 0.012
single organism catabolic process GO:0044712 228 0.012
regulation of growth GO:0040008 233 0.012
response to endogenous stimulus GO:0009719 119 0.012
positive regulation of response to stimulus GO:0048584 323 0.012
intracellular signal transduction GO:0035556 300 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
morphogenesis of an epithelium GO:0002009 276 0.012
columnar cuboidal epithelial cell development GO:0002066 249 0.012
amine metabolic process GO:0009308 12 0.012
protein dna complex subunit organization GO:0071824 86 0.012
mating GO:0007618 120 0.012
positive regulation of cell communication GO:0010647 250 0.012
notch signaling pathway GO:0007219 120 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
ribose phosphate metabolic process GO:0019693 145 0.011
hematopoietic progenitor cell differentiation GO:0002244 1 0.011
regulation of notch signaling pathway GO:0008593 100 0.011
response to external biotic stimulus GO:0043207 293 0.011
tissue death GO:0016271 102 0.011
Fly
spindle organization GO:0007051 253 0.011
meiotic cell cycle process GO:1903046 132 0.011
response to organonitrogen compound GO:0010243 75 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
regulation of endocytosis GO:0030100 37 0.011
response to hexose GO:0009746 3 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.011
centrosome organization GO:0051297 163 0.011
nucleoside phosphate metabolic process GO:0006753 162 0.011
actin cytoskeleton organization GO:0030036 206 0.011
gene silencing GO:0016458 138 0.011
single organism intracellular transport GO:1902582 207 0.011
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.011
gliogenesis GO:0042063 80 0.011
developmental maturation GO:0021700 172 0.011
lipid localization GO:0010876 54 0.011
innate immune response GO:0045087 144 0.011
neuron death GO:0070997 27 0.011
response to monosaccharide GO:0034284 4 0.011
nucleosome organization GO:0034728 59 0.011
phosphorylation GO:0016310 294 0.011
defense response to other organism GO:0098542 225 0.011
protein complex biogenesis GO:0070271 201 0.010
embryonic morphogenesis GO:0048598 206 0.010
protein maturation GO:0051604 71 0.010
cytoplasmic transport GO:0016482 130 0.010
central nervous system development GO:0007417 201 0.010
cation transmembrane transport GO:0098655 88 0.010
rna processing GO:0006396 147 0.010
response to fungus GO:0009620 50 0.010

eIF4E-3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
parkinson s disease DOID:14330 0 0.016
synucleinopathy DOID:0050890 0 0.016
central nervous system disease DOID:331 0 0.016
disease of anatomical entity DOID:7 0 0.016
neurodegenerative disease DOID:1289 0 0.016
nervous system disease DOID:863 0 0.016