Drosophila melanogaster

149 known processes

CSN8 (Dmel_CG42522)

COP9 complex homolog subunit 8

(Aliases: CG13383,Dmel_CG13383,Dmel\CG42522,csn8,CG42522,l(2)SH1829,Dch8,l(2)SH2 1829,CG33297,CH8,Csn8)

CSN8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of biosynthetic process GO:0009891 316 0.804
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.784
regionalization GO:0003002 416 0.764
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.717
imaginal disc derived appendage development GO:0048737 399 0.676
regulation of protein metabolic process GO:0051246 256 0.535
post embryonic appendage morphogenesis GO:0035120 385 0.510
positive regulation of macromolecule metabolic process GO:0010604 405 0.507
negative regulation of transcription dna templated GO:0045892 237 0.499
negative regulation of cellular biosynthetic process GO:0031327 277 0.482
posttranscriptional regulation of gene expression GO:0010608 145 0.435
negative regulation of biosynthetic process GO:0009890 277 0.434
positive regulation of antimicrobial peptide production GO:0002225 28 0.428
development of primary sexual characteristics GO:0045137 50 0.401
protein modification process GO:0036211 438 0.366
regulation of cellular protein metabolic process GO:0032268 243 0.346
proteolysis GO:0006508 192 0.301
dorsal ventral pattern formation GO:0009953 133 0.300
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.268
negative regulation of cellular metabolic process GO:0031324 382 0.266
sex differentiation GO:0007548 81 0.257
regulation of mitotic cell cycle phase transition GO:1901990 130 0.251
catabolic process GO:0009056 409 0.238
tissue death GO:0016271 102 0.229
negative regulation of nucleic acid templated transcription GO:1903507 240 0.221
appendage development GO:0048736 401 0.221
mitotic cell cycle phase transition GO:0044772 138 0.218
protein modification by small protein removal GO:0070646 28 0.217
mitotic cell cycle checkpoint GO:0007093 88 0.213
positive regulation of growth GO:0045927 75 0.212
mitotic g2 m transition checkpoint GO:0044818 70 0.205
positive regulation of gene expression GO:0010628 290 0.201
positive regulation of rna metabolic process GO:0051254 271 0.194
positive regulation of developmental process GO:0051094 143 0.191
gland morphogenesis GO:0022612 145 0.191
histolysis GO:0007559 102 0.184
positive regulation of multi organism process GO:0043902 40 0.184
multicellular organismal reproductive behavior GO:0033057 110 0.182
negative regulation of rna metabolic process GO:0051253 251 0.176
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.173
regulation of cell differentiation GO:0045595 302 0.170
regulation of cellular ketone metabolic process GO:0010565 3 0.170
response to other organism GO:0051707 293 0.168
positive regulation of rna biosynthetic process GO:1902680 266 0.166
histone modification GO:0016570 106 0.165
regulation of growth GO:0040008 233 0.165
reproductive structure development GO:0048608 74 0.159
cell cycle phase transition GO:0044770 140 0.153
positive regulation of transcription dna templated GO:0045893 266 0.149
regulation of rna splicing GO:0043484 69 0.149
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.149
regulation of multi organism process GO:0043900 131 0.148
positive regulation of cellular protein metabolic process GO:0032270 118 0.136
negative regulation of cell cycle phase transition GO:1901988 103 0.132
regulation of mitotic cell cycle GO:0007346 190 0.127
gland development GO:0048732 191 0.124
growth GO:0040007 359 0.122
developmental programmed cell death GO:0010623 138 0.120
rna splicing GO:0008380 83 0.119
positive regulation of protein metabolic process GO:0051247 128 0.119
defense response GO:0006952 300 0.118
imaginal disc derived appendage morphogenesis GO:0035114 395 0.118
positive regulation of cellular biosynthetic process GO:0031328 316 0.114
nucleosome organization GO:0034728 59 0.109
dorsal ventral axis specification GO:0009950 66 0.109
positive regulation of signal transduction GO:0009967 223 0.108
regulation of cell cycle phase transition GO:1901987 130 0.106
regulation of cell proliferation GO:0042127 163 0.105
regulation of cell cycle process GO:0010564 181 0.105
positive regulation of multicellular organismal process GO:0051240 143 0.098
muscle organ development GO:0007517 127 0.098
peptidyl amino acid modification GO:0018193 105 0.098
organic substance catabolic process GO:1901575 308 0.094
negative regulation of gene expression GO:0010629 387 0.094
modification dependent macromolecule catabolic process GO:0043632 79 0.093
g1 s transition of mitotic cell cycle GO:0000082 31 0.093
apposition of dorsal and ventral imaginal disc derived wing surfaces GO:0007475 15 0.092
negative regulation of cell proliferation GO:0008285 69 0.090
salivary gland cell autophagic cell death GO:0035071 83 0.090
modification dependent protein catabolic process GO:0019941 78 0.089
salivary gland morphogenesis GO:0007435 145 0.084
cell death GO:0008219 279 0.083
exocrine system development GO:0035272 162 0.081
axon development GO:0061564 297 0.080
columnar cuboidal epithelial cell development GO:0002066 249 0.080
positive regulation of cell death GO:0010942 69 0.079
ubiquitin dependent protein catabolic process GO:0006511 78 0.079
eye development GO:0001654 323 0.078
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.074
positive regulation of cellular amine metabolic process GO:0033240 0 0.073
immune system process GO:0002376 347 0.072
positive regulation of nucleic acid templated transcription GO:1903508 266 0.072
heart development GO:0007507 82 0.072
peptidyl lysine modification GO:0018205 57 0.072
protein ubiquitination GO:0016567 70 0.070
response to biotic stimulus GO:0009607 294 0.068
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.067
negative regulation of protein metabolic process GO:0051248 85 0.065
transcription from rna polymerase ii promoter GO:0006366 368 0.064
wing disc pattern formation GO:0035222 66 0.063
negative regulation of cellular protein metabolic process GO:0032269 85 0.063
cellular protein modification process GO:0006464 438 0.063
macromolecule catabolic process GO:0009057 161 0.063
cellular amine metabolic process GO:0044106 12 0.061
genitalia development GO:0048806 26 0.061
negative regulation of cell differentiation GO:0045596 143 0.060
autophagic cell death GO:0048102 83 0.059
compound eye morphogenesis GO:0001745 249 0.059
rna catabolic process GO:0006401 37 0.058
regulation of neural precursor cell proliferation GO:2000177 35 0.057
negative regulation of cell cycle process GO:0010948 109 0.056
regulation of chromosome organization GO:0033044 64 0.056
negative regulation of rna biosynthetic process GO:1902679 240 0.056
protein modification by small protein conjugation or removal GO:0070647 106 0.055
amine metabolic process GO:0009308 12 0.055
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.055
regulation of protein stability GO:0031647 43 0.055
negative regulation of neural precursor cell proliferation GO:2000178 27 0.054
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.054
defense response to other organism GO:0098542 225 0.054
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.052
positive regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032436 19 0.052
macromolecular complex assembly GO:0065003 256 0.051
cellular macromolecule catabolic process GO:0044265 136 0.051
salivary gland histolysis GO:0035070 88 0.051
negative regulation of multicellular organismal process GO:0051241 142 0.051
negative regulation of mitotic cell cycle GO:0045930 109 0.051
organonitrogen compound metabolic process GO:1901564 318 0.050
imaginal disc derived wing morphogenesis GO:0007476 337 0.050
regulation of cellular amine metabolic process GO:0033238 3 0.049
protein catabolic process GO:0030163 101 0.049
cellular amide metabolic process GO:0043603 80 0.049
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.048
cytokinesis GO:0000910 90 0.046
appendage morphogenesis GO:0035107 397 0.046
chromosome organization GO:0051276 360 0.045
positive regulation of cell communication GO:0010647 250 0.044
oocyte development GO:0048599 124 0.044
cell maturation GO:0048469 144 0.043
cellular amino acid metabolic process GO:0006520 61 0.043
mrna metabolic process GO:0016071 124 0.043
regulation of catalytic activity GO:0050790 185 0.042
positive regulation of cellular component organization GO:0051130 156 0.041
organ growth GO:0035265 56 0.041
positive regulation of developmental growth GO:0048639 62 0.041
reproductive system development GO:0061458 74 0.040
rna processing GO:0006396 147 0.039
positive regulation of apoptotic process GO:0043065 47 0.038
epithelial cell differentiation GO:0030855 322 0.038
chromatin organization GO:0006325 207 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.038
positive regulation of proteolysis GO:0045862 52 0.038
response to endogenous stimulus GO:0009719 119 0.037
mitotic g2 dna damage checkpoint GO:0007095 69 0.037
regulation of programmed cell death GO:0043067 152 0.036
establishment or maintenance of cell polarity GO:0007163 167 0.035
positive regulation of molecular function GO:0044093 136 0.035
mrna catabolic process GO:0006402 33 0.034
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.034
regulation of molecular function GO:0065009 217 0.034
endocytosis GO:0006897 310 0.034
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.034
mitotic dna damage checkpoint GO:0044773 74 0.034
death GO:0016265 284 0.034
larval lymph gland hemopoiesis GO:0035167 17 0.034
muscle structure development GO:0061061 224 0.034
nephron morphogenesis GO:0072028 3 0.033
nephron tubule morphogenesis GO:0072078 3 0.033
regulation of mrna splicing via spliceosome GO:0048024 64 0.033
salivary gland development GO:0007431 162 0.033
covalent chromatin modification GO:0016569 106 0.032
posttranscriptional gene silencing by rna GO:0035194 45 0.031
programmed cell death GO:0012501 257 0.030
axonogenesis GO:0007409 290 0.030
cullin deneddylation GO:0010388 3 0.030
nephron epithelium morphogenesis GO:0072088 3 0.029
regulation of stem cell proliferation GO:0072091 40 0.029
kidney morphogenesis GO:0060993 3 0.029
negative regulation of defense response GO:0031348 35 0.029
photoreceptor cell differentiation GO:0046530 170 0.028
response to external biotic stimulus GO:0043207 293 0.028
regulation of immune system process GO:0002682 176 0.028
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.028
eye photoreceptor cell differentiation GO:0001754 145 0.027
regulation of mrna processing GO:0050684 71 0.027
regulation of proteolysis GO:0030162 87 0.027
cellular protein catabolic process GO:0044257 83 0.027
cell cycle g1 s phase transition GO:0044843 31 0.026
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.026
intracellular signal transduction GO:0035556 300 0.026
segmentation GO:0035282 207 0.026
cellular macromolecular complex assembly GO:0034622 153 0.025
positive regulation of signaling GO:0023056 243 0.025
oocyte dorsal ventral axis specification GO:0007310 34 0.025
peptide metabolic process GO:0006518 80 0.024
vesicle mediated transport GO:0016192 381 0.024
gonad development GO:0008406 50 0.024
reproductive behavior GO:0019098 122 0.024
imaginal disc pattern formation GO:0007447 91 0.024
multi organism reproductive behavior GO:0044705 121 0.024
positive regulation of intracellular signal transduction GO:1902533 116 0.023
regulation of cell cycle GO:0051726 291 0.023
respiratory system development GO:0060541 213 0.023
regulation of cellular catabolic process GO:0031329 157 0.023
negative regulation of developmental process GO:0051093 201 0.023
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.023
regulation of organelle organization GO:0033043 196 0.023
multi organism behavior GO:0051705 175 0.023
nephron development GO:0072006 3 0.022
cell division GO:0051301 248 0.022
positive regulation of response to stimulus GO:0048584 323 0.022
compound eye photoreceptor cell differentiation GO:0001751 140 0.022
enzyme linked receptor protein signaling pathway GO:0007167 179 0.022
organic acid metabolic process GO:0006082 103 0.022
developmental growth GO:0048589 280 0.022
regulation of translation GO:0006417 56 0.021
peptide biosynthetic process GO:0043043 42 0.021
rna splicing via transesterification reactions GO:0000375 73 0.021
oocyte differentiation GO:0009994 145 0.021
nuclear transcribed mrna catabolic process GO:0000956 24 0.020
regulation of protein catabolic process GO:0042176 55 0.020
developmental maturation GO:0021700 172 0.020
regulation of protein modification process GO:0031399 112 0.020
oxoacid metabolic process GO:0043436 103 0.020
mrna processing GO:0006397 104 0.020
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.020
regulation of epithelial cell differentiation GO:0030856 4 0.019
positive regulation of cellular protein catabolic process GO:1903364 24 0.019
protein modification by small protein conjugation GO:0032446 79 0.019
immune system development GO:0002520 57 0.019
spinal cord development GO:0021510 1 0.019
cellular protein localization GO:0034613 160 0.018
cellular catabolic process GO:0044248 372 0.018
cellular response to dna damage stimulus GO:0006974 223 0.018
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.018
negative regulation of neuroblast proliferation GO:0007406 27 0.018
defense response to bacterium GO:0042742 178 0.018
kidney epithelium development GO:0072073 3 0.018
mrna splicing via spliceosome GO:0000398 73 0.018
negative regulation of translation GO:0017148 28 0.018
dna integrity checkpoint GO:0031570 81 0.018
positive regulation of organelle organization GO:0010638 65 0.017
regulation of cellular protein catabolic process GO:1903362 44 0.017
regulation of cell development GO:0060284 215 0.017
regulation of proteasomal protein catabolic process GO:0061136 39 0.017
mitotic dna integrity checkpoint GO:0044774 75 0.017
positive regulation of antimicrobial humoral response GO:0002760 28 0.017
long term memory GO:0007616 62 0.017
stem cell proliferation GO:0072089 88 0.016
proteasomal protein catabolic process GO:0010498 59 0.016
cellular macromolecule localization GO:0070727 220 0.016
regulation of immune effector process GO:0002697 52 0.016
positive regulation of programmed cell death GO:0043068 62 0.015
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.015
apoptotic process GO:0006915 159 0.015
multicellular organism growth GO:0035264 46 0.015
regulation of multicellular organism growth GO:0040014 40 0.015
wing disc morphogenesis GO:0007472 344 0.014
notch signaling pathway GO:0007219 120 0.014
positive regulation of cellular catabolic process GO:0031331 95 0.014
regulation of localization GO:0032879 275 0.014
regulation of transport GO:0051049 181 0.014
regulation of nuclear division GO:0051783 58 0.014
protein alkylation GO:0008213 43 0.014
nephron epithelium development GO:0072009 3 0.014
cellular response to extracellular stimulus GO:0031668 64 0.014
cell proliferation GO:0008283 299 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.013
regulation of cellular amide metabolic process GO:0034248 39 0.013
histone ubiquitination GO:0016574 4 0.013
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.013
chromatin modification GO:0016568 147 0.013
positive regulation of response to biotic stimulus GO:0002833 31 0.013
regulation of response to stress GO:0080134 200 0.013
positive regulation of catabolic process GO:0009896 105 0.013
single organism catabolic process GO:0044712 228 0.012
posttranscriptional gene silencing GO:0016441 46 0.012
immune effector process GO:0002252 98 0.012
protein import GO:0017038 55 0.012
protein deubiquitination GO:0016579 17 0.012
dendrite development GO:0016358 204 0.012
peptidyl lysine acetylation GO:0018394 39 0.012
regulation of imaginal disc growth GO:0045570 26 0.012
axis specification GO:0009798 167 0.012
regulation of notch signaling pathway GO:0008593 100 0.012
regulation of cellular localization GO:0060341 136 0.012
regulation of defense response GO:0031347 102 0.012
regulation of antimicrobial peptide production GO:0002784 44 0.011
ribonucleoprotein complex biogenesis GO:0022613 31 0.011
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.011
neuron fate commitment GO:0048663 50 0.011
alternative mrna splicing via spliceosome GO:0000380 60 0.011
regulation of chromosome segregation GO:0051983 32 0.011
regulation of cell death GO:0010941 173 0.011
stem cell development GO:0048864 79 0.011
oviposition GO:0018991 19 0.011
multi multicellular organism process GO:0044706 123 0.011
striated muscle tissue development GO:0014706 27 0.011
positive regulation of protein catabolic process GO:0045732 34 0.011
positive regulation of transport GO:0051050 92 0.011
ncrna metabolic process GO:0034660 43 0.011
carboxylic acid metabolic process GO:0019752 92 0.011
cellular ketone metabolic process GO:0042180 24 0.011
regulation of intracellular signal transduction GO:1902531 236 0.011
regulation of mrna metabolic process GO:1903311 72 0.010
centrosome cycle GO:0007098 137 0.010
lipid localization GO:0010876 54 0.010
cellular nitrogen compound catabolic process GO:0044270 165 0.010
regulation of meiosis GO:0040020 3 0.010
cellular response to nutrient levels GO:0031669 62 0.010
regulation of epidermal cell differentiation GO:0045604 3 0.010
histone h4 acetylation GO:0043967 13 0.010
male gamete generation GO:0048232 201 0.010
protein localization to nucleus GO:0034504 55 0.010
protein localization GO:0008104 284 0.010
morphogenesis of an epithelium GO:0002009 276 0.010

CSN8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org