Drosophila melanogaster

106 known processes

Nelf-E (Dmel_CG5994)

Negative elongation factor E

(Aliases: dNelf-E,NELF,Dmel\CG5994,Nelf-e,CG5994,cg5994,anon-66Da,NELF-E)

Nelf-E biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.363
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.360
negative regulation of cellular metabolic process GO:0031324 382 0.331
negative regulation of cellular biosynthetic process GO:0031327 277 0.310
negative regulation of rna metabolic process GO:0051253 251 0.305
negative regulation of transcription dna templated GO:0045892 237 0.300
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.235
negative regulation of biosynthetic process GO:0009890 277 0.198
negative regulation of nucleic acid templated transcription GO:1903507 240 0.191
negative regulation of gene expression GO:0010629 387 0.184
appendage development GO:0048736 401 0.182
segmentation GO:0035282 207 0.172
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.169
cellular protein modification process GO:0006464 438 0.152
transcription from rna polymerase ii promoter GO:0006366 368 0.144
positive regulation of biosynthetic process GO:0009891 316 0.141
chromatin organization GO:0006325 207 0.136
establishment or maintenance of cell polarity GO:0007163 167 0.128
regulation of gene expression epigenetic GO:0040029 128 0.125
compound eye development GO:0048749 307 0.124
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.109
regulation of multicellular organismal development GO:2000026 414 0.100
positive regulation of rna metabolic process GO:0051254 271 0.098
vesicle mediated transport GO:0016192 381 0.098
axis specification GO:0009798 167 0.098
phosphorylation GO:0016310 294 0.096
regulation of cell differentiation GO:0045595 302 0.090
positive regulation of transcription dna templated GO:0045893 266 0.090
protein modification process GO:0036211 438 0.085
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.082
chromosome organization GO:0051276 360 0.081
imaginal disc derived appendage development GO:0048737 399 0.078
regulation of neurogenesis GO:0050767 158 0.076
regionalization GO:0003002 416 0.075
dendrite development GO:0016358 204 0.072
establishment of localization in cell GO:0051649 402 0.072
positive regulation of cellular biosynthetic process GO:0031328 316 0.072
negative regulation of rna biosynthetic process GO:1902679 240 0.070
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.069
tissue morphogenesis GO:0048729 297 0.068
cellular response to dna damage stimulus GO:0006974 223 0.068
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.067
central nervous system development GO:0007417 201 0.067
regulation of nervous system development GO:0051960 248 0.066
anterior posterior pattern specification GO:0009952 136 0.065
imaginal disc derived appendage morphogenesis GO:0035114 395 0.062
spindle assembly GO:0051225 80 0.062
chemical homeostasis GO:0048878 92 0.061
positive regulation of gene expression GO:0010628 290 0.059
regulation of molecular function GO:0065009 217 0.059
axon development GO:0061564 297 0.057
embryonic axis specification GO:0000578 107 0.057
regulation of cell development GO:0060284 215 0.054
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.054
wing disc morphogenesis GO:0007472 344 0.053
adult behavior GO:0030534 137 0.051
post embryonic appendage morphogenesis GO:0035120 385 0.051
segment specification GO:0007379 33 0.050
macromolecular complex assembly GO:0065003 256 0.050
anterior posterior axis specification GO:0009948 109 0.047
protein complex assembly GO:0006461 200 0.046
cell proliferation GO:0008283 299 0.046
positive regulation of macromolecule metabolic process GO:0010604 405 0.046
eye photoreceptor cell differentiation GO:0001754 145 0.045
response to abiotic stimulus GO:0009628 341 0.044
oocyte development GO:0048599 124 0.044
positive regulation of protein metabolic process GO:0051247 128 0.043
anterior posterior axis specification embryo GO:0008595 103 0.042
positive regulation of phosphate metabolic process GO:0045937 139 0.042
gene silencing GO:0016458 138 0.042
cell maturation GO:0048469 144 0.041
developmental maturation GO:0021700 172 0.041
organonitrogen compound metabolic process GO:1901564 318 0.040
organic substance catabolic process GO:1901575 308 0.039
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.039
appendage morphogenesis GO:0035107 397 0.039
regulation of localization GO:0032879 275 0.038
regulation of neuron differentiation GO:0045664 103 0.038
imaginal disc derived wing morphogenesis GO:0007476 337 0.037
phagocytosis GO:0006909 215 0.036
histone modification GO:0016570 106 0.036
embryonic development via the syncytial blastoderm GO:0001700 148 0.036
nucleobase containing compound catabolic process GO:0034655 165 0.035
dendrite morphogenesis GO:0048813 199 0.035
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.034
compound eye photoreceptor cell differentiation GO:0001751 140 0.034
posttranscriptional gene silencing by rna GO:0035194 45 0.033
atp dependent chromatin remodeling GO:0043044 22 0.033
endocytosis GO:0006897 310 0.033
protein complex biogenesis GO:0070271 201 0.032
organelle assembly GO:0070925 198 0.032
regulation of phosphate metabolic process GO:0019220 210 0.032
oocyte differentiation GO:0009994 145 0.032
signal transduction by phosphorylation GO:0023014 107 0.032
neuroblast proliferation GO:0007405 74 0.031
response to organic substance GO:0010033 284 0.031
locomotory behavior GO:0007626 176 0.031
embryonic pattern specification GO:0009880 174 0.031
positive regulation of rna biosynthetic process GO:1902680 266 0.031
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.030
morphogenesis of an epithelium GO:0002009 276 0.030
regulation of cellular protein metabolic process GO:0032268 243 0.030
compound eye morphogenesis GO:0001745 249 0.030
catabolic process GO:0009056 409 0.030
neurological system process GO:0050877 358 0.029
cellular component assembly involved in morphogenesis GO:0010927 151 0.029
response to oxygen containing compound GO:1901700 200 0.028
muscle structure development GO:0061061 224 0.028
tripartite regional subdivision GO:0007351 103 0.027
eye morphogenesis GO:0048592 260 0.027
cellular macromolecule catabolic process GO:0044265 136 0.027
response to other organism GO:0051707 293 0.027
negative regulation of developmental process GO:0051093 201 0.027
cell division GO:0051301 248 0.026
positive regulation of cell communication GO:0010647 250 0.026
defense response GO:0006952 300 0.026
positive regulation of phosphorus metabolic process GO:0010562 139 0.026
programmed cell death GO:0012501 257 0.026
rna processing GO:0006396 147 0.025
death GO:0016265 284 0.025
cellular catabolic process GO:0044248 372 0.024
mitotic spindle organization GO:0007052 220 0.024
covalent chromatin modification GO:0016569 106 0.024
eye development GO:0001654 323 0.024
mitotic sister chromatid segregation GO:0000070 87 0.023
small molecule metabolic process GO:0044281 305 0.023
regulation of protein metabolic process GO:0051246 256 0.023
positive regulation of response to stimulus GO:0048584 323 0.023
oocyte anterior posterior axis specification GO:0007314 72 0.023
r7 cell differentiation GO:0045466 43 0.023
embryonic morphogenesis GO:0048598 206 0.023
sensory organ morphogenesis GO:0090596 260 0.022
spindle organization GO:0007051 253 0.022
stem cell differentiation GO:0048863 117 0.022
neuron projection guidance GO:0097485 241 0.022
regulation of catalytic activity GO:0050790 185 0.022
chromatin modification GO:0016568 147 0.021
single organism behavior GO:0044708 391 0.021
negative regulation of gene expression epigenetic GO:0045814 77 0.021
axonogenesis GO:0007409 290 0.021
dorsal closure GO:0007391 79 0.020
dna conformation change GO:0071103 105 0.020
axon guidance GO:0007411 233 0.020
social behavior GO:0035176 4 0.020
regulation of organelle organization GO:0033043 196 0.020
adult locomotory behavior GO:0008344 76 0.020
cell death GO:0008219 279 0.020
cellular nitrogen compound catabolic process GO:0044270 165 0.019
oocyte axis specification GO:0007309 108 0.019
microtubule organizing center organization GO:0031023 168 0.019
single organism intracellular transport GO:1902582 207 0.019
immune system process GO:0002376 347 0.019
blastoderm segmentation GO:0007350 159 0.019
photoreceptor cell differentiation GO:0046530 170 0.019
stem cell proliferation GO:0072089 88 0.019
mapk cascade GO:0000165 107 0.019
intraspecies interaction between organisms GO:0051703 4 0.019
positive regulation of transport GO:0051050 92 0.018
regulation of protein modification process GO:0031399 112 0.018
regulation of phosphorus metabolic process GO:0051174 210 0.018
localization of cell GO:0051674 257 0.018
protein phosphorylation GO:0006468 169 0.018
positive regulation of nucleic acid templated transcription GO:1903508 266 0.018
macromolecule catabolic process GO:0009057 161 0.018
multi organism behavior GO:0051705 175 0.018
intracellular signal transduction GO:0035556 300 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.017
muscle organ development GO:0007517 127 0.017
brain development GO:0007420 120 0.016
aging GO:0007568 143 0.016
sister chromatid segregation GO:0000819 92 0.016
regulation of transport GO:0051049 181 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
dna metabolic process GO:0006259 227 0.016
carboxylic acid metabolic process GO:0019752 92 0.016
positive regulation of protein modification process GO:0031401 58 0.016
positive regulation of cell proliferation GO:0008284 47 0.015
tube morphogenesis GO:0035239 191 0.015
organic cyclic compound catabolic process GO:1901361 168 0.015
regulation of epithelial cell proliferation GO:0050678 4 0.015
neuromuscular junction development GO:0007528 149 0.015
regulation of anatomical structure morphogenesis GO:0022603 242 0.015
regulation of cell cycle GO:0051726 291 0.015
aromatic compound catabolic process GO:0019439 166 0.014
gliogenesis GO:0042063 80 0.014
regulation of intracellular signal transduction GO:1902531 236 0.014
inorganic ion transmembrane transport GO:0098660 73 0.014
protein complex disassembly GO:0043241 36 0.014
photoreceptor cell development GO:0042461 96 0.014
cell motility GO:0048870 251 0.014
oocyte construction GO:0007308 112 0.014
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.013
single organism cellular localization GO:1902580 180 0.013
positive regulation of signaling GO:0023056 243 0.013
organelle fission GO:0048285 340 0.013
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.012
maternal determination of anterior posterior axis embryo GO:0008358 74 0.012
determination of left right symmetry GO:0007368 9 0.012
secretion by cell GO:0032940 101 0.012
oxoacid metabolic process GO:0043436 103 0.012
learning GO:0007612 75 0.012
immune response GO:0006955 246 0.012
regulation of cell proliferation GO:0042127 163 0.012
positive regulation of phosphorylation GO:0042327 87 0.012
neuron fate commitment GO:0048663 50 0.012
mitotic nuclear division GO:0007067 213 0.012
heterocycle catabolic process GO:0046700 166 0.012
regulation of mapk cascade GO:0043408 92 0.012
cytoplasm organization GO:0007028 64 0.011
protein localization GO:0008104 284 0.011
chemotaxis GO:0006935 249 0.011
positive regulation of cellular component organization GO:0051130 156 0.011
rna localization GO:0006403 115 0.011
regulation of apoptotic process GO:0042981 130 0.011
regulation of phosphorylation GO:0042325 147 0.011
spindle assembly involved in mitosis GO:0090307 50 0.011
centrosome organization GO:0051297 163 0.011
gene silencing by rna GO:0031047 57 0.011
positive regulation of molecular function GO:0044093 136 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
forebrain development GO:0030900 2 0.011
response to alcohol GO:0097305 95 0.011
stress activated protein kinase signaling cascade GO:0031098 55 0.011
eye antennal disc development GO:0035214 60 0.010
secretion GO:0046903 109 0.010
digestive system development GO:0055123 149 0.010
stem cell division GO:0017145 69 0.010
cellular response to nitrogen compound GO:1901699 51 0.010
negative regulation of phosphorus metabolic process GO:0010563 45 0.010
imaginal disc derived leg morphogenesis GO:0007480 80 0.010
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.010
histone lysine methylation GO:0034968 32 0.010
gastrulation GO:0007369 70 0.010

Nelf-E disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011