Drosophila melanogaster

274 known processes

dpp (Dmel_CG9885)

decapentaplegic

(Aliases: CG9885,DPP-C,shv,DPP,Dmel\CG9885,TGFbeta,Dpp,l(2)10638,blk,Hin-d,BMP,M(2)23AB,ho,TGF-beta,Dm-DPP,Tg,l(2)k17036,TGF-b,l(2)22Fa,M(2)LS1)

dpp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryonic morphogenesis GO:0048598 206 0.999
tissue morphogenesis GO:0048729 297 0.997
genital disc pattern formation GO:0035221 8 0.997
genital disc anterior posterior pattern formation GO:0035224 8 0.996
renal tubule development GO:0061326 64 0.995
regulation of cell fate specification GO:0042659 27 0.994
Zebrafish
morphogenesis of a branching epithelium GO:0061138 45 0.993
Human Mouse
heart morphogenesis GO:0003007 32 0.993
Human Zebrafish Mouse
cell surface receptor signaling pathway involved in heart development GO:0061311 3 0.991
Human Zebrafish
regulation of organ formation GO:0003156 3 0.991
Human Mouse
regulation of heart morphogenesis GO:2000826 3 0.991
Human
transcription from rna polymerase ii promoter GO:0006366 368 0.987
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.986
Human Mouse
anterior posterior pattern specification imaginal disc GO:0007448 16 0.984
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.984
regulation of organ morphogenesis GO:2000027 78 0.984
Human Mouse
immune system process GO:0002376 347 0.983
segmentation GO:0035282 207 0.978
Mouse
sensory organ morphogenesis GO:0090596 260 0.978
muscle structure development GO:0061061 224 0.977
hemopoiesis GO:0030097 46 0.976
morphogenesis of an epithelium GO:0002009 276 0.972
regionalization GO:0003002 416 0.972
negative regulation of cellular biosynthetic process GO:0031327 277 0.970
Human Mouse
positive regulation of transcription dna templated GO:0045893 266 0.967
Human Mouse
anterior posterior pattern specification GO:0009952 136 0.966
cardiocyte differentiation GO:0035051 29 0.958
regulation of stem cell proliferation GO:0072091 40 0.956
Human
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.951
heart development GO:0007507 82 0.951
eye morphogenesis GO:0048592 260 0.948
open tracheal system development GO:0007424 204 0.938
apoptotic process involved in morphogenesis GO:0060561 3 0.935
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.933
embryonic pattern specification GO:0009880 174 0.933
mesoderm formation GO:0001707 21 0.932
Human Zebrafish Mouse
positive regulation of muscle organ development GO:0048636 6 0.930
bmp signaling pathway GO:0030509 27 0.929
regulation of cell fate commitment GO:0010453 29 0.928
Human Zebrafish
cell fate specification GO:0001708 71 0.927
ovarian follicle cell development GO:0030707 248 0.925
epithelial cell differentiation GO:0030855 322 0.918
localization of cell GO:0051674 257 0.917
stem cell development GO:0048864 79 0.915
kidney morphogenesis GO:0060993 3 0.910
Human Mouse
neuron projection guidance GO:0097485 241 0.909
glial cell migration GO:0008347 31 0.905
malpighian tubule morphogenesis GO:0007443 44 0.903
muscle cell differentiation GO:0042692 103 0.898
Human Zebrafish Mouse
embryonic hindgut morphogenesis GO:0048619 48 0.890
malpighian tubule development GO:0072002 64 0.886
negative regulation of developmental process GO:0051093 201 0.882
morphogenesis of an epithelial bud GO:0060572 3 0.880
Mouse
gastrulation GO:0007369 70 0.877
Human Zebrafish Mouse
embryonic heart tube development GO:0035050 22 0.873
Zebrafish Mouse
appendage morphogenesis GO:0035107 397 0.868
positive regulation of pathway restricted smad protein phosphorylation GO:0010862 1 0.865
Human
cell fate commitment involved in formation of primary germ layer GO:0060795 10 0.863
Zebrafish Mouse
imaginal disc derived wing morphogenesis GO:0007476 337 0.862
negative regulation of cell fate specification GO:0009996 15 0.861
Zebrafish
digestive tract morphogenesis GO:0048546 127 0.854
digestive system development GO:0055123 149 0.854
positive regulation of cell differentiation GO:0045597 64 0.852
Human Mouse
spinal cord dorsal ventral patterning GO:0021513 1 0.851
cardioblast differentiation GO:0010002 20 0.839
embryonic development via the syncytial blastoderm GO:0001700 148 0.836
cell motility GO:0048870 251 0.833
cell fate specification involved in pattern specification GO:0060573 8 0.828
cardiovascular system development GO:0072358 82 0.826
hindgut development GO:0061525 58 0.825
positive regulation of growth GO:0045927 75 0.823
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.816
Human Mouse
embryonic axis specification GO:0000578 107 0.813
determination of genital disc primordium GO:0035225 10 0.812
eye development GO:0001654 323 0.811
negative regulation of rna biosynthetic process GO:1902679 240 0.803
Human Mouse
regulation of embryonic development GO:0045995 68 0.802
Zebrafish Mouse
developmental programmed cell death GO:0010623 138 0.798
central nervous system development GO:0007417 201 0.798
Human Mouse
head development GO:0060322 135 0.796
Human Mouse
brain development GO:0007420 120 0.795
Human Mouse
defense response GO:0006952 300 0.795
Mouse
regulation of protein metabolic process GO:0051246 256 0.795
Human Mouse
regulation of imaginal disc derived wing size GO:0044719 20 0.794
gland morphogenesis GO:0022612 145 0.793
Mouse
axon guidance GO:0007411 233 0.783
organ induction GO:0001759 3 0.779
Human Mouse
wing disc morphogenesis GO:0007472 344 0.778
spinal cord patterning GO:0021511 1 0.776
hemocyte differentiation GO:0042386 38 0.773
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.771
Human Mouse
wing disc pattern formation GO:0035222 66 0.771
imaginal disc derived appendage morphogenesis GO:0035114 395 0.769
motor neuron axon guidance GO:0008045 58 0.767
appendage development GO:0048736 401 0.762
chemotaxis GO:0006935 249 0.760
salivary gland morphogenesis GO:0007435 145 0.755
skeletal muscle organ development GO:0060538 48 0.754
Human Mouse
regulation of cell cycle GO:0051726 291 0.751
Human
germ cell migration GO:0008354 43 0.733
regulation of cell differentiation GO:0045595 302 0.732
renal system development GO:0072001 72 0.730
axonogenesis GO:0007409 290 0.728
blastoderm segmentation GO:0007350 159 0.726
mesoderm development GO:0007498 78 0.722
compound eye morphogenesis GO:0001745 249 0.714
epithelial tube morphogenesis GO:0060562 88 0.712
positive regulation of cellular biosynthetic process GO:0031328 316 0.711
Human Mouse
anterior posterior axis specification GO:0009948 109 0.710
Mouse
nephron morphogenesis GO:0072028 3 0.705
Human Mouse
regulation of tube size GO:0035150 46 0.705
organelle fission GO:0048285 340 0.704
Human
embryonic organ development GO:0048568 50 0.702
Zebrafish Mouse
cell fate commitment involved in pattern specification GO:0060581 31 0.693
neuroblast proliferation GO:0007405 74 0.690
morphogenesis of a branching structure GO:0001763 45 0.683
Human Mouse
enteroendocrine cell differentiation GO:0035883 1 0.680
Human
positive regulation of rna biosynthetic process GO:1902680 266 0.675
Human Mouse
positive regulation of rna metabolic process GO:0051254 271 0.673
Human Mouse
photoreceptor cell differentiation GO:0046530 170 0.671
respiratory system development GO:0060541 213 0.669
wing and notum subfield formation GO:0035309 13 0.658
taxis GO:0042330 304 0.657
negative regulation of transcription dna templated GO:0045892 237 0.652
Human Mouse
myotube cell development GO:0014904 3 0.651
Human Mouse
stem cell differentiation GO:0048863 117 0.641
cell division GO:0051301 248 0.638
mesodermal cell fate commitment GO:0001710 7 0.632
Zebrafish Mouse
negative regulation of cardiac cell fate specification GO:2000044 7 0.624
regulation of secretion by cell GO:1903530 39 0.622
aging GO:0007568 143 0.615
germ line stem cell maintenance GO:0030718 50 0.613
regulation of neuroblast proliferation GO:1902692 34 0.613
tube formation GO:0035148 21 0.611
Human Zebrafish Mouse
cell migration GO:0016477 238 0.610
camera type eye development GO:0043010 4 0.602
Mouse
stem cell proliferation GO:0072089 88 0.597
Human Mouse
spiracle morphogenesis open tracheal system GO:0035277 22 0.593
regulation of epithelial cell proliferation GO:0050678 4 0.590
Human Mouse
branching morphogenesis of an epithelial tube GO:0048754 45 0.587
Human Mouse
organic substance transport GO:0071702 257 0.581
Human
determination of dorsal ventral asymmetry GO:0048262 3 0.580
Zebrafish
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.579
Human Mouse
negative regulation of cell cell adhesion GO:0022408 8 0.578
Human
muscle organ development GO:0007517 127 0.578
determination of imaginal disc primordium GO:0007445 11 0.577
regulation of cardioblast differentiation GO:0051890 9 0.571
connective tissue development GO:0061448 3 0.551
Human Mouse
regulation of cardiac cell fate specification GO:2000043 8 0.545
positive regulation of cell development GO:0010720 61 0.541
Human Mouse
positive regulation of gene expression GO:0010628 290 0.539
Human Mouse
male gamete generation GO:0048232 201 0.534
mesenchymal cell differentiation GO:0048762 1 0.533
Human Mouse
regulation of transport GO:0051049 181 0.527
Human
dorsal ventral pattern formation GO:0009953 133 0.525
regulation of multicellular organismal development GO:2000026 414 0.523
striated muscle cell differentiation GO:0051146 90 0.520
Human Zebrafish Mouse
salivary gland development GO:0007431 162 0.505
columnar cuboidal epithelial cell development GO:0002066 249 0.501
cell adhesion GO:0007155 136 0.500
Human
muscle fiber development GO:0048747 12 0.500
Human Mouse
mesodermal cell fate specification GO:0007501 2 0.497
Zebrafish
immune system development GO:0002520 57 0.495
imaginal disc pattern formation GO:0007447 91 0.493
regulation of muscle organ development GO:0048634 13 0.491
regulation of developmental growth GO:0048638 174 0.486
cell death GO:0008219 279 0.477
Human Mouse
torso signaling pathway GO:0008293 21 0.477
labial disc development GO:0035217 4 0.475
formation of primary germ layer GO:0001704 24 0.473
Human Zebrafish Mouse
genital disc development GO:0035215 44 0.472
ameboidal type cell migration GO:0001667 151 0.472
regulation of heart induction GO:0090381 3 0.472
organ growth GO:0035265 56 0.470
negative regulation of rna metabolic process GO:0051253 251 0.461
Human Mouse
body morphogenesis GO:0010171 2 0.452
regulation of mitotic cell cycle GO:0007346 190 0.445
Human
gliogenesis GO:0042063 80 0.442
Mouse
negative regulation of gene expression GO:0010629 387 0.441
axon development GO:0061564 297 0.439
renal tubule morphogenesis GO:0061333 44 0.436
heart field specification GO:0003128 0 0.432
Human
gland development GO:0048732 191 0.424
genital disc sexually dimorphic development GO:0035263 4 0.423
photoreceptor cell fate commitment GO:0046552 41 0.417
positive regulation of epithelial cell differentiation GO:0030858 1 0.416
Human Mouse
spermatogenesis GO:0007283 200 0.415
tube development GO:0035295 244 0.413
telencephalon development GO:0021537 2 0.405
Human Mouse
cardiac cell fate commitment GO:0060911 17 0.402
synaptic transmission GO:0007268 288 0.401
heart formation GO:0060914 6 0.398
Human
regulation of stem cell differentiation GO:2000736 14 0.395
Human Mouse
forebrain development GO:0030900 2 0.394
Human Mouse
leg disc development GO:0035218 92 0.387
negative regulation of cellular metabolic process GO:0031324 382 0.385
Human Mouse
response to growth factor GO:0070848 31 0.384
Human Mouse
nephron epithelium morphogenesis GO:0072088 3 0.383
Human Mouse
imaginal disc derived appendage development GO:0048737 399 0.379
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.379
Human Mouse
limb morphogenesis GO:0035108 1 0.375
Mouse
regulation of bmp signaling pathway GO:0030510 23 0.373
Mouse
negative regulation of bmp signaling pathway GO:0030514 12 0.368
circulatory system development GO:0072359 82 0.368
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.367
Human Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.361
Human Mouse
epithelial cell migration open tracheal system GO:0007427 32 0.361
mesoderm morphogenesis GO:0048332 22 0.356
Human Zebrafish Mouse
growth GO:0040007 359 0.352
negative regulation of cardioblast differentiation GO:0051892 7 0.350
positive regulation of multicellular organismal process GO:0051240 143 0.348
response to biotic stimulus GO:0009607 294 0.346
stem cell division GO:0017145 69 0.343
regulation of cardioblast cell fate specification GO:0042686 8 0.341
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.341
Human Mouse
mesenchyme development GO:0060485 9 0.332
Human Zebrafish Mouse
negative regulation of immune system process GO:0002683 50 0.331
Human
single organismal cell cell adhesion GO:0016337 45 0.331
Human
eye photoreceptor cell differentiation GO:0001754 145 0.327
limb development GO:0060173 1 0.321
Mouse
imaginal disc growth GO:0007446 37 0.320
autophagy GO:0006914 108 0.319
epidermis development GO:0008544 65 0.311
Human
muscle cell fate specification GO:0042694 7 0.310
specification of organ identity GO:0010092 3 0.309
Human Mouse
larval development GO:0002164 104 0.309
positive regulation of macromolecule metabolic process GO:0010604 405 0.306
Human Mouse
cellular response to chemical stimulus GO:0070887 199 0.303
dna metabolic process GO:0006259 227 0.299
Human
nephron development GO:0072006 3 0.298
Human Mouse
muscle tissue development GO:0060537 30 0.298
Human Zebrafish Mouse
positive regulation of nucleic acid templated transcription GO:1903508 266 0.298
Human Mouse
muscle cell fate commitment GO:0042693 14 0.293
cellular response to organic substance GO:0071310 132 0.293
Human Mouse
skin development GO:0043588 65 0.286
Human
enzyme linked receptor protein signaling pathway GO:0007167 179 0.286
negative regulation of programmed cell death GO:0043069 72 0.285
Human Mouse
heart induction GO:0003129 3 0.284
Human
cell cycle phase transition GO:0044770 140 0.281
axis specification GO:0009798 167 0.279
regulation of multicellular organism growth GO:0040014 40 0.272
organ formation GO:0048645 39 0.271
Human Mouse
determination of ventral identity GO:0048264 1 0.268
Zebrafish
regulation of hemocyte differentiation GO:0045610 22 0.262
anterior posterior axis specification embryo GO:0008595 103 0.262
embryonic organ morphogenesis GO:0048562 5 0.261
Zebrafish Mouse
negative regulation of cell fate commitment GO:0010454 17 0.256
Zebrafish
molting cycle GO:0042303 56 0.256
cell maturation GO:0048469 144 0.256
hindgut morphogenesis GO:0007442 58 0.254
positive regulation of developmental growth GO:0048639 62 0.252
multi organism reproductive behavior GO:0044705 121 0.251
response to radiation GO:0009314 155 0.249
eye antennal disc development GO:0035214 60 0.249
morphogenesis of an epithelial fold GO:0060571 6 0.248
Mouse
post embryonic appendage morphogenesis GO:0035120 385 0.247
kidney development GO:0001822 3 0.241
Human Zebrafish Mouse
hair cell differentiation GO:0035315 47 0.240
negative regulation of cell differentiation GO:0045596 143 0.240
positive regulation of stem cell proliferation GO:2000648 8 0.240
tripartite regional subdivision GO:0007351 103 0.236
embryo development ending in birth or egg hatching GO:0009792 152 0.236
positive regulation of cell proliferation GO:0008284 47 0.234
Human Zebrafish Mouse
nephron tubule morphogenesis GO:0072078 3 0.230
Human Mouse
digestive tract development GO:0048565 149 0.229
cell proliferation GO:0008283 299 0.227
Human Zebrafish Mouse
organic acid metabolic process GO:0006082 103 0.224
regulation of anatomical structure morphogenesis GO:0022603 242 0.224
Human Zebrafish Mouse
positive regulation of signaling GO:0023056 243 0.223
Human Mouse
establishment or maintenance of cell polarity GO:0007163 167 0.222
response to organic substance GO:0010033 284 0.222
Human Mouse
wing disc anterior posterior pattern formation GO:0048100 5 0.219
compound eye photoreceptor cell differentiation GO:0001751 140 0.219
chorion containing eggshell formation GO:0007304 105 0.216
hematopoietic progenitor cell differentiation GO:0002244 1 0.213
Human Mouse
gastrulation with mouth forming first GO:0001703 36 0.210
kidney epithelium development GO:0072073 3 0.205
Human Mouse
regulation of cellular protein metabolic process GO:0032268 243 0.204
Human Mouse
spinal cord development GO:0021510 1 0.204
regulation of apoptotic process GO:0042981 130 0.200
Human Mouse
branching involved in open tracheal system development GO:0060446 45 0.200
positive regulation of phosphorylation GO:0042327 87 0.196
Human Mouse
neural precursor cell proliferation GO:0061351 75 0.195
regulation of intracellular signal transduction GO:1902531 236 0.194
Human Mouse
regulation of system process GO:0044057 36 0.194
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.193
regulation of cell death GO:0010941 173 0.190
Human Mouse
exocrine system development GO:0035272 162 0.186
cellular response to growth factor stimulus GO:0071363 30 0.182
Human Mouse
hematopoietic or lymphoid organ development GO:0048534 57 0.180
regulation of localization GO:0032879 275 0.176
Human Mouse
negative regulation of cell communication GO:0010648 223 0.174
Human
positive regulation of cell migration GO:0030335 2 0.172
Human Mouse
negative regulation of cellular protein metabolic process GO:0032269 85 0.170
Human
regulation of cell proliferation GO:0042127 163 0.170
Human Zebrafish Mouse
regulation of nervous system development GO:0051960 248 0.168
Mouse
haltere disc development GO:0035216 10 0.168
ventral midline development GO:0007418 9 0.167
multicellular organismal aging GO:0010259 140 0.166
regulation of protein modification process GO:0031399 112 0.165
Human Mouse
death GO:0016265 284 0.165
Human Mouse
visceral muscle development GO:0007522 14 0.162
regulation of apoptotic signaling pathway GO:2001233 10 0.162
regulation of neurogenesis GO:0050767 158 0.162
Mouse
neuron fate commitment GO:0048663 50 0.161
Mouse
negative regulation of catalytic activity GO:0043086 42 0.159
Human
specification of symmetry GO:0009799 13 0.158
Human Zebrafish
imaginal disc derived wing vein specification GO:0007474 48 0.156
endodermal cell differentiation GO:0035987 3 0.154
Zebrafish
cellular response to abiotic stimulus GO:0071214 58 0.152
striated muscle cell development GO:0055002 50 0.152
Human Zebrafish Mouse
negative regulation of apoptotic process GO:0043066 63 0.151
Human Mouse
secretion by cell GO:0032940 101 0.150
histolysis GO:0007559 102 0.150
cell growth GO:0016049 108 0.149
organelle localization GO:0051640 148 0.148
wing cell fate specification GO:0035311 3 0.148
peptidyl amino acid modification GO:0018193 105 0.148
oxoacid metabolic process GO:0043436 103 0.148
multicellular organism growth GO:0035264 46 0.147
regulation of cellular amino acid metabolic process GO:0006521 0 0.147
protein localization GO:0008104 284 0.143
Human
lymph gland development GO:0048542 28 0.140
protein catabolic process GO:0030163 101 0.139
multicellular organismal reproductive behavior GO:0033057 110 0.139
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.137
determination of left right symmetry GO:0007368 9 0.137
Zebrafish
endocytosis GO:0006897 310 0.136
extracellular structure organization GO:0043062 46 0.131
apoptotic process GO:0006915 159 0.130
Human Mouse
formation of anatomical boundary GO:0048859 37 0.128
Mouse
larval lymph gland hemopoiesis GO:0035167 17 0.127
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.127
Human Mouse
imaginal disc derived wing hair organization GO:0035317 45 0.126
positive regulation of ribosome biogenesis GO:0090070 3 0.126
negative regulation of multicellular organismal process GO:0051241 142 0.124
Human Zebrafish Mouse
vesicle mediated transport GO:0016192 381 0.122
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.121
Human Mouse
cellular response to nitrogen compound GO:1901699 51 0.121
carboxylic acid metabolic process GO:0019752 92 0.121
morphogenesis of a polarized epithelium GO:0001738 93 0.120
male gonad development GO:0008584 9 0.119
intracellular signal transduction GO:0035556 300 0.119
Human Mouse
nitrogen compound transport GO:0071705 85 0.118
hindbrain development GO:0030902 2 0.117
nuclear division GO:0000280 332 0.117
Human
skeletal muscle fiber development GO:0048741 3 0.116
Human Mouse
actin filament based process GO:0030029 220 0.115
negative regulation of nervous system development GO:0051961 92 0.115
negative regulation of cell death GO:0060548 81 0.114
Human Mouse
single organism behavior GO:0044708 391 0.112
regulation of cell motility GO:2000145 23 0.111
Human Mouse
sex differentiation GO:0007548 81 0.110
cellular catabolic process GO:0044248 372 0.110
positive regulation of protein metabolic process GO:0051247 128 0.108
Human Mouse
regulation of tube architecture open tracheal system GO:0035152 68 0.108
mesenchymal cell development GO:0014031 1 0.106
Human Mouse
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.105
regulation of cell cycle phase transition GO:1901987 130 0.102
response to other organism GO:0051707 293 0.101
negative regulation of biosynthetic process GO:0009890 277 0.101
Human Mouse
crystal cell differentiation GO:0042688 7 0.101
epithelial cell proliferation involved in malpighian tubule morphogenesis GO:0061331 11 0.101
positive regulation of biosynthetic process GO:0009891 316 0.101
Human Mouse
cellular amino acid metabolic process GO:0006520 61 0.100
compound eye retinal cell programmed cell death GO:0046667 23 0.099
regulation of cell development GO:0060284 215 0.098
Human Mouse
positive regulation of neurogenesis GO:0050769 41 0.098
Mouse
regulation of rac gtpase activity GO:0032314 1 0.097
gastrulation involving germ band extension GO:0010004 36 0.096
ectodermal placode morphogenesis GO:0071697 4 0.096
epithelial cell development GO:0002064 274 0.096
regulation of cellular localization GO:0060341 136 0.095
Human
spermatid differentiation GO:0048515 114 0.095
programmed cell death GO:0012501 257 0.093
Human Mouse
eye photoreceptor cell fate commitment GO:0042706 37 0.091
positive regulation of developmental process GO:0051094 143 0.091
positive regulation of stem cell differentiation GO:2000738 3 0.090
Human Mouse
endoderm formation GO:0001706 3 0.090
Zebrafish
epithelium migration GO:0090132 148 0.090
dendrite regeneration GO:0031104 2 0.090
learning or memory GO:0007611 141 0.090
negative regulation of signaling GO:0023057 219 0.089
Human
nephron tubule development GO:0072080 3 0.089
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 3 0.089
Human
mitotic nuclear division GO:0007067 213 0.089
Human
dorsal closure GO:0007391 79 0.089
single organism biosynthetic process GO:0044711 206 0.088
Human
regulation of eye pigmentation GO:0048073 7 0.087
regulation of pathway restricted smad protein phosphorylation GO:0060393 1 0.087
Human
circulatory system process GO:0003013 37 0.085
leg disc morphogenesis GO:0007478 80 0.083
positive regulation of cellular amine metabolic process GO:0033240 0 0.081
regulation of secretion GO:0051046 44 0.081
regulation of glial cell differentiation GO:0045685 1 0.081
Mouse
determination of adult lifespan GO:0008340 137 0.079
regulation of cell cycle checkpoint GO:1901976 2 0.079
regulation of muscle cell differentiation GO:0051147 8 0.079
Human Mouse
endocrine system development GO:0035270 5 0.079
Human Mouse
negative regulation of signal transduction GO:0009968 206 0.079
Human
regulation of nuclear division GO:0051783 58 0.079
Human
cell activation GO:0001775 9 0.078
Human
regulation of anatomical structure size GO:0090066 163 0.078
regulation of locomotion GO:0040012 42 0.077
Human Mouse
regulation of growth GO:0040008 233 0.076
gonadal mesoderm development GO:0007506 8 0.076
imaginal disc derived leg segmentation GO:0036011 26 0.076
camera type eye photoreceptor cell differentiation GO:0060219 2 0.076
regulation of planar cell polarity pathway involved in axis elongation GO:2000040 2 0.074
negative regulation of heart induction GO:1901320 3 0.074
locomotor rhythm GO:0045475 56 0.074
amine metabolic process GO:0009308 12 0.072
organelle assembly GO:0070925 198 0.072
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 5 0.072
ectodermal placode development GO:0071696 4 0.071
multi organism behavior GO:0051705 175 0.071
ectodermal placode formation GO:0060788 4 0.071
morphogenesis of larval imaginal disc epithelium GO:0016335 5 0.071
compound eye photoreceptor fate commitment GO:0001752 36 0.070
oocyte morphogenesis GO:0048601 3 0.069
regulation of organelle organization GO:0033043 196 0.069
Human
male sex differentiation GO:0046661 25 0.069
negative regulation of cell cycle GO:0045786 116 0.069
Human
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.068
Human
eye photoreceptor cell development GO:0042462 81 0.068
regulation of cellular response to growth factor stimulus GO:0090287 13 0.068
neuroblast development GO:0014019 13 0.068
meiotic nuclear envelope disassembly GO:0051078 2 0.067
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded GO:0008070 2 0.067
positive regulation of neural precursor cell proliferation GO:2000179 8 0.067
defense response to bacterium GO:0042742 178 0.067
tendon development GO:0035989 1 0.066
Mouse
tube morphogenesis GO:0035239 191 0.065
cellular response to endogenous stimulus GO:0071495 80 0.064
Human
response to organic cyclic compound GO:0014070 89 0.064
Human Mouse
cardioblast cell fate specification GO:0042685 9 0.063
epithelial cell type specification open tracheal system GO:0035153 11 0.063
retina development in camera type eye GO:0060041 4 0.062
imaginal disc derived leg morphogenesis GO:0007480 80 0.062
neural retina development GO:0003407 4 0.062
regulation of protein catabolic process GO:0042176 55 0.061
photoreceptor cell development GO:0042461 96 0.061
peptidyl threonine phosphorylation GO:0018107 2 0.061
multi multicellular organism process GO:0044706 123 0.060
wing disc dorsal ventral pattern formation GO:0048190 47 0.060
negative regulation of molecular function GO:0044092 51 0.060
Human
dendrite development GO:0016358 204 0.059
cuticle development GO:0042335 86 0.058
oocyte differentiation GO:0009994 145 0.058
establishment of planar polarity GO:0001736 87 0.058
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.058
positive regulation of signal transduction GO:0009967 223 0.057
Human Mouse
embryonic hemopoiesis GO:0035162 26 0.057
Zebrafish
epithelial cell proliferation GO:0050673 15 0.057
Human Mouse
positive regulation of neuroblast proliferation GO:0002052 7 0.057
extrinsic apoptotic signaling pathway GO:0097191 1 0.057
negative regulation of nucleic acid templated transcription GO:1903507 240 0.056
Human Mouse
anatomical structure homeostasis GO:0060249 97 0.056
negative regulation of response to stimulus GO:0048585 258 0.056
Human
regulation of cell proliferation involved in compound eye morphogenesis GO:2000495 2 0.055
nephron epithelium development GO:0072009 3 0.055
Human Mouse
attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation GO:0051316 1 0.055
organelle inheritance GO:0048308 2 0.054
mesodermal cell differentiation GO:0048333 7 0.054
Human Zebrafish Mouse
juvenile hormone mediated signaling pathway GO:0035626 3 0.053
positive regulation of phosphate metabolic process GO:0045937 139 0.053
Human Mouse
development of primary sexual characteristics GO:0045137 50 0.053
regulation of cell adhesion GO:0030155 27 0.053
Human
positive regulation of catabolic process GO:0009896 105 0.052
positive regulation of multicellular organism growth GO:0040018 21 0.052
regulation of phosphate metabolic process GO:0019220 210 0.052
Human Mouse
positive regulation of immune system process GO:0002684 68 0.051
camera type eye morphogenesis GO:0048593 2 0.050
Mouse
peptidyl threonine modification GO:0018210 3 0.048
neurological system process GO:0050877 358 0.048
actin filament organization GO:0007015 126 0.048
negative regulation of developmental growth GO:0048640 64 0.048
Human
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 4 0.048
stem cell maintenance GO:0019827 67 0.047
single organism cell adhesion GO:0098602 47 0.047
Human
establishment of organelle localization GO:0051656 122 0.047
notum cell fate specification GO:0035310 5 0.047
establishment or maintenance of polarity of larval imaginal disc epithelium GO:0016336 3 0.046
regulation of programmed cell death GO:0043067 152 0.046
Human Mouse
determination of bilateral symmetry GO:0009855 13 0.046
Zebrafish
negative regulation of mitotic anaphase promoting complex activity GO:0060564 2 0.046
positive regulation of nervous system development GO:0051962 69 0.046
Mouse
cell elongation involved in imaginal disc derived wing morphogenesis GO:0090254 5 0.046
oocyte development GO:0048599 124 0.045
striated muscle tissue development GO:0014706 27 0.045
Human Zebrafish Mouse
biological adhesion GO:0022610 138 0.045
Human
cellular response to oxygen containing compound GO:1901701 79 0.045

dpp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
brachydactyly DOID:0050581 0 0.118
Human
bone development disease DOID:0080006 0 0.118
Human
bone disease DOID:0080001 0 0.118
Human
disease of anatomical entity DOID:7 0 0.118
Human
dysostosis DOID:1934 0 0.118
Human
musculoskeletal system disease DOID:17 0 0.118
Human
connective tissue disease DOID:65 0 0.118
Human