Drosophila melanogaster

73 known processes

RnrL (Dmel_CG5371)

Ribonucleoside diphosphate reductase large subunit

(Aliases: CG5371,l(2)k06709,Dmel\CG5371,DmRNR1,RNR1,RntL,RnrM1)

RnrL biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
double strand break repair via homologous recombination GO:0000724 13 0.622
nuclear dna replication GO:0033260 1 0.530
dna repair GO:0006281 54 0.526
double strand break repair GO:0006302 26 0.476
cellular response to dna damage stimulus GO:0006974 223 0.407
single organism biosynthetic process GO:0044711 206 0.353
protein dna complex assembly GO:0065004 63 0.337
positive regulation of endopeptidase activity GO:0010950 26 0.327
dna metabolic process GO:0006259 227 0.317
nucleotide excision repair GO:0006289 8 0.309
homeostatic process GO:0042592 199 0.239
double strand break repair via nonhomologous end joining GO:0006303 5 0.227
dna recombination GO:0006310 32 0.219
regulation of cell cycle phase transition GO:1901987 130 0.217
dna damage checkpoint GO:0000077 78 0.207
mitotic dna damage checkpoint GO:0044773 74 0.198
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.185
positive regulation of hydrolase activity GO:0051345 78 0.173
cell cycle checkpoint GO:0000075 95 0.170
regulation of cell cycle process GO:0010564 181 0.162
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.144
protein import GO:0017038 55 0.142
cell cycle dna replication GO:0044786 23 0.125
g2 dna damage checkpoint GO:0031572 69 0.115
cell proliferation GO:0008283 299 0.114
eye development GO:0001654 323 0.107
regulation of cell cycle GO:0051726 291 0.106
regulation of endopeptidase activity GO:0052548 36 0.105
dna endoreduplication GO:0042023 22 0.102
negative regulation of cell cycle phase transition GO:1901988 103 0.102
regulation of mitotic cell cycle GO:0007346 190 0.097
aging GO:0007568 143 0.095
mitotic cell cycle phase transition GO:0044772 138 0.094
dna integrity checkpoint GO:0031570 81 0.094
camera type eye morphogenesis GO:0048593 2 0.087
regulation of cytoskeleton organization GO:0051493 89 0.087
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.087
body morphogenesis GO:0010171 2 0.087
negative regulation of biosynthetic process GO:0009890 277 0.083
cell division GO:0051301 248 0.080
protein complex assembly GO:0006461 200 0.075
response to light stimulus GO:0009416 124 0.071
positive regulation of peptidase activity GO:0010952 29 0.070
enzyme linked receptor protein signaling pathway GO:0007167 179 0.069
nucleobase containing small molecule metabolic process GO:0055086 174 0.069
regulation of catabolic process GO:0009894 170 0.069
immune response GO:0006955 246 0.069
mitotic dna integrity checkpoint GO:0044774 75 0.067
cell cycle phase transition GO:0044770 140 0.067
single organism intracellular transport GO:1902582 207 0.065
compound eye development GO:0048749 307 0.064
single organism behavior GO:0044708 391 0.063
cellular protein complex disassembly GO:0043624 35 0.062
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.062
dna replication GO:0006260 48 0.061
negative regulation of cellular biosynthetic process GO:0031327 277 0.061
negative regulation of cell cycle GO:0045786 116 0.060
cellular component disassembly GO:0022411 46 0.060
positive regulation of proteolysis GO:0045862 52 0.058
heterocycle catabolic process GO:0046700 166 0.057
mitotic cell cycle checkpoint GO:0007093 88 0.057
single organism cellular localization GO:1902580 180 0.056
zymogen activation GO:0031638 20 0.055
establishment of protein localization to organelle GO:0072594 62 0.055
small molecule metabolic process GO:0044281 305 0.055
anatomical structure homeostasis GO:0060249 97 0.054
negative regulation of nucleic acid templated transcription GO:1903507 240 0.054
single organism nuclear import GO:1902593 51 0.053
response to abiotic stimulus GO:0009628 341 0.053
cellular macromolecule localization GO:0070727 220 0.053
organic cyclic compound catabolic process GO:1901361 168 0.053
proteolysis GO:0006508 192 0.052
positive regulation of cellular component organization GO:0051130 156 0.051
response to wounding GO:0009611 94 0.051
negative regulation of cell cycle process GO:0010948 109 0.051
negative regulation of transcription dna templated GO:0045892 237 0.051
mitotic spindle organization GO:0007052 220 0.051
translesion synthesis GO:0019985 2 0.050
nucleosome assembly GO:0006334 35 0.050
regulation of catalytic activity GO:0050790 185 0.048
negative regulation of rna biosynthetic process GO:1902679 240 0.048
positive regulation of protein metabolic process GO:0051247 128 0.048
organophosphate metabolic process GO:0019637 195 0.048
determination of adult lifespan GO:0008340 137 0.047
immune system process GO:0002376 347 0.046
macromolecule catabolic process GO:0009057 161 0.046
cellular protein modification process GO:0006464 438 0.045
camera type eye development GO:0043010 4 0.045
female meiotic division GO:0007143 70 0.045
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.045
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.044
macromolecular complex disassembly GO:0032984 37 0.043
macromolecular complex assembly GO:0065003 256 0.043
regulation of molecular function GO:0065009 217 0.043
eye morphogenesis GO:0048592 260 0.043
multicellular organism growth GO:0035264 46 0.043
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.042
gonad development GO:0008406 50 0.042
response to external biotic stimulus GO:0043207 293 0.042
spermatogenesis GO:0007283 200 0.042
regulation of cellular catabolic process GO:0031329 157 0.042
meiotic cell cycle process GO:1903046 132 0.041
meiotic cell cycle GO:0051321 171 0.041
dna dependent dna replication GO:0006261 17 0.041
intracellular transport GO:0046907 228 0.041
nucleoside phosphate metabolic process GO:0006753 162 0.040
regulation of mitotic cell cycle phase transition GO:1901990 130 0.040
positive regulation of catalytic activity GO:0043085 118 0.040
death GO:0016265 284 0.040
regulation of notch signaling pathway GO:0008593 100 0.040
response to other organism GO:0051707 293 0.039
regulation of hydrolase activity GO:0051336 97 0.039
organic substance catabolic process GO:1901575 308 0.039
regulation of protein complex assembly GO:0043254 42 0.039
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.039
dna double strand break processing GO:0000729 3 0.038
positive regulation of molecular function GO:0044093 136 0.038
spindle organization GO:0007051 253 0.038
regulation of multicellular organismal development GO:2000026 414 0.038
regulation of cellular component biogenesis GO:0044087 201 0.037
cellular catabolic process GO:0044248 372 0.037
notch signaling pathway GO:0007219 120 0.037
head development GO:0060322 135 0.036
protein targeting GO:0006605 64 0.036
multicellular organismal aging GO:0010259 140 0.036
nucleotide metabolic process GO:0009117 161 0.035
cellular nitrogen compound catabolic process GO:0044270 165 0.035
actin cytoskeleton organization GO:0030036 206 0.035
dna replication initiation GO:0006270 6 0.034
larval development GO:0002164 104 0.034
male gamete generation GO:0048232 201 0.034
actin filament based process GO:0030029 220 0.033
carbohydrate derivative metabolic process GO:1901135 217 0.033
nucleotide biosynthetic process GO:0009165 34 0.033
positive regulation of cell proliferation GO:0008284 47 0.033
negative regulation of rna metabolic process GO:0051253 251 0.033
tube development GO:0035295 244 0.033
intracellular protein transport GO:0006886 104 0.033
single organism catabolic process GO:0044712 228 0.033
sex differentiation GO:0007548 81 0.032
g1 s transition of mitotic cell cycle GO:0000082 31 0.032
programmed cell death GO:0012501 257 0.032
protein targeting to nucleus GO:0044744 51 0.032
nucleobase containing compound catabolic process GO:0034655 165 0.032
embryonic morphogenesis GO:0048598 206 0.031
cellular amine metabolic process GO:0044106 12 0.031
negative regulation of gene expression GO:0010629 387 0.030
ribonucleoside metabolic process GO:0009119 127 0.030
axonogenesis GO:0007409 290 0.030
reproductive structure development GO:0048608 74 0.029
activation of cysteine type endopeptidase activity GO:0097202 17 0.029
multi organism reproductive behavior GO:0044705 121 0.029
postreplication repair GO:0006301 2 0.029
glycosyl compound metabolic process GO:1901657 127 0.029
response to biotic stimulus GO:0009607 294 0.029
cell motility GO:0048870 251 0.028
respiratory system development GO:0060541 213 0.028
protein complex disassembly GO:0043241 36 0.028
response to organic substance GO:0010033 284 0.028
positive regulation of catabolic process GO:0009896 105 0.027
meiotic chromosome segregation GO:0045132 59 0.027
negative regulation of molecular function GO:0044092 51 0.027
cell death GO:0008219 279 0.027
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.027
cell migration GO:0016477 238 0.027
antimicrobial humoral response GO:0019730 99 0.027
intracellular signal transduction GO:0035556 300 0.026
production of molecular mediator of immune response GO:0002440 46 0.026
cell cycle g1 s phase transition GO:0044843 31 0.026
regulation of developmental growth GO:0048638 174 0.026
eggshell formation GO:0030703 105 0.026
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.026
regulation of proteolysis GO:0030162 87 0.026
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.025
telomere organization GO:0032200 21 0.025
organonitrogen compound metabolic process GO:1901564 318 0.025
cell aging GO:0007569 2 0.025
dna conformation change GO:0071103 105 0.025
ion transport GO:0006811 145 0.025
protein transport GO:0015031 155 0.025
cell fate specification GO:0001708 71 0.025
carbohydrate derivative catabolic process GO:1901136 118 0.024
chromosome segregation GO:0007059 157 0.024
recombinational repair GO:0000725 13 0.024
catabolic process GO:0009056 409 0.024
ribose phosphate metabolic process GO:0019693 145 0.024
mitotic g2 m transition checkpoint GO:0044818 70 0.024
development of primary sexual characteristics GO:0045137 50 0.024
response to inorganic substance GO:0010035 44 0.023
regulation of cellular ketone metabolic process GO:0010565 3 0.023
positive regulation of macromolecule metabolic process GO:0010604 405 0.023
aromatic compound catabolic process GO:0019439 166 0.023
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.023
signal transduction in response to dna damage GO:0042770 3 0.023
positive regulation of cellular catabolic process GO:0031331 95 0.023
ribonucleotide metabolic process GO:0009259 145 0.022
regulation of gene expression epigenetic GO:0040029 128 0.022
multi organism behavior GO:0051705 175 0.022
regulation of cell morphogenesis GO:0022604 163 0.022
actin filament organization GO:0007015 126 0.022
regulation of localization GO:0032879 275 0.022
regulation of peptidase activity GO:0052547 39 0.021
carboxylic acid metabolic process GO:0019752 92 0.021
regulation of nervous system development GO:0051960 248 0.021
nucleoside phosphate biosynthetic process GO:1901293 34 0.021
response to lipopolysaccharide GO:0032496 4 0.021
regulation of organelle organization GO:0033043 196 0.021
meiotic nuclear division GO:0007126 151 0.021
protein localization GO:0008104 284 0.021
organonitrogen compound biosynthetic process GO:1901566 117 0.021
cellular macromolecular complex assembly GO:0034622 153 0.020
regionalization GO:0003002 416 0.020
organic substance transport GO:0071702 257 0.020
cellular response to organic substance GO:0071310 132 0.020
regulation of cell differentiation GO:0045595 302 0.020
positive regulation of protein complex assembly GO:0031334 22 0.020
purine nucleotide metabolic process GO:0006163 146 0.020
gene silencing GO:0016458 138 0.020
response to endogenous stimulus GO:0009719 119 0.019
ribonucleotide catabolic process GO:0009261 109 0.019
regulation of cell cycle g1 s phase transition GO:1902806 23 0.019
developmental growth GO:0048589 280 0.019
connective tissue development GO:0061448 3 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
negative regulation of mitotic cell cycle GO:0045930 109 0.019
tissue morphogenesis GO:0048729 297 0.019
protein modification process GO:0036211 438 0.019
maintenance of location in cell GO:0051651 28 0.019
non recombinational repair GO:0000726 7 0.019
protein localization to organelle GO:0033365 82 0.018
telomere maintenance GO:0000723 21 0.018
establishment of protein localization GO:0045184 163 0.018
regulation of programmed cell death GO:0043067 152 0.018
nuclear import GO:0051170 51 0.018
positive regulation of nucleotide metabolic process GO:0045981 55 0.018
dna duplex unwinding GO:0032508 16 0.018
appendage development GO:0048736 401 0.018
retina development in camera type eye GO:0060041 4 0.018
nuclear division GO:0000280 332 0.018
dna geometric change GO:0032392 16 0.018
purine ribonucleotide metabolic process GO:0009150 145 0.018
positive regulation of phosphorus metabolic process GO:0010562 139 0.018
purine containing compound catabolic process GO:0072523 112 0.018
dorsal ventral pattern formation GO:0009953 133 0.017
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.017
brain development GO:0007420 120 0.017
positive regulation of developmental process GO:0051094 143 0.017
embryo development ending in birth or egg hatching GO:0009792 152 0.017
response to ionizing radiation GO:0010212 32 0.017
locomotory behavior GO:0007626 176 0.017
regulation of cell proliferation GO:0042127 163 0.017
protein maturation GO:0051604 71 0.017
reproductive system development GO:0061458 74 0.017
chorion containing eggshell formation GO:0007304 105 0.017
purine containing compound metabolic process GO:0072521 155 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.017
negative regulation of cell cycle g1 s phase transition GO:1902807 13 0.017
chemosensory behavior GO:0007635 106 0.017
positive regulation of cellular component biogenesis GO:0044089 80 0.016
positive regulation of protein transport GO:0051222 37 0.016
positive regulation of multicellular organismal process GO:0051240 143 0.016
chromosome organization GO:0051276 360 0.016
dna packaging GO:0006323 91 0.016
cellular macromolecule catabolic process GO:0044265 136 0.016
regulation of phosphorus metabolic process GO:0051174 210 0.016
cell recognition GO:0008037 102 0.016
nucleocytoplasmic transport GO:0006913 72 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
kidney development GO:0001822 3 0.016
organelle assembly GO:0070925 198 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
regulation of dna replication GO:0006275 13 0.016
humoral immune response GO:0006959 117 0.016
positive regulation of cellular protein metabolic process GO:0032270 118 0.016
cellular component assembly involved in morphogenesis GO:0010927 151 0.016
positive regulation of phosphate metabolic process GO:0045937 139 0.015
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.015
compound eye morphogenesis GO:0001745 249 0.015
immune effector process GO:0002252 98 0.015
amine metabolic process GO:0009308 12 0.015
defense response GO:0006952 300 0.015
positive regulation of signaling GO:0023056 243 0.015
vesicle mediated transport GO:0016192 381 0.015
mitotic g2 dna damage checkpoint GO:0007095 69 0.015
wound healing GO:0042060 75 0.015
reproductive behavior GO:0019098 122 0.015
phagocytosis GO:0006909 215 0.015
regulation of transcription factor import into nucleus GO:0042990 22 0.015
endocytosis GO:0006897 310 0.015
positive regulation of cellular biosynthetic process GO:0031328 316 0.015
stem cell differentiation GO:0048863 117 0.015
chromatin remodeling GO:0006338 72 0.015
positive regulation of programmed cell death GO:0043068 62 0.015
purine ribonucleoside metabolic process GO:0046128 127 0.015
purine nucleoside catabolic process GO:0006152 112 0.014
smad protein import into nucleus GO:0007184 11 0.014
nuclear transport GO:0051169 72 0.014
nucleoside triphosphate catabolic process GO:0009143 108 0.014
cellular protein localization GO:0034613 160 0.014
maintenance of protein location GO:0045185 28 0.014
renal system development GO:0072001 72 0.014
cellular response to chemical stimulus GO:0070887 199 0.014
regulation of production of molecular mediator of immune response GO:0002700 44 0.014
growth GO:0040007 359 0.014
defense response to other organism GO:0098542 225 0.014
urogenital system development GO:0001655 72 0.014
response to growth factor GO:0070848 31 0.014
compound eye photoreceptor cell differentiation GO:0001751 140 0.014
taxis GO:0042330 304 0.014
regulation of cellular response to stress GO:0080135 89 0.014
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.014
central nervous system development GO:0007417 201 0.014
mitotic chromosome condensation GO:0007076 22 0.014
purine nucleoside triphosphate metabolic process GO:0009144 119 0.013
embryonic development via the syncytial blastoderm GO:0001700 148 0.013
maintenance of protein location in cell GO:0032507 26 0.013
morphogenesis of an epithelium GO:0002009 276 0.013
purine nucleotide catabolic process GO:0006195 109 0.013
dna amplification GO:0006277 11 0.013
oxoacid metabolic process GO:0043436 103 0.013
regulation of nucleotide metabolic process GO:0006140 62 0.013
resolution of meiotic recombination intermediates GO:0000712 6 0.013
positive regulation of protein import into nucleus GO:0042307 21 0.013
ribonucleoside catabolic process GO:0042454 112 0.013
cellular protein catabolic process GO:0044257 83 0.013
positive regulation of signal transduction GO:0009967 223 0.013
transcription from rna polymerase ii promoter GO:0006366 368 0.013
establishment of localization in cell GO:0051649 402 0.013
positive regulation of cell migration GO:0030335 2 0.013
protein phosphorylation GO:0006468 169 0.013
regulation of response to external stimulus GO:0032101 115 0.013
lateral inhibition GO:0046331 206 0.012
centrosome cycle GO:0007098 137 0.012
organophosphate catabolic process GO:0046434 112 0.012
purine ribonucleotide catabolic process GO:0009154 109 0.012
hematopoietic progenitor cell differentiation GO:0002244 1 0.012
positive regulation of protein localization to nucleus GO:1900182 21 0.012
gtp catabolic process GO:0006184 72 0.012
protein localization to nucleus GO:0034504 55 0.012
cell cell signaling involved in cell fate commitment GO:0045168 210 0.012
imaginal disc derived appendage development GO:0048737 399 0.012
gland development GO:0048732 191 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.012
regulation of purine nucleotide catabolic process GO:0033121 48 0.012
negative regulation of cell death GO:0060548 81 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
positive regulation of histone deacetylation GO:0031065 2 0.012
negative regulation of cellular metabolic process GO:0031324 382 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
open tracheal system development GO:0007424 204 0.012
purine ribonucleoside catabolic process GO:0046130 112 0.012
positive regulation of cell cycle GO:0045787 43 0.012
positive regulation of gtpase activity GO:0043547 43 0.012
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.012
chromatin silencing GO:0006342 76 0.012
male meiosis GO:0007140 52 0.012
ubiquitin dependent protein catabolic process GO:0006511 78 0.012
digestive system development GO:0055123 149 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.012
gtp metabolic process GO:0046039 72 0.012
organic acid metabolic process GO:0006082 103 0.011
positive regulation of cell differentiation GO:0045597 64 0.011
response to uv GO:0009411 24 0.011
purine nucleoside metabolic process GO:0042278 127 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
ectopic germ cell programmed cell death GO:0035234 8 0.011
regulation of cell development GO:0060284 215 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
protein polymerization GO:0051258 42 0.011
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
maintenance of location GO:0051235 73 0.011
developmental cell growth GO:0048588 52 0.011
epithelium migration GO:0090132 148 0.011
nucleoside triphosphate metabolic process GO:0009141 120 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.011
purine nucleoside triphosphate catabolic process GO:0009146 108 0.011
positive regulation of cell death GO:0010942 69 0.011
ameboidal type cell migration GO:0001667 151 0.010
regulation of actin cytoskeleton organization GO:0032956 42 0.010
regulation of chromatin organization GO:1902275 32 0.010
defense response to bacterium GO:0042742 178 0.010
nucleoside metabolic process GO:0009116 127 0.010
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
protein import into nucleus GO:0006606 51 0.010
metal ion transport GO:0030001 74 0.010
response to radiation GO:0009314 155 0.010
nucleoside catabolic process GO:0009164 112 0.010
negative regulation of organelle organization GO:0010639 56 0.010
nitrogen compound transport GO:0071705 85 0.010

RnrL disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.101
musculoskeletal system cancer DOID:0060100 0 0.084
connective tissue cancer DOID:201 0 0.084
cancer DOID:162 0 0.084
disease of cellular proliferation DOID:14566 0 0.084
organ system cancer DOID:0050686 0 0.084
nervous system disease DOID:863 0 0.044
central nervous system disease DOID:331 0 0.015
neurodegenerative disease DOID:1289 0 0.014
disease of metabolism DOID:0014667 0 0.011