Drosophila melanogaster

137 known processes

Pi3K59F (Dmel_CG5373)

Phosphotidylinositol 3 kinase 59F

(Aliases: CG5373,VPS34,dVps34/PI3K59F,PI3K,DmVps34,dVps34,dPI3K,PI3K-59F,Dmel\CG5373,PI[[3]]K,PI(3)K,PI3K_59F,Pi3K_59F,Vps34)

Pi3K59F biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval midgut histolysis GO:0035069 22 0.997
autophagic vacuole assembly GO:0000045 2 0.954
Rat
positive regulation of autophagy GO:0010508 21 0.943
regulation of autophagy GO:0010506 62 0.937
autophagy GO:0006914 108 0.854
developmental programmed cell death GO:0010623 138 0.812
programmed cell death GO:0012501 257 0.770
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.708
cellular response to extracellular stimulus GO:0031668 64 0.701
larval midgut cell programmed cell death GO:0035096 19 0.694
cellular catabolic process GO:0044248 372 0.683
regulation of cellular catabolic process GO:0031329 157 0.677
cellular response to starvation GO:0009267 61 0.648
death GO:0016265 284 0.622
tissue death GO:0016271 102 0.605
regulation of catabolic process GO:0009894 170 0.501
regulation of tor signaling GO:0032006 21 0.492
cellular response to nutrient levels GO:0031669 62 0.424
growth GO:0040007 359 0.404
cell death GO:0008219 279 0.377
histolysis GO:0007559 102 0.295
catabolic process GO:0009056 409 0.294
response to nutrient levels GO:0031667 114 0.287
response to extracellular stimulus GO:0009991 116 0.285
response to starvation GO:0042594 97 0.235
cellular response to external stimulus GO:0071496 66 0.214
macroautophagy GO:0016236 42 0.210
Rat
apoptotic process GO:0006915 159 0.209
regulation of growth GO:0040008 233 0.203
organelle assembly GO:0070925 198 0.178
Rat
positive regulation of multicellular organismal process GO:0051240 143 0.162
positive regulation of catabolic process GO:0009896 105 0.161
endosome transport via multivesicular body sorting pathway GO:0032509 12 0.159
positive regulation of macromolecule metabolic process GO:0010604 405 0.147
lipid metabolic process GO:0006629 121 0.137
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.136
tor signaling GO:0031929 32 0.128
phosphorylation GO:0016310 294 0.126
positive regulation of phosphate metabolic process GO:0045937 139 0.113
salivary gland development GO:0007431 162 0.106
regulation of developmental growth GO:0048638 174 0.100
cell growth GO:0016049 108 0.100
protein maturation GO:0051604 71 0.098
Rat
vacuolar transport GO:0007034 13 0.097
positive regulation of developmental process GO:0051094 143 0.097
positive regulation of nurse cell apoptotic process GO:0045850 5 0.095
cellular protein modification process GO:0006464 438 0.095
organelle membrane fusion GO:0090174 16 0.095
response to biotic stimulus GO:0009607 294 0.092
salivary gland morphogenesis GO:0007435 145 0.089
intracellular signal transduction GO:0035556 300 0.088
Rat
protein modification process GO:0036211 438 0.086
membrane organization GO:0061024 112 0.085
endosomal transport GO:0016197 44 0.083
autophagic vacuole fusion GO:0000046 15 0.082
single organism membrane organization GO:0044802 93 0.080
regulation of intracellular signal transduction GO:1902531 236 0.079
salivary gland histolysis GO:0035070 88 0.076
ribonucleoside metabolic process GO:0009119 127 0.076
positive regulation of signaling GO:0023056 243 0.075
regulation of multi organism process GO:0043900 131 0.072
regulation of response to external stimulus GO:0032101 115 0.072
regulation of cell death GO:0010941 173 0.070
vacuole organization GO:0007033 8 0.070
Rat
single organism intracellular transport GO:1902582 207 0.070
regulation of response to biotic stimulus GO:0002831 63 0.068
multicellular organism growth GO:0035264 46 0.066
single organism membrane fusion GO:0044801 42 0.064
response to other organism GO:0051707 293 0.064
positive regulation of growth GO:0045927 75 0.062
proteolysis GO:0006508 192 0.061
positive regulation of cellular catabolic process GO:0031331 95 0.061
exocrine system development GO:0035272 162 0.060
carbohydrate derivative metabolic process GO:1901135 217 0.060
negative regulation of signal transduction GO:0009968 206 0.059
gland morphogenesis GO:0022612 145 0.058
phosphatidylinositol mediated signaling GO:0048015 4 0.057
Rat
macromolecular complex assembly GO:0065003 256 0.056
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.055
epithelial cell differentiation GO:0030855 322 0.054
negative regulation of cellular metabolic process GO:0031324 382 0.053
insulin receptor signaling pathway GO:0008286 25 0.053
regionalization GO:0003002 416 0.052
aging GO:0007568 143 0.051
negative regulation of rna metabolic process GO:0051253 251 0.051
positive regulation of biosynthetic process GO:0009891 316 0.050
positive regulation of rna biosynthetic process GO:1902680 266 0.050
protein complex assembly GO:0006461 200 0.050
positive regulation of phosphorus metabolic process GO:0010562 139 0.049
regulation of cell growth GO:0001558 43 0.049
organonitrogen compound metabolic process GO:1901564 318 0.049
negative regulation of response to stimulus GO:0048585 258 0.048
regulation of multicellular organism growth GO:0040014 40 0.048
autophagic cell death GO:0048102 83 0.048
positive regulation of programmed cell death GO:0043068 62 0.048
salivary gland cell autophagic cell death GO:0035071 83 0.047
endocytosis GO:0006897 310 0.047
positive regulation of nucleic acid templated transcription GO:1903508 266 0.047
small molecule metabolic process GO:0044281 305 0.047
negative regulation of growth GO:0045926 84 0.045
multicellular organismal aging GO:0010259 140 0.045
positive regulation of rna metabolic process GO:0051254 271 0.044
mapk cascade GO:0000165 107 0.043
establishment of protein localization to membrane GO:0090150 11 0.042
positive regulation of signal transduction GO:0009967 223 0.042
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.042
positive regulation of cellular biosynthetic process GO:0031328 316 0.041
developmental growth GO:0048589 280 0.041
vesicle organization GO:0016050 44 0.041
vesicle fusion GO:0006906 19 0.041
determination of adult lifespan GO:0008340 137 0.041
positive regulation of cell communication GO:0010647 250 0.041
cellular macromolecule catabolic process GO:0044265 136 0.040
vesicle mediated transport GO:0016192 381 0.040
regulation of phosphorus metabolic process GO:0051174 210 0.040
single organism behavior GO:0044708 391 0.040
regulation of defense response to virus GO:0050688 14 0.039
regulation of programmed cell death GO:0043067 152 0.039
regulation of mapk cascade GO:0043408 92 0.037
regulation of apoptotic process GO:0042981 130 0.037
regulation of nurse cell apoptotic process GO:0045477 9 0.037
ribonucleotide metabolic process GO:0009259 145 0.037
organic substance catabolic process GO:1901575 308 0.036
positive regulation of gene expression GO:0010628 290 0.036
ribose phosphate metabolic process GO:0019693 145 0.035
regulation of cellular protein metabolic process GO:0032268 243 0.035
inositol lipid mediated signaling GO:0048017 4 0.035
Rat
positive regulation of developmental growth GO:0048639 62 0.034
positive regulation of molecular function GO:0044093 136 0.034
regulation of cell development GO:0060284 215 0.034
regulation of catalytic activity GO:0050790 185 0.034
cellular macromolecule localization GO:0070727 220 0.033
cellular protein localization GO:0034613 160 0.033
cytoplasmic transport GO:0016482 130 0.033
regulation of immune system process GO:0002682 176 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.032
response to oxidative stress GO:0006979 86 0.032
single organism cellular localization GO:1902580 180 0.032
regulation of multicellular organismal development GO:2000026 414 0.031
cellular metal ion homeostasis GO:0006875 31 0.031
cellular amino acid metabolic process GO:0006520 61 0.031
regulation of epithelial cell proliferation GO:0050678 4 0.031
organic acid metabolic process GO:0006082 103 0.031
protein catabolic process GO:0030163 101 0.031
macromolecule catabolic process GO:0009057 161 0.031
lateral inhibition GO:0046331 206 0.030
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.030
purine ribonucleoside metabolic process GO:0046128 127 0.030
purine containing compound metabolic process GO:0072521 155 0.029
establishment of localization in cell GO:0051649 402 0.029
Rat
intracellular transport GO:0046907 228 0.029
positive regulation of transcription dna templated GO:0045893 266 0.028
positive regulation of mapk cascade GO:0043410 63 0.028
positive regulation of response to stimulus GO:0048584 323 0.028
positive regulation of multicellular organism growth GO:0040018 21 0.027
early endosome to late endosome transport GO:0045022 3 0.027
stress activated protein kinase signaling cascade GO:0031098 55 0.027
oxoacid metabolic process GO:0043436 103 0.027
regulation of localization GO:0032879 275 0.027
Rat
organophosphate metabolic process GO:0019637 195 0.027
regulation of phosphate metabolic process GO:0019220 210 0.027
columnar cuboidal epithelial cell development GO:0002066 249 0.027
maintenance of location GO:0051235 73 0.027
cellular nitrogen compound catabolic process GO:0044270 165 0.027
nucleoside triphosphate metabolic process GO:0009141 120 0.027
cellular ion homeostasis GO:0006873 39 0.026
protein complex biogenesis GO:0070271 201 0.026
signal transduction by phosphorylation GO:0023014 107 0.026
regulation of humoral immune response GO:0002920 51 0.026
organic cyclic compound catabolic process GO:1901361 168 0.026
positive regulation of tor signaling GO:0032008 13 0.026
stress activated mapk cascade GO:0051403 52 0.025
positive regulation of cell development GO:0010720 61 0.025
guanosine containing compound metabolic process GO:1901068 74 0.025
glycosyl compound metabolic process GO:1901657 127 0.025
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.025
response to external biotic stimulus GO:0043207 293 0.024
protein modification by small protein conjugation or removal GO:0070647 106 0.024
phagocytosis GO:0006909 215 0.024
nucleoside triphosphate catabolic process GO:0009143 108 0.024
nucleobase containing compound catabolic process GO:0034655 165 0.024
carboxylic acid metabolic process GO:0019752 92 0.024
purine ribonucleotide metabolic process GO:0009150 145 0.024
membrane budding GO:0006900 4 0.024
response to oxygen containing compound GO:1901700 200 0.023
Rat
nucleobase containing small molecule metabolic process GO:0055086 174 0.023
lipoprotein biosynthetic process GO:0042158 6 0.023
translation GO:0006412 69 0.023
nucleoside metabolic process GO:0009116 127 0.023
purine nucleotide metabolic process GO:0006163 146 0.023
regulation of cytoskeleton organization GO:0051493 89 0.022
negative regulation of cellular component organization GO:0051129 108 0.022
positive regulation of phosphorylation GO:0042327 87 0.022
negative regulation of organ growth GO:0046621 15 0.022
single organism catabolic process GO:0044712 228 0.022
Rat
mitochondrion degradation GO:0000422 8 0.021
purine ribonucleotide catabolic process GO:0009154 109 0.021
cellular ketone metabolic process GO:0042180 24 0.021
response to organophosphorus GO:0046683 2 0.021
protein modification by small protein conjugation GO:0032446 79 0.021
cellular protein catabolic process GO:0044257 83 0.021
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.021
gland development GO:0048732 191 0.021
necrotic cell death GO:0070265 1 0.021
lipid localization GO:0010876 54 0.020
organonitrogen compound catabolic process GO:1901565 128 0.020
regulation of immune response GO:0050776 118 0.020
positive regulation of cell death GO:0010942 69 0.020
protein processing GO:0016485 68 0.020
Rat
neurological system process GO:0050877 358 0.020
negative regulation of signaling GO:0023057 219 0.020
negative regulation of multicellular organismal process GO:0051241 142 0.020
negative regulation of nucleic acid templated transcription GO:1903507 240 0.019
positive regulation of apoptotic process GO:0043065 47 0.019
positive regulation of intracellular signal transduction GO:1902533 116 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.019
regulation of hydrolase activity GO:0051336 97 0.019
regulation of proteolysis GO:0030162 87 0.019
axon development GO:0061564 297 0.018
protein lipidation GO:0006497 6 0.018
oocyte construction GO:0007308 112 0.018
establishment of protein localization GO:0045184 163 0.018
Rat
negative regulation of epithelial cell proliferation GO:0050680 4 0.018
negative regulation of cell proliferation GO:0008285 69 0.018
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 4 0.018
guanosine containing compound catabolic process GO:1901069 74 0.018
embryo development ending in birth or egg hatching GO:0009792 152 0.018
protein localization GO:0008104 284 0.017
Rat
cellular response to oxidative stress GO:0034599 28 0.017
regulation of ras gtpase activity GO:0032318 38 0.017
regulation of protein catabolic process GO:0042176 55 0.017
hindbrain development GO:0030902 2 0.017
heterocycle catabolic process GO:0046700 166 0.017
purine nucleoside metabolic process GO:0042278 127 0.017
phosphatidylinositol phosphorylation GO:0046854 10 0.017
nucleotide metabolic process GO:0009117 161 0.017
cellular cation homeostasis GO:0030003 38 0.017
positive regulation of protein metabolic process GO:0051247 128 0.017
ribonucleoside triphosphate metabolic process GO:0009199 119 0.017
actin cytoskeleton organization GO:0030036 206 0.016
protein targeting to membrane GO:0006612 2 0.016
cellular iron ion homeostasis GO:0006879 3 0.016
regulation of defense response GO:0031347 102 0.016
embryonic development via the syncytial blastoderm GO:0001700 148 0.016
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.016
imaginal disc pattern formation GO:0007447 91 0.016
oxidation reduction process GO:0055114 123 0.016
purine containing compound catabolic process GO:0072523 112 0.016
vesicle targeting to from or within golgi GO:0048199 1 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
carbohydrate metabolic process GO:0005975 82 0.016
cell type specific apoptotic process GO:0097285 38 0.016
organic substance transport GO:0071702 257 0.016
antimicrobial humoral response GO:0019730 99 0.016
humoral immune response GO:0006959 117 0.016
defense response to other organism GO:0098542 225 0.015
proteasomal protein catabolic process GO:0010498 59 0.015
cellular macromolecular complex assembly GO:0034622 153 0.015
purine nucleoside catabolic process GO:0006152 112 0.015
negative regulation of protein metabolic process GO:0051248 85 0.015
positive regulation of cell differentiation GO:0045597 64 0.015
small gtpase mediated signal transduction GO:0007264 88 0.015
regulation of cell cycle GO:0051726 291 0.015
transcription from rna polymerase ii promoter GO:0006366 368 0.015
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.015
cellular response to insulin stimulus GO:0032869 28 0.015
protein localization to organelle GO:0033365 82 0.015
glycerolipid metabolic process GO:0046486 34 0.015
protein transport GO:0015031 155 0.015
Rat
purine nucleotide catabolic process GO:0006195 109 0.015
protein ubiquitination GO:0016567 70 0.014
negative regulation of developmental growth GO:0048640 64 0.014
cellular protein complex assembly GO:0043623 71 0.014
establishment or maintenance of cell polarity GO:0007163 167 0.014
gtp metabolic process GO:0046039 72 0.014
modification dependent protein catabolic process GO:0019941 78 0.014
single organism carbohydrate metabolic process GO:0044723 72 0.014
immune system process GO:0002376 347 0.014
ion homeostasis GO:0050801 55 0.014
protein localization to plasma membrane GO:0072659 13 0.014
cellular amine metabolic process GO:0044106 12 0.014
enzyme linked receptor protein signaling pathway GO:0007167 179 0.014
cellular calcium ion homeostasis GO:0006874 21 0.014
ion transport GO:0006811 145 0.014
membrane biogenesis GO:0044091 8 0.014
epithelial cell development GO:0002064 274 0.014
regulation of macroautophagy GO:0016241 15 0.014
regulation of cell shape GO:0008360 113 0.014
lipid storage GO:0019915 38 0.014
cellular lipid metabolic process GO:0044255 83 0.013
regulation of cellular component size GO:0032535 98 0.013
positive regulation of reproductive process GO:2000243 7 0.013
purine nucleoside triphosphate metabolic process GO:0009144 119 0.013
protein heterooligomerization GO:0051291 4 0.013
gtp catabolic process GO:0006184 72 0.013
telencephalon development GO:0021537 2 0.013
establishment of protein localization to organelle GO:0072594 62 0.013
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.013
axonogenesis GO:0007409 290 0.013
endosome organization GO:0007032 9 0.013
Rat
nucleoside phosphate catabolic process GO:1901292 110 0.013
appendage development GO:0048736 401 0.013
negative regulation of cell communication GO:0010648 223 0.013
oocyte differentiation GO:0009994 145 0.013
cellular response to nitrogen compound GO:1901699 51 0.012
regulation of nucleotide metabolic process GO:0006140 62 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
rho protein signal transduction GO:0007266 14 0.012
larval development GO:0002164 104 0.012
wing disc morphogenesis GO:0007472 344 0.012
positive regulation of cellular protein metabolic process GO:0032270 118 0.012
protein phosphorylation GO:0006468 169 0.012
oocyte development GO:0048599 124 0.012
kidney development GO:0001822 3 0.012
regulation of rac protein signal transduction GO:0035020 3 0.012
negative regulation of intracellular signal transduction GO:1902532 57 0.012
ras protein signal transduction GO:0007265 88 0.012
endomembrane system organization GO:0010256 119 0.012
Rat
golgi vesicle transport GO:0048193 27 0.012
negative regulation of biosynthetic process GO:0009890 277 0.012
membrane fusion GO:0061025 42 0.012
cellular homeostasis GO:0019725 80 0.012
ethanolamine containing compound metabolic process GO:0042439 4 0.012
chromosome organization GO:0051276 360 0.012
embryonic morphogenesis GO:0048598 206 0.012
positive regulation of exocytosis GO:0045921 4 0.012
somatic muscle development GO:0007525 66 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.011
actin filament based process GO:0030029 220 0.011
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.011
positive regulation of cell growth GO:0030307 19 0.011
single organism membrane budding GO:1902591 2 0.011
ovarian follicle cell development GO:0030707 248 0.011
response to abiotic stimulus GO:0009628 341 0.011
intracellular protein transport GO:0006886 104 0.011
positive regulation of transport GO:0051050 92 0.011
mitotic nuclear division GO:0007067 213 0.011
ribonucleotide catabolic process GO:0009261 109 0.011
ubiquitin dependent protein catabolic process GO:0006511 78 0.011
innate immune response GO:0045087 144 0.011
purine ribonucleoside catabolic process GO:0046130 112 0.011
regulation of nucleoside metabolic process GO:0009118 50 0.011
cation homeostasis GO:0055080 51 0.011
cell maturation GO:0048469 144 0.011
regulation of molecular function GO:0065009 217 0.011
membrane invagination GO:0010324 11 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
immune response GO:0006955 246 0.011
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 24 0.011
positive regulation of cellular response to insulin stimulus GO:1900078 4 0.011
protein kinase b signaling GO:0043491 1 0.011
regulation of phosphorylation GO:0042325 147 0.011
skeletal muscle fiber development GO:0048741 3 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
positive regulation of hydrolase activity GO:0051345 78 0.010
regulation of purine nucleotide catabolic process GO:0033121 48 0.010
ubiquitin dependent protein catabolic process via the multivesicular body sorting pathway GO:0043162 8 0.010
regulation of ras protein signal transduction GO:0046578 93 0.010
organophosphate catabolic process GO:0046434 112 0.010
smoothened signaling pathway GO:0007224 49 0.010
protein localization to membrane GO:0072657 19 0.010
nucleoside phosphate metabolic process GO:0006753 162 0.010

Pi3K59F disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.017
disease of anatomical entity DOID:7 0 0.013
cancer DOID:162 0 0.013
nervous system disease DOID:863 0 0.013