Drosophila melanogaster

50 known processes

Sod2 (Dmel_CG8905)

Superoxide dismutase 2 (Mn)

(Aliases: dSOD2,MnSOD,Mn-SOD2,SOD-2,SOD2,mnSOD,MnSODII,Dmel\CG8905,Mn[2+]SOD,Mn-SOD,CG8905,Mn SOD,Sod-2,SOD)

Sod2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to reactive oxygen species GO:0000302 24 0.989
Mouse Worm
response to oxidative stress GO:0006979 86 0.987
Mouse Worm
response to hydrogen peroxide GO:0042542 11 0.986
Mouse
multicellular organismal aging GO:0010259 140 0.917
single organism behavior GO:0044708 391 0.850
locomotory behavior GO:0007626 176 0.799
Mouse
aging GO:0007568 143 0.790
cellular response to oxidative stress GO:0034599 28 0.766
Mouse Worm
determination of adult lifespan GO:0008340 137 0.751
oxidative phosphorylation GO:0006119 9 0.663
nucleoside phosphate metabolic process GO:0006753 162 0.561
growth GO:0040007 359 0.507
nucleoside triphosphate metabolic process GO:0009141 120 0.504
oxidation reduction process GO:0055114 123 0.465
Mouse Worm
cellular respiration GO:0045333 26 0.454
Mouse
nucleoside metabolic process GO:0009116 127 0.382
purine ribonucleoside metabolic process GO:0046128 127 0.332
organonitrogen compound metabolic process GO:1901564 318 0.288
Mouse
purine containing compound metabolic process GO:0072521 155 0.274
nucleobase containing small molecule metabolic process GO:0055086 174 0.269
glycosyl compound metabolic process GO:1901657 127 0.253
respiratory electron transport chain GO:0022904 11 0.246
Mouse
ribonucleoside triphosphate metabolic process GO:0009199 119 0.233
purine nucleoside metabolic process GO:0042278 127 0.233
catabolic process GO:0009056 409 0.221
mitochondrial fusion GO:0008053 7 0.219
developmental growth GO:0048589 280 0.217
purine nucleoside triphosphate metabolic process GO:0009144 119 0.211
single organism catabolic process GO:0044712 228 0.192
purine nucleoside biosynthetic process GO:0042451 3 0.190
sperm mitochondrion organization GO:0030382 7 0.188
ribonucleotide metabolic process GO:0009259 145 0.184
adult locomotory behavior GO:0008344 76 0.183
ribose phosphate metabolic process GO:0019693 145 0.183
cellular response to hydrogen peroxide GO:0070301 7 0.171
negative regulation of developmental process GO:0051093 201 0.170
Mouse
electron transport chain GO:0022900 14 0.170
Mouse
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.159
purine nucleoside monophosphate metabolic process GO:0009126 50 0.155
purine ribonucleotide metabolic process GO:0009150 145 0.154
atp metabolic process GO:0046034 49 0.150
mitochondrial atp synthesis coupled electron transport GO:0042775 8 0.149
atp synthesis coupled electron transport GO:0042773 8 0.149
carbohydrate derivative metabolic process GO:1901135 217 0.143
regulation of response to oxidative stress GO:1902882 4 0.142
death GO:0016265 284 0.139
Mouse
sperm individualization GO:0007291 48 0.139
small molecule metabolic process GO:0044281 305 0.138
Mouse
organophosphate metabolic process GO:0019637 195 0.138
positive regulation of apoptotic signaling pathway GO:2001235 4 0.133
ribonucleoside metabolic process GO:0009119 127 0.124
regulation of growth GO:0040008 233 0.123
immune system process GO:0002376 347 0.123
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.120
hydrogen peroxide catabolic process GO:0042744 6 0.120
cellular protein modification process GO:0006464 438 0.119
heart process GO:0003015 37 0.109
response to bacterium GO:0009617 198 0.108
cell redox homeostasis GO:0045454 5 0.105
adult chitin containing cuticle pigmentation GO:0048085 16 0.098
regulation of cellular response to oxidative stress GO:1900407 4 0.095
lipid metabolic process GO:0006629 121 0.092
cellular catabolic process GO:0044248 372 0.090
hydrogen peroxide metabolic process GO:0042743 6 0.086
regulation of cell development GO:0060284 215 0.085
positive regulation of developmental process GO:0051094 143 0.084
organic substance catabolic process GO:1901575 308 0.083
adult behavior GO:0030534 137 0.081
negative regulation of cell differentiation GO:0045596 143 0.080
Mouse
anatomical structure homeostasis GO:0060249 97 0.078
energy derivation by oxidation of organic compounds GO:0015980 32 0.078
Mouse
reactive oxygen species metabolic process GO:0072593 22 0.077
protein complex biogenesis GO:0070271 201 0.077
immune response GO:0006955 246 0.076
negative regulation of multicellular organismal process GO:0051241 142 0.074
nucleotide metabolic process GO:0009117 161 0.071
membrane organization GO:0061024 112 0.069
regulation of developmental growth GO:0048638 174 0.069
regulation of mitochondrial membrane potential GO:0051881 2 0.067
Mouse
age dependent response to oxidative stress GO:0001306 3 0.066
Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.066
nucleoside triphosphate catabolic process GO:0009143 108 0.066
vesicle mediated transport GO:0016192 381 0.066
regulation of molecular function GO:0065009 217 0.065
Mouse
negative regulation of neuron apoptotic process GO:0043524 14 0.064
purine nucleotide metabolic process GO:0006163 146 0.064
regulation of multicellular organismal development GO:2000026 414 0.063
regulation of phosphate metabolic process GO:0019220 210 0.061
atp biosynthetic process GO:0006754 2 0.061
defense response GO:0006952 300 0.058
regulation of response to stress GO:0080134 200 0.055
spinal cord development GO:0021510 1 0.055
nucleoside monophosphate metabolic process GO:0009123 52 0.055
response to oxygen containing compound GO:1901700 200 0.053
Mouse Worm
organic acid metabolic process GO:0006082 103 0.052
Mouse
regulation of cellular protein metabolic process GO:0032268 243 0.052
cell migration GO:0016477 238 0.050
ribose phosphate biosynthetic process GO:0046390 28 0.050
positive regulation of macromolecule metabolic process GO:0010604 405 0.050
embryonic organ development GO:0048568 50 0.049
regulation of immune system process GO:0002682 176 0.049
regulation of phosphorus metabolic process GO:0051174 210 0.047
negative regulation of response to oxidative stress GO:1902883 1 0.047
intracellular signal transduction GO:0035556 300 0.047
Mouse
positive regulation of programmed cell death GO:0043068 62 0.046
nucleoside phosphate catabolic process GO:1901292 110 0.046
regulation of intracellular signal transduction GO:1902531 236 0.046
generation of precursor metabolites and energy GO:0006091 42 0.045
Mouse
defense response to gram negative bacterium GO:0050829 94 0.045
homeostatic process GO:0042592 199 0.045
Mouse
epithelial cell differentiation GO:0030855 322 0.045
regulation of apoptotic process GO:0042981 130 0.044
cell death GO:0008219 279 0.044
Mouse
defense response to other organism GO:0098542 225 0.044
regulation of cellular amine metabolic process GO:0033238 3 0.044
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.043
ribonucleoside monophosphate metabolic process GO:0009161 51 0.043
response to inorganic substance GO:0010035 44 0.042
Zebrafish Mouse Worm
endocytosis GO:0006897 310 0.042
cellular response to dna damage stimulus GO:0006974 223 0.041
Mouse
localization of cell GO:0051674 257 0.040
negative regulation of immune response GO:0050777 39 0.040
cell growth GO:0016049 108 0.038
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.038
positive regulation of cell death GO:0010942 69 0.037
regulation of protein metabolic process GO:0051246 256 0.037
purine nucleoside triphosphate catabolic process GO:0009146 108 0.036
response to oxygen radical GO:0000305 3 0.036
Mouse Worm
single organism intracellular transport GO:1902582 207 0.035
sensory organ morphogenesis GO:0090596 260 0.034
heart development GO:0007507 82 0.034
regulation of programmed cell death GO:0043067 152 0.032
learning or memory GO:0007611 141 0.030
regulation of hydrolase activity GO:0051336 97 0.030
embryo development ending in birth or egg hatching GO:0009792 152 0.029
negative regulation of cellular metabolic process GO:0031324 382 0.029
phosphorylation GO:0016310 294 0.029
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.029
regulation of neuron apoptotic process GO:0043523 16 0.028
cellular amino acid metabolic process GO:0006520 61 0.028
Mouse
neuron death GO:0070997 27 0.028
positive regulation of signal transduction GO:0009967 223 0.028
carboxylic acid metabolic process GO:0019752 92 0.028
Mouse
nucleoside phosphate biosynthetic process GO:1901293 34 0.028
negative regulation of apoptotic process GO:0043066 63 0.027
macromolecular complex assembly GO:0065003 256 0.027
negative regulation of programmed cell death GO:0043069 72 0.027
neuron apoptotic process GO:0051402 17 0.027
regulation of membrane potential GO:0042391 35 0.026
Mouse
negative regulation of cellular response to oxidative stress GO:1900408 1 0.026
negative regulation of response to stimulus GO:0048585 258 0.026
negative regulation of signaling GO:0023057 219 0.026
muscle contraction GO:0006936 13 0.026
ribonucleoside biosynthetic process GO:0042455 3 0.026
positive regulation of cell communication GO:0010647 250 0.025
single organism biosynthetic process GO:0044711 206 0.025
regulation of anatomical structure morphogenesis GO:0022603 242 0.025
regulation of peptidase activity GO:0052547 39 0.025
cell motility GO:0048870 251 0.025
cellular macromolecular complex assembly GO:0034622 153 0.025
circulatory system process GO:0003013 37 0.025
Mouse
positive regulation of peptidase activity GO:0010952 29 0.024
cell type specific apoptotic process GO:0097285 38 0.024
organonitrogen compound catabolic process GO:1901565 128 0.024
eye morphogenesis GO:0048592 260 0.024
apoptotic process GO:0006915 159 0.023
Mouse
regulation of transmembrane transport GO:0034762 27 0.023
acyl coa metabolic process GO:0006637 3 0.023
nucleobase containing compound catabolic process GO:0034655 165 0.023
cellular nitrogen compound catabolic process GO:0044270 165 0.023
purine ribonucleoside monophosphate biosynthetic process GO:0009168 3 0.023
nucleotide catabolic process GO:0009166 109 0.023
positive regulation of endopeptidase activity GO:0010950 26 0.023
ribonucleoside catabolic process GO:0042454 112 0.023
oxoacid metabolic process GO:0043436 103 0.023
Mouse
protein complex assembly GO:0006461 200 0.023
phagocytosis GO:0006909 215 0.023
spermatogenesis GO:0007283 200 0.023
ribonucleoside triphosphate catabolic process GO:0009203 108 0.022
regulation of defense response GO:0031347 102 0.022
proteolysis GO:0006508 192 0.022
regulation of cell death GO:0010941 173 0.022
negative regulation of defense response GO:0031348 35 0.022
aromatic compound catabolic process GO:0019439 166 0.022
ion transport GO:0006811 145 0.022
response to abiotic stimulus GO:0009628 341 0.021
Mouse
brain development GO:0007420 120 0.021
negative regulation of signal transduction GO:0009968 206 0.021
negative regulation of neuron death GO:1901215 18 0.021
enzyme linked receptor protein signaling pathway GO:0007167 179 0.021
negative regulation of nervous system development GO:0051961 92 0.021
carbohydrate derivative catabolic process GO:1901136 118 0.021
cation transmembrane transport GO:0098655 88 0.021
intracellular transport GO:0046907 228 0.021
negative regulation of growth GO:0045926 84 0.020
response to nitrogen compound GO:1901698 90 0.020
nucleoside catabolic process GO:0009164 112 0.020
multicellular organismal homeostasis GO:0048871 41 0.020
regulation of protein modification process GO:0031399 112 0.020
neurological system process GO:0050877 358 0.020
Mouse
epithelial cell development GO:0002064 274 0.020
regulation of proteolysis GO:0030162 87 0.020
establishment or maintenance of cell polarity GO:0007163 167 0.019
response to organic cyclic compound GO:0014070 89 0.019
regulation of hemocyte proliferation GO:0035206 37 0.019
cellular protein complex assembly GO:0043623 71 0.019
response to biotic stimulus GO:0009607 294 0.019
purine nucleotide catabolic process GO:0006195 109 0.019
mitotic nuclear division GO:0007067 213 0.019
negative regulation of developmental growth GO:0048640 64 0.018
positive regulation of transcription dna templated GO:0045893 266 0.018
positive regulation of proteolysis GO:0045862 52 0.018
organophosphate catabolic process GO:0046434 112 0.018
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.018
negative regulation of immune system process GO:0002683 50 0.017
gtp catabolic process GO:0006184 72 0.017
activation of innate immune response GO:0002218 4 0.017
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.017
purine containing compound catabolic process GO:0072523 112 0.017
positive regulation of protein modification process GO:0031401 58 0.017
response to external biotic stimulus GO:0043207 293 0.017
organophosphate biosynthetic process GO:0090407 46 0.017
regulation of endopeptidase activity GO:0052548 36 0.016
regulation of immune response GO:0050776 118 0.016
positive regulation of apoptotic process GO:0043065 47 0.016
cellular response to reactive oxygen species GO:0034614 14 0.015
Mouse Worm
response to extracellular stimulus GO:0009991 116 0.015
cytoskeleton dependent intracellular transport GO:0030705 44 0.015
regulation of catalytic activity GO:0050790 185 0.015
Mouse
single organism membrane organization GO:0044802 93 0.015
purine ribonucleotide catabolic process GO:0009154 109 0.015
larval development GO:0002164 104 0.015
Worm
purine containing compound biosynthetic process GO:0072522 30 0.015
ion transmembrane transport GO:0034220 122 0.015
purine ribonucleotide biosynthetic process GO:0009152 28 0.015
purine nucleoside catabolic process GO:0006152 112 0.015
nucleotide biosynthetic process GO:0009165 34 0.015
ribonucleotide catabolic process GO:0009261 109 0.015
positive regulation of molecular function GO:0044093 136 0.015
tissue homeostasis GO:0001894 36 0.014
macroautophagy GO:0016236 42 0.014
cellular amine metabolic process GO:0044106 12 0.014
reproductive structure development GO:0048608 74 0.014
paracrine signaling GO:0038001 7 0.014
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.014
eye development GO:0001654 323 0.014
regulation of cysteine type endopeptidase activity GO:2000116 27 0.014
glycosyl compound biosynthetic process GO:1901659 3 0.013
organic cyclic compound catabolic process GO:1901361 168 0.013
sex differentiation GO:0007548 81 0.013
cellular response to superoxide GO:0071451 3 0.013
Mouse Worm
purine nucleoside monophosphate biosynthetic process GO:0009127 3 0.013
regulation of stem cell proliferation GO:0072091 40 0.013
purine nucleotide biosynthetic process GO:0006164 29 0.013
transmembrane transport GO:0055085 139 0.013
positive regulation of multicellular organismal process GO:0051240 143 0.013
molting cycle GO:0042303 56 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.012
cellular homeostasis GO:0019725 80 0.012
positive regulation of intracellular signal transduction GO:1902533 116 0.012
pyridine containing compound metabolic process GO:0072524 3 0.012
central nervous system development GO:0007417 201 0.012
tissue morphogenesis GO:0048729 297 0.012
compound eye retinal cell programmed cell death GO:0046667 23 0.012
negative regulation of biosynthetic process GO:0009890 277 0.012
regulation of cellular response to stress GO:0080135 89 0.012
regulation of nervous system development GO:0051960 248 0.012
extracellular matrix organization GO:0030198 32 0.012
positive regulation of phosphorus metabolic process GO:0010562 139 0.012
defense response to bacterium GO:0042742 178 0.012
tube morphogenesis GO:0035239 191 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
rhythmic behavior GO:0007622 76 0.012
negative regulation of cell communication GO:0010648 223 0.012
protein maturation GO:0051604 71 0.012
negative regulation of cell death GO:0060548 81 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.011
cellular response to extracellular stimulus GO:0031668 64 0.011
glycosyl compound catabolic process GO:1901658 112 0.011
ribonucleotide biosynthetic process GO:0009260 28 0.011
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.011
response to organonitrogen compound GO:0010243 75 0.011
organonitrogen compound biosynthetic process GO:1901566 117 0.011
regulation of insulin receptor signaling pathway GO:0046626 17 0.011
ras protein signal transduction GO:0007265 88 0.011
regulation of dna templated transcription in response to stress GO:0043620 4 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.011
Mouse
response to nutrient levels GO:0031667 114 0.011
positive regulation of rna metabolic process GO:0051254 271 0.011
cation transport GO:0006812 110 0.011
regulation of ras protein signal transduction GO:0046578 93 0.011
hemocyte differentiation GO:0042386 38 0.010
positive regulation of catalytic activity GO:0043085 118 0.010
positive regulation of phosphate metabolic process GO:0045937 139 0.010
regulation of phosphorylation GO:0042325 147 0.010

Sod2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.127
disease of cellular proliferation DOID:14566 0 0.127
organ system cancer DOID:0050686 0 0.127
disease of anatomical entity DOID:7 0 0.055
nervous system disease DOID:863 0 0.055
disease of metabolism DOID:0014667 0 0.016
central nervous system disease DOID:331 0 0.010