Drosophila melanogaster

79 known processes

Atg8a (Dmel_CG32672)

Autophagy-specific gene 8a

(Aliases: atg8a,DrAtg8a,BcDNA:LD05816,CG1534,ATG8a,CG32672,atg8,Dmel\CG32672,Atg8A,Atg8/LC3)

Atg8a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
macroautophagy GO:0016236 42 0.999
autophagy GO:0006914 108 0.997
cellular response to starvation GO:0009267 61 0.990
larval midgut histolysis GO:0035069 22 0.988
regulation of autophagy GO:0010506 62 0.978
cellular response to nutrient levels GO:0031669 62 0.976
cellular response to extracellular stimulus GO:0031668 64 0.963
cellular catabolic process GO:0044248 372 0.946
larval midgut cell programmed cell death GO:0035096 19 0.944
determination of adult lifespan GO:0008340 137 0.943
cellular response to external stimulus GO:0071496 66 0.938
catabolic process GO:0009056 409 0.931
aging GO:0007568 143 0.929
multicellular organismal aging GO:0010259 140 0.918
histolysis GO:0007559 102 0.906
response to starvation GO:0042594 97 0.850
single organism catabolic process GO:0044712 228 0.787
autophagic vacuole assembly GO:0000045 2 0.783
positive regulation of autophagy GO:0010508 21 0.768
organelle membrane fusion GO:0090174 16 0.751
developmental programmed cell death GO:0010623 138 0.735
response to extracellular stimulus GO:0009991 116 0.734
regulation of endopeptidase activity GO:0052548 36 0.677
protein localization GO:0008104 284 0.676
organelle assembly GO:0070925 198 0.653
programmed cell death GO:0012501 257 0.635
cell death GO:0008219 279 0.570
regulation of catabolic process GO:0009894 170 0.565
vacuolar transport GO:0007034 13 0.541
death GO:0016265 284 0.537
autophagic vacuole fusion GO:0000046 15 0.506
exocrine system development GO:0035272 162 0.469
response to nutrient levels GO:0031667 114 0.465
intracellular transport GO:0046907 228 0.446
single organism intracellular transport GO:1902582 207 0.434
regulation of peptidase activity GO:0052547 39 0.423
regulation of cellular catabolic process GO:0031329 157 0.351
establishment of localization in cell GO:0051649 402 0.321
positive regulation of macroautophagy GO:0016239 8 0.310
positive regulation of biosynthetic process GO:0009891 316 0.310
regulation of protein metabolic process GO:0051246 256 0.299
positive regulation of developmental process GO:0051094 143 0.291
membrane fusion GO:0061025 42 0.274
cytoplasmic transport GO:0016482 130 0.264
tissue death GO:0016271 102 0.264
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.250
proteolysis GO:0006508 192 0.249
actin cytoskeleton organization GO:0030036 206 0.236
gland morphogenesis GO:0022612 145 0.224
regulation of cellular protein metabolic process GO:0032268 243 0.214
regulation of cysteine type endopeptidase activity GO:2000116 27 0.213
negative regulation of response to stimulus GO:0048585 258 0.211
regulation of programmed cell death GO:0043067 152 0.211
negative regulation of signal transduction GO:0009968 206 0.207
regulation of macroautophagy GO:0016241 15 0.195
protein modification by small protein conjugation GO:0032446 79 0.193
regulation of nurse cell apoptotic process GO:0045477 9 0.184
salivary gland development GO:0007431 162 0.179
regulation of cellular component biogenesis GO:0044087 201 0.177
larval development GO:0002164 104 0.175
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.163
response to organic substance GO:0010033 284 0.155
regulation of apoptotic process GO:0042981 130 0.154
single organism membrane fusion GO:0044801 42 0.152
gland development GO:0048732 191 0.151
regulation of cell morphogenesis GO:0022604 163 0.142
short term memory GO:0007614 19 0.138
regulation of cell differentiation GO:0045595 302 0.132
salivary gland histolysis GO:0035070 88 0.129
regulation of proteolysis GO:0030162 87 0.125
regulation of hydrolase activity GO:0051336 97 0.125
positive regulation of rna biosynthetic process GO:1902680 266 0.125
regulation of response to nutrient levels GO:0032107 18 0.123
chromosome organization GO:0051276 360 0.120
cell motility GO:0048870 251 0.113
cellular protein localization GO:0034613 160 0.110
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.110
response to oxygen containing compound GO:1901700 200 0.109
cellular response to chemical stimulus GO:0070887 199 0.108
protein maturation GO:0051604 71 0.107
gliogenesis GO:0042063 80 0.103
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.103
regulation of tor signaling GO:0032006 21 0.103
positive regulation of programmed cell death GO:0043068 62 0.101
positive regulation of catabolic process GO:0009896 105 0.098
autophagic cell death GO:0048102 83 0.097
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.097
adult behavior GO:0030534 137 0.096
positive regulation of cell death GO:0010942 69 0.095
cellular homeostasis GO:0019725 80 0.092
covalent chromatin modification GO:0016569 106 0.092
nitrogen compound transport GO:0071705 85 0.092
response to bacterium GO:0009617 198 0.091
protein transport GO:0015031 155 0.087
protein complex assembly GO:0006461 200 0.081
regulation of cellular component size GO:0032535 98 0.080
tissue morphogenesis GO:0048729 297 0.079
dorsal ventral pattern formation GO:0009953 133 0.078
protein processing GO:0016485 68 0.078
homeostatic process GO:0042592 199 0.078
regulation of response to extracellular stimulus GO:0032104 18 0.077
salivary gland morphogenesis GO:0007435 145 0.077
negative regulation of cell proliferation GO:0008285 69 0.076
muscle structure development GO:0061061 224 0.075
protein modification process GO:0036211 438 0.075
endosomal transport GO:0016197 44 0.074
regulation of phosphorus metabolic process GO:0051174 210 0.074
salivary gland cell autophagic cell death GO:0035071 83 0.074
intracellular signal transduction GO:0035556 300 0.072
organic substance transport GO:0071702 257 0.070
positive regulation of gene expression GO:0010628 290 0.070
apoptotic process GO:0006915 159 0.069
positive regulation of cellular biosynthetic process GO:0031328 316 0.069
actin filament based process GO:0030029 220 0.069
developmental maturation GO:0021700 172 0.068
positive regulation of cellular catabolic process GO:0031331 95 0.068
regulation of cell death GO:0010941 173 0.067
positive regulation of transcription dna templated GO:0045893 266 0.066
negative regulation of cell communication GO:0010648 223 0.061
organic substance catabolic process GO:1901575 308 0.060
regulation of multicellular organism growth GO:0040014 40 0.060
positive regulation of signaling GO:0023056 243 0.060
cell migration GO:0016477 238 0.060
positive regulation of nucleic acid templated transcription GO:1903508 266 0.060
positive regulation of response to stimulus GO:0048584 323 0.059
positive regulation of tor signaling GO:0032008 13 0.058
insulin receptor signaling pathway GO:0008286 25 0.058
chromatin modification GO:0016568 147 0.056
macromolecule catabolic process GO:0009057 161 0.056
chromatin organization GO:0006325 207 0.056
negative regulation of developmental process GO:0051093 201 0.055
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.054
posttranscriptional regulation of gene expression GO:0010608 145 0.053
hematopoietic or lymphoid organ development GO:0048534 57 0.053
establishment of protein localization GO:0045184 163 0.053
response to alcohol GO:0097305 95 0.052
single organism behavior GO:0044708 391 0.052
response to abiotic stimulus GO:0009628 341 0.050
dendrite development GO:0016358 204 0.050
positive regulation of signal transduction GO:0009967 223 0.050
single organism cellular localization GO:1902580 180 0.050
positive regulation of multicellular organism growth GO:0040018 21 0.049
positive regulation of protein metabolic process GO:0051247 128 0.049
post embryonic appendage morphogenesis GO:0035120 385 0.048
single organism membrane organization GO:0044802 93 0.048
phosphatidylinositol 3 kinase signaling GO:0014065 4 0.047
regionalization GO:0003002 416 0.047
cellular cation homeostasis GO:0030003 38 0.046
regulation of intracellular signal transduction GO:1902531 236 0.044
positive regulation of proteolysis GO:0045862 52 0.043
positive regulation of apoptotic process GO:0043065 47 0.043
dendrite morphogenesis GO:0048813 199 0.043
response to other organism GO:0051707 293 0.043
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.042
regulation of growth GO:0040008 233 0.040
morphogenesis of an epithelium GO:0002009 276 0.040
body morphogenesis GO:0010171 2 0.039
response to external biotic stimulus GO:0043207 293 0.039
cellular response to oxygen containing compound GO:1901701 79 0.038
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.038
protein complex biogenesis GO:0070271 201 0.038
appendage morphogenesis GO:0035107 397 0.038
negative regulation of autophagy GO:0010507 16 0.037
cellular pigmentation GO:0033059 12 0.037
endocytosis GO:0006897 310 0.037
protein catabolic process GO:0030163 101 0.036
vesicle mediated transport GO:0016192 381 0.036
negative regulation of programmed cell death GO:0043069 72 0.036
regulation of developmental growth GO:0048638 174 0.035
response to peptide hormone GO:0043434 29 0.035
membrane organization GO:0061024 112 0.035
regulation of anatomical structure morphogenesis GO:0022603 242 0.034
negative regulation of transcription dna templated GO:0045892 237 0.034
positive regulation of macromolecule metabolic process GO:0010604 405 0.032
response to temperature stimulus GO:0009266 106 0.032
negative regulation of cellular metabolic process GO:0031324 382 0.032
positive regulation of cell differentiation GO:0045597 64 0.031
regulation of response to stress GO:0080134 200 0.031
ribonucleotide metabolic process GO:0009259 145 0.031
reproductive system development GO:0061458 74 0.031
imaginal disc pattern formation GO:0007447 91 0.031
nucleocytoplasmic transport GO:0006913 72 0.031
vacuole organization GO:0007033 8 0.030
regulation of cell development GO:0060284 215 0.029
regulation of catalytic activity GO:0050790 185 0.029
embryo development ending in birth or egg hatching GO:0009792 152 0.029
appendage development GO:0048736 401 0.029
defense response GO:0006952 300 0.029
cellular component assembly involved in morphogenesis GO:0010927 151 0.028
apoptotic process involved in development GO:1902742 20 0.028
zymogen activation GO:0031638 20 0.028
rna localization GO:0006403 115 0.028
heterocycle catabolic process GO:0046700 166 0.028
establishment or maintenance of cell polarity GO:0007163 167 0.027
defense response to other organism GO:0098542 225 0.027
response to biotic stimulus GO:0009607 294 0.027
positive regulation of rna metabolic process GO:0051254 271 0.027
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.027
cellular response to insulin stimulus GO:0032869 28 0.027
neurological system process GO:0050877 358 0.027
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.026
camera type eye development GO:0043010 4 0.026
inositol lipid mediated signaling GO:0048017 4 0.026
reproductive structure development GO:0048608 74 0.026
regulation of cellular response to insulin stimulus GO:1900076 17 0.026
regulation of gene expression epigenetic GO:0040029 128 0.026
activation of cysteine type endopeptidase activity GO:0097202 17 0.026
locomotory behavior GO:0007626 176 0.026
asymmetric protein localization GO:0008105 33 0.026
lysosomal transport GO:0007041 13 0.026
positive regulation of cell migration GO:0030335 2 0.025
regulation of histone modification GO:0031056 20 0.025
cellular metal ion homeostasis GO:0006875 31 0.025
epithelial cell differentiation GO:0030855 322 0.025
phosphatidylinositol mediated signaling GO:0048015 4 0.024
regulation of localization GO:0032879 275 0.024
protein acetylation GO:0006473 39 0.024
cellular response to hormone stimulus GO:0032870 44 0.024
regulation of molecular function GO:0065009 217 0.024
macromolecule methylation GO:0043414 45 0.024
mesenchymal cell differentiation GO:0048762 1 0.023
protein acylation GO:0043543 42 0.023
induction of programmed cell death by ecdysone GO:0035078 12 0.023
protein ubiquitination GO:0016567 70 0.023
protein alkylation GO:0008213 43 0.023
cellular protein modification process GO:0006464 438 0.022
regulation of steroid metabolic process GO:0019218 2 0.022
nuclear transport GO:0051169 72 0.022
cellular protein catabolic process GO:0044257 83 0.022
response to nitrogen compound GO:1901698 90 0.022
negative regulation of catabolic process GO:0009895 36 0.022
camera type eye morphogenesis GO:0048593 2 0.022
nuclear export GO:0051168 24 0.022
regulation of response to external stimulus GO:0032101 115 0.021
phagocytosis GO:0006909 215 0.021
developmental growth GO:0048589 280 0.021
negative regulation of growth of symbiont involved in interaction with host GO:0044146 9 0.021
cellular response to oxidative stress GO:0034599 28 0.021
cell aging GO:0007569 2 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.021
hemopoiesis GO:0030097 46 0.020
activation of cysteine type endopeptidase activity involved in apoptotic process GO:0006919 16 0.020
small molecule metabolic process GO:0044281 305 0.020
apoptotic signaling pathway GO:0097190 27 0.020
cell type specific apoptotic process GO:0097285 38 0.020
regulation of cellular ketone metabolic process GO:0010565 3 0.020
cellular response to organic substance GO:0071310 132 0.020
positive regulation of multicellular organismal process GO:0051240 143 0.020
immune system process GO:0002376 347 0.020
organelle localization GO:0051640 148 0.019
cellular response to dna damage stimulus GO:0006974 223 0.019
instar larval development GO:0002168 55 0.019
negative regulation of protein metabolic process GO:0051248 85 0.019
chemical homeostasis GO:0048878 92 0.019
positive regulation of developmental growth GO:0048639 62 0.019
nucleobase containing compound catabolic process GO:0034655 165 0.019
positive regulation of growth GO:0045927 75 0.019
defense response to virus GO:0051607 23 0.019
chromatin silencing GO:0006342 76 0.019
regulation of chromatin modification GO:1903308 28 0.018
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.018
regulation of defense response to virus GO:0050688 14 0.018
convergent extension involved in gastrulation GO:0060027 2 0.018
positive regulation of endopeptidase activity GO:0010950 26 0.018
negative regulation of growth GO:0045926 84 0.018
phosphorylation GO:0016310 294 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
regulation of translation GO:0006417 56 0.017
purine nucleoside metabolic process GO:0042278 127 0.017
negative regulation of cell death GO:0060548 81 0.017
regulation of nucleocytoplasmic transport GO:0046822 35 0.017
muscle cell differentiation GO:0042692 103 0.017
organic acid metabolic process GO:0006082 103 0.017
intracellular protein transport GO:0006886 104 0.017
central nervous system development GO:0007417 201 0.017
positive regulation of molecular function GO:0044093 136 0.017
regulation of defense response GO:0031347 102 0.017
multicellular organism growth GO:0035264 46 0.016
brain development GO:0007420 120 0.016
membrane invagination GO:0010324 11 0.016
ribonucleoside triphosphate metabolic process GO:0009199 119 0.016
long term memory GO:0007616 62 0.016
histone modification GO:0016570 106 0.016
cellular response to endogenous stimulus GO:0071495 80 0.016
striated muscle cell development GO:0055002 50 0.016
dna metabolic process GO:0006259 227 0.016
negative regulation of rna metabolic process GO:0051253 251 0.016
immune system development GO:0002520 57 0.016
wing disc pattern formation GO:0035222 66 0.016
cell adhesion GO:0007155 136 0.016
induction of programmed cell death GO:0012502 12 0.016
positive regulation of peptidase activity GO:0010952 29 0.015
regulation of phosphatidylinositol 3 kinase signaling GO:0014066 4 0.015
cellular protein complex assembly GO:0043623 71 0.015
localization of cell GO:0051674 257 0.015
organophosphate metabolic process GO:0019637 195 0.015
nucleoside phosphate metabolic process GO:0006753 162 0.015
mapk cascade GO:0000165 107 0.015
positive regulation of hydrolase activity GO:0051345 78 0.015
positive regulation of response to external stimulus GO:0032103 44 0.015
sensory perception of chemical stimulus GO:0007606 116 0.015
enzyme linked receptor protein signaling pathway GO:0007167 179 0.015
negative regulation of cellular biosynthetic process GO:0031327 277 0.015
ion transport GO:0006811 145 0.015
cell cycle g1 s phase transition GO:0044843 31 0.014
neuron death GO:0070997 27 0.014
glycosyl compound metabolic process GO:1901657 127 0.014
anatomical structure homeostasis GO:0060249 97 0.014
nucleoside triphosphate metabolic process GO:0009141 120 0.014
skeletal muscle organ development GO:0060538 48 0.014
negative regulation of protein processing GO:0010955 31 0.014
negative regulation of apoptotic process GO:0043066 63 0.014
cell division GO:0051301 248 0.014
negative regulation of notch signaling pathway GO:0045746 41 0.014
regulation of anatomical structure size GO:0090066 163 0.014
phagosome acidification GO:0090383 1 0.014
cellular macromolecule localization GO:0070727 220 0.014
growth GO:0040007 359 0.014
internal protein amino acid acetylation GO:0006475 38 0.014
regulation of cellular localization GO:0060341 136 0.014
establishment of protein localization to organelle GO:0072594 62 0.014
positive regulation of cell communication GO:0010647 250 0.014
heart development GO:0007507 82 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
immune response regulating signaling pathway GO:0002764 2 0.013
negative regulation of catalytic activity GO:0043086 42 0.013
regulation of cell proliferation GO:0042127 163 0.013
golgi vesicle transport GO:0048193 27 0.013
mitochondrion degradation GO:0000422 8 0.013
axonogenesis GO:0007409 290 0.013
stem cell proliferation GO:0072089 88 0.013
cell proliferation GO:0008283 299 0.013
single organism cell adhesion GO:0098602 47 0.013
regulation of chromatin organization GO:1902275 32 0.013
compound eye development GO:0048749 307 0.013
axon ensheathment GO:0008366 10 0.013
glycerolipid metabolic process GO:0046486 34 0.013
organonitrogen compound metabolic process GO:1901564 318 0.013
ecdysone mediated induction of salivary gland cell autophagic cell death GO:0035072 12 0.013
endosome transport via multivesicular body sorting pathway GO:0032509 12 0.013
response to oxidative stress GO:0006979 86 0.013
imaginal disc derived appendage morphogenesis GO:0035114 395 0.013
positive regulation of nurse cell apoptotic process GO:0045850 5 0.012
cation homeostasis GO:0055080 51 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
extrinsic apoptotic signaling pathway GO:0097191 1 0.012
cell maturation GO:0048469 144 0.012
purine containing compound metabolic process GO:0072521 155 0.012
regulation of cell cycle g1 s phase transition GO:1902806 23 0.012
purine nucleotide catabolic process GO:0006195 109 0.012
regulation of establishment of protein localization GO:0070201 61 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.012
regulation of insulin receptor signaling pathway GO:0046626 17 0.012
cellular ion homeostasis GO:0006873 39 0.012
regulation of protein modification process GO:0031399 112 0.012
regulation of multi organism process GO:0043900 131 0.012
endomembrane system organization GO:0010256 119 0.012
mitotic cell cycle phase transition GO:0044772 138 0.012
induction of programmed cell death by hormones GO:0035081 12 0.012
nucleotide metabolic process GO:0009117 161 0.011
cytoskeleton dependent intracellular transport GO:0030705 44 0.011
regulation of protein ubiquitination GO:0031396 22 0.011
negative regulation of gene expression GO:0010629 387 0.011
nucleoside metabolic process GO:0009116 127 0.011
positive regulation of response to nutrient levels GO:0032109 8 0.011
regulation of protein catabolic process GO:0042176 55 0.011
defense response to bacterium GO:0042742 178 0.011
positive regulation of execution phase of apoptosis GO:1900119 4 0.011
response to virus GO:0009615 28 0.011
response to ionizing radiation GO:0010212 32 0.011
gtp metabolic process GO:0046039 72 0.011
photoreceptor cell differentiation GO:0046530 170 0.011
regulation of organelle organization GO:0033043 196 0.011
response to endogenous stimulus GO:0009719 119 0.011
posttranscriptional gene silencing GO:0016441 46 0.011
negative regulation of stem cell proliferation GO:2000647 30 0.011
mesenchymal cell development GO:0014031 1 0.011
imaginal disc derived wing morphogenesis GO:0007476 337 0.011
response to ethanol GO:0045471 59 0.011
glial cell differentiation GO:0010001 35 0.011
imaginal disc derived appendage development GO:0048737 399 0.011
regulation of cell cycle phase transition GO:1901987 130 0.011
regulation of response to biotic stimulus GO:0002831 63 0.010
regulation of protein processing GO:0070613 32 0.010
nucleobase containing small molecule metabolic process GO:0055086 174 0.010
protein localization to organelle GO:0033365 82 0.010
methylation GO:0032259 47 0.010
spinal cord dorsal ventral patterning GO:0021513 1 0.010
regulation of cell shape GO:0008360 113 0.010
negative regulation of mitotic cell cycle GO:0045930 109 0.010
biological adhesion GO:0022610 138 0.010
ion homeostasis GO:0050801 55 0.010
purine nucleoside catabolic process GO:0006152 112 0.010

Atg8a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016