Drosophila melanogaster

95 known processes

Hcf (Dmel_CG1710)

Host cell factor

(Aliases: Dmel\CG1710,dHCF,HCF,anon-WO0172774.48,CG1710)

Hcf biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
peptidyl lysine modification GO:0018205 57 1.000
internal protein amino acid acetylation GO:0006475 38 0.994
histone acetylation GO:0016573 38 0.990
internal peptidyl lysine acetylation GO:0018393 38 0.983
protein acetylation GO:0006473 39 0.983
protein acylation GO:0043543 42 0.981
chromatin modification GO:0016568 147 0.965
peptidyl lysine acetylation GO:0018394 39 0.956
chromatin organization GO:0006325 207 0.942
cellular response to extracellular stimulus GO:0031668 64 0.917
covalent chromatin modification GO:0016569 106 0.898
peptidyl amino acid modification GO:0018193 105 0.867
cellular protein modification process GO:0006464 438 0.866
histone h4 acetylation GO:0043967 13 0.863
imaginal disc derived wing morphogenesis GO:0007476 337 0.859
wing disc morphogenesis GO:0007472 344 0.852
histone modification GO:0016570 106 0.809
imaginal disc derived appendage development GO:0048737 399 0.803
post embryonic appendage morphogenesis GO:0035120 385 0.782
histone h4 k16 acetylation GO:0043984 4 0.775
histone h3 acetylation GO:0043966 11 0.718
chromosome organization GO:0051276 360 0.692
cellular ketone metabolic process GO:0042180 24 0.683
appendage morphogenesis GO:0035107 397 0.673
regulation of organelle organization GO:0033043 196 0.639
appendage development GO:0048736 401 0.630
negative regulation of signaling GO:0023057 219 0.614
cellular amino acid metabolic process GO:0006520 61 0.588
regulation of multicellular organism growth GO:0040014 40 0.556
protein modification process GO:0036211 438 0.511
negative regulation of cell cycle phase transition GO:1901988 103 0.509
stem cell maintenance GO:0019827 67 0.508
multicellular organism growth GO:0035264 46 0.503
regulation of gene expression epigenetic GO:0040029 128 0.488
regionalization GO:0003002 416 0.484
regulation of cellular amino acid metabolic process GO:0006521 0 0.467
maintenance of gastrointestinal epithelium GO:0030277 3 0.460
oxoacid metabolic process GO:0043436 103 0.451
regulation of cellular ketone metabolic process GO:0010565 3 0.441
organic acid metabolic process GO:0006082 103 0.438
spermatogenesis GO:0007283 200 0.416
spermatid differentiation GO:0048515 114 0.398
imaginal disc derived wing vein specification GO:0007474 48 0.387
response to starvation GO:0042594 97 0.383
positive regulation of cell size GO:0045793 21 0.379
small molecule metabolic process GO:0044281 305 0.376
cytoplasmic transport GO:0016482 130 0.374
chromatin remodeling GO:0006338 72 0.367
imaginal disc derived appendage morphogenesis GO:0035114 395 0.361
carboxylic acid metabolic process GO:0019752 92 0.358
male gamete generation GO:0048232 201 0.345
positive regulation of transcription dna templated GO:0045893 266 0.344
negative regulation of gene expression GO:0010629 387 0.335
Rat
negative regulation of cell cycle process GO:0010948 109 0.314
pattern recognition receptor signaling pathway GO:0002221 2 0.313
response to organic substance GO:0010033 284 0.306
Rat
spermatid development GO:0007286 98 0.295
immune response activating signal transduction GO:0002757 2 0.284
response to nutrient levels GO:0031667 114 0.279
cell fate determination GO:0001709 91 0.277
dorsal ventral pattern formation GO:0009953 133 0.267
negative regulation of cellular metabolic process GO:0031324 382 0.264
Rat
compound eye morphogenesis GO:0001745 249 0.256
organonitrogen compound metabolic process GO:1901564 318 0.253
female meiotic division GO:0007143 70 0.248
regulation of protein acetylation GO:1901983 7 0.241
regulation of cell cycle process GO:0010564 181 0.238
phosphorylation GO:0016310 294 0.237
autophagy GO:0006914 108 0.227
growth GO:0040007 359 0.223
catabolic process GO:0009056 409 0.219
activation of innate immune response GO:0002218 4 0.216
immune response GO:0006955 246 0.215
positive regulation of multicellular organism growth GO:0040018 21 0.209
positive regulation of cellular biosynthetic process GO:0031328 316 0.209
regulation of intracellular protein transport GO:0033157 46 0.209
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 4 0.207
methylation GO:0032259 47 0.205
establishment of localization in cell GO:0051649 402 0.204
regulation of chromatin modification GO:1903308 28 0.203
response to extracellular stimulus GO:0009991 116 0.199
small molecule biosynthetic process GO:0044283 37 0.198
meiotic cell cycle process GO:1903046 132 0.196
hemopoiesis GO:0030097 46 0.185
negative regulation of signal transduction GO:0009968 206 0.184
ovarian follicle cell development GO:0030707 248 0.183
dosage compensation GO:0007549 16 0.183
nephron morphogenesis GO:0072028 3 0.181
cellular response to starvation GO:0009267 61 0.178
cell death GO:0008219 279 0.174
cellular response to abiotic stimulus GO:0071214 58 0.173
cell cycle checkpoint GO:0000075 95 0.171
amine metabolic process GO:0009308 12 0.167
positive regulation of insulin receptor signaling pathway GO:0046628 3 0.164
regulation of cellular protein metabolic process GO:0032268 243 0.154
columnar cuboidal epithelial cell development GO:0002066 249 0.154
compound eye development GO:0048749 307 0.153
histone lysine methylation GO:0034968 32 0.150
pigmentation GO:0043473 75 0.150
regulation of cellular amine metabolic process GO:0033238 3 0.149
negative regulation of developmental process GO:0051093 201 0.149
mitotic g2 m transition checkpoint GO:0044818 70 0.148
positive regulation of nucleic acid templated transcription GO:1903508 266 0.147
somatic muscle development GO:0007525 66 0.146
sex determination GO:0007530 18 0.145
r7 cell differentiation GO:0045466 43 0.144
cellular amine metabolic process GO:0044106 12 0.144
organic substance transport GO:0071702 257 0.141
protein import GO:0017038 55 0.139
cellular response to nutrient levels GO:0031669 62 0.137
negative regulation of cell cycle GO:0045786 116 0.136
dna metabolic process GO:0006259 227 0.135
apoptotic process GO:0006915 159 0.134
regulation of chromatin organization GO:1902275 32 0.134
negative regulation of chromatin silencing GO:0031936 9 0.133
regulation of chromosome organization GO:0033044 64 0.132
response to endogenous stimulus GO:0009719 119 0.129
negative regulation of cell differentiation GO:0045596 143 0.129
regulation of peptidyl lysine acetylation GO:2000756 7 0.128
cellular response to external stimulus GO:0071496 66 0.127
positive regulation of rna metabolic process GO:0051254 271 0.123
cellular response to endogenous stimulus GO:0071495 80 0.122
epithelial cell development GO:0002064 274 0.121
imaginal disc pattern formation GO:0007447 91 0.121
stem cell differentiation GO:0048863 117 0.121
nuclear import GO:0051170 51 0.121
programmed cell death GO:0012501 257 0.120
mitotic cell cycle phase transition GO:0044772 138 0.119
positive regulation of histone acetylation GO:0035066 3 0.119
negative regulation of cell communication GO:0010648 223 0.119
g2 dna damage checkpoint GO:0031572 69 0.118
response to transforming growth factor beta GO:0071559 18 0.118
cellular response to chemical stimulus GO:0070887 199 0.117
Rat
positive regulation of cellular amine metabolic process GO:0033240 0 0.117
nucleocytoplasmic transport GO:0006913 72 0.115
regulation of apoptotic process GO:0042981 130 0.114
chromatin assembly GO:0031497 48 0.112
positive regulation of molecular function GO:0044093 136 0.111
mitotic dna damage checkpoint GO:0044773 74 0.111
regulation of immune response GO:0050776 118 0.111
regulation of programmed cell death GO:0043067 152 0.109
cellular response to dna damage stimulus GO:0006974 223 0.109
negative regulation of transcription dna templated GO:0045892 237 0.109
Rat
regulation of protein import into nucleus GO:0042306 28 0.108
jak stat cascade GO:0007259 49 0.107
cellular component disassembly GO:0022411 46 0.107
protein targeting to nucleus GO:0044744 51 0.107
transcription from rna polymerase ii promoter GO:0006366 368 0.107
Mouse Rat
stem cell development GO:0048864 79 0.106
regulation of cytoplasmic transport GO:1903649 47 0.106
response to hexose GO:0009746 3 0.106
mitotic g2 dna damage checkpoint GO:0007095 69 0.105
regulation of histone modification GO:0031056 20 0.102
regulation of cell cycle GO:0051726 291 0.102
intracellular protein transport GO:0006886 104 0.101
cell proliferation involved in imaginal disc derived wing morphogenesis GO:0090255 2 0.100
immune response regulating signaling pathway GO:0002764 2 0.100
protein phosphorylation GO:0006468 169 0.100
neuromuscular junction development GO:0007528 149 0.099
regulation of hemocyte differentiation GO:0045610 22 0.099
developmental pigmentation GO:0048066 68 0.099
enteroendocrine cell differentiation GO:0035883 1 0.098
organelle assembly GO:0070925 198 0.097
response to peptide GO:1901652 29 0.097
maintenance of location GO:0051235 73 0.097
regulation of cell death GO:0010941 173 0.097
regulation of cell differentiation GO:0045595 302 0.097
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.095
anatomical structure homeostasis GO:0060249 97 0.095
regulation of immune system process GO:0002682 176 0.095
protein catabolic process GO:0030163 101 0.092
mitotic cell cycle checkpoint GO:0007093 88 0.092
chromatin silencing GO:0006342 76 0.092
regulation of intracellular transport GO:0032386 64 0.092
localization of cell GO:0051674 257 0.092
regulation of autophagy GO:0010506 62 0.091
nephron tubule morphogenesis GO:0072078 3 0.090
sperm individualization GO:0007291 48 0.089
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.088
protein localization to nucleus GO:0034504 55 0.088
response to monosaccharide GO:0034284 4 0.087
multi multicellular organism process GO:0044706 123 0.087
regulation of phosphate metabolic process GO:0019220 210 0.087
modification dependent macromolecule catabolic process GO:0043632 79 0.086
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.086
endomitotic cell cycle GO:0007113 7 0.086
defense response GO:0006952 300 0.085
regulation of phosphatidylinositol 3 kinase activity GO:0043551 2 0.085
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.084
Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.083
Rat
positive regulation of protein metabolic process GO:0051247 128 0.083
positive regulation of immune system process GO:0002684 68 0.083
synaptic growth at neuromuscular junction GO:0051124 119 0.083
positive regulation of organelle organization GO:0010638 65 0.082
innate immune response activating signal transduction GO:0002758 2 0.081
regulation of histone acetylation GO:0035065 7 0.079
positive regulation of macromolecule metabolic process GO:0010604 405 0.079
morphogenesis of follicular epithelium GO:0016333 36 0.078
sulfur compound biosynthetic process GO:0044272 16 0.077
divalent inorganic cation homeostasis GO:0072507 29 0.077
tor signaling GO:0031929 32 0.077
modification dependent protein catabolic process GO:0019941 78 0.077
enzyme linked receptor protein signaling pathway GO:0007167 179 0.075
lipid metabolic process GO:0006629 121 0.075
positive regulation of immune response GO:0050778 63 0.075
response to growth factor GO:0070848 31 0.075
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.074
chorion containing eggshell formation GO:0007304 105 0.074
cell fate specification GO:0001708 71 0.074
cellular protein localization GO:0034613 160 0.074
protein localization to organelle GO:0033365 82 0.073
neuron fate commitment GO:0048663 50 0.073
regulation of organ morphogenesis GO:2000027 78 0.073
regulation of retinal cell programmed cell death GO:0046668 18 0.072
response to glucose GO:0009749 2 0.071
regulation of chromatin silencing GO:0031935 36 0.070
neuroblast differentiation GO:0014016 29 0.070
death GO:0016265 284 0.070
regulation of protein localization GO:0032880 76 0.069
cell type specific apoptotic process GO:0097285 38 0.069
regulation of molecular function GO:0065009 217 0.069
innate immune response GO:0045087 144 0.068
positive regulation of protein import into nucleus GO:0042307 21 0.068
apoptotic signaling pathway GO:0097190 27 0.068
eye antennal disc development GO:0035214 60 0.067
developmental growth GO:0048589 280 0.067
immune system development GO:0002520 57 0.066
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.066
regulation of protein modification process GO:0031399 112 0.066
rhabdomere development GO:0042052 38 0.065
regulation of cell cycle phase transition GO:1901987 130 0.065
negative regulation of synapse assembly GO:0051964 39 0.065
kidney epithelium development GO:0072073 3 0.064
cellular cation homeostasis GO:0030003 38 0.064
nuclear transport GO:0051169 72 0.063
fusome organization GO:0045478 13 0.063
meiotic cell cycle GO:0051321 171 0.062
regulation of mitotic cell cycle GO:0007346 190 0.061
hematopoietic or lymphoid organ development GO:0048534 57 0.061
spinal cord dorsal ventral patterning GO:0021513 1 0.061
positive regulation of biosynthetic process GO:0009891 316 0.061
response to abiotic stimulus GO:0009628 341 0.060
regulation of cellular localization GO:0060341 136 0.060
cellular modified amino acid metabolic process GO:0006575 45 0.059
protein import into nucleus GO:0006606 51 0.058
phosphatidylinositol mediated signaling GO:0048015 4 0.057
positive regulation of phosphate metabolic process GO:0045937 139 0.057
intracellular signal transduction GO:0035556 300 0.057
intracellular transport GO:0046907 228 0.057
epithelial cell differentiation GO:0030855 322 0.056
negative regulation of immune system process GO:0002683 50 0.056
positive regulation of cellular component organization GO:0051130 156 0.056
mitotic dna integrity checkpoint GO:0044774 75 0.055
memory GO:0007613 94 0.055
histone deubiquitination GO:0016578 8 0.053
regulation of mitotic cell cycle phase transition GO:1901990 130 0.053
cellular response to growth factor stimulus GO:0071363 30 0.053
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.053
forebrain development GO:0030900 2 0.053
positive regulation of rna biosynthetic process GO:1902680 266 0.053
regulation of protein metabolic process GO:0051246 256 0.052
multi organism reproductive behavior GO:0044705 121 0.052
negative regulation of cell division GO:0051782 17 0.052
negative regulation of response to stimulus GO:0048585 258 0.050
regulation of transcription factor import into nucleus GO:0042990 22 0.050
regulation of cell fate commitment GO:0010453 29 0.049
response to alcohol GO:0097305 95 0.048
phagocytosis GO:0006909 215 0.048
single organism biosynthetic process GO:0044711 206 0.048
positive regulation of transcription factor import into nucleus GO:0042993 19 0.048
cellular response to ionizing radiation GO:0071479 15 0.047
cell division GO:0051301 248 0.047
maintenance of location in cell GO:0051651 28 0.047
oocyte construction GO:0007308 112 0.047
regulation of compound eye cone cell fate specification GO:0042682 4 0.046
kidney morphogenesis GO:0060993 3 0.046
regulation of innate immune response GO:0045088 71 0.046
cellular response to transforming growth factor beta stimulus GO:0071560 18 0.046
positive regulation of r7 cell differentiation GO:0045678 7 0.046
positive regulation of intracellular transport GO:0032388 42 0.045
axis specification GO:0009798 167 0.045
macromolecule methylation GO:0043414 45 0.044
response to hormone GO:0009725 45 0.044
cellular protein catabolic process GO:0044257 83 0.044
macromolecular complex assembly GO:0065003 256 0.044
asymmetric cell division GO:0008356 37 0.044
cellular macromolecule localization GO:0070727 220 0.044
cellular metal ion homeostasis GO:0006875 31 0.043
regulation of rna splicing GO:0043484 69 0.043
nucleosome organization GO:0034728 59 0.042
divalent inorganic cation transport GO:0072511 30 0.042
regulation of intracellular signal transduction GO:1902531 236 0.042
protein alkylation GO:0008213 43 0.042
histone h3 k9 acetylation GO:0043970 3 0.042
chitin based cuticle sclerotization GO:0007593 19 0.042
cellularization GO:0007349 90 0.041
regulation of kinase activity GO:0043549 53 0.041
carbohydrate derivative biosynthetic process GO:1901137 85 0.041
histone h3 k4 methylation GO:0051568 16 0.041
establishment of protein localization to organelle GO:0072594 62 0.041
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.041
Mouse
germ line stem cell maintenance GO:0030718 50 0.041
positive regulation of phosphorus metabolic process GO:0010562 139 0.040
metal ion homeostasis GO:0055065 44 0.040
single organism cellular localization GO:1902580 180 0.040
endocytosis GO:0006897 310 0.040
protein ubiquitination GO:0016567 70 0.040
translation GO:0006412 69 0.040
regulation of carbohydrate metabolic process GO:0006109 10 0.040
muscle cell differentiation GO:0042692 103 0.040
multicellular organismal reproductive behavior GO:0033057 110 0.040
cellular response to hormone stimulus GO:0032870 44 0.040
regulation of nucleocytoplasmic transport GO:0046822 35 0.040
single organism nuclear import GO:1902593 51 0.039
positive regulation of cyclic nucleotide metabolic process GO:0030801 9 0.039
germ band shortening GO:0007390 19 0.039
regulation of growth GO:0040008 233 0.039
regulation of defense response GO:0031347 102 0.039
regulation of gene silencing GO:0060968 63 0.039
cellular macromolecule catabolic process GO:0044265 136 0.039
adult chitin containing cuticle pigmentation GO:0048085 16 0.038
positive regulation of apoptotic signaling pathway GO:2001235 4 0.038
positive regulation of catalytic activity GO:0043085 118 0.038
cellular response to organic substance GO:0071310 132 0.038
Rat
positive regulation of peptidase activity GO:0010952 29 0.037
dna damage checkpoint GO:0000077 78 0.037
eye morphogenesis GO:0048592 260 0.037
nephron tubule development GO:0072080 3 0.037
negative regulation of apoptotic process GO:0043066 63 0.037
sensory organ morphogenesis GO:0090596 260 0.037
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.037
eggshell formation GO:0030703 105 0.037
cellular carbohydrate metabolic process GO:0044262 22 0.037
antifungal peptide biosynthetic process GO:0002783 5 0.036
organic substance catabolic process GO:1901575 308 0.036
ubiquitin dependent protein catabolic process GO:0006511 78 0.036
neuron projection guidance GO:0097485 241 0.036
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.036
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.036
muscle structure development GO:0061061 224 0.036
regulation of phosphorylation GO:0042325 147 0.036
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.036
homeostatic process GO:0042592 199 0.036
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.035
embryonic development via the syncytial blastoderm GO:0001700 148 0.035
sulfur compound metabolic process GO:0006790 59 0.035
regulation of bmp signaling pathway GO:0030510 23 0.035
cellular divalent inorganic cation homeostasis GO:0072503 23 0.035
imaginal disc derived wing margin morphogenesis GO:0008587 41 0.034
telencephalon development GO:0021537 2 0.034
positive regulation of protein transport GO:0051222 37 0.034
carbohydrate derivative metabolic process GO:1901135 217 0.034
regulation of response to stress GO:0080134 200 0.034
compound eye retinal cell programmed cell death GO:0046667 23 0.034
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.033
single organism intracellular transport GO:1902582 207 0.033
peptidyl tyrosine phosphorylation GO:0018108 24 0.033
positive regulation of cell death GO:0010942 69 0.033
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.033
Mouse Rat
negative regulation of cellular response to oxidative stress GO:1900408 1 0.033
response to temperature stimulus GO:0009266 106 0.033
positive regulation of mitotic cell cycle GO:0045931 34 0.033
negative regulation of cellular component organization GO:0051129 108 0.033
histone methylation GO:0016571 40 0.032
genital disc pattern formation GO:0035221 8 0.032
intrinsic apoptotic signaling pathway in response to dna damage GO:0008630 11 0.032
regulation of mitosis GO:0007088 56 0.032
nf kappab import into nucleus GO:0042348 1 0.032
eye development GO:0001654 323 0.032
retinal cell programmed cell death GO:0046666 25 0.032
vesicle mediated transport GO:0016192 381 0.032
positive regulation of calcium ion transport GO:0051928 4 0.031
multi organism behavior GO:0051705 175 0.031
generation of precursor metabolites and energy GO:0006091 42 0.031
negative regulation of mitotic cell cycle GO:0045930 109 0.030
hemocyte differentiation GO:0042386 38 0.030
single organism catabolic process GO:0044712 228 0.030
regulation of mrna processing GO:0050684 71 0.030
regulation of epithelial cell differentiation GO:0030856 4 0.030
regulation of localization GO:0032879 275 0.030
nephron epithelium morphogenesis GO:0072088 3 0.029
dedifferentiation GO:0043696 2 0.029
establishment or maintenance of cell polarity GO:0007163 167 0.029
male mating behavior GO:0060179 70 0.029
positive regulation of cell communication GO:0010647 250 0.029
eye antennal disc morphogenesis GO:0007455 34 0.029
spiracle morphogenesis open tracheal system GO:0035277 22 0.029
skeletal muscle fiber development GO:0048741 3 0.029
negative regulation of cellular biosynthetic process GO:0031327 277 0.029
Rat
oocyte axis specification GO:0007309 108 0.029
spinal cord development GO:0021510 1 0.029
mating behavior GO:0007617 106 0.028
response to external biotic stimulus GO:0043207 293 0.028
positive regulation of cellular response to insulin stimulus GO:1900078 4 0.028
positive regulation of phosphorylation GO:0042327 87 0.028
macromolecule catabolic process GO:0009057 161 0.028
negative regulation of neural precursor cell proliferation GO:2000178 27 0.028
positive regulation of developmental growth GO:0048639 62 0.028
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.028
cellular homeostasis GO:0019725 80 0.028
regulation of developmental pigmentation GO:0048070 24 0.027
regulation of establishment of protein localization GO:0070201 61 0.027
regulation of phosphorus metabolic process GO:0051174 210 0.027
positive regulation of cell motility GO:2000147 3 0.027
dna replication GO:0006260 48 0.027
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.027
insulin receptor signaling pathway GO:0008286 25 0.027
response to ethanol GO:0045471 59 0.027
regulation of hormone levels GO:0010817 40 0.026
regulation of protein transport GO:0051223 57 0.026
regulation of cellular response to stress GO:0080135 89 0.026
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.026
regulation of response to oxidative stress GO:1902882 4 0.026
negative regulation of cellular catabolic process GO:0031330 34 0.026
telomere organization GO:0032200 21 0.026
rna splicing GO:0008380 83 0.026
negative regulation of autophagy GO:0010507 16 0.026
organ or tissue specific immune response GO:0002251 10 0.026
reproductive behavior GO:0019098 122 0.026
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.025
ion homeostasis GO:0050801 55 0.025
cell cycle phase transition GO:0044770 140 0.025
spindle organization GO:0007051 253 0.025
regulation of neuron differentiation GO:0045664 103 0.025
ovarian fusome organization GO:0030723 11 0.025
regulation of steroid metabolic process GO:0019218 2 0.025
negative regulation of smoothened signaling pathway GO:0045879 16 0.025
embryonic morphogenesis GO:0048598 206 0.025
myotube cell development GO:0014904 3 0.025
oocyte differentiation GO:0009994 145 0.025
cognition GO:0050890 141 0.024
regulation of cell development GO:0060284 215 0.024
triglyceride biosynthetic process GO:0019432 2 0.024
photoreceptor cell differentiation GO:0046530 170 0.024
neuron fate specification GO:0048665 12 0.023
atp dependent chromatin remodeling GO:0043044 22 0.023
protein complex biogenesis GO:0070271 201 0.023
cellular response to insulin stimulus GO:0032869 28 0.023
protein transport GO:0015031 155 0.023
dna integrity checkpoint GO:0031570 81 0.023
positive regulation of innate immune response GO:0045089 38 0.023
learning or memory GO:0007611 141 0.023
regulation of wnt signaling pathway GO:0030111 68 0.023
lipid biosynthetic process GO:0008610 46 0.023
regulation of jnk cascade GO:0046328 40 0.023
post embryonic hemopoiesis GO:0035166 17 0.023
chorion containing eggshell pattern formation GO:0030381 11 0.023
purine nucleoside biosynthetic process GO:0042451 3 0.023
purine nucleoside triphosphate catabolic process GO:0009146 108 0.022
regulation of nuclear division GO:0051783 58 0.022
bmp signaling pathway involved in malpighian tubule cell chemotaxis GO:0061353 3 0.022
positive regulation of signaling GO:0023056 243 0.022
signal transduction in response to dna damage GO:0042770 3 0.022
transforming growth factor beta receptor signaling pathway GO:0007179 16 0.022
positive regulation of cellular protein metabolic process GO:0032270 118 0.021
single organism carbohydrate metabolic process GO:0044723 72 0.021
ion transport GO:0006811 145 0.021
response to organonitrogen compound GO:0010243 75 0.021
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.021
response to bacterium GO:0009617 198 0.021
nucleotide catabolic process GO:0009166 109 0.021
anterior posterior pattern specification GO:0009952 136 0.021
regulation of microtubule cytoskeleton organization GO:0070507 41 0.021
negative regulation of catalytic activity GO:0043086 42 0.021
neurological system process GO:0050877 358 0.021
meiotic nuclear division GO:0007126 151 0.021
negative regulation of intracellular signal transduction GO:1902532 57 0.021
neuron death GO:0070997 27 0.021
nuclear division GO:0000280 332 0.021
cilium assembly GO:0042384 38 0.020
nucleosome mobilization GO:0042766 9 0.020
cellular catabolic process GO:0044248 372 0.020
cellular ion homeostasis GO:0006873 39 0.020
response to nitrogen compound GO:1901698 90 0.020
regulation of synapse organization GO:0050807 110 0.020
response to oxygen containing compound GO:1901700 200 0.020
chromosome separation GO:0051304 42 0.020
regulation of catalytic activity GO:0050790 185 0.020
negative regulation of nucleic acid templated transcription GO:1903507 240 0.020
Rat
germarium derived female germ line cyst encapsulation GO:0030708 8 0.020
dna packaging GO:0006323 91 0.019
inositol lipid mediated signaling GO:0048017 4 0.019
cellular protein complex assembly GO:0043623 71 0.019
regulation of mitotic sister chromatid segregation GO:0033047 28 0.019
negative regulation of rna metabolic process GO:0051253 251 0.019
Rat
regulation of tor signaling GO:0032006 21 0.019
ameboidal type cell migration GO:0001667 151 0.019
protein modification by small protein conjugation or removal GO:0070647 106 0.019
microtubule depolymerization GO:0007019 25 0.019
synapse assembly GO:0007416 143 0.019
phosphatidylinositol phosphorylation GO:0046854 10 0.019
negative regulation of cell development GO:0010721 62 0.019

Hcf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.267
acquired metabolic disease DOID:0060158 0 0.267
cancer DOID:162 0 0.044
disease of cellular proliferation DOID:14566 0 0.044
organ system cancer DOID:0050686 0 0.034
carbohydrate metabolism disease DOID:0050013 0 0.022
glucose metabolism disease DOID:4194 0 0.022