Drosophila melanogaster

18 known processes

Sln (Dmel_CG8271)

Silnoon

(Aliases: Dmel\CG8271,CG8271)

Sln biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
growth GO:0040007 359 0.159
developmental growth GO:0048589 280 0.053
response to abiotic stimulus GO:0009628 341 0.053
positive regulation of multicellular organismal process GO:0051240 143 0.053
response to radiation GO:0009314 155 0.052
protein modification process GO:0036211 438 0.052
regulation of growth GO:0040008 233 0.051
negative regulation of signal transduction GO:0009968 206 0.049
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.049
negative regulation of response to stimulus GO:0048585 258 0.048
transcription from rna polymerase ii promoter GO:0006366 368 0.048
intracellular signal transduction GO:0035556 300 0.048
neuropeptide signaling pathway GO:0007218 45 0.047
cellular response to chemical stimulus GO:0070887 199 0.047
response to organic substance GO:0010033 284 0.047
kidney development GO:0001822 3 0.047
establishment or maintenance of cell polarity GO:0007163 167 0.044
cell death GO:0008219 279 0.044
imaginal disc derived appendage development GO:0048737 399 0.042
cell division GO:0051301 248 0.042
eye morphogenesis GO:0048592 260 0.041
organonitrogen compound metabolic process GO:1901564 318 0.040
positive regulation of response to stimulus GO:0048584 323 0.040
negative regulation of cell communication GO:0010648 223 0.040
oxoacid metabolic process GO:0043436 103 0.039
g protein coupled receptor signaling pathway GO:0007186 136 0.037
positive regulation of developmental process GO:0051094 143 0.037
death GO:0016265 284 0.037
salt aversion GO:0035199 3 0.037
phosphorylation GO:0016310 294 0.037
multi multicellular organism process GO:0044706 123 0.036
cellular amino acid metabolic process GO:0006520 61 0.036
biological adhesion GO:0022610 138 0.035
negative regulation of signaling GO:0023057 219 0.035
sensory organ morphogenesis GO:0090596 260 0.035
head development GO:0060322 135 0.034
positive regulation of cell communication GO:0010647 250 0.034
cellular protein modification process GO:0006464 438 0.033
regulation of localization GO:0032879 275 0.033
regulation of developmental growth GO:0048638 174 0.033
organic substance transport GO:0071702 257 0.033
post embryonic appendage morphogenesis GO:0035120 385 0.033
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.033
locomotor rhythm GO:0045475 56 0.032
response to oxygen containing compound GO:1901700 200 0.032
cellular response to abiotic stimulus GO:0071214 58 0.032
appendage development GO:0048736 401 0.032
homeostatic process GO:0042592 199 0.032
imaginal disc derived appendage morphogenesis GO:0035114 395 0.031
cell cell signaling involved in cell fate commitment GO:0045168 210 0.030
amine metabolic process GO:0009308 12 0.030
sensory perception of chemical stimulus GO:0007606 116 0.029
protein localization GO:0008104 284 0.029
appendage morphogenesis GO:0035107 397 0.029
leg disc morphogenesis GO:0007478 80 0.029
positive regulation of nucleic acid templated transcription GO:1903508 266 0.029
cell adhesion GO:0007155 136 0.028
negative regulation of biosynthetic process GO:0009890 277 0.028
regulation of cellular ketone metabolic process GO:0010565 3 0.028
single organism catabolic process GO:0044712 228 0.028
cell proliferation GO:0008283 299 0.028
nuclear division GO:0000280 332 0.027
eye development GO:0001654 323 0.027
positive regulation of developmental growth GO:0048639 62 0.027
enzyme linked receptor protein signaling pathway GO:0007167 179 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
establishment of protein localization GO:0045184 163 0.027
regulation of phosphorus metabolic process GO:0051174 210 0.027
compound eye development GO:0048749 307 0.027
regulation of cell cycle process GO:0010564 181 0.027
regulation of cellular amine metabolic process GO:0033238 3 0.027
imaginal disc derived wing morphogenesis GO:0007476 337 0.027
cellular macromolecule localization GO:0070727 220 0.027
small molecule metabolic process GO:0044281 305 0.027
actin filament organization GO:0007015 126 0.026
regulation of anatomical structure size GO:0090066 163 0.026
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.026
organelle localization GO:0051640 148 0.026
chromosome organization GO:0051276 360 0.026
negative regulation of cellular metabolic process GO:0031324 382 0.026
positive regulation of macromolecule metabolic process GO:0010604 405 0.026
proteolysis GO:0006508 192 0.026
secretion by cell GO:0032940 101 0.026
cellular ketone metabolic process GO:0042180 24 0.025
cellular amine metabolic process GO:0044106 12 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.025
organelle fission GO:0048285 340 0.025
carboxylic acid metabolic process GO:0019752 92 0.025
cellular protein localization GO:0034613 160 0.025
regulation of intracellular signal transduction GO:1902531 236 0.025
regulation of multicellular organismal development GO:2000026 414 0.025
central nervous system development GO:0007417 201 0.024
camera type eye development GO:0043010 4 0.024
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.024
regionalization GO:0003002 416 0.024
chemical homeostasis GO:0048878 92 0.024
negative regulation of cellular biosynthetic process GO:0031327 277 0.024
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.024
anion homeostasis GO:0055081 3 0.024
positive regulation of growth GO:0045927 75 0.024
regulation of catalytic activity GO:0050790 185 0.024
mitotic cell cycle phase transition GO:0044772 138 0.024
regulation of cell death GO:0010941 173 0.023
organic substance catabolic process GO:1901575 308 0.023
regulation of phosphorylation GO:0042325 147 0.023
signal transduction by phosphorylation GO:0023014 107 0.023
organic acid metabolic process GO:0006082 103 0.023
neuron projection guidance GO:0097485 241 0.023
positive regulation of cellular amine metabolic process GO:0033240 0 0.022
single organism biosynthetic process GO:0044711 206 0.022
Fly
regulation of cell cycle GO:0051726 291 0.022
protein phosphorylation GO:0006468 169 0.022
circadian rhythm GO:0007623 105 0.022
endocytosis GO:0006897 310 0.022
actin filament based process GO:0030029 220 0.022
adult behavior GO:0030534 137 0.022
cytokinesis GO:0000910 90 0.022
regulation of organelle organization GO:0033043 196 0.022
secretion GO:0046903 109 0.022
developmental maturation GO:0021700 172 0.022
regulation of response to stress GO:0080134 200 0.022
cell motility GO:0048870 251 0.022
response to monosaccharide GO:0034284 4 0.021
single organism intracellular transport GO:1902582 207 0.021
compound eye morphogenesis GO:0001745 249 0.021
positive regulation of phosphate metabolic process GO:0045937 139 0.021
vesicle mediated transport GO:0016192 381 0.021
positive regulation of gene expression GO:0010628 290 0.021
eye photoreceptor cell differentiation GO:0001754 145 0.021
positive regulation of cellular component organization GO:0051130 156 0.021
regulation of molecular function GO:0065009 217 0.021
cellular catabolic process GO:0044248 372 0.021
protein transport GO:0015031 155 0.021
taxis GO:0042330 304 0.021
forebrain development GO:0030900 2 0.021
spinal cord development GO:0021510 1 0.021
establishment of localization in cell GO:0051649 402 0.021
segmentation GO:0035282 207 0.020
multi organism reproductive behavior GO:0044705 121 0.020
phagocytosis GO:0006909 215 0.020
regulation of cell division GO:0051302 72 0.020
embryonic pattern specification GO:0009880 174 0.020
maintenance of location GO:0051235 73 0.020
intracellular protein transport GO:0006886 104 0.020
catabolic process GO:0009056 409 0.020
mapk cascade GO:0000165 107 0.020
determination of adult lifespan GO:0008340 137 0.020
cytoskeleton dependent cytokinesis GO:0061640 81 0.020
localization of cell GO:0051674 257 0.020
rhythmic behavior GO:0007622 76 0.020
positive regulation of signaling GO:0023056 243 0.019
tube development GO:0035295 244 0.019
feeding behavior GO:0007631 50 0.019
cellular response to organic substance GO:0071310 132 0.019
mating behavior GO:0007617 106 0.019
positive regulation of rna biosynthetic process GO:1902680 266 0.019
negative regulation of nucleic acid templated transcription GO:1903507 240 0.019
regulation of cell proliferation GO:0042127 163 0.019
brain development GO:0007420 120 0.019
wing disc morphogenesis GO:0007472 344 0.019
positive regulation of cell motility GO:2000147 3 0.019
chromosome segregation GO:0007059 157 0.019
regulation of cell differentiation GO:0045595 302 0.019
activation of innate immune response GO:0002218 4 0.019
regulation of neuron differentiation GO:0045664 103 0.019
spindle organization GO:0007051 253 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.018
retina development in camera type eye GO:0060041 4 0.018
establishment of organelle localization GO:0051656 122 0.018
telencephalon development GO:0021537 2 0.018
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.018
neural precursor cell proliferation GO:0061351 75 0.018
intracellular transport GO:0046907 228 0.018
salivary gland development GO:0007431 162 0.018
single organism behavior GO:0044708 391 0.018
mitotic cytokinesis GO:0000281 50 0.018
positive regulation of rna metabolic process GO:0051254 271 0.018
regulation of anatomical structure morphogenesis GO:0022603 242 0.018
negative regulation of gene expression GO:0010629 387 0.018
mitotic nuclear division GO:0007067 213 0.018
cell cycle phase transition GO:0044770 140 0.018
defense response GO:0006952 300 0.018
positive regulation of multicellular organism growth GO:0040018 21 0.018
lipid metabolic process GO:0006629 121 0.017
single organism cellular localization GO:1902580 180 0.017
positive regulation of endopeptidase activity GO:0010950 26 0.017
negative regulation of insulin secretion GO:0046676 1 0.017
multicellular organism growth GO:0035264 46 0.017
circadian behavior GO:0048512 76 0.017
axon guidance GO:0007411 233 0.017
morphogenesis of an epithelium GO:0002009 276 0.017
response to light stimulus GO:0009416 124 0.017
regulation of cell cycle phase transition GO:1901987 130 0.017
response to glucose GO:0009749 2 0.016
negative regulation of rna biosynthetic process GO:1902679 240 0.016
regulation of wnt signaling pathway GO:0030111 68 0.016
exocrine system development GO:0035272 162 0.016
axon development GO:0061564 297 0.016
meiotic cell cycle process GO:1903046 132 0.016
programmed cell death GO:0012501 257 0.016
positive regulation of intracellular signal transduction GO:1902533 116 0.016
regulation of protein metabolic process GO:0051246 256 0.016
regulation of cellular response to stress GO:0080135 89 0.016
cellular homeostasis GO:0019725 80 0.016
wnt signaling pathway GO:0016055 98 0.016
regulation of cellular component size GO:0032535 98 0.016
regulation of mapk cascade GO:0043408 92 0.016
lateral inhibition GO:0046331 206 0.016
positive regulation of signal transduction GO:0009967 223 0.016
positive regulation of phosphorus metabolic process GO:0010562 139 0.016
respiratory system development GO:0060541 213 0.016
gland morphogenesis GO:0022612 145 0.016
positive regulation of catalytic activity GO:0043085 118 0.016
regulation of mitotic cell cycle GO:0007346 190 0.016
apoptotic process GO:0006915 159 0.016
salivary gland morphogenesis GO:0007435 145 0.016
carbohydrate derivative biosynthetic process GO:1901137 85 0.015
open tracheal system development GO:0007424 204 0.015
response to organophosphorus GO:0046683 2 0.015
mitotic spindle organization GO:0007052 220 0.015
regulation of phosphate metabolic process GO:0019220 210 0.015
regulation of heart rate GO:0002027 11 0.015
regulation of epithelial cell proliferation GO:0050678 4 0.015
negative regulation of peptide hormone secretion GO:0090278 1 0.015
nephron development GO:0072006 3 0.015
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.015
response to nutrient levels GO:0031667 114 0.015
regulation of cellular localization GO:0060341 136 0.015
extrinsic apoptotic signaling pathway GO:0097191 1 0.015
positive regulation of proteolysis GO:0045862 52 0.015
cell migration GO:0016477 238 0.015
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.015
regulation of protein localization GO:0032880 76 0.014
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.014
regulation of hydrolase activity GO:0051336 97 0.014
photoreceptor cell differentiation GO:0046530 170 0.014
camera type eye morphogenesis GO:0048593 2 0.014
immune system process GO:0002376 347 0.014
regulation of notch signaling pathway GO:0008593 100 0.014
negative regulation of developmental process GO:0051093 201 0.014
mating GO:0007618 120 0.014
chromatin organization GO:0006325 207 0.014
regulation of multicellular organism growth GO:0040014 40 0.014
response to alcohol GO:0097305 95 0.014
cellular response to dna damage stimulus GO:0006974 223 0.014
protein localization to organelle GO:0033365 82 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
positive regulation of phosphorylation GO:0042327 87 0.014
immune response regulating signaling pathway GO:0002764 2 0.014
regulation of synapse structure and activity GO:0050803 128 0.014
mesenchymal cell development GO:0014031 1 0.014
nucleobase containing small molecule metabolic process GO:0055086 174 0.014
stem cell differentiation GO:0048863 117 0.014
sensory perception of pain GO:0019233 4 0.014
mrna splicing via spliceosome GO:0000398 73 0.014
neurological system process GO:0050877 358 0.014
regulation of mitotic cell cycle phase transition GO:1901990 130 0.014
response to hexose GO:0009746 3 0.014
positive regulation of cellular biosynthetic process GO:0031328 316 0.014
dendrite morphogenesis GO:0048813 199 0.014
cellular response to organonitrogen compound GO:0071417 36 0.014
embryo development ending in birth or egg hatching GO:0009792 152 0.013
dna metabolic process GO:0006259 227 0.013
aging GO:0007568 143 0.013
kidney morphogenesis GO:0060993 3 0.013
chemotaxis GO:0006935 249 0.013
immune response activating signal transduction GO:0002757 2 0.013
response to organonitrogen compound GO:0010243 75 0.013
negative regulation of cell differentiation GO:0045596 143 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.013
compound eye photoreceptor cell differentiation GO:0001751 140 0.013
response to biotic stimulus GO:0009607 294 0.013
mrna processing GO:0006397 104 0.013
gland development GO:0048732 191 0.013
muscle structure development GO:0061061 224 0.013
tissue migration GO:0090130 155 0.013
response to ethanol GO:0045471 59 0.013
positive regulation of cell migration GO:0030335 2 0.013
regulation of neurogenesis GO:0050767 158 0.013
cell fate determination GO:0001709 91 0.013
nucleotide metabolic process GO:0009117 161 0.013
negative regulation of rna metabolic process GO:0051253 251 0.013
hindbrain development GO:0030902 2 0.013
female meiotic division GO:0007143 70 0.013
cell cell adhesion GO:0098609 26 0.013
regulation of endopeptidase activity GO:0052548 36 0.013
epithelial cell development GO:0002064 274 0.013
protein complex biogenesis GO:0070271 201 0.013
small gtpase mediated signal transduction GO:0007264 88 0.013
male gamete generation GO:0048232 201 0.013
regulation of organ growth GO:0046620 42 0.013
ameboidal type cell migration GO:0001667 151 0.013
renal system development GO:0072001 72 0.013
cellular response to hexose stimulus GO:0071331 1 0.012
rna splicing via transesterification reactions GO:0000375 73 0.012
rna splicing GO:0008380 83 0.012
salivary gland cell autophagic cell death GO:0035071 83 0.012
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.012
autophagic cell death GO:0048102 83 0.012
tissue morphogenesis GO:0048729 297 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.012
defense response to other organism GO:0098542 225 0.012
regulation of immune system process GO:0002682 176 0.012
single organism cell adhesion GO:0098602 47 0.012
regulation of establishment of protein localization GO:0070201 61 0.012
regulation of erk1 and erk2 cascade GO:0070372 39 0.012
cellular response to insulin stimulus GO:0032869 28 0.012
nitrogen compound transport GO:0071705 85 0.012
stem cell proliferation GO:0072089 88 0.012
regulation of cell substrate adhesion GO:0010810 2 0.012
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.012
positive regulation of biosynthetic process GO:0009891 316 0.012
regulation of cell development GO:0060284 215 0.012
response to nitrogen compound GO:1901698 90 0.012
kidney epithelium development GO:0072073 3 0.012
cytoplasmic transport GO:0016482 130 0.012
pattern recognition receptor signaling pathway GO:0002221 2 0.012
mushroom body development GO:0016319 70 0.012
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.012
carbohydrate derivative metabolic process GO:1901135 217 0.012
negative regulation of epithelial cell proliferation GO:0050680 4 0.012
macromolecular complex assembly GO:0065003 256 0.012
stem cell division GO:0017145 69 0.012
regulation of transport GO:0051049 181 0.012
neuromuscular junction development GO:0007528 149 0.012
protein maturation GO:0051604 71 0.012
regulation of apoptotic process GO:0042981 130 0.012
protein ubiquitination GO:0016567 70 0.012
regulation of cell projection organization GO:0031344 92 0.012
cellular response to radiation GO:0071478 52 0.012
store operated calcium entry GO:0002115 3 0.012
activation of cysteine type endopeptidase activity GO:0097202 17 0.012
cellular response to monosaccharide stimulus GO:0071326 2 0.012
blastoderm segmentation GO:0007350 159 0.012
positive regulation of transcription dna templated GO:0045893 266 0.011
chaeta development GO:0022416 97 0.011
regulation of gene silencing GO:0060968 63 0.011
regulation of neuron projection development GO:0010975 69 0.011
response to wounding GO:0009611 94 0.011
somatic muscle development GO:0007525 66 0.011
spermatogenesis GO:0007283 200 0.011
body morphogenesis GO:0010171 2 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
leg disc development GO:0035218 92 0.011
nucleoside phosphate catabolic process GO:1901292 110 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
innate immune response activating signal transduction GO:0002758 2 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 4 0.011
organelle fusion GO:0048284 46 0.011
positive regulation of programmed cell death GO:0043068 62 0.011
synaptic transmission GO:0007268 288 0.011
positive regulation of apoptotic signaling pathway GO:2001235 4 0.011
negative regulation of cell development GO:0010721 62 0.011
regulation of protein transport GO:0051223 57 0.011
neuroblast proliferation GO:0007405 74 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
dorsal ventral pattern formation GO:0009953 133 0.011
meiotic cell cycle GO:0051321 171 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
cellular amide metabolic process GO:0043603 80 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.011
actin cytoskeleton organization GO:0030036 206 0.011
sensory perception of salty taste GO:0050914 3 0.011
motor neuron axon guidance GO:0008045 58 0.011
carbohydrate derivative catabolic process GO:1901136 118 0.011
neuron recognition GO:0008038 101 0.011
insulin receptor signaling pathway GO:0008286 25 0.011
apoptotic signaling pathway GO:0097190 27 0.011
carbohydrate metabolic process GO:0005975 82 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.011
negative regulation of intracellular signal transduction GO:1902532 57 0.011
regulation of protein modification process GO:0031399 112 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
tripartite regional subdivision GO:0007351 103 0.011
photoreceptor cell development GO:0042461 96 0.011
erk1 and erk2 cascade GO:0070371 39 0.010
mrna metabolic process GO:0016071 124 0.010
ubiquitin dependent protein catabolic process GO:0006511 78 0.010
anterior posterior pattern specification GO:0009952 136 0.010
tube morphogenesis GO:0035239 191 0.010
protein complex assembly GO:0006461 200 0.010
negative regulation of transcription dna templated GO:0045892 237 0.010
positive regulation of mapk cascade GO:0043410 63 0.010
regulation of synapse organization GO:0050807 110 0.010
regulation of programmed cell death GO:0043067 152 0.010
epithelium migration GO:0090132 148 0.010
imaginal disc derived leg morphogenesis GO:0007480 80 0.010
regulation of secretion GO:0051046 44 0.010
organophosphate metabolic process GO:0019637 195 0.010
sensory perception GO:0007600 196 0.010
ribonucleotide catabolic process GO:0009261 109 0.010
immune effector process GO:0002252 98 0.010
response to endogenous stimulus GO:0009719 119 0.010
purine nucleoside triphosphate catabolic process GO:0009146 108 0.010
single organism carbohydrate metabolic process GO:0044723 72 0.010
regulation of peptidase activity GO:0052547 39 0.010
positive regulation of erk1 and erk2 cascade GO:0070374 36 0.010

Sln disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
nervous system disease DOID:863 0 0.036
disease of cellular proliferation DOID:14566 0 0.031
cancer DOID:162 0 0.025
organ system cancer DOID:0050686 0 0.024
sensory system disease DOID:0050155 0 0.016
cardiovascular system disease DOID:1287 0 0.014
renal tubular transport disease DOID:447 0 0.013
kidney disease DOID:557 0 0.013
urinary system disease DOID:18 0 0.013
vascular disease DOID:178 0 0.013
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
central nervous system disease DOID:331 0 0.011
disease of metabolism DOID:0014667 0 0.010
inherited metabolic disorder DOID:655 0 0.010