Drosophila melanogaster

5 known processes

Pde8 (Dmel_CG5411)

Phosphodiesterase 8

(Aliases: CG5411,pde8,Dmel\CG5411,PDE8)

Pde8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cyclic nucleotide biosynthetic process GO:0009190 25 0.923
purine containing compound biosynthetic process GO:0072522 30 0.867
cyclic purine nucleotide metabolic process GO:0052652 25 0.772
ribose phosphate biosynthetic process GO:0046390 28 0.708
regulation of camp biosynthetic process GO:0030817 12 0.701
camp biosynthetic process GO:0006171 17 0.660
camp metabolic process GO:0046058 19 0.619
g protein coupled receptor signaling pathway GO:0007186 136 0.505
organelle fusion GO:0048284 46 0.436
purine ribonucleotide biosynthetic process GO:0009152 28 0.420
carbohydrate derivative biosynthetic process GO:1901137 85 0.357
negative regulation of cellular biosynthetic process GO:0031327 277 0.290
Mouse
single organism biosynthetic process GO:0044711 206 0.289
Mouse
aging GO:0007568 143 0.287
cyclic nucleotide metabolic process GO:0009187 28 0.286
regulation of purine nucleotide biosynthetic process GO:1900371 14 0.285
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 17 0.284
determination of adult lifespan GO:0008340 137 0.275
organophosphate biosynthetic process GO:0090407 46 0.258
negative regulation of biosynthetic process GO:0009890 277 0.249
Mouse
synaptic vesicle transport GO:0048489 50 0.236
positive regulation of biosynthetic process GO:0009891 316 0.234
cellular protein modification process GO:0006464 438 0.230
regulation of nucleotide biosynthetic process GO:0030808 14 0.227
regulation of phosphate metabolic process GO:0019220 210 0.221
organophosphate metabolic process GO:0019637 195 0.221
mating GO:0007618 120 0.212
protein modification process GO:0036211 438 0.210
nucleoside phosphate biosynthetic process GO:1901293 34 0.208
nucleotide metabolic process GO:0009117 161 0.199
purine nucleotide biosynthetic process GO:0006164 29 0.196
regulation of camp metabolic process GO:0030814 12 0.196
ribonucleotide biosynthetic process GO:0009260 28 0.194
membrane fusion GO:0061025 42 0.192
establishment of localization in cell GO:0051649 402 0.187
Rat
actin cytoskeleton organization GO:0030036 206 0.177
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.164
regulation of cyclic nucleotide metabolic process GO:0030799 13 0.161
actin filament based process GO:0030029 220 0.161
regulation of multicellular organismal development GO:2000026 414 0.160
locomotor rhythm GO:0045475 56 0.157
multicellular organismal aging GO:0010259 140 0.150
regulation of phosphorus metabolic process GO:0051174 210 0.150
phosphorylation GO:0016310 294 0.148
synaptic vesicle exocytosis GO:0016079 16 0.147
regulation of intracellular signal transduction GO:1902531 236 0.147
Fly
response to extracellular stimulus GO:0009991 116 0.145
regulation of cyclic nucleotide biosynthetic process GO:0030802 13 0.145
positive regulation of macromolecule metabolic process GO:0010604 405 0.144
establishment of synaptic vesicle localization GO:0097480 50 0.143
learning or memory GO:0007611 141 0.142
Mouse Fly
positive regulation of cellular component organization GO:0051130 156 0.140
positive regulation of rna biosynthetic process GO:1902680 266 0.132
regulation of cellular ketone metabolic process GO:0010565 3 0.131
establishment of vesicle localization GO:0051650 51 0.130
defense response to bacterium GO:0042742 178 0.130
exocytosis GO:0006887 28 0.126
imaginal disc derived wing morphogenesis GO:0007476 337 0.124
cell death GO:0008219 279 0.124
regulation of adenylate cyclase activity GO:0045761 12 0.122
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.119
circadian behavior GO:0048512 76 0.119
negative regulation of camp metabolic process GO:0030815 3 0.119
positive regulation of cellular biosynthetic process GO:0031328 316 0.115
regulation of cellular component biogenesis GO:0044087 201 0.115
axon development GO:0061564 297 0.114
Worm Fly
negative regulation of cellular metabolic process GO:0031324 382 0.114
Mouse
organonitrogen compound metabolic process GO:1901564 318 0.113
organonitrogen compound biosynthetic process GO:1901566 117 0.110
imaginal disc derived appendage morphogenesis GO:0035114 395 0.110
nucleobase containing small molecule metabolic process GO:0055086 174 0.108
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 17 0.107
establishment of organelle localization GO:0051656 122 0.106
membrane organization GO:0061024 112 0.106
organic substance transport GO:0071702 257 0.105
Rat
regulation of cell cycle GO:0051726 291 0.104
small molecule metabolic process GO:0044281 305 0.102
catabolic process GO:0009056 409 0.102
purine nucleotide metabolic process GO:0006163 146 0.100
regulation of localization GO:0032879 275 0.097
Rat
regulation of lipid metabolic process GO:0019216 15 0.097
Mouse
eye development GO:0001654 323 0.096
response to radiation GO:0009314 155 0.094
Mouse
negative regulation of multicellular organismal process GO:0051241 142 0.093
Worm
regulation of protein metabolic process GO:0051246 256 0.092
rhythmic process GO:0048511 106 0.090
mapk cascade GO:0000165 107 0.089
ribonucleotide metabolic process GO:0009259 145 0.088
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.086
body morphogenesis GO:0010171 2 0.083
positive regulation of developmental process GO:0051094 143 0.083
skeletal muscle fiber development GO:0048741 3 0.082
enzyme linked receptor protein signaling pathway GO:0007167 179 0.082
positive regulation of phosphate metabolic process GO:0045937 139 0.082
signal transduction by phosphorylation GO:0023014 107 0.081
regulation of mapk cascade GO:0043408 92 0.081
programmed cell death GO:0012501 257 0.081
nucleotide biosynthetic process GO:0009165 34 0.080
regulation of nervous system development GO:0051960 248 0.079
response to oxidative stress GO:0006979 86 0.079
myotube differentiation GO:0014902 46 0.078
appendage development GO:0048736 401 0.078
neurotransmitter secretion GO:0007269 35 0.078
negative regulation of developmental process GO:0051093 201 0.078
Worm
embryonic development via the syncytial blastoderm GO:0001700 148 0.078
single organism behavior GO:0044708 391 0.077
Mouse Fly
positive regulation of response to stimulus GO:0048584 323 0.077
response to abiotic stimulus GO:0009628 341 0.077
Mouse Fly
striated muscle cell differentiation GO:0051146 90 0.075
regulation of programmed cell death GO:0043067 152 0.075
regulation of organelle organization GO:0033043 196 0.074
carbohydrate derivative metabolic process GO:1901135 217 0.074
morphogenesis of an epithelium GO:0002009 276 0.074
taxis GO:0042330 304 0.074
Worm
cellular ketone metabolic process GO:0042180 24 0.072
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.071
camera type eye development GO:0043010 4 0.071
dna metabolic process GO:0006259 227 0.071
organelle localization GO:0051640 148 0.070
synaptic vesicle localization GO:0097479 53 0.070
sensory organ morphogenesis GO:0090596 260 0.070
peptidyl threonine phosphorylation GO:0018107 2 0.070
multicellular organismal reproductive behavior GO:0033057 110 0.069
positive regulation of rna metabolic process GO:0051254 271 0.068
exocrine system development GO:0035272 162 0.068
ribose phosphate metabolic process GO:0019693 145 0.068
positive regulation of gene expression GO:0010628 290 0.068
regulation of nucleotide metabolic process GO:0006140 62 0.067
positive regulation of multicellular organismal process GO:0051240 143 0.067
positive regulation of nucleic acid templated transcription GO:1903508 266 0.067
mucosal immune response GO:0002385 10 0.066
negative regulation of cellular component organization GO:0051129 108 0.065
forebrain development GO:0030900 2 0.065
negative regulation of cell communication GO:0010648 223 0.065
Rat
death GO:0016265 284 0.065
neurotransmitter transport GO:0006836 37 0.064
protein phosphorylation GO:0006468 169 0.064
extrinsic apoptotic signaling pathway GO:0097191 1 0.064
amine metabolic process GO:0009308 12 0.063
chemotaxis GO:0006935 249 0.063
Worm
mitotic cell cycle phase transition GO:0044772 138 0.062
regulation of vesicle mediated transport GO:0060627 59 0.062
nitrogen compound transport GO:0071705 85 0.062
Rat
cell proliferation GO:0008283 299 0.062
purine containing compound metabolic process GO:0072521 155 0.062
regulation of cellular localization GO:0060341 136 0.062
Rat
purine ribonucleotide metabolic process GO:0009150 145 0.061
regulation of catabolic process GO:0009894 170 0.061
nucleoside phosphate metabolic process GO:0006753 162 0.060
regulation of response to stress GO:0080134 200 0.060
vesicle mediated transport GO:0016192 381 0.060
single organism membrane fusion GO:0044801 42 0.057
regulation of phosphorylation GO:0042325 147 0.057
myotube cell development GO:0014904 3 0.057
axonogenesis GO:0007409 290 0.057
Worm Fly
positive regulation of signaling GO:0023056 243 0.056
cell adhesion GO:0007155 136 0.056
regulation of purine nucleotide metabolic process GO:1900542 62 0.056
muscle structure development GO:0061061 224 0.055
organelle fission GO:0048285 340 0.054
secretion GO:0046903 109 0.054
Rat
cell maturation GO:0048469 144 0.052
Worm
homeostatic process GO:0042592 199 0.052
appendage morphogenesis GO:0035107 397 0.052
regulation of growth GO:0040008 233 0.051
positive regulation of protein metabolic process GO:0051247 128 0.051
positive regulation of cell development GO:0010720 61 0.051
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.051
response to starvation GO:0042594 97 0.051
regulation of meiosis GO:0040020 3 0.050
regulation of cell proliferation GO:0042127 163 0.050
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.050
stress activated protein kinase signaling cascade GO:0031098 55 0.050
entrainment of circadian clock GO:0009649 16 0.049
regulation of mitotic cell cycle GO:0007346 190 0.049
regulation of cellular amino acid metabolic process GO:0006521 0 0.049
negative regulation of phosphorus metabolic process GO:0010563 45 0.049
skeletal muscle organ development GO:0060538 48 0.049
peptidyl amino acid modification GO:0018193 105 0.048
negative regulation of gene expression GO:0010629 387 0.048
salivary gland morphogenesis GO:0007435 145 0.048
regulation of developmental growth GO:0048638 174 0.048
eye morphogenesis GO:0048592 260 0.048
growth GO:0040007 359 0.047
Fly
negative regulation of purine nucleotide biosynthetic process GO:1900372 3 0.046
germ cell migration GO:0008354 43 0.046
regulation of transport GO:0051049 181 0.046
Rat
cellular lipid metabolic process GO:0044255 83 0.046
alcohol metabolic process GO:0006066 25 0.045
regulation of secretion GO:0051046 44 0.045
Rat
developmental programmed cell death GO:0010623 138 0.045
organ growth GO:0035265 56 0.045
single organism membrane organization GO:0044802 93 0.045
cell migration GO:0016477 238 0.044
regulation of mitotic cell cycle phase transition GO:1901990 130 0.044
synapse assembly GO:0007416 143 0.044
synaptic transmission GO:0007268 288 0.044
Fly
larval development GO:0002164 104 0.044
tissue morphogenesis GO:0048729 297 0.043
spermatogenesis GO:0007283 200 0.043
response to organic substance GO:0010033 284 0.043
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.042
small gtpase mediated signal transduction GO:0007264 88 0.042
negative regulation of rna biosynthetic process GO:1902679 240 0.042
organic hydroxy compound metabolic process GO:1901615 83 0.042
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.042
peptide transport GO:0015833 10 0.042
Rat
protein catabolic process GO:0030163 101 0.042
immune system process GO:0002376 347 0.041
cell cycle phase transition GO:0044770 140 0.041
response to organic cyclic compound GO:0014070 89 0.041
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.040
regulation of cell cycle phase transition GO:1901987 130 0.040
positive regulation of transcription dna templated GO:0045893 266 0.040
regulation of cellular protein metabolic process GO:0032268 243 0.040
oxoacid metabolic process GO:0043436 103 0.039
organic substance catabolic process GO:1901575 308 0.039
male gamete generation GO:0048232 201 0.039
gland morphogenesis GO:0022612 145 0.039
negative regulation of cell differentiation GO:0045596 143 0.039
Worm
regulation of cellular amine metabolic process GO:0033238 3 0.039
macromolecule catabolic process GO:0009057 161 0.038
post embryonic appendage morphogenesis GO:0035120 385 0.038
positive regulation of nervous system development GO:0051962 69 0.038
meiotic cell cycle GO:0051321 171 0.038
neuron projection guidance GO:0097485 241 0.037
Worm
developmental growth GO:0048589 280 0.037
Fly
intracellular signal transduction GO:0035556 300 0.037
Fly
branching involved in open tracheal system development GO:0060446 45 0.037
compound eye development GO:0048749 307 0.037
regulation of cell cycle process GO:0010564 181 0.037
localization of cell GO:0051674 257 0.037
regulation of cell morphogenesis GO:0022604 163 0.036
compound eye morphogenesis GO:0001745 249 0.036
regulation of membrane potential GO:0042391 35 0.036
regulation of protein kinase activity GO:0045859 51 0.036
regulation of peptide secretion GO:0002791 6 0.035
Rat
compound eye retinal cell programmed cell death GO:0046667 23 0.035
negative regulation of peptide hormone secretion GO:0090278 1 0.035
Rat
transcription from rna polymerase ii promoter GO:0006366 368 0.035
response to ethanol GO:0045471 59 0.034
regulation of synapse organization GO:0050807 110 0.034
negative regulation of growth GO:0045926 84 0.034
positive regulation of phosphorus metabolic process GO:0010562 139 0.034
head development GO:0060322 135 0.034
wing disc morphogenesis GO:0007472 344 0.033
muscle organ development GO:0007517 127 0.033
response to alcohol GO:0097305 95 0.033
extracellular matrix organization GO:0030198 32 0.033
regulation of protein modification process GO:0031399 112 0.033
cellular response to chemical stimulus GO:0070887 199 0.033
response to nutrient levels GO:0031667 114 0.033
axon guidance GO:0007411 233 0.032
Worm
positive regulation of cellular amine metabolic process GO:0033240 0 0.032
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.032
imaginal disc growth GO:0007446 37 0.032
regulation of cell death GO:0010941 173 0.032
positive regulation of cell communication GO:0010647 250 0.032
secretion by cell GO:0032940 101 0.031
Rat
negative regulation of phosphate metabolic process GO:0045936 45 0.031
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.031
response to endogenous stimulus GO:0009719 119 0.031
regulation of cell division GO:0051302 72 0.031
male mating behavior GO:0060179 70 0.031
stress activated mapk cascade GO:0051403 52 0.031
adult locomotory behavior GO:0008344 76 0.031
regulation of muscle organ development GO:0048634 13 0.030
salivary gland development GO:0007431 162 0.030
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.030
regulation of synaptic transmission GO:0050804 69 0.030
positive regulation of exocytosis GO:0045921 4 0.029
negative regulation of nucleic acid templated transcription GO:1903507 240 0.029
stem cell proliferation GO:0072089 88 0.029
dendrite development GO:0016358 204 0.029
camera type eye morphogenesis GO:0048593 2 0.029
negative regulation of cell cycle phase transition GO:1901988 103 0.029
regulation of dna metabolic process GO:0051052 34 0.028
negative regulation of catalytic activity GO:0043086 42 0.028
response to reactive oxygen species GO:0000302 24 0.028
signal release GO:0023061 49 0.028
Rat
positive regulation of signal transduction GO:0009967 223 0.028
memory GO:0007613 94 0.028
Fly
endocytosis GO:0006897 310 0.028
vesicle localization GO:0051648 55 0.028
regulation of cellular response to stress GO:0080135 89 0.028
negative regulation of insulin secretion GO:0046676 1 0.028
Rat
negative regulation of mitotic cell cycle GO:0045930 109 0.028
mitotic nuclear division GO:0007067 213 0.027
regulation of behavior GO:0050795 75 0.027
proteolysis GO:0006508 192 0.027
phagocytosis GO:0006909 215 0.027
imaginal disc derived appendage development GO:0048737 399 0.027
dephosphorylation GO:0016311 51 0.027
tube development GO:0035295 244 0.027
positive regulation of neuron differentiation GO:0045666 26 0.027
glial cell differentiation GO:0010001 35 0.027
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.026
organonitrogen compound catabolic process GO:1901565 128 0.026
negative regulation of rna metabolic process GO:0051253 251 0.026
positive regulation of cell motility GO:2000147 3 0.026
regulation of striated muscle cell differentiation GO:0051153 8 0.026
defense response GO:0006952 300 0.026
Mouse
morphogenesis of a branching structure GO:0001763 45 0.026
peptidyl threonine modification GO:0018210 3 0.025
positive regulation of apoptotic signaling pathway GO:2001235 4 0.025
regulation of protein phosphorylation GO:0001932 64 0.025
digestive system development GO:0055123 149 0.025
positive regulation of phosphorylation GO:0042327 87 0.025
tube morphogenesis GO:0035239 191 0.025
rhythmic behavior GO:0007622 76 0.025
chromatin modification GO:0016568 147 0.025
cellular amino acid metabolic process GO:0006520 61 0.025
protein polymerization GO:0051258 42 0.025
regulation of imaginal disc growth GO:0045570 26 0.025
carboxylic acid metabolic process GO:0019752 92 0.024
striated muscle cell development GO:0055002 50 0.024
neuromuscular synaptic transmission GO:0007274 67 0.024
telencephalon development GO:0021537 2 0.024
regulation of embryonic development GO:0045995 68 0.024
positive regulation of mapk cascade GO:0043410 63 0.024
cellular catabolic process GO:0044248 372 0.024
kidney development GO:0001822 3 0.024
response to biotic stimulus GO:0009607 294 0.024
organic hydroxy compound biosynthetic process GO:1901617 21 0.024
regulation of neurotransmitter levels GO:0001505 38 0.024
positive regulation of nucleotide metabolic process GO:0045981 55 0.024
amide transport GO:0042886 10 0.024
Rat
gliogenesis GO:0042063 80 0.023
negative regulation of response to stimulus GO:0048585 258 0.023
positive regulation of cell migration GO:0030335 2 0.023
stem cell differentiation GO:0048863 117 0.023
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.023
negative regulation of cell death GO:0060548 81 0.023
mitotic cell cycle checkpoint GO:0007093 88 0.023
positive regulation of protein complex assembly GO:0031334 22 0.023
regulation of cell development GO:0060284 215 0.023
Worm
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.023
regulation of organ morphogenesis GO:2000027 78 0.023
neurological system process GO:0050877 358 0.023
Mouse Fly
protein localization GO:0008104 284 0.022
regulation of small gtpase mediated signal transduction GO:0051056 93 0.022
regulation of molecular function GO:0065009 217 0.022
intracellular transport GO:0046907 228 0.022
branching morphogenesis of an epithelial tube GO:0048754 45 0.022
negative regulation of developmental growth GO:0048640 64 0.022
negative regulation of phosphorylation GO:0042326 35 0.022
single organism catabolic process GO:0044712 228 0.022
monocarboxylic acid transport GO:0015718 3 0.022
response to monosaccharide GO:0034284 4 0.022
wnt signaling pathway GO:0016055 98 0.022
response to glucose GO:0009749 2 0.022
regulation of apoptotic process GO:0042981 130 0.022
positive regulation of cell projection organization GO:0031346 29 0.022
regionalization GO:0003002 416 0.022
cellular response to growth factor stimulus GO:0071363 30 0.022
regulation of cell migration GO:0030334 22 0.022
regulation of stem cell proliferation GO:0072091 40 0.022
positive regulation of neurogenesis GO:0050769 41 0.022
regulation of actin filament based process GO:0032970 42 0.021
negative regulation of molecular function GO:0044092 51 0.021
epithelial cell differentiation GO:0030855 322 0.021
negative regulation of cyclic nucleotide biosynthetic process GO:0030803 3 0.021
regulation of pathway restricted smad protein phosphorylation GO:0060393 1 0.021
central nervous system development GO:0007417 201 0.021
ameboidal type cell migration GO:0001667 151 0.020
negative regulation of transcription dna templated GO:0045892 237 0.020
cellular amine metabolic process GO:0044106 12 0.020
regulation of synapse assembly GO:0051963 94 0.020
cell division GO:0051301 248 0.020
lipid metabolic process GO:0006629 121 0.020
Mouse
regulation of striated muscle tissue development GO:0016202 5 0.020
cellular protein complex assembly GO:0043623 71 0.020
synapse organization GO:0050808 196 0.020
cellular response to external stimulus GO:0071496 66 0.020
morphogenesis of a branching epithelium GO:0061138 45 0.020
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.019
positive regulation of lipid metabolic process GO:0045834 4 0.019
positive regulation of organelle organization GO:0010638 65 0.019
regulation of stress activated mapk cascade GO:0032872 41 0.019
cell cycle checkpoint GO:0000075 95 0.019
skin development GO:0043588 65 0.019
formation of primary germ layer GO:0001704 24 0.019
regulation of hormone levels GO:0010817 40 0.019
Mouse Rat
regulation of circadian rhythm GO:0042752 49 0.019
polyol biosynthetic process GO:0046173 3 0.019
positive regulation of catabolic process GO:0009896 105 0.019
sleep GO:0030431 49 0.019
innate immune response GO:0045087 144 0.019
response to osmotic stress GO:0006970 14 0.019
regulation of wnt signaling pathway GO:0030111 68 0.019
jak stat cascade GO:0007259 49 0.019
regulation of neurogenesis GO:0050767 158 0.019
protein modification by small protein conjugation or removal GO:0070647 106 0.019
ras protein signal transduction GO:0007265 88 0.019
nuclear division GO:0000280 332 0.019
regulation of cell motility GO:2000145 23 0.019
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.019
detection of stimulus involved in sensory perception GO:0050906 92 0.019
negative regulation of cell proliferation GO:0008285 69 0.018
response to temperature stimulus GO:0009266 106 0.018
Fly
negative regulation of autophagy GO:0010507 16 0.018
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.018
muscle cell differentiation GO:0042692 103 0.018
organic acid metabolic process GO:0006082 103 0.018
response to growth factor GO:0070848 31 0.018
chromatin organization GO:0006325 207 0.018
gland development GO:0048732 191 0.017
skeletal muscle tissue development GO:0007519 13 0.017
developmental growth involved in morphogenesis GO:0060560 65 0.017
Fly
epithelial tube morphogenesis GO:0060562 88 0.017
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.017
histone modification GO:0016570 106 0.017
cellular response to starvation GO:0009267 61 0.017
cell recognition GO:0008037 102 0.017
regulation of steroid metabolic process GO:0019218 2 0.017
Mouse
glycosyl compound metabolic process GO:1901657 127 0.017
positive regulation of cyclic nucleotide metabolic process GO:0030801 9 0.017
vesicle fusion GO:0006906 19 0.017
negative regulation of cyclic nucleotide metabolic process GO:0030800 3 0.017
cellular response to organic substance GO:0071310 132 0.017
stem cell development GO:0048864 79 0.017
regulation of protein catabolic process GO:0042176 55 0.017
negative regulation of signaling GO:0023057 219 0.017
Rat
terminal button organization GO:0072553 19 0.017
limb morphogenesis GO:0035108 1 0.017
adult behavior GO:0030534 137 0.017
negative regulation of protein metabolic process GO:0051248 85 0.017
nuclear import GO:0051170 51 0.016
cell motility GO:0048870 251 0.016
vesicle organization GO:0016050 44 0.016
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.016
regulation of multicellular organism growth GO:0040014 40 0.016
courtship behavior GO:0007619 68 0.016
negative regulation of organelle organization GO:0010639 56 0.016
retina development in camera type eye GO:0060041 4 0.016
protein acylation GO:0043543 42 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.016
regulation of catalytic activity GO:0050790 185 0.016
regulation of protein complex assembly GO:0043254 42 0.016
muscle tissue development GO:0060537 30 0.016
glial cell development GO:0021782 27 0.016
gastrulation GO:0007369 70 0.016
cellular component maintenance GO:0043954 23 0.016
single organism intracellular transport GO:1902582 207 0.016
regulation of muscle tissue development GO:1901861 5 0.015
regulation of secretion by cell GO:1903530 39 0.015
Rat
regulation of ras protein signal transduction GO:0046578 93 0.015
adenylate cyclase activating g protein coupled receptor signaling pathway GO:0007189 9 0.015
positive regulation of cellular component biogenesis GO:0044089 80 0.015
nucleoside metabolic process GO:0009116 127 0.015
tissue migration GO:0090130 155 0.015
regulation of epithelial cell differentiation GO:0030856 4 0.015
tissue death GO:0016271 102 0.015
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 9 0.015
phosphatidylinositol mediated signaling GO:0048015 4 0.015
kidney epithelium development GO:0072073 3 0.015
positive regulation of cell differentiation GO:0045597 64 0.015
chorion containing eggshell formation GO:0007304 105 0.015
jnk cascade GO:0007254 50 0.015
mesenchymal cell development GO:0014031 1 0.014
maternal determination of anterior posterior axis embryo GO:0008358 74 0.014
cell cell signaling involved in cell fate commitment GO:0045168 210 0.014
Fly
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.014
detection of stimulus GO:0051606 156 0.014
reproductive structure development GO:0048608 74 0.014
morphogenesis of embryonic epithelium GO:0016331 94 0.014
tripartite regional subdivision GO:0007351 103 0.014
regulation of locomotion GO:0040012 42 0.014
cellular homeostasis GO:0019725 80 0.014
positive regulation of neuron projection development GO:0010976 14 0.014
response to oxygen containing compound GO:1901700 200 0.014
sex differentiation GO:0007548 81 0.014
regulation of cellular catabolic process GO:0031329 157 0.014
actin polymerization or depolymerization GO:0008154 31 0.014
regulation of apoptotic signaling pathway GO:2001233 10 0.014
epithelium migration GO:0090132 148 0.014
multicellular organismal signaling GO:0035637 12 0.014
cellular response to carbon dioxide GO:0071244 2 0.014
immune system development GO:0002520 57 0.014
regulation of nuclear division GO:0051783 58 0.014
organophosphate catabolic process GO:0046434 112 0.014
endodermal cell fate commitment GO:0001711 3 0.014
negative regulation of programmed cell death GO:0043069 72 0.013
notch signaling pathway GO:0007219 120 0.013
ribonucleoside metabolic process GO:0009119 127 0.013
establishment of protein localization GO:0045184 163 0.013

Pde8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.161
Human
nervous system disease DOID:863 0 0.040
Human
musculoskeletal system disease DOID:17 0 0.034
bone disease DOID:0080001 0 0.025
connective tissue disease DOID:65 0 0.025
disease of metabolism DOID:0014667 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
cancer DOID:162 0 0.017
organ system cancer DOID:0050686 0 0.017