Drosophila melanogaster

124 known processes

mbl (Dmel_CG33197)

muscleblind

(Aliases: chst,n(2)k07110,CG14477,l(2)k05507,CG33197,mm,chaste,l(2)k01212,Dmel\CG33197,cht,l(2)01038,CG10941)

mbl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
detection of external stimulus GO:0009581 66 0.778
muscle structure development GO:0061061 224 0.728
imaginal disc derived appendage morphogenesis GO:0035114 395 0.721
appendage development GO:0048736 401 0.653
wing disc morphogenesis GO:0007472 344 0.636
regionalization GO:0003002 416 0.605
myofibril assembly GO:0030239 36 0.555
post embryonic appendage morphogenesis GO:0035120 385 0.550
muscle attachment GO:0016203 36 0.466
imaginal disc derived wing morphogenesis GO:0007476 337 0.395
imaginal disc derived appendage development GO:0048737 399 0.326
regulation of cell differentiation GO:0045595 302 0.302
organelle assembly GO:0070925 198 0.281
digestive tract development GO:0048565 149 0.253
negative regulation of nucleic acid templated transcription GO:1903507 240 0.245
morphogenesis of a polarized epithelium GO:0001738 93 0.235
cell maturation GO:0048469 144 0.224
negative regulation of rna metabolic process GO:0051253 251 0.222
response to nutrient levels GO:0031667 114 0.216
negative regulation of cellular biosynthetic process GO:0031327 277 0.190
appendage morphogenesis GO:0035107 397 0.176
stem cell differentiation GO:0048863 117 0.174
embryonic morphogenesis GO:0048598 206 0.172
response to starvation GO:0042594 97 0.171
sarcomere organization GO:0045214 26 0.168
regulation of anatomical structure morphogenesis GO:0022603 242 0.160
stem cell proliferation GO:0072089 88 0.140
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.140
regulation of cell proliferation GO:0042127 163 0.133
positive regulation of cellular biosynthetic process GO:0031328 316 0.126
somatic muscle development GO:0007525 66 0.124
segmentation GO:0035282 207 0.124
cell fate determination GO:0001709 91 0.121
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.120
axis specification GO:0009798 167 0.119
sensory perception GO:0007600 196 0.115
response to extracellular stimulus GO:0009991 116 0.114
cellular component assembly involved in morphogenesis GO:0010927 151 0.113
neuroblast proliferation GO:0007405 74 0.113
cell proliferation GO:0008283 299 0.110
protein catabolic process GO:0030163 101 0.103
eye development GO:0001654 323 0.102
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.102
phosphorylation GO:0016310 294 0.096
muscle organ development GO:0007517 127 0.096
gastrulation GO:0007369 70 0.095
negative regulation of gene expression GO:0010629 387 0.090
digestive system development GO:0055123 149 0.090
cellular macromolecular complex assembly GO:0034622 153 0.089
lipid biosynthetic process GO:0008610 46 0.088
biological adhesion GO:0022610 138 0.087
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.087
positive regulation of gene expression GO:0010628 290 0.086
endodermal cell differentiation GO:0035987 3 0.084
oocyte development GO:0048599 124 0.084
innate immune response GO:0045087 144 0.082
heart development GO:0007507 82 0.079
cellular ketone metabolic process GO:0042180 24 0.078
detection of stimulus GO:0051606 156 0.077
actomyosin structure organization GO:0031032 56 0.071
single organismal cell cell adhesion GO:0016337 45 0.069
gland development GO:0048732 191 0.069
skeletal muscle organ development GO:0060538 48 0.068
single organism biosynthetic process GO:0044711 206 0.067
neuroblast differentiation GO:0014016 29 0.064
camera type eye morphogenesis GO:0048593 2 0.063
circulatory system development GO:0072359 82 0.062
taxis GO:0042330 304 0.062
peripheral nervous system development GO:0007422 52 0.061
striated muscle cell differentiation GO:0051146 90 0.059
negative regulation of cellular metabolic process GO:0031324 382 0.057
tissue morphogenesis GO:0048729 297 0.055
immune response GO:0006955 246 0.052
morphogenesis of an epithelium GO:0002009 276 0.052
male gamete generation GO:0048232 201 0.051
positive regulation of response to stimulus GO:0048584 323 0.051
multicellular organism growth GO:0035264 46 0.050
regulation of localization GO:0032879 275 0.049
steroid metabolic process GO:0008202 20 0.048
lipid metabolic process GO:0006629 121 0.048
phototransduction GO:0007602 52 0.048
regulation of cell development GO:0060284 215 0.048
rna localization GO:0006403 115 0.045
detection of stimulus involved in sensory perception GO:0050906 92 0.044
striated muscle cell development GO:0055002 50 0.044
response to bacterium GO:0009617 198 0.043
multicellular organismal homeostasis GO:0048871 41 0.043
connective tissue development GO:0061448 3 0.042
death GO:0016265 284 0.042
salivary gland cell autophagic cell death GO:0035071 83 0.042
salivary gland development GO:0007431 162 0.041
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.041
establishment of planar polarity GO:0001736 87 0.041
tube morphogenesis GO:0035239 191 0.040
imaginal disc derived wing hair organization GO:0035317 45 0.039
organic substance catabolic process GO:1901575 308 0.039
establishment of tissue polarity GO:0007164 87 0.039
embryonic organ development GO:0048568 50 0.039
endoderm formation GO:0001706 3 0.037
ecdysteroid metabolic process GO:0045455 19 0.036
regulation of reproductive process GO:2000241 54 0.036
hormone biosynthetic process GO:0042446 20 0.036
cell surface receptor signaling pathway involved in heart development GO:0061311 3 0.036
cellular response to extracellular stimulus GO:0031668 64 0.036
tube development GO:0035295 244 0.034
muscle cell differentiation GO:0042692 103 0.034
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.034
heart morphogenesis GO:0003007 32 0.034
endodermal cell fate commitment GO:0001711 3 0.034
torso signaling pathway GO:0008293 21 0.034
oxidation reduction process GO:0055114 123 0.033
cellular hormone metabolic process GO:0034754 23 0.033
positive regulation of nucleic acid templated transcription GO:1903508 266 0.033
mrna metabolic process GO:0016071 124 0.033
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.033
positive regulation of neurogenesis GO:0050769 41 0.033
establishment or maintenance of cell polarity GO:0007163 167 0.032
transcription from rna polymerase ii promoter GO:0006366 368 0.030
nuclear division GO:0000280 332 0.030
developmental maturation GO:0021700 172 0.029
cell death GO:0008219 279 0.029
embryonic pattern specification GO:0009880 174 0.028
hormone metabolic process GO:0042445 33 0.028
cellular metal ion homeostasis GO:0006875 31 0.028
developmental programmed cell death GO:0010623 138 0.028
steroid biosynthetic process GO:0006694 16 0.027
response to oxygen containing compound GO:1901700 200 0.027
ion transport GO:0006811 145 0.027
camera type eye development GO:0043010 4 0.026
response to other organism GO:0051707 293 0.026
tissue death GO:0016271 102 0.026
histolysis GO:0007559 102 0.025
regulation of multicellular organismal development GO:2000026 414 0.025
programmed cell death GO:0012501 257 0.025
carboxylic acid metabolic process GO:0019752 92 0.025
salivary gland histolysis GO:0035070 88 0.024
negative regulation of cell communication GO:0010648 223 0.024
autophagic cell death GO:0048102 83 0.024
negative regulation of developmental process GO:0051093 201 0.024
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.024
negative regulation of rna biosynthetic process GO:1902679 240 0.024
cellular response to nutrient levels GO:0031669 62 0.024
eye morphogenesis GO:0048592 260 0.024
regulation of organ morphogenesis GO:2000027 78 0.024
single organism cell adhesion GO:0098602 47 0.023
response to lipid GO:0033993 38 0.023
regulation of protein metabolic process GO:0051246 256 0.023
negative regulation of response to stimulus GO:0048585 258 0.023
multi multicellular organism process GO:0044706 123 0.023
maintenance of location GO:0051235 73 0.023
mesoderm development GO:0007498 78 0.022
limb development GO:0060173 1 0.022
digestive tract morphogenesis GO:0048546 127 0.022
chitin based cuticle development GO:0040003 49 0.022
immune system process GO:0002376 347 0.022
small molecule metabolic process GO:0044281 305 0.021
defense response GO:0006952 300 0.021
negative regulation of transcription dna templated GO:0045892 237 0.021
anterior posterior pattern specification GO:0009952 136 0.021
exocrine system development GO:0035272 162 0.021
positive regulation of transcription dna templated GO:0045893 266 0.021
retina development in camera type eye GO:0060041 4 0.021
epidermis development GO:0008544 65 0.021
terminal region determination GO:0007362 25 0.021
wnt signaling pathway GO:0016055 98 0.021
negative regulation of growth GO:0045926 84 0.020
detection of abiotic stimulus GO:0009582 66 0.020
organic acid metabolic process GO:0006082 103 0.020
chemotaxis GO:0006935 249 0.020
regulation of growth GO:0040008 233 0.020
sensory organ morphogenesis GO:0090596 260 0.019
skeletal muscle fiber development GO:0048741 3 0.019
adult locomotory behavior GO:0008344 76 0.019
forebrain development GO:0030900 2 0.019
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.019
stem cell development GO:0048864 79 0.019
imaginal disc derived wing vein specification GO:0007474 48 0.019
negative regulation of wnt signaling pathway GO:0030178 28 0.018
mitotic g2 dna damage checkpoint GO:0007095 69 0.018
notch signaling pathway GO:0007219 120 0.018
embryonic axis specification GO:0000578 107 0.018
regulation of histone modification GO:0031056 20 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.017
regulation of cell morphogenesis GO:0022604 163 0.017
adult behavior GO:0030534 137 0.017
cellular response to organic cyclic compound GO:0071407 32 0.017
wound healing GO:0042060 75 0.017
anatomical structure homeostasis GO:0060249 97 0.017
cardiocyte differentiation GO:0035051 29 0.017
regulation of neuron differentiation GO:0045664 103 0.017
g protein coupled receptor signaling pathway GO:0007186 136 0.016
body morphogenesis GO:0010171 2 0.016
thermotaxis GO:0043052 16 0.016
homeostatic process GO:0042592 199 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.015
salivary gland morphogenesis GO:0007435 145 0.015
response to light stimulus GO:0009416 124 0.015
dendrite morphogenesis GO:0048813 199 0.015
regulation of smoothened signaling pathway GO:0008589 28 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.015
apoptotic process GO:0006915 159 0.015
muscle tissue morphogenesis GO:0060415 2 0.015
cardiac muscle tissue development GO:0048738 9 0.015
dorsal ventral pattern formation GO:0009953 133 0.015
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.015
small molecule biosynthetic process GO:0044283 37 0.015
rna splicing GO:0008380 83 0.015
mapk cascade GO:0000165 107 0.014
regulation of nervous system development GO:0051960 248 0.014
response to organic substance GO:0010033 284 0.014
regulation of protein catabolic process GO:0042176 55 0.014
response to external biotic stimulus GO:0043207 293 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
mrna processing GO:0006397 104 0.014
stem cell fate commitment GO:0048865 25 0.013
maintenance of location in cell GO:0051651 28 0.013
cellular amino acid metabolic process GO:0006520 61 0.013
anterior posterior axis specification GO:0009948 109 0.013
negative regulation of synapse assembly GO:0051964 39 0.013
response to oxygen levels GO:0070482 59 0.013
regulation of neuron projection development GO:0010975 69 0.013
regulation of programmed cell death GO:0043067 152 0.013
central nervous system development GO:0007417 201 0.013
cell cell signaling involved in cell fate commitment GO:0045168 210 0.013
regulation of cell death GO:0010941 173 0.013
lateral inhibition GO:0046331 206 0.013
response to endoplasmic reticulum stress GO:0034976 28 0.013
regulation of organelle organization GO:0033043 196 0.013
cellular amine metabolic process GO:0044106 12 0.013
blastoderm segmentation GO:0007350 159 0.012
neuroblast fate commitment GO:0014017 19 0.012
sensory perception of chemical stimulus GO:0007606 116 0.012
segment specification GO:0007379 33 0.012
response to temperature stimulus GO:0009266 106 0.012
positive regulation of cell differentiation GO:0045597 64 0.012
positive regulation of biosynthetic process GO:0009891 316 0.012
maintenance of epithelial integrity open tracheal system GO:0035160 12 0.012
oocyte differentiation GO:0009994 145 0.012
negative regulation of cytoskeleton organization GO:0051494 30 0.012
mushroom body development GO:0016319 70 0.012
cellular iron ion homeostasis GO:0006879 3 0.012
positive regulation of macromolecule metabolic process GO:0010604 405 0.012
convergent extension involved in gastrulation GO:0060027 2 0.012
dendrite development GO:0016358 204 0.011
lipid modification GO:0030258 24 0.011
sensory perception of sound GO:0007605 56 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
embryonic heart tube development GO:0035050 22 0.011
zygotic determination of anterior posterior axis embryo GO:0007354 27 0.011
maintenance of protein location GO:0045185 28 0.011
regulation of multicellular organism growth GO:0040014 40 0.011
regulation of apoptotic process GO:0042981 130 0.011
negative regulation of signaling GO:0023057 219 0.011
regulation of erbb signaling pathway GO:1901184 42 0.011
organ formation GO:0048645 39 0.011
compound eye morphogenesis GO:0001745 249 0.011
multicellular organismal aging GO:0010259 140 0.011
spinal cord development GO:0021510 1 0.011
muscle cell development GO:0055001 50 0.011
cellular response to dna damage stimulus GO:0006974 223 0.010
meiotic g2 mi transition GO:0008315 3 0.010
cardiac muscle cell differentiation GO:0055007 4 0.010
female meiotic division GO:0007143 70 0.010
regulation of hydrolase activity GO:0051336 97 0.010
cell type specific apoptotic process GO:0097285 38 0.010
cellular macromolecule localization GO:0070727 220 0.010
cellular response to starvation GO:0009267 61 0.010
wing disc pattern formation GO:0035222 66 0.010

mbl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
myopathy DOID:423 0 0.016
muscular disease DOID:0080000 0 0.016
heart disease DOID:114 0 0.016
cardiomyopathy DOID:0050700 0 0.016
disease of anatomical entity DOID:7 0 0.016
intrinsic cardiomyopathy DOID:0060036 0 0.016
cardiovascular system disease DOID:1287 0 0.016
musculoskeletal system disease DOID:17 0 0.016
muscle tissue disease DOID:66 0 0.016