Drosophila melanogaster

113 known processes

sav (Dmel_CG33193)

salvador

(Aliases: CG33193,anon-WO0172774.152,CG13831,CG13832,Salvador/Shar-pei,Dmel\CG33193,Sav,shar-pei)

sav biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
hippo signaling GO:0035329 20 1.000
Mouse
regulation of hippo signaling GO:0035330 14 0.774
cell proliferation GO:0008283 299 0.653
compound eye morphogenesis GO:0001745 249 0.469
eye photoreceptor cell differentiation GO:0001754 145 0.436
protein transport GO:0015031 155 0.414
negative regulation of response to stimulus GO:0048585 258 0.398
eye development GO:0001654 323 0.393
r3 r4 cell fate commitment GO:0007464 10 0.377
regulation of cellular component size GO:0032535 98 0.335
establishment or maintenance of cell polarity GO:0007163 167 0.328
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.321
eye morphogenesis GO:0048592 260 0.253
compound eye development GO:0048749 307 0.245
compound eye photoreceptor cell differentiation GO:0001751 140 0.230
negative regulation of cell proliferation GO:0008285 69 0.224
positive regulation of developmental process GO:0051094 143 0.208
Mouse
notch signaling pathway GO:0007219 120 0.189
protein localization GO:0008104 284 0.186
negative regulation of cell communication GO:0010648 223 0.186
positive regulation of cell differentiation GO:0045597 64 0.177
Mouse
cell adhesion GO:0007155 136 0.176
regulation of notch signaling pathway GO:0008593 100 0.170
enzyme linked receptor protein signaling pathway GO:0007167 179 0.157
regulation of localization GO:0032879 275 0.154
negative regulation of signal transduction GO:0009968 206 0.141
negative regulation of gene expression GO:0010629 387 0.140
negative regulation of organ growth GO:0046621 15 0.140
Mouse
autophagic vacuole assembly GO:0000045 2 0.139
response to peptide hormone GO:0043434 29 0.133
centrosome organization GO:0051297 163 0.127
respiratory system development GO:0060541 213 0.123
Mouse
microtubule organizing center organization GO:0031023 168 0.121
regulation of intracellular signal transduction GO:1902531 236 0.120
single organism intracellular transport GO:1902582 207 0.113
photoreceptor cell differentiation GO:0046530 170 0.112
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.112
signal transduction by phosphorylation GO:0023014 107 0.111
regulation of actin filament polymerization GO:0030833 25 0.108
protein targeting GO:0006605 64 0.108
single organism membrane fusion GO:0044801 42 0.106
response to light stimulus GO:0009416 124 0.106
protein phosphorylation GO:0006468 169 0.103
compound eye photoreceptor development GO:0042051 78 0.102
cellular macromolecule localization GO:0070727 220 0.099
regulation of cell differentiation GO:0045595 302 0.099
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.096
organic substance transport GO:0071702 257 0.094
intracellular protein transport GO:0006886 104 0.093
regulation of anatomical structure morphogenesis GO:0022603 242 0.093
compound eye photoreceptor fate commitment GO:0001752 36 0.090
establishment of protein localization GO:0045184 163 0.090
negative regulation of glial cell proliferation GO:0060253 6 0.090
intracellular signal transduction GO:0035556 300 0.090
Mouse
gliogenesis GO:0042063 80 0.090
regulation of cell proliferation GO:0042127 163 0.084
organ growth GO:0035265 56 0.079
Mouse
positive regulation of cell communication GO:0010647 250 0.078
autophagy GO:0006914 108 0.077
morphogenesis of follicular epithelium GO:0016333 36 0.075
positive regulation of response to stimulus GO:0048584 323 0.073
protein import into nucleus GO:0006606 51 0.068
protein localization to nucleus GO:0034504 55 0.068
regulation of protein transport GO:0051223 57 0.068
cell cell junction organization GO:0045216 55 0.067
regulation of cell cycle process GO:0010564 181 0.065
regulation of phosphorus metabolic process GO:0051174 210 0.064
single organism nuclear import GO:1902593 51 0.064
positive regulation of macromolecule metabolic process GO:0010604 405 0.063
centrosome duplication GO:0051298 121 0.063
regulation of purine nucleotide metabolic process GO:1900542 62 0.062
regulation of cell development GO:0060284 215 0.061
regulation of phosphate metabolic process GO:0019220 210 0.060
nucleocytoplasmic transport GO:0006913 72 0.060
nuclear import GO:0051170 51 0.060
positive regulation of nervous system development GO:0051962 69 0.059
regulation of actin filament based process GO:0032970 42 0.059
negative regulation of rna metabolic process GO:0051253 251 0.058
positive regulation of signal transduction GO:0009967 223 0.057
regulation of transport GO:0051049 181 0.057
negative regulation of cellular metabolic process GO:0031324 382 0.057
negative regulation of signaling GO:0023057 219 0.055
protein modification process GO:0036211 438 0.055
regulation of protein metabolic process GO:0051246 256 0.054
regulation of mitotic cell cycle GO:0007346 190 0.054
cellular protein modification process GO:0006464 438 0.054
epidermal cell differentiation GO:0009913 51 0.054
Mouse
cell junction organization GO:0034330 57 0.053
regulation of growth GO:0040008 233 0.051
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.051
protein localization to organelle GO:0033365 82 0.050
cellular macromolecule catabolic process GO:0044265 136 0.049
homeostatic process GO:0042592 199 0.048
multi multicellular organism process GO:0044706 123 0.047
regulation of response to stress GO:0080134 200 0.047
protein depolymerization GO:0051261 31 0.046
regulation of cytoskeleton organization GO:0051493 89 0.046
protein targeting to nucleus GO:0044744 51 0.046
response to radiation GO:0009314 155 0.045
body morphogenesis GO:0010171 2 0.045
positive regulation of signaling GO:0023056 243 0.045
negative regulation of intracellular signal transduction GO:1902532 57 0.045
regulation of molecular function GO:0065009 217 0.044
Mouse
tube development GO:0035295 244 0.043
ribonucleoside catabolic process GO:0042454 112 0.043
regulation of actin filament length GO:0030832 27 0.043
regulation of actin polymerization or depolymerization GO:0008064 27 0.042
eye photoreceptor cell fate commitment GO:0042706 37 0.042
centrosome cycle GO:0007098 137 0.042
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.041
olfactory behavior GO:0042048 97 0.041
organic substance catabolic process GO:1901575 308 0.040
reproductive behavior GO:0019098 122 0.040
positive regulation of phosphate metabolic process GO:0045937 139 0.040
positive regulation of cell proliferation GO:0008284 47 0.040
regulation of phosphorylation GO:0042325 147 0.039
spermatid differentiation GO:0048515 114 0.039
regulation of epithelial cell proliferation GO:0050678 4 0.039
Mouse
anatomical structure homeostasis GO:0060249 97 0.038
mitotic dna integrity checkpoint GO:0044774 75 0.038
cellular protein catabolic process GO:0044257 83 0.038
adherens junction organization GO:0034332 27 0.038
multi organism behavior GO:0051705 175 0.038
sister chromatid segregation GO:0000819 92 0.037
biological adhesion GO:0022610 138 0.037
membrane organization GO:0061024 112 0.037
sensory organ morphogenesis GO:0090596 260 0.037
regulation of establishment of protein localization GO:0070201 61 0.037
macromolecule catabolic process GO:0009057 161 0.037
sex differentiation GO:0007548 81 0.036
regulation of glial cell proliferation GO:0060251 11 0.036
establishment or maintenance of polarity of follicular epithelium GO:0016334 26 0.036
positive regulation of intracellular signal transduction GO:1902533 116 0.036
cell cell adhesion GO:0098609 26 0.035
response to peptide GO:1901652 29 0.035
insulin receptor signaling pathway GO:0008286 25 0.035
negative regulation of mitotic cell cycle GO:0045930 109 0.035
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.035
regulation of mitotic cell cycle phase transition GO:1901990 130 0.034
regulation of cellular ketone metabolic process GO:0010565 3 0.033
protein complex assembly GO:0006461 200 0.033
protein import GO:0017038 55 0.032
regulation of nervous system development GO:0051960 248 0.032
regulation of endocytosis GO:0030100 37 0.032
exocrine system development GO:0035272 162 0.031
regulation of vesicle mediated transport GO:0060627 59 0.031
negative regulation of biosynthetic process GO:0009890 277 0.031
regulation of neurogenesis GO:0050767 158 0.031
regulation of protein localization GO:0032880 76 0.031
regulation of erbb signaling pathway GO:1901184 42 0.031
proteasomal protein catabolic process GO:0010498 59 0.030
cellular response to dna damage stimulus GO:0006974 223 0.030
establishment of protein localization to organelle GO:0072594 62 0.030
negative regulation of cell cycle GO:0045786 116 0.030
negative regulation of notch signaling pathway GO:0045746 41 0.030
positive regulation of cell cycle GO:0045787 43 0.030
regulation of cellular response to stress GO:0080135 89 0.029
regulation of actin cytoskeleton organization GO:0032956 42 0.029
positive regulation of cellular protein metabolic process GO:0032270 118 0.029
positive regulation of neurogenesis GO:0050769 41 0.029
cell fate specification GO:0001708 71 0.028
cellular response to nitrogen compound GO:1901699 51 0.028
response to decreased oxygen levels GO:0036293 58 0.028
purine ribonucleotide metabolic process GO:0009150 145 0.028
negative regulation of cellular biosynthetic process GO:0031327 277 0.028
salivary gland morphogenesis GO:0007435 145 0.028
establishment of planar polarity GO:0001736 87 0.028
response to hypoxia GO:0001666 53 0.027
glial cell proliferation GO:0014009 13 0.027
multicellular organismal reproductive behavior GO:0033057 110 0.027
cell cycle phase transition GO:0044770 140 0.027
nucleobase containing small molecule metabolic process GO:0055086 174 0.026
cellular nitrogen compound catabolic process GO:0044270 165 0.026
negative regulation of hippo signaling GO:0035331 5 0.026
axonogenesis GO:0007409 290 0.026
regulation of cell junction assembly GO:1901888 2 0.026
response to insulin GO:0032868 29 0.025
mapk cascade GO:0000165 107 0.025
larval midgut histolysis GO:0035069 22 0.025
morphogenesis of a polarized epithelium GO:0001738 93 0.025
regulation of mapk cascade GO:0043408 92 0.024
photoreceptor cell development GO:0042461 96 0.024
negative regulation of cell cycle process GO:0010948 109 0.024
regionalization GO:0003002 416 0.024
positive regulation of phosphorylation GO:0042327 87 0.024
cellular response to organic cyclic compound GO:0071407 32 0.023
positive regulation of developmental growth GO:0048639 62 0.023
regulation of neuron projection development GO:0010975 69 0.023
proteolysis GO:0006508 192 0.023
wnt signaling pathway GO:0016055 98 0.023
response to organonitrogen compound GO:0010243 75 0.023
negative regulation of kinase activity GO:0033673 16 0.023
regulation of imaginal disc growth GO:0045570 26 0.023
purine nucleotide metabolic process GO:0006163 146 0.023
cellular component disassembly GO:0022411 46 0.022
multi organism reproductive behavior GO:0044705 121 0.022
regulation of anatomical structure size GO:0090066 163 0.022
dendrite development GO:0016358 204 0.022
negative regulation of programmed cell death GO:0043069 72 0.021
erbb signaling pathway GO:0038127 58 0.021
cellular response to peptide GO:1901653 28 0.021
axon development GO:0061564 297 0.021
cellular amino acid metabolic process GO:0006520 61 0.021
regulation of rac protein signal transduction GO:0035020 3 0.021
reproductive structure development GO:0048608 74 0.020
cytoplasmic transport GO:0016482 130 0.020
positive regulation of cell death GO:0010942 69 0.020
establishment of localization in cell GO:0051649 402 0.020
negative regulation of phosphorus metabolic process GO:0010563 45 0.020
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.020
cellular response to insulin stimulus GO:0032869 28 0.020
establishment of ommatidial planar polarity GO:0042067 49 0.020
imaginal disc growth GO:0007446 37 0.020
negative regulation of transcription dna templated GO:0045892 237 0.019
phagocytosis GO:0006909 215 0.019
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.019
nuclear transport GO:0051169 72 0.019
cellular response to chemical stimulus GO:0070887 199 0.019
single organism cellular localization GO:1902580 180 0.019
negative regulation of cell cycle phase transition GO:1901988 103 0.019
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.019
positive regulation of protein metabolic process GO:0051247 128 0.019
establishment or maintenance of apical basal cell polarity GO:0035088 34 0.018
regulation of gliogenesis GO:0014013 11 0.018
single organism catabolic process GO:0044712 228 0.018
ribonucleotide catabolic process GO:0009261 109 0.018
morphogenesis of an epithelium GO:0002009 276 0.018
cellular response to hormone stimulus GO:0032870 44 0.018
regulation of protein ubiquitination GO:0031396 22 0.018
positive regulation of multicellular organismal process GO:0051240 143 0.018
regulation of cellular protein metabolic process GO:0032268 243 0.018
lipid metabolic process GO:0006629 121 0.018
modification dependent protein catabolic process GO:0019941 78 0.017
cellular response to peptide hormone stimulus GO:0071375 28 0.017
rac protein signal transduction GO:0016601 3 0.017
nucleotide metabolic process GO:0009117 161 0.017
actin filament polymerization GO:0030041 27 0.017
positive regulation of protein transport GO:0051222 37 0.017
regulation of transferase activity GO:0051338 58 0.017
purine nucleoside monophosphate metabolic process GO:0009126 50 0.017
actin filament organization GO:0007015 126 0.017
negative regulation of epithelial cell proliferation GO:0050680 4 0.017
Mouse
apoptotic process GO:0006915 159 0.017
response to alcohol GO:0097305 95 0.017
regulation of epidermal cell differentiation GO:0045604 3 0.017
nucleoside phosphate metabolic process GO:0006753 162 0.017
actin polymerization or depolymerization GO:0008154 31 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
positive regulation of cell development GO:0010720 61 0.016
regulation of insulin receptor signaling pathway GO:0046626 17 0.016
regulation of neuron differentiation GO:0045664 103 0.016
cellular amine metabolic process GO:0044106 12 0.016
cellular protein localization GO:0034613 160 0.016
negative regulation of apoptotic process GO:0043066 63 0.016
positive regulation of actin filament polymerization GO:0030838 11 0.016
spindle assembly GO:0051225 80 0.016
positive regulation of phosphorus metabolic process GO:0010562 139 0.016
regulation of programmed cell death GO:0043067 152 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.016
imaginal disc derived leg morphogenesis GO:0007480 80 0.015
regulation of apoptotic process GO:0042981 130 0.015
response to nitrogen compound GO:1901698 90 0.015
mating GO:0007618 120 0.015
cellular response to decreased oxygen levels GO:0036294 30 0.015
positive regulation of mitotic cell cycle GO:0045931 34 0.015
death GO:0016265 284 0.015
carbohydrate derivative catabolic process GO:1901136 118 0.015
mesenchymal cell differentiation GO:0048762 1 0.015
cellular response to oxygen levels GO:0071453 30 0.015
positive regulation of protein modification process GO:0031401 58 0.015
protein complex biogenesis GO:0070271 201 0.015
negative regulation of g1 s transition of mitotic cell cycle GO:2000134 13 0.015
regulation of protein phosphorylation GO:0001932 64 0.015
regulation of organ growth GO:0046620 42 0.015
Mouse
regulation of stem cell proliferation GO:0072091 40 0.015
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.014
spindle organization GO:0007051 253 0.014
negative regulation of cellular catabolic process GO:0031330 34 0.014
phosphorylation GO:0016310 294 0.014
organonitrogen compound metabolic process GO:1901564 318 0.014
intracellular transport GO:0046907 228 0.014
rho protein signal transduction GO:0007266 14 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.014
establishment or maintenance of epithelial cell apical basal polarity GO:0045197 24 0.013
post embryonic appendage morphogenesis GO:0035120 385 0.013
phosphatidylinositol phosphorylation GO:0046854 10 0.013
dendrite morphogenesis GO:0048813 199 0.013
response to hormone GO:0009725 45 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
regulation of synapse structural plasticity GO:0051823 3 0.013
regulation of cellular localization GO:0060341 136 0.013
cellular response to organonitrogen compound GO:0071417 36 0.013
salivary gland development GO:0007431 162 0.013
regulation of cell cycle GO:0051726 291 0.013
macromolecular complex assembly GO:0065003 256 0.013
endocytosis GO:0006897 310 0.013
regulation of cell death GO:0010941 173 0.013
oxoacid metabolic process GO:0043436 103 0.013
regulation of cell cycle phase transition GO:1901987 130 0.013
nucleobase containing compound catabolic process GO:0034655 165 0.013
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.013
nucleosome organization GO:0034728 59 0.013
embryonic axis specification GO:0000578 107 0.013
response to oxygen levels GO:0070482 59 0.013
regulation of protein modification process GO:0031399 112 0.012
cell cycle checkpoint GO:0000075 95 0.012
organelle localization GO:0051640 148 0.012
small gtpase mediated signal transduction GO:0007264 88 0.012
gland development GO:0048732 191 0.012
establishment of mitotic spindle localization GO:0040001 17 0.012
segmentation GO:0035282 207 0.012
connective tissue development GO:0061448 3 0.012
cell cycle arrest GO:0007050 4 0.012
cellular response to organic substance GO:0071310 132 0.012
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.012
stem cell proliferation GO:0072089 88 0.012
gland morphogenesis GO:0022612 145 0.012
imaginal disc derived appendage development GO:0048737 399 0.012
regulation of protein polymerization GO:0032271 28 0.012
rhabdomere membrane biogenesis GO:0045313 6 0.012
regulation of cell size GO:0008361 63 0.012
negative regulation of rna biosynthetic process GO:1902679 240 0.012
central nervous system development GO:0007417 201 0.012
regulation of cell shape GO:0008360 113 0.012
chemotaxis GO:0006935 249 0.012
organic acid metabolic process GO:0006082 103 0.012
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 18 0.012
mitotic dna damage checkpoint GO:0044773 74 0.012
cell cell adhesion via plasma membrane adhesion molecules GO:0098742 26 0.012
skin development GO:0043588 65 0.011
Mouse
negative regulation of mapk cascade GO:0043409 23 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.011
regulation of intracellular protein transport GO:0033157 46 0.011
regulation of protein localization to nucleus GO:1900180 29 0.011
purine containing compound metabolic process GO:0072521 155 0.011
endomembrane system organization GO:0010256 119 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
organelle fusion GO:0048284 46 0.011
instar larval development GO:0002168 55 0.011
regulation of sister chromatid cohesion GO:0007063 2 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
epidermis development GO:0008544 65 0.011
Mouse
negative regulation of protein phosphorylation GO:0001933 17 0.011
positive regulation of nucleocytoplasmic transport GO:0046824 24 0.011
regulation of cell cycle g1 s phase transition GO:1902806 23 0.011
golgi organization GO:0007030 66 0.011
organic cyclic compound catabolic process GO:1901361 168 0.010
programmed cell death GO:0012501 257 0.010
maintenance of location in cell GO:0051651 28 0.010
amine metabolic process GO:0009308 12 0.010
regulation of catabolic process GO:0009894 170 0.010
mitotic g2 m transition checkpoint GO:0044818 70 0.010
protein polymerization GO:0051258 42 0.010
dorsal ventral pattern formation GO:0009953 133 0.010

sav disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.025
cancer DOID:162 0 0.020
organ system cancer DOID:0050686 0 0.020