Drosophila melanogaster

33 known processes

Best1 (Dmel_CG6264)

Bestrophin 1

(Aliases: anon-WO0118547.380,Dmel\CG6264,Dbest,dmBest1,CG6264,dbest1,best)

Best1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of transport GO:0051049 181 0.128
regulation of localization GO:0032879 275 0.102
organonitrogen compound metabolic process GO:1901564 318 0.091
organic substance transport GO:0071702 257 0.080
programmed cell death GO:0012501 257 0.071
establishment of localization in cell GO:0051649 402 0.071
regionalization GO:0003002 416 0.070
single organism biosynthetic process GO:0044711 206 0.069
small molecule metabolic process GO:0044281 305 0.068
death GO:0016265 284 0.066
response to abiotic stimulus GO:0009628 341 0.061
response to bacterium GO:0009617 198 0.058
taxis GO:0042330 304 0.057
post embryonic appendage morphogenesis GO:0035120 385 0.056
negative regulation of cell communication GO:0010648 223 0.055
negative regulation of signaling GO:0023057 219 0.052
nucleobase containing small molecule metabolic process GO:0055086 174 0.052
imaginal disc derived wing morphogenesis GO:0007476 337 0.050
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.049
single organism catabolic process GO:0044712 228 0.049
cell death GO:0008219 279 0.049
cellular protein modification process GO:0006464 438 0.047
protein modification process GO:0036211 438 0.047
negative regulation of signal transduction GO:0009968 206 0.047
regulation of phosphorus metabolic process GO:0051174 210 0.046
organic acid metabolic process GO:0006082 103 0.046
imaginal disc derived appendage development GO:0048737 399 0.046
protein localization GO:0008104 284 0.045
response to biotic stimulus GO:0009607 294 0.045
response to lipopolysaccharide GO:0032496 4 0.045
growth GO:0040007 359 0.044
cellular amine metabolic process GO:0044106 12 0.044
endocytosis GO:0006897 310 0.043
homeostatic process GO:0042592 199 0.043
epithelial cell differentiation GO:0030855 322 0.042
regulation of cellular amine metabolic process GO:0033238 3 0.042
intracellular signal transduction GO:0035556 300 0.041
regulation of multicellular organismal development GO:2000026 414 0.039
endomembrane system organization GO:0010256 119 0.038
glycosyl compound catabolic process GO:1901658 112 0.038
nucleoside phosphate metabolic process GO:0006753 162 0.037
single organism behavior GO:0044708 391 0.037
regulation of catalytic activity GO:0050790 185 0.037
organophosphate metabolic process GO:0019637 195 0.036
small gtpase mediated signal transduction GO:0007264 88 0.036
cellular amino acid metabolic process GO:0006520 61 0.036
defense response to other organism GO:0098542 225 0.036
regulation of intracellular signal transduction GO:1902531 236 0.035
carboxylic acid metabolic process GO:0019752 92 0.035
cation transmembrane transport GO:0098655 88 0.035
regulation of apoptotic process GO:0042981 130 0.035
wing disc morphogenesis GO:0007472 344 0.035
positive regulation of phosphate metabolic process GO:0045937 139 0.034
exocrine system development GO:0035272 162 0.034
vesicle mediated transport GO:0016192 381 0.034
synaptic transmission GO:0007268 288 0.034
cation transport GO:0006812 110 0.033
amine metabolic process GO:0009308 12 0.033
detection of stimulus GO:0051606 156 0.033
regulation of phosphate metabolic process GO:0019220 210 0.033
positive regulation of signaling GO:0023056 243 0.033
appendage development GO:0048736 401 0.033
salivary gland development GO:0007431 162 0.032
ion transmembrane transport GO:0034220 122 0.032
regulation of cellular component biogenesis GO:0044087 201 0.032
negative regulation of response to stimulus GO:0048585 258 0.032
apoptotic process GO:0006915 159 0.031
regulation of cellular ketone metabolic process GO:0010565 3 0.031
aromatic compound catabolic process GO:0019439 166 0.031
ameboidal type cell migration GO:0001667 151 0.031
positive regulation of phosphorus metabolic process GO:0010562 139 0.030
imaginal disc derived appendage morphogenesis GO:0035114 395 0.030
regulation of cellular amino acid metabolic process GO:0006521 0 0.030
single organism membrane organization GO:0044802 93 0.030
localization of cell GO:0051674 257 0.030
cytoplasmic transport GO:0016482 130 0.029
autophagic cell death GO:0048102 83 0.029
regulation of protein metabolic process GO:0051246 256 0.029
transmembrane transport GO:0055085 139 0.029
ribonucleoside triphosphate metabolic process GO:0009199 119 0.029
nucleobase containing compound catabolic process GO:0034655 165 0.029
purine ribonucleotide catabolic process GO:0009154 109 0.028
nucleoside triphosphate metabolic process GO:0009141 120 0.028
response to hexose GO:0009746 3 0.028
phosphorylation GO:0016310 294 0.028
positive regulation of multicellular organismal process GO:0051240 143 0.028
single organism intracellular transport GO:1902582 207 0.028
tissue death GO:0016271 102 0.028
gtp metabolic process GO:0046039 72 0.027
cellular catabolic process GO:0044248 372 0.027
positive regulation of response to stimulus GO:0048584 323 0.027
defense response GO:0006952 300 0.027
carbohydrate derivative metabolic process GO:1901135 217 0.027
epidermal growth factor receptor signaling pathway GO:0007173 58 0.027
lipid metabolic process GO:0006629 121 0.027
appendage morphogenesis GO:0035107 397 0.027
response to oxygen containing compound GO:1901700 200 0.026
cellular macromolecule localization GO:0070727 220 0.026
response to other organism GO:0051707 293 0.026
regulation of hydrolase activity GO:0051336 97 0.026
ribose phosphate metabolic process GO:0019693 145 0.026
positive regulation of cell communication GO:0010647 250 0.026
regulation of cell development GO:0060284 215 0.026
nitrogen compound transport GO:0071705 85 0.026
cellular response to lipopolysaccharide GO:0071222 3 0.026
regulation of molecular function GO:0065009 217 0.026
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.026
positive regulation of biosynthetic process GO:0009891 316 0.025
positive regulation of catalytic activity GO:0043085 118 0.025
oxoacid metabolic process GO:0043436 103 0.025
membrane organization GO:0061024 112 0.025
heterocycle catabolic process GO:0046700 166 0.025
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.025
ion transport GO:0006811 145 0.025
cellular ketone metabolic process GO:0042180 24 0.025
organic cyclic compound catabolic process GO:1901361 168 0.025
tissue morphogenesis GO:0048729 297 0.024
epithelial cell development GO:0002064 274 0.024
positive regulation of gtpase activity GO:0043547 43 0.024
positive regulation of molecular function GO:0044093 136 0.024
ribonucleotide catabolic process GO:0009261 109 0.024
protein transport GO:0015031 155 0.024
purine containing compound metabolic process GO:0072521 155 0.024
single organism cellular localization GO:1902580 180 0.024
regulation of cell differentiation GO:0045595 302 0.024
ribonucleoside triphosphate catabolic process GO:0009203 108 0.024
ribonucleoside catabolic process GO:0042454 112 0.024
immune response regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002433 3 0.024
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.024
protein phosphorylation GO:0006468 169 0.024
ribonucleotide metabolic process GO:0009259 145 0.024
phagocytosis recognition GO:0006910 1 0.024
regulation of erbb signaling pathway GO:1901184 42 0.023
purine nucleotide metabolic process GO:0006163 146 0.023
gland morphogenesis GO:0022612 145 0.023
phagocytosis GO:0006909 215 0.023
salivary gland morphogenesis GO:0007435 145 0.023
response to organic substance GO:0010033 284 0.023
organic substance catabolic process GO:1901575 308 0.023
positive regulation of signal transduction GO:0009967 223 0.023
salivary gland histolysis GO:0035070 88 0.023
regulation of cellular protein metabolic process GO:0032268 243 0.022
ras protein signal transduction GO:0007265 88 0.022
purine ribonucleoside metabolic process GO:0046128 127 0.022
positive regulation of cellular biosynthetic process GO:0031328 316 0.022
purine nucleoside triphosphate metabolic process GO:0009144 119 0.022
skin development GO:0043588 65 0.022
response to radiation GO:0009314 155 0.022
purine nucleoside catabolic process GO:0006152 112 0.022
developmental programmed cell death GO:0010623 138 0.022
glycosyl compound metabolic process GO:1901657 127 0.022
purine nucleotide catabolic process GO:0006195 109 0.022
catabolic process GO:0009056 409 0.022
response to external biotic stimulus GO:0043207 293 0.021
purine ribonucleotide metabolic process GO:0009150 145 0.021
negative regulation of cellular metabolic process GO:0031324 382 0.021
organonitrogen compound catabolic process GO:1901565 128 0.021
positive regulation of nervous system development GO:0051962 69 0.021
detection of chemical stimulus GO:0009593 93 0.021
compound eye development GO:0048749 307 0.021
spermatid development GO:0007286 98 0.021
nucleoside phosphate catabolic process GO:1901292 110 0.021
regulation of gtp catabolic process GO:0033124 44 0.021
purine containing compound catabolic process GO:0072523 112 0.021
enzyme linked receptor protein signaling pathway GO:0007167 179 0.021
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.021
positive regulation of ras gtpase activity GO:0032320 36 0.021
regulation of anatomical structure morphogenesis GO:0022603 242 0.021
negative regulation of erbb signaling pathway GO:1901185 29 0.021
chemical homeostasis GO:0048878 92 0.021
cell proliferation GO:0008283 299 0.020
nucleoside catabolic process GO:0009164 112 0.020
purine nucleoside triphosphate catabolic process GO:0009146 108 0.020
gland development GO:0048732 191 0.020
nucleotide metabolic process GO:0009117 161 0.020
carbohydrate derivative catabolic process GO:1901136 118 0.020
positive regulation of nucleotide metabolic process GO:0045981 55 0.020
dna metabolic process GO:0006259 227 0.020
columnar cuboidal epithelial cell development GO:0002066 249 0.020
cell motility GO:0048870 251 0.020
gtp catabolic process GO:0006184 72 0.020
sensory organ morphogenesis GO:0090596 260 0.020
cellular response to molecule of bacterial origin GO:0071219 3 0.020
rna localization GO:0006403 115 0.020
inorganic cation transmembrane transport GO:0098662 61 0.020
histolysis GO:0007559 102 0.019
defense response to bacterium GO:0042742 178 0.019
chemotaxis GO:0006935 249 0.019
purine ribonucleoside catabolic process GO:0046130 112 0.019
regulation of cellular localization GO:0060341 136 0.019
establishment of protein localization GO:0045184 163 0.019
epithelium migration GO:0090132 148 0.019
cellular response to chemical stimulus GO:0070887 199 0.019
monocarboxylic acid transport GO:0015718 3 0.019
intracellular protein transport GO:0006886 104 0.019
axonogenesis GO:0007409 290 0.019
actin cytoskeleton organization GO:0030036 206 0.019
regulation of nucleotide metabolic process GO:0006140 62 0.018
immune system process GO:0002376 347 0.018
salivary gland cell autophagic cell death GO:0035071 83 0.018
compound eye photoreceptor cell differentiation GO:0001751 140 0.018
cell division GO:0051301 248 0.018
positive regulation of hydrolase activity GO:0051345 78 0.018
purine nucleoside metabolic process GO:0042278 127 0.018
ribonucleoside metabolic process GO:0009119 127 0.018
cognition GO:0050890 141 0.017
organophosphate catabolic process GO:0046434 112 0.017
regulation of nucleotide catabolic process GO:0030811 48 0.017
cellular nitrogen compound catabolic process GO:0044270 165 0.017
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.017
central nervous system development GO:0007417 201 0.017
immune response activating signal transduction GO:0002757 2 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.017
l amino acid import GO:0043092 2 0.017
cholesterol transport GO:0030301 2 0.016
biological adhesion GO:0022610 138 0.016
regulation of small gtpase mediated signal transduction GO:0051056 93 0.016
cell adhesion GO:0007155 136 0.016
positive regulation of developmental process GO:0051094 143 0.016
body morphogenesis GO:0010171 2 0.016
regulation of nucleoside metabolic process GO:0009118 50 0.016
regulation of neurogenesis GO:0050767 158 0.016
response to light stimulus GO:0009416 124 0.016
neuron projection guidance GO:0097485 241 0.016
ovarian follicle cell development GO:0030707 248 0.016
negative regulation of biosynthetic process GO:0009890 277 0.016
regulation of neuron differentiation GO:0045664 103 0.016
forebrain development GO:0030900 2 0.016
nucleoside metabolic process GO:0009116 127 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.015
positive regulation of cell migration GO:0030335 2 0.015
positive regulation of transport GO:0051050 92 0.015
cell recognition GO:0008037 102 0.015
positive regulation of macromolecule metabolic process GO:0010604 405 0.015
regulation of nervous system development GO:0051960 248 0.015
axis specification GO:0009798 167 0.015
eggshell formation GO:0030703 105 0.015
tissue migration GO:0090130 155 0.015
organelle localization GO:0051640 148 0.015
lipid localization GO:0010876 54 0.015
immune response regulating signaling pathway GO:0002764 2 0.015
neurological system process GO:0050877 358 0.015
nucleotide catabolic process GO:0009166 109 0.015
axon guidance GO:0007411 233 0.015
nucleoside triphosphate catabolic process GO:0009143 108 0.015
compound eye morphogenesis GO:0001745 249 0.015
negative regulation of epithelial cell proliferation GO:0050680 4 0.015
regulation of protein modification process GO:0031399 112 0.014
regulation of protein localization GO:0032880 76 0.014
regulation of epithelial cell proliferation GO:0050678 4 0.014
hindbrain development GO:0030902 2 0.014
regulation of ras gtpase activity GO:0032318 38 0.014
regulation of ion transport GO:0043269 39 0.014
eye development GO:0001654 323 0.014
meiotic cell cycle process GO:1903046 132 0.014
cellular lipid metabolic process GO:0044255 83 0.014
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.014
learning or memory GO:0007611 141 0.014
negative regulation of developmental process GO:0051093 201 0.014
segmentation GO:0035282 207 0.014
positive regulation of cell development GO:0010720 61 0.014
positive regulation of cellular catabolic process GO:0031331 95 0.014
metal ion transport GO:0030001 74 0.014
chaeta development GO:0022416 97 0.014
cytokinesis GO:0000910 90 0.014
positive regulation of nucleoside metabolic process GO:0045979 47 0.014
peptide metabolic process GO:0006518 80 0.013
divalent inorganic cation transport GO:0072511 30 0.013
regulation of ras protein signal transduction GO:0046578 93 0.013
guanosine containing compound catabolic process GO:1901069 74 0.013
anion transport GO:0006820 41 0.013
regulation of protein phosphorylation GO:0001932 64 0.013
regulation of purine nucleotide metabolic process GO:1900542 62 0.013
regulation of growth GO:0040008 233 0.013
negative regulation of cellular biosynthetic process GO:0031327 277 0.013
plasma membrane organization GO:0007009 26 0.013
regulation of gtpase activity GO:0043087 44 0.013
dorsal appendage formation GO:0046843 47 0.013
negative regulation of cellular protein metabolic process GO:0032269 85 0.013
synapse organization GO:0050808 196 0.013
establishment of rna localization GO:0051236 47 0.013
eye pigmentation GO:0048069 43 0.013
immune response GO:0006955 246 0.013
innate immune response GO:0045087 144 0.013
regulation of cell death GO:0010941 173 0.013
response to monosaccharide GO:0034284 4 0.013
positive regulation of rna metabolic process GO:0051254 271 0.013
mrna metabolic process GO:0016071 124 0.012
intracellular transport GO:0046907 228 0.012
centrosome organization GO:0051297 163 0.012
chromosome organization GO:0051276 360 0.012
sterol homeostasis GO:0055092 4 0.012
regulation of synapse assembly GO:0051963 94 0.012
photoreceptor cell differentiation GO:0046530 170 0.012
cellular protein localization GO:0034613 160 0.012
neuron recognition GO:0008038 101 0.012
negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 29 0.012
regulation of cell projection organization GO:0031344 92 0.012
immune effector process GO:0002252 98 0.012
glutathione metabolic process GO:0006749 37 0.012
epithelial cell migration GO:0010631 148 0.012
acid secretion GO:0046717 1 0.012
ethanolamine containing compound metabolic process GO:0042439 4 0.012
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.012
positive regulation of cell motility GO:2000147 3 0.012
regulation of catabolic process GO:0009894 170 0.012
regulation of vesicle mediated transport GO:0060627 59 0.012
guanosine containing compound metabolic process GO:1901068 74 0.012
epidermis development GO:0008544 65 0.012
dendrite morphogenesis GO:0048813 199 0.012
memory GO:0007613 94 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.012
erbb signaling pathway GO:0038127 58 0.012
positive regulation of cellular component biogenesis GO:0044089 80 0.011
wound healing GO:0042060 75 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.011
positive regulation of nucleic acid templated transcription GO:1903508 266 0.011
regulation of cellular response to stress GO:0080135 89 0.011
head development GO:0060322 135 0.011
peptidyl amino acid modification GO:0018193 105 0.011
inorganic ion transmembrane transport GO:0098660 73 0.011
regulation of establishment of protein localization GO:0070201 61 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 46 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
medium chain fatty acid metabolic process GO:0051791 1 0.011
cellular response to organic substance GO:0071310 132 0.011
positive regulation of gene expression GO:0010628 290 0.011
regulation of programmed cell death GO:0043067 152 0.011
negative regulation of rna biosynthetic process GO:1902679 240 0.011
regulation of intracellular protein transport GO:0033157 46 0.011
chorion containing eggshell formation GO:0007304 105 0.011
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.011
olfactory behavior GO:0042048 97 0.011
sulfur compound metabolic process GO:0006790 59 0.011
developmental growth GO:0048589 280 0.011
regulation of actin filament based process GO:0032970 42 0.011
secretion GO:0046903 109 0.011
regulation of lipid transport GO:0032368 3 0.011
negative regulation of rna metabolic process GO:0051253 251 0.011
regulation of epidermal growth factor receptor signaling pathway GO:0042058 42 0.011
negative regulation of gene expression GO:0010629 387 0.011
notch signaling pathway GO:0007219 120 0.010
positive regulation of neurogenesis GO:0050769 41 0.010
cell migration GO:0016477 238 0.010
positive regulation of rna biosynthetic process GO:1902680 266 0.010
regulation of developmental growth GO:0048638 174 0.010
camera type eye development GO:0043010 4 0.010
response to glucose GO:0009749 2 0.010
nucleocytoplasmic transport GO:0006913 72 0.010
telencephalon development GO:0021537 2 0.010
positive regulation of immune response GO:0050778 63 0.010
cholesterol homeostasis GO:0042632 3 0.010
cellular response to biotic stimulus GO:0071216 4 0.010
regulation of purine nucleotide catabolic process GO:0033121 48 0.010
cellular component disassembly GO:0022411 46 0.010
establishment or maintenance of cell polarity GO:0007163 167 0.010

Best1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.048
Human
nervous system disease DOID:863 0 0.025
Human
central nervous system disease DOID:331 0 0.016
disease of metabolism DOID:0014667 0 0.012
inherited metabolic disorder DOID:655 0 0.012
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011