Drosophila melanogaster

15 known processes

Rat1 (Dmel_CG10354)

CG10354 gene product from transcript CG10354-RA

(Aliases: dhp1,RAT1,XRN2,dRAT1,CG10354,Dmel\CG10354)

Rat1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna processing GO:0006396 147 0.776
Worm
mrna metabolic process GO:0016071 124 0.614
cell division GO:0051301 248 0.283
rna splicing GO:0008380 83 0.270
mrna processing GO:0006397 104 0.249
regulation of rna splicing GO:0043484 69 0.228
regulation of cell cycle GO:0051726 291 0.224
cell death GO:0008219 279 0.197
regulation of cell cycle process GO:0010564 181 0.196
nuclear division GO:0000280 332 0.178
larval development GO:0002164 104 0.174
Worm
spindle organization GO:0007051 253 0.158
gene silencing GO:0016458 138 0.153
Worm
protein modification process GO:0036211 438 0.153
alternative mrna splicing via spliceosome GO:0000380 60 0.153
death GO:0016265 284 0.152
response to organic substance GO:0010033 284 0.144
rna splicing via transesterification reactions GO:0000375 73 0.140
embryo development ending in birth or egg hatching GO:0009792 152 0.116
Worm
organelle assembly GO:0070925 198 0.108
positive regulation of developmental growth GO:0048639 62 0.107
posttranscriptional gene silencing GO:0016441 46 0.097
Worm
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.096
regulation of cell division GO:0051302 72 0.096
cellular response to chemical stimulus GO:0070887 199 0.092
regulation of cell death GO:0010941 173 0.092
negative regulation of cell cycle process GO:0010948 109 0.092
regulation of mrna processing GO:0050684 71 0.091
organelle fission GO:0048285 340 0.090
regulation of mrna splicing via spliceosome GO:0048024 64 0.090
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.090
body morphogenesis GO:0010171 2 0.087
mitotic spindle elongation GO:0000022 81 0.085
cytokinesis GO:0000910 90 0.084
cell proliferation GO:0008283 299 0.075
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.075
macromolecule catabolic process GO:0009057 161 0.074
Worm
positive regulation of transcription dna templated GO:0045893 266 0.074
regulation of cell cycle phase transition GO:1901987 130 0.073
vesicle mediated transport GO:0016192 381 0.072
regulation of programmed cell death GO:0043067 152 0.070
growth GO:0040007 359 0.070
regulation of mrna metabolic process GO:1903311 72 0.069
positive regulation of macromolecule metabolic process GO:0010604 405 0.068
negative regulation of gene expression GO:0010629 387 0.068
Worm
meiotic cell cycle GO:0051321 171 0.067
regulation of mitotic cell cycle GO:0007346 190 0.067
negative regulation of mitotic cell cycle GO:0045930 109 0.065
mrna splicing via spliceosome GO:0000398 73 0.065
anatomical structure homeostasis GO:0060249 97 0.065
regulation of gene expression epigenetic GO:0040029 128 0.062
Worm
programmed cell death GO:0012501 257 0.062
meiotic nuclear division GO:0007126 151 0.061
organophosphate metabolic process GO:0019637 195 0.059
negative regulation of signaling GO:0023057 219 0.058
dna metabolic process GO:0006259 227 0.058
catabolic process GO:0009056 409 0.055
Worm
negative regulation of response to stimulus GO:0048585 258 0.052
axon development GO:0061564 297 0.051
intracellular signal transduction GO:0035556 300 0.050
nucleobase containing compound catabolic process GO:0034655 165 0.050
Worm
purine ribonucleoside metabolic process GO:0046128 127 0.050
response to abiotic stimulus GO:0009628 341 0.050
cellular catabolic process GO:0044248 372 0.049
Worm
cellular response to nitrogen compound GO:1901699 51 0.049
organic cyclic compound catabolic process GO:1901361 168 0.048
Worm
cell cycle phase transition GO:0044770 140 0.048
single organism biosynthetic process GO:0044711 206 0.048
aging GO:0007568 143 0.048
gonad development GO:0008406 50 0.046
regulation of meiosis GO:0040020 3 0.045
small molecule metabolic process GO:0044281 305 0.043
protein complex assembly GO:0006461 200 0.043
organonitrogen compound metabolic process GO:1901564 318 0.043
organic substance catabolic process GO:1901575 308 0.043
Worm
establishment of localization in cell GO:0051649 402 0.043
cellular response to organic substance GO:0071310 132 0.042
multi multicellular organism process GO:0044706 123 0.041
mitotic dna integrity checkpoint GO:0044774 75 0.041
protein catabolic process GO:0030163 101 0.040
positive regulation of growth GO:0045927 75 0.040
regulation of mrna 3 end processing GO:0031440 7 0.039
cellular macromolecular complex assembly GO:0034622 153 0.038
regulation of mitotic cell cycle phase transition GO:1901990 130 0.038
gene silencing by mirna GO:0035195 22 0.038
Worm
endocytosis GO:0006897 310 0.036
mitotic g2 m transition checkpoint GO:0044818 70 0.036
nucleoside triphosphate catabolic process GO:0009143 108 0.036
g2 dna damage checkpoint GO:0031572 69 0.036
positive regulation of signal transduction GO:0009967 223 0.035
regulation of dna metabolic process GO:0051052 34 0.035
protein phosphorylation GO:0006468 169 0.035
rna interference GO:0016246 27 0.034
regulation of apoptotic process GO:0042981 130 0.034
regulation of catalytic activity GO:0050790 185 0.034
posttranscriptional regulation of gene expression GO:0010608 145 0.034
Worm
cell cycle checkpoint GO:0000075 95 0.034
nucleotide catabolic process GO:0009166 109 0.034
reproductive system development GO:0061458 74 0.034
axonogenesis GO:0007409 290 0.034
apoptotic process GO:0006915 159 0.033
positive regulation of multicellular organismal process GO:0051240 143 0.033
negative regulation of cell communication GO:0010648 223 0.032
negative regulation of developmental process GO:0051093 201 0.032
carbohydrate derivative metabolic process GO:1901135 217 0.031
protein complex biogenesis GO:0070271 201 0.031
nucleoside metabolic process GO:0009116 127 0.031
development of primary sexual characteristics GO:0045137 50 0.031
response to nitrogen compound GO:1901698 90 0.030
maintenance of location GO:0051235 73 0.030
reproductive structure development GO:0048608 74 0.030
cellular protein localization GO:0034613 160 0.029
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.029
dna integrity checkpoint GO:0031570 81 0.029
cell motility GO:0048870 251 0.029
regulation of developmental growth GO:0048638 174 0.029
transcription from rna polymerase ii promoter GO:0006366 368 0.028
response to endogenous stimulus GO:0009719 119 0.028
multi organism reproductive behavior GO:0044705 121 0.028
wnt signaling pathway GO:0016055 98 0.028
positive regulation of gene expression GO:0010628 290 0.028
positive regulation of cellular component organization GO:0051130 156 0.028
cellular macromolecule catabolic process GO:0044265 136 0.028
Worm
oxoacid metabolic process GO:0043436 103 0.027
ribonucleotide metabolic process GO:0009259 145 0.027
cellular protein modification process GO:0006464 438 0.027
cellular macromolecule localization GO:0070727 220 0.027
cellular response to dna damage stimulus GO:0006974 223 0.027
dna damage checkpoint GO:0000077 78 0.027
dna replication GO:0006260 48 0.027
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.027
spindle elongation GO:0051231 83 0.027
regulation of anatomical structure morphogenesis GO:0022603 242 0.027
axon guidance GO:0007411 233 0.027
purine ribonucleotide catabolic process GO:0009154 109 0.026
purine nucleoside triphosphate metabolic process GO:0009144 119 0.026
single organism intracellular transport GO:1902582 207 0.026
posttranscriptional gene silencing by rna GO:0035194 45 0.026
Worm
regulation of phosphorus metabolic process GO:0051174 210 0.025
positive regulation of rna metabolic process GO:0051254 271 0.025
negative regulation of signal transduction GO:0009968 206 0.024
nucleoside phosphate metabolic process GO:0006753 162 0.024
localization of cell GO:0051674 257 0.024
sex differentiation GO:0007548 81 0.024
regulation of protein complex assembly GO:0043254 42 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.023
regulation of organelle organization GO:0033043 196 0.023
camera type eye development GO:0043010 4 0.023
aromatic compound catabolic process GO:0019439 166 0.022
Worm
single organism nuclear import GO:1902593 51 0.022
regionalization GO:0003002 416 0.022
negative regulation of biosynthetic process GO:0009890 277 0.022
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.022
protein localization to organelle GO:0033365 82 0.022
nucleotide excision repair GO:0006289 8 0.021
positive regulation of response to stimulus GO:0048584 323 0.021
nucleoside phosphate catabolic process GO:1901292 110 0.021
purine containing compound metabolic process GO:0072521 155 0.021
ribonucleoprotein complex subunit organization GO:0071826 28 0.021
carboxylic acid metabolic process GO:0019752 92 0.021
heterocycle catabolic process GO:0046700 166 0.021
Worm
negative regulation of cell death GO:0060548 81 0.021
mitotic cell cycle checkpoint GO:0007093 88 0.021
multicellular organismal reproductive behavior GO:0033057 110 0.021
negative regulation of rna metabolic process GO:0051253 251 0.021
intracellular transport GO:0046907 228 0.020
ribonucleoside catabolic process GO:0042454 112 0.020
protein ubiquitination GO:0016567 70 0.020
cell migration GO:0016477 238 0.020
nucleoside catabolic process GO:0009164 112 0.020
regulation of transport GO:0051049 181 0.020
protein transport GO:0015031 155 0.020
ribonucleoside metabolic process GO:0009119 127 0.020
glycosyl compound metabolic process GO:1901657 127 0.020
phagocytosis GO:0006909 215 0.019
negative regulation of cell cycle phase transition GO:1901988 103 0.019
nucleoside triphosphate metabolic process GO:0009141 120 0.019
regulation of phosphorylation GO:0042325 147 0.019
regulation of cellular component size GO:0032535 98 0.018
regulation of multicellular organismal development GO:2000026 414 0.018
Worm
stem cell differentiation GO:0048863 117 0.018
positive regulation of cellular biosynthetic process GO:0031328 316 0.018
sensory organ morphogenesis GO:0090596 260 0.018
cytoplasmic transport GO:0016482 130 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
purine nucleoside metabolic process GO:0042278 127 0.018
hematopoietic or lymphoid organ development GO:0048534 57 0.017
mitotic dna damage checkpoint GO:0044773 74 0.017
single organism catabolic process GO:0044712 228 0.017
rna 3 end processing GO:0031123 45 0.017
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.017
regulation of cell proliferation GO:0042127 163 0.017
multi organism behavior GO:0051705 175 0.017
ras protein signal transduction GO:0007265 88 0.016
negative regulation of cellular metabolic process GO:0031324 382 0.016
mitotic cell cycle phase transition GO:0044772 138 0.016
purine nucleotide metabolic process GO:0006163 146 0.016
positive regulation of signaling GO:0023056 243 0.016
establishment of organelle localization GO:0051656 122 0.016
cellular nitrogen compound catabolic process GO:0044270 165 0.016
Worm
cellular protein complex assembly GO:0043623 71 0.016
reproductive behavior GO:0019098 122 0.016
positive regulation of cell communication GO:0010647 250 0.016
purine nucleoside monophosphate metabolic process GO:0009126 50 0.016
protein modification by small protein conjugation GO:0032446 79 0.016
establishment of protein localization GO:0045184 163 0.016
negative regulation of cell cycle GO:0045786 116 0.016
purine nucleoside catabolic process GO:0006152 112 0.016
regulation of localization GO:0032879 275 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.015
protein import GO:0017038 55 0.015
protein modification by small protein conjugation or removal GO:0070647 106 0.015
regulation of nuclear division GO:0051783 58 0.015
genitalia development GO:0048806 26 0.015
positive regulation of epidermal growth factor activated receptor activity GO:0045741 1 0.015
regulation of wnt signaling pathway GO:0030111 68 0.015
response to oxygen containing compound GO:1901700 200 0.015
homeostatic process GO:0042592 199 0.015
guanosine containing compound catabolic process GO:1901069 74 0.015
purine ribonucleotide metabolic process GO:0009150 145 0.014
regulation of protein metabolic process GO:0051246 256 0.014
glycosyl compound catabolic process GO:1901658 112 0.014
regulation of cellular component biogenesis GO:0044087 201 0.014
positive regulation of rna biosynthetic process GO:1902680 266 0.014
response to oxidative stress GO:0006979 86 0.014
positive regulation of cellular component biogenesis GO:0044089 80 0.014
cellular homeostasis GO:0019725 80 0.014
interspecies interaction between organisms GO:0044419 16 0.014
response to organic cyclic compound GO:0014070 89 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
gene silencing by rna GO:0031047 57 0.014
Worm
regulation of cellular protein metabolic process GO:0032268 243 0.014
multicellular organismal aging GO:0010259 140 0.014
ribosomal large subunit biogenesis GO:0042273 1 0.014
stem cell maintenance GO:0019827 67 0.013
small gtpase mediated signal transduction GO:0007264 88 0.013
taxis GO:0042330 304 0.013
purine ribonucleoside catabolic process GO:0046130 112 0.013
mitotic spindle organization GO:0007052 220 0.013
organic acid metabolic process GO:0006082 103 0.013
purine nucleoside triphosphate catabolic process GO:0009146 108 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.013
ubiquitin dependent protein catabolic process GO:0006511 78 0.013
morphogenesis of follicular epithelium GO:0016333 36 0.013
retina development in camera type eye GO:0060041 4 0.012
cellular amine metabolic process GO:0044106 12 0.012
organic substance transport GO:0071702 257 0.012
organophosphate catabolic process GO:0046434 112 0.012
positive regulation of multicellular organism growth GO:0040018 21 0.012
cellular amino acid metabolic process GO:0006520 61 0.012
regulation of multicellular organism growth GO:0040014 40 0.012
purine nucleotide catabolic process GO:0006195 109 0.012
determination of adult lifespan GO:0008340 137 0.011
negative regulation of intracellular signal transduction GO:1902532 57 0.011
negative regulation of neurotransmitter secretion GO:0046929 2 0.011
mitotic g2 dna damage checkpoint GO:0007095 69 0.011
mrna 3 end processing GO:0031124 28 0.011
tricarboxylic acid metabolic process GO:0072350 1 0.011
kidney morphogenesis GO:0060993 3 0.011
organelle localization GO:0051640 148 0.010
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.010
dendrite development GO:0016358 204 0.010
response to dsrna GO:0043331 15 0.010
negative regulation of programmed cell death GO:0043069 72 0.010
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.010
cell cell signaling involved in cell fate commitment GO:0045168 210 0.010
axis specification GO:0009798 167 0.010

Rat1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
osteochondrodysplasia DOID:2256 0 0.018
osteogenesis imperfecta DOID:12347 0 0.018
bone development disease DOID:0080006 0 0.018
bone disease DOID:0080001 0 0.018
musculoskeletal system disease DOID:17 0 0.018
connective tissue disease DOID:65 0 0.018