Drosophila melanogaster

64 known processes

elB (Dmel_CG4220)

elbow B

(Aliases: el,el[B],BG:DS06238.3,CG4220,P10,elb,elbow,Dmel\CG4220)

elB biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
open tracheal system development GO:0007424 204 0.745
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.681
epithelial tube morphogenesis GO:0060562 88 0.662
Fly
regulation of multicellular organismal development GO:2000026 414 0.636
Human
morphogenesis of a branching epithelium GO:0061138 45 0.607
Fly
negative regulation of biosynthetic process GO:0009890 277 0.588
Human Zebrafish
negative regulation of nucleic acid templated transcription GO:1903507 240 0.559
Human Zebrafish
transcription from rna polymerase ii promoter GO:0006366 368 0.532
respiratory system development GO:0060541 213 0.524
branching involved in open tracheal system development GO:0060446 45 0.493
Fly
positive regulation of biosynthetic process GO:0009891 316 0.412
positive regulation of nucleic acid templated transcription GO:1903508 266 0.400
stem cell differentiation GO:0048863 117 0.368
morphogenesis of a branching structure GO:0001763 45 0.346
Fly
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.337
Human Zebrafish
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.333
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.317
positive regulation of transcription dna templated GO:0045893 266 0.305
circulatory system development GO:0072359 82 0.300
negative regulation of transcription dna templated GO:0045892 237 0.281
Human Zebrafish
positive regulation of rna biosynthetic process GO:1902680 266 0.268
dendrite development GO:0016358 204 0.242
negative regulation of cellular metabolic process GO:0031324 382 0.235
Human Zebrafish
negative regulation of cellular biosynthetic process GO:0031327 277 0.232
Human Zebrafish
branching morphogenesis of an epithelial tube GO:0048754 45 0.232
Fly
positive regulation of rna metabolic process GO:0051254 271 0.231
morphogenesis of an epithelium GO:0002009 276 0.224
Fly
compound eye development GO:0048749 307 0.213
regulation of cellular protein metabolic process GO:0032268 243 0.211
Zebrafish
kidney epithelium development GO:0072073 3 0.191
positive regulation of macromolecule metabolic process GO:0010604 405 0.181
Zebrafish
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.179
proteolysis GO:0006508 192 0.176
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.172
Human Zebrafish
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.170
regulation of cell proliferation GO:0042127 163 0.166
Human
sensory organ morphogenesis GO:0090596 260 0.162
stem cell development GO:0048864 79 0.157
eye antennal disc development GO:0035214 60 0.157
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.156
regulation of cell development GO:0060284 215 0.154
eye development GO:0001654 323 0.148
tube development GO:0035295 244 0.145
Fly
cell proliferation GO:0008283 299 0.143
neural precursor cell proliferation GO:0061351 75 0.132
Mouse
tissue morphogenesis GO:0048729 297 0.132
Fly
chromosome organization GO:0051276 360 0.130
Zebrafish
nephron morphogenesis GO:0072028 3 0.122
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.121
Human Zebrafish
epithelial cell differentiation GO:0030855 322 0.121
Human
regulation of cell differentiation GO:0045595 302 0.117
stem cell maintenance GO:0019827 67 0.116
dendrite morphogenesis GO:0048813 199 0.116
positive regulation of cellular component organization GO:0051130 156 0.114
Zebrafish
cell maturation GO:0048469 144 0.111
positive regulation of cellular biosynthetic process GO:0031328 316 0.111
protein complex biogenesis GO:0070271 201 0.109
nephron development GO:0072006 3 0.108
appendage development GO:0048736 401 0.106
negative regulation of rna biosynthetic process GO:1902679 240 0.105
Human Zebrafish
molting cycle GO:0042303 56 0.102
response to abiotic stimulus GO:0009628 341 0.095
positive regulation of developmental process GO:0051094 143 0.087
Human
positive regulation of gene expression GO:0010628 290 0.086
regulation of protein metabolic process GO:0051246 256 0.081
Zebrafish
gastrulation involving germ band extension GO:0010004 36 0.077
vesicle mediated transport GO:0016192 381 0.075
nephron epithelium development GO:0072009 3 0.070
limb development GO:0060173 1 0.070
dna metabolic process GO:0006259 227 0.069
regulation of response to stress GO:0080134 200 0.069
positive regulation of compound eye retinal cell programmed cell death GO:0046672 9 0.067
positive regulation of cellular protein metabolic process GO:0032270 118 0.067
Zebrafish
cellular response to fibroblast growth factor stimulus GO:0044344 10 0.065
negative regulation of cell cycle GO:0045786 116 0.064
epithelial cell migration GO:0010631 148 0.063
positive regulation of protein metabolic process GO:0051247 128 0.062
Zebrafish
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.061
cellular protein modification process GO:0006464 438 0.060
Zebrafish
brain development GO:0007420 120 0.059
Zebrafish Fly
cell division GO:0051301 248 0.059
macromolecular complex assembly GO:0065003 256 0.057
protein modification process GO:0036211 438 0.057
Zebrafish
regulation of steroid metabolic process GO:0019218 2 0.056
regulation of cellular ketone metabolic process GO:0010565 3 0.055
negative regulation of signaling GO:0023057 219 0.054
kidney development GO:0001822 3 0.054
programmed cell death GO:0012501 257 0.053
regulation of protein modification process GO:0031399 112 0.052
Zebrafish
ovarian follicle cell development GO:0030707 248 0.051
rna splicing via transesterification reactions GO:0000375 73 0.050
negative regulation of smoothened signaling pathway GO:0045879 16 0.050
small gtpase mediated signal transduction GO:0007264 88 0.050
taxis GO:0042330 304 0.049
regulation of transport GO:0051049 181 0.049
negative regulation of response to stimulus GO:0048585 258 0.049
connective tissue development GO:0061448 3 0.049
urogenital system development GO:0001655 72 0.049
regulation of chromosome organization GO:0033044 64 0.048
Zebrafish
cellular ketone metabolic process GO:0042180 24 0.047
chromatin organization GO:0006325 207 0.046
Zebrafish
purine ribonucleotide catabolic process GO:0009154 109 0.046
mrna splicing via spliceosome GO:0000398 73 0.045
macromolecule deacylation GO:0098732 11 0.045
Zebrafish
regulation of anatomical structure morphogenesis GO:0022603 242 0.045
regulation of cellular amino acid metabolic process GO:0006521 0 0.044
endocytosis GO:0006897 310 0.043
nucleoside metabolic process GO:0009116 127 0.043
embryonic organ development GO:0048568 50 0.042
Zebrafish
cellular response to extracellular stimulus GO:0031668 64 0.041
skin development GO:0043588 65 0.041
bmp signaling pathway GO:0030509 27 0.041
positive regulation of signal transduction GO:0009967 223 0.041
positive regulation of multicellular organismal process GO:0051240 143 0.041
Human
kidney morphogenesis GO:0060993 3 0.040
cellular response to organic substance GO:0071310 132 0.040
Human
positive regulation of programmed cell death GO:0043068 62 0.039
protein complex assembly GO:0006461 200 0.038
organonitrogen compound metabolic process GO:1901564 318 0.038
imaginal disc derived wing vein specification GO:0007474 48 0.037
genital disc development GO:0035215 44 0.037
regulation of intracellular signal transduction GO:1902531 236 0.037
glycosyl compound metabolic process GO:1901657 127 0.037
negative regulation of molecular function GO:0044092 51 0.037
ion transport GO:0006811 145 0.037
cellular response to chemical stimulus GO:0070887 199 0.036
Human
positive regulation of cell communication GO:0010647 250 0.036
rna splicing GO:0008380 83 0.036
intracellular signal transduction GO:0035556 300 0.035
epithelial cell development GO:0002064 274 0.035
regulation of cellular response to growth factor stimulus GO:0090287 13 0.035
Human
histone modification GO:0016570 106 0.035
Zebrafish
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.034
oocyte development GO:0048599 124 0.034
neuron projection guidance GO:0097485 241 0.034
developmental maturation GO:0021700 172 0.034
cellular response to growth factor stimulus GO:0071363 30 0.034
Human
response to endogenous stimulus GO:0009719 119 0.033
Human
endodermal cell differentiation GO:0035987 3 0.033
amine metabolic process GO:0009308 12 0.033
compound eye morphogenesis GO:0001745 249 0.032
cellular macromolecule localization GO:0070727 220 0.032
regulation of organelle organization GO:0033043 196 0.032
Zebrafish
negative regulation of gene expression GO:0010629 387 0.032
chemotaxis GO:0006935 249 0.032
oxoacid metabolic process GO:0043436 103 0.032
embryonic heart tube development GO:0035050 22 0.032
renal tubule development GO:0061326 64 0.031
regulation of hydrolase activity GO:0051336 97 0.031
death GO:0016265 284 0.031
positive regulation of catalytic activity GO:0043085 118 0.031
small molecule metabolic process GO:0044281 305 0.030
cranial nerve development GO:0021545 1 0.030
forebrain development GO:0030900 2 0.030
anterior posterior pattern specification GO:0009952 136 0.029
immune response GO:0006955 246 0.029
mitotic nuclear division GO:0007067 213 0.029
positive regulation of cell death GO:0010942 69 0.029
organelle assembly GO:0070925 198 0.029
smoothened signaling pathway GO:0007224 49 0.029
epithelial cell morphogenesis GO:0003382 25 0.029
regulation of cellular amine metabolic process GO:0033238 3 0.028
regulation of localization GO:0032879 275 0.028
spiracle morphogenesis open tracheal system GO:0035277 22 0.028
embryonic hindgut morphogenesis GO:0048619 48 0.028
regulation of molecular function GO:0065009 217 0.027
regulation of programmed cell death GO:0043067 152 0.027
actin cytoskeleton organization GO:0030036 206 0.026
phosphorylation GO:0016310 294 0.026
developmental growth GO:0048589 280 0.026
imaginal disc derived appendage development GO:0048737 399 0.026
positive regulation of cellular component biogenesis GO:0044089 80 0.026
axon guidance GO:0007411 233 0.026
eye photoreceptor cell differentiation GO:0001754 145 0.026
regulation of anatomical structure size GO:0090066 163 0.026
positive regulation of signaling GO:0023056 243 0.026
negative regulation of cell communication GO:0010648 223 0.026
covalent chromatin modification GO:0016569 106 0.025
Zebrafish
regulation of cell morphogenesis GO:0022604 163 0.025
response to organic substance GO:0010033 284 0.025
Human
organic substance transport GO:0071702 257 0.025
organic acid metabolic process GO:0006082 103 0.024
nitrogen compound transport GO:0071705 85 0.024
regulation of cell death GO:0010941 173 0.024
negative regulation of rna metabolic process GO:0051253 251 0.024
Human Zebrafish
rho protein signal transduction GO:0007266 14 0.024
response to fibroblast growth factor GO:0071774 10 0.024
purine nucleoside triphosphate catabolic process GO:0009146 108 0.024
regulation of vesicle mediated transport GO:0060627 59 0.023
regionalization GO:0003002 416 0.023
protein modification by small protein conjugation or removal GO:0070647 106 0.023
nephron epithelium morphogenesis GO:0072088 3 0.023
epidermal cell differentiation GO:0009913 51 0.023
defense response GO:0006952 300 0.023
negative regulation of developmental process GO:0051093 201 0.023
ras protein signal transduction GO:0007265 88 0.022
renal system development GO:0072001 72 0.022
positive regulation of cell differentiation GO:0045597 64 0.022
ribonucleoside catabolic process GO:0042454 112 0.022
single organism behavior GO:0044708 391 0.022
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.022
positive regulation of molecular function GO:0044093 136 0.022
regulation of neuron differentiation GO:0045664 103 0.021
limb morphogenesis GO:0035108 1 0.021
regulation of immune system process GO:0002682 176 0.021
regulation of rho protein signal transduction GO:0035023 20 0.021
phagocytosis GO:0006909 215 0.021
regulation of bmp signaling pathway GO:0030510 23 0.021
negative regulation of cellular protein metabolic process GO:0032269 85 0.021
carbohydrate derivative metabolic process GO:1901135 217 0.021
organ induction GO:0001759 3 0.021
ocellus development GO:0008056 4 0.021
Fly
regulation of small gtpase mediated signal transduction GO:0051056 93 0.021
epithelial cell migration open tracheal system GO:0007427 32 0.020
cellular homeostasis GO:0019725 80 0.020
single organism biosynthetic process GO:0044711 206 0.020
hemopoiesis GO:0030097 46 0.020
regulation of phosphorus metabolic process GO:0051174 210 0.020
retinal cell programmed cell death GO:0046666 25 0.020
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.020
regulation of peptidase activity GO:0052547 39 0.019
regulation of proteolysis GO:0030162 87 0.019
regulation of growth GO:0040008 233 0.019
regulation of phosphate metabolic process GO:0019220 210 0.019
skeletal muscle adaptation GO:0043501 1 0.019
regulation of smoothened signaling pathway GO:0008589 28 0.019
myotube cell development GO:0014904 3 0.019
regulation of mrna splicing via spliceosome GO:0048024 64 0.019
endodermal cell fate commitment GO:0001711 3 0.019
axon development GO:0061564 297 0.018
organ growth GO:0035265 56 0.018
stem cell proliferation GO:0072089 88 0.018
maintenance of location GO:0051235 73 0.018
regulation of dendrite development GO:0050773 37 0.018
regulation of cell shape GO:0008360 113 0.018
cuticle development GO:0042335 86 0.017
alternative mrna splicing via spliceosome GO:0000380 60 0.017
pattern recognition receptor signaling pathway GO:0002221 2 0.017
photoreceptor cell differentiation GO:0046530 170 0.017
post embryonic appendage morphogenesis GO:0035120 385 0.017
negative regulation of signal transduction GO:0009968 206 0.017
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.017
organic substance catabolic process GO:1901575 308 0.017
specification of organ identity GO:0010092 3 0.016
regulation of neuron projection development GO:0010975 69 0.016
branch fusion open tracheal system GO:0035147 17 0.016
regulation of myotube differentiation GO:0010830 6 0.016
regulation of ras protein signal transduction GO:0046578 93 0.016
negative regulation of protein metabolic process GO:0051248 85 0.016
appendage morphogenesis GO:0035107 397 0.016
regulation of secretion by cell GO:1903530 39 0.016
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.016
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.016
single organism cell adhesion GO:0098602 47 0.016
cell death GO:0008219 279 0.016
synaptic transmission GO:0007268 288 0.016
purine containing compound catabolic process GO:0072523 112 0.016
positive regulation of transport GO:0051050 92 0.016
cellular protein localization GO:0034613 160 0.016
ribonucleoside triphosphate catabolic process GO:0009203 108 0.016
cellular response to endogenous stimulus GO:0071495 80 0.015
Human
purine ribonucleoside catabolic process GO:0046130 112 0.015
mesodermal cell fate specification GO:0007501 2 0.015
tube morphogenesis GO:0035239 191 0.015
Fly
positive regulation of cell proliferation GO:0008284 47 0.015
Human
mrna processing GO:0006397 104 0.015
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.015
Human Zebrafish
chaeta development GO:0022416 97 0.015
nucleobase containing small molecule metabolic process GO:0055086 174 0.015
nucleotide catabolic process GO:0009166 109 0.015
cellular transition metal ion homeostasis GO:0046916 9 0.015
inorganic ion transmembrane transport GO:0098660 73 0.015
response to other organism GO:0051707 293 0.015
nephron tubule morphogenesis GO:0072078 3 0.015
hindgut development GO:0061525 58 0.015
outflow tract morphogenesis GO:0003151 4 0.014
cuticle pigmentation GO:0048067 22 0.014
regulation of cell division GO:0051302 72 0.014
regulation of protein kinase activity GO:0045859 51 0.014
regulation of organ formation GO:0003156 3 0.014
regulation of neurogenesis GO:0050767 158 0.014
nucleoside catabolic process GO:0009164 112 0.014
oocyte differentiation GO:0009994 145 0.014
establishment of localization in cell GO:0051649 402 0.014
positive regulation of protein modification process GO:0031401 58 0.014
Zebrafish
eye morphogenesis GO:0048592 260 0.014
positive regulation of histone deacetylation GO:0031065 2 0.014
Zebrafish
stem cell division GO:0017145 69 0.014
positive regulation of lipid metabolic process GO:0045834 4 0.014
ribonucleoside triphosphate metabolic process GO:0009199 119 0.014
aging GO:0007568 143 0.014
organophosphate metabolic process GO:0019637 195 0.013
synaptic vesicle localization GO:0097479 53 0.013
heart development GO:0007507 82 0.013
cellular amine metabolic process GO:0044106 12 0.013
intracellular transport GO:0046907 228 0.013
mrna metabolic process GO:0016071 124 0.013
histone deacetylation GO:0016575 9 0.013
Zebrafish
response to bacterium GO:0009617 198 0.013
jak stat cascade GO:0007259 49 0.013
body morphogenesis GO:0010171 2 0.013
cellular nitrogen compound catabolic process GO:0044270 165 0.013
inorganic cation transmembrane transport GO:0098662 61 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
protein phosphorylation GO:0006468 169 0.013
purine ribonucleoside metabolic process GO:0046128 127 0.013
compound eye retinal cell programmed cell death GO:0046667 23 0.013
carboxylic acid metabolic process GO:0019752 92 0.013
regulation of stem cell proliferation GO:0072091 40 0.013
reproductive system development GO:0061458 74 0.013
mesenchymal cell development GO:0014031 1 0.013
protein modification by small protein conjugation GO:0032446 79 0.012
homeostatic process GO:0042592 199 0.012
chemical homeostasis GO:0048878 92 0.012
glycosyl compound catabolic process GO:1901658 112 0.012
regulation of developmental pigmentation GO:0048070 24 0.012
regulation of histone modification GO:0031056 20 0.012
Zebrafish
regulation of lipid biosynthetic process GO:0046890 6 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
cardiovascular system development GO:0072358 82 0.012
gastrulation GO:0007369 70 0.012
digestive tract development GO:0048565 149 0.012
muscle tissue development GO:0060537 30 0.012
positive regulation of secretion GO:0051047 22 0.012
purine nucleoside metabolic process GO:0042278 127 0.012
peptidyl amino acid modification GO:0018193 105 0.012
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.012
gastrulation with mouth forming first GO:0001703 36 0.012
cell fate specification GO:0001708 71 0.012
positive regulation of organelle organization GO:0010638 65 0.012
Zebrafish
central nervous system development GO:0007417 201 0.012
Zebrafish Fly
hematopoietic progenitor cell differentiation GO:0002244 1 0.012
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.012
immune system development GO:0002520 57 0.011
positive regulation of proteolysis GO:0045862 52 0.011
negative regulation of cell proliferation GO:0008285 69 0.011
Human
positive regulation of rho gtpase activity GO:0032321 19 0.011
regulation of kinase activity GO:0043549 53 0.011
imaginal disc derived wing morphogenesis GO:0007476 337 0.011
blastoderm segmentation GO:0007350 159 0.011
positive regulation of hydrolase activity GO:0051345 78 0.011
regulation of chromatin modification GO:1903308 28 0.011
Zebrafish
nucleoside phosphate catabolic process GO:1901292 110 0.011
apoptotic process GO:0006915 159 0.011
cell migration GO:0016477 238 0.011
endoderm formation GO:0001706 3 0.011
posttranscriptional regulation of gene expression GO:0010608 145 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
regulation of embryonic development GO:0045995 68 0.011
skeletal muscle fiber development GO:0048741 3 0.011
positive regulation of intracellular signal transduction GO:1902533 116 0.011
male genitalia development GO:0030539 19 0.011
antennal joint development GO:0048098 5 0.011
single organism membrane organization GO:0044802 93 0.011
cellular response to monosaccharide stimulus GO:0071326 2 0.011
regulation of muscle cell differentiation GO:0051147 8 0.011
metal ion transport GO:0030001 74 0.011
response to glucose GO:0009749 2 0.011
lipid metabolic process GO:0006629 121 0.011
embryonic pattern specification GO:0009880 174 0.010
regulation of epidermal cell differentiation GO:0045604 3 0.010
anterior malpighian tubule development GO:0061327 12 0.010
somatic muscle development GO:0007525 66 0.010
wnt signaling pathway GO:0016055 98 0.010
tube fusion GO:0035146 17 0.010
cellular component assembly involved in morphogenesis GO:0010927 151 0.010
tissue migration GO:0090130 155 0.010

elB disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
disease of cellular proliferation DOID:14566 0 0.029
nervous system disease DOID:863 0 0.019
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.014
cardiovascular system disease DOID:1287 0 0.014
vascular disease DOID:178 0 0.013