Drosophila melanogaster

8 known processes

HP4 (Dmel_CG8044)

Heterochromatin protein 4

(Aliases: BcDNA:GM01628,CG8044,Hip,hip,Dmel\CG8044)

HP4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.748
negative regulation of rna metabolic process GO:0051253 251 0.617
negative regulation of gene expression GO:0010629 387 0.552
negative regulation of cellular biosynthetic process GO:0031327 277 0.490
negative regulation of biosynthetic process GO:0009890 277 0.472
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.412
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.402
chromosome organization GO:0051276 360 0.371
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.353
negative regulation of gene expression epigenetic GO:0045814 77 0.341
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.341
chromatin silencing GO:0006342 76 0.326
regulation of gene expression epigenetic GO:0040029 128 0.310
positive regulation of cellular biosynthetic process GO:0031328 316 0.298
positive regulation of nucleic acid templated transcription GO:1903508 266 0.272
negative regulation of rna biosynthetic process GO:1902679 240 0.271
gene silencing GO:0016458 138 0.262
negative regulation of cellular metabolic process GO:0031324 382 0.212
chromatin organization GO:0006325 207 0.197
positive regulation of rna metabolic process GO:0051254 271 0.197
positive regulation of rna biosynthetic process GO:1902680 266 0.182
macromolecular complex assembly GO:0065003 256 0.176
positive regulation of gene expression GO:0010628 290 0.172
positive regulation of transcription dna templated GO:0045893 266 0.168
defense response to other organism GO:0098542 225 0.157
negative regulation of nucleic acid templated transcription GO:1903507 240 0.147
response to other organism GO:0051707 293 0.143
negative regulation of transcription dna templated GO:0045892 237 0.132
positive regulation of biosynthetic process GO:0009891 316 0.132
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.129
defense response to bacterium GO:0042742 178 0.127
response to bacterium GO:0009617 198 0.126
response to biotic stimulus GO:0009607 294 0.124
positive regulation of macromolecule metabolic process GO:0010604 405 0.114
chromatin assembly or disassembly GO:0006333 52 0.104
dna metabolic process GO:0006259 227 0.089
regionalization GO:0003002 416 0.086
response to external biotic stimulus GO:0043207 293 0.086
cellular macromolecular complex assembly GO:0034622 153 0.086
chromatin modification GO:0016568 147 0.086
regulation of cellular component biogenesis GO:0044087 201 0.085
protein complex biogenesis GO:0070271 201 0.085
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.083
cell proliferation GO:0008283 299 0.081
mrna processing GO:0006397 104 0.079
transcription from rna polymerase ii promoter GO:0006366 368 0.079
positive regulation of response to stimulus GO:0048584 323 0.079
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.073
death GO:0016265 284 0.067
protein dna complex subunit organization GO:0071824 86 0.066
dna conformation change GO:0071103 105 0.065
covalent chromatin modification GO:0016569 106 0.065
regulation of chromatin silencing GO:0031935 36 0.063
catabolic process GO:0009056 409 0.062
rna processing GO:0006396 147 0.061
regulation of immune system process GO:0002682 176 0.061
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.060
immune response GO:0006955 246 0.057
rna splicing GO:0008380 83 0.055
defense response to gram negative bacterium GO:0050829 94 0.054
negative regulation of response to stimulus GO:0048585 258 0.054
defense response GO:0006952 300 0.053
mrna metabolic process GO:0016071 124 0.052
anatomical structure homeostasis GO:0060249 97 0.050
histone modification GO:0016570 106 0.050
neurological system process GO:0050877 358 0.049
regulation of response to stress GO:0080134 200 0.049
immune system process GO:0002376 347 0.048
positive regulation of signal transduction GO:0009967 223 0.047
imaginal disc derived appendage morphogenesis GO:0035114 395 0.046
enzyme linked receptor protein signaling pathway GO:0007167 179 0.046
rna interference GO:0016246 27 0.045
protein complex assembly GO:0006461 200 0.044
regulation of immune response GO:0050776 118 0.043
atp dependent chromatin remodeling GO:0043044 22 0.043
positive regulation of cell communication GO:0010647 250 0.043
protein dna complex assembly GO:0065004 63 0.042
regulation of growth GO:0040008 233 0.042
cellular protein modification process GO:0006464 438 0.042
appendage morphogenesis GO:0035107 397 0.040
chromatin assembly GO:0031497 48 0.039
rna splicing via transesterification reactions GO:0000375 73 0.038
mrna splicing via spliceosome GO:0000398 73 0.038
spindle organization GO:0007051 253 0.037
nucleosome organization GO:0034728 59 0.037
growth GO:0040007 359 0.037
heterochromatin organization GO:0070828 25 0.036
cell death GO:0008219 279 0.036
regulation of mrna splicing via spliceosome GO:0048024 64 0.036
chromatin remodeling GO:0006338 72 0.034
regulation of gene silencing GO:0060968 63 0.034
regulation of organelle organization GO:0033043 196 0.033
response to organic substance GO:0010033 284 0.033
apoptotic process GO:0006915 159 0.031
negative regulation of cell communication GO:0010648 223 0.031
programmed cell death GO:0012501 257 0.031
dendrite development GO:0016358 204 0.030
intracellular transport GO:0046907 228 0.030
regulation of multicellular organismal development GO:2000026 414 0.030
appendage development GO:0048736 401 0.028
dorsal ventral pattern formation GO:0009953 133 0.028
microtubule organizing center organization GO:0031023 168 0.028
cellular amino acid metabolic process GO:0006520 61 0.027
dna packaging GO:0006323 91 0.027
peptidyl amino acid modification GO:0018193 105 0.026
body morphogenesis GO:0010171 2 0.026
single organism behavior GO:0044708 391 0.025
mitotic spindle organization GO:0007052 220 0.025
regulation of cellular localization GO:0060341 136 0.025
positive regulation of signaling GO:0023056 243 0.025
regulation of innate immune response GO:0045088 71 0.024
regulation of cell proliferation GO:0042127 163 0.024
regulation of cell cycle GO:0051726 291 0.024
organelle assembly GO:0070925 198 0.024
positive regulation of cellular amine metabolic process GO:0033240 0 0.023
muscle structure development GO:0061061 224 0.023
regulation of mrna processing GO:0050684 71 0.023
homeostatic process GO:0042592 199 0.022
pole plasm oskar mrna localization GO:0045451 46 0.021
regulation of defense response GO:0031347 102 0.020
dendrite morphogenesis GO:0048813 199 0.020
regulation of cellular ketone metabolic process GO:0010565 3 0.020
organic substance catabolic process GO:1901575 308 0.020
innate immune response GO:0045087 144 0.020
establishment of localization in cell GO:0051649 402 0.020
regulation of apoptotic process GO:0042981 130 0.020
centrosome cycle GO:0007098 137 0.019
carboxylic acid metabolic process GO:0019752 92 0.019
embryo development ending in birth or egg hatching GO:0009792 152 0.019
response to nitrogen compound GO:1901698 90 0.019
organonitrogen compound metabolic process GO:1901564 318 0.019
histone methylation GO:0016571 40 0.019
developmental programmed cell death GO:0010623 138 0.019
organic substance transport GO:0071702 257 0.018
negative regulation of cellular protein metabolic process GO:0032269 85 0.018
regulation of protein metabolic process GO:0051246 256 0.018
cellular response to dna damage stimulus GO:0006974 223 0.018
regulation of cell differentiation GO:0045595 302 0.018
negative regulation of signaling GO:0023057 219 0.017
imaginal disc derived wing morphogenesis GO:0007476 337 0.017
organic acid metabolic process GO:0006082 103 0.017
intracellular signal transduction GO:0035556 300 0.017
post embryonic appendage morphogenesis GO:0035120 385 0.016
negative regulation of cellular component organization GO:0051129 108 0.016
positive regulation of defense response GO:0031349 59 0.016
regulation of transcription by chromatin organization GO:0034401 3 0.016
developmental growth GO:0048589 280 0.016
salivary gland morphogenesis GO:0007435 145 0.015
negative regulation of signal transduction GO:0009968 206 0.015
protein localization GO:0008104 284 0.015
organelle fission GO:0048285 340 0.015
small molecule metabolic process GO:0044281 305 0.015
oxoacid metabolic process GO:0043436 103 0.014
rna localization GO:0006403 115 0.014
chromatin silencing at centromere GO:0030702 3 0.014
gland morphogenesis GO:0022612 145 0.014
organic cyclic compound catabolic process GO:1901361 168 0.014
cellular protein complex assembly GO:0043623 71 0.014
muscle organ development GO:0007517 127 0.014
aromatic compound catabolic process GO:0019439 166 0.014
respiratory system development GO:0060541 213 0.014
regulation of cellular response to stress GO:0080135 89 0.013
protein modification process GO:0036211 438 0.013
regulation of cellular protein metabolic process GO:0032268 243 0.013
sex differentiation GO:0007548 81 0.013
macromolecule catabolic process GO:0009057 161 0.013
imaginal disc derived appendage development GO:0048737 399 0.013
gland development GO:0048732 191 0.013
cellular catabolic process GO:0044248 372 0.013
centrosome organization GO:0051297 163 0.013
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.013
positive regulation of immune response GO:0050778 63 0.013
regulation of protein modification process GO:0031399 112 0.013
regulation of cell death GO:0010941 173 0.013
posttranscriptional gene silencing by rna GO:0035194 45 0.013
regulation of rna splicing GO:0043484 69 0.013
negative regulation of organelle organization GO:0010639 56 0.013
regulation of cellular amine metabolic process GO:0033238 3 0.012
methylation GO:0032259 47 0.012
cellular macromolecule localization GO:0070727 220 0.012
histone exchange GO:0043486 21 0.012
cellular response to organic substance GO:0071310 132 0.012
salivary gland cell autophagic cell death GO:0035071 83 0.012
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.012
exocrine system development GO:0035272 162 0.012
regulation of programmed cell death GO:0043067 152 0.012
developmental maturation GO:0021700 172 0.012
cytoplasmic transport GO:0016482 130 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
positive regulation of apoptotic signaling pathway GO:2001235 4 0.011
sequestering of calcium ion GO:0051208 5 0.011
regulation of localization GO:0032879 275 0.011
nucleobase containing compound catabolic process GO:0034655 165 0.011
heterocycle catabolic process GO:0046700 166 0.011
cellular amine metabolic process GO:0044106 12 0.011
regulation of molecular function GO:0065009 217 0.011
endocytosis GO:0006897 310 0.010

HP4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org