Drosophila melanogaster

32 known processes

kuk (Dmel_CG5175)

kugelkern

(Aliases: char,CG5175,Kuk,Dmel\CG5175,kuk/char)

kuk biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of nucleic acid templated transcription GO:1903508 266 0.687
negative regulation of biosynthetic process GO:0009890 277 0.477
positive regulation of rna metabolic process GO:0051254 271 0.380
negative regulation of gene expression GO:0010629 387 0.352
positive regulation of macromolecule metabolic process GO:0010604 405 0.334
regulation of cellular protein metabolic process GO:0032268 243 0.309
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.302
positive regulation of rna biosynthetic process GO:1902680 266 0.299
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.291
transcription from rna polymerase ii promoter GO:0006366 368 0.276
regulation of protein metabolic process GO:0051246 256 0.256
positive regulation of transcription dna templated GO:0045893 266 0.253
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.240
negative regulation of cellular biosynthetic process GO:0031327 277 0.195
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.190
negative regulation of cell cycle GO:0045786 116 0.182
positive regulation of gene expression GO:0010628 290 0.170
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.157
camera type eye development GO:0043010 4 0.154
regulation of cell cycle process GO:0010564 181 0.153
positive regulation of cellular biosynthetic process GO:0031328 316 0.150
negative regulation of rna metabolic process GO:0051253 251 0.136
metaphase anaphase transition of cell cycle GO:0044784 28 0.133
response to abiotic stimulus GO:0009628 341 0.132
negative regulation of cell cycle phase transition GO:1901988 103 0.126
chromatin assembly or disassembly GO:0006333 52 0.126
regulation of mitotic cell cycle phase transition GO:1901990 130 0.121
protein import into nucleus GO:0006606 51 0.119
embryonic morphogenesis GO:0048598 206 0.114
macromolecular complex assembly GO:0065003 256 0.113
mitotic cell cycle checkpoint GO:0007093 88 0.113
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.113
lateral inhibition GO:0046331 206 0.111
regulation of cell cycle phase transition GO:1901987 130 0.104
single organism behavior GO:0044708 391 0.092
negative regulation of rna biosynthetic process GO:1902679 240 0.092
intracellular transport GO:0046907 228 0.090
nucleocytoplasmic transport GO:0006913 72 0.089
regulation of sister chromatid segregation GO:0033045 28 0.085
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.083
chromosome organization GO:0051276 360 0.082
regulation of chromosome organization GO:0033044 64 0.079
chromatin organization GO:0006325 207 0.078
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.078
regulation of cell cycle GO:0051726 291 0.075
negative regulation of cellular metabolic process GO:0031324 382 0.075
chromosome separation GO:0051304 42 0.074
death GO:0016265 284 0.074
regulation of cellular localization GO:0060341 136 0.073
proteolysis GO:0006508 192 0.072
positive regulation of biosynthetic process GO:0009891 316 0.070
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.067
retina development in camera type eye GO:0060041 4 0.066
programmed cell death GO:0012501 257 0.064
cell cycle checkpoint GO:0000075 95 0.064
nuclear transport GO:0051169 72 0.063
circulatory system development GO:0072359 82 0.063
positive regulation of response to stimulus GO:0048584 323 0.061
morphogenesis of an epithelium GO:0002009 276 0.058
regulation of chromatin modification GO:1903308 28 0.056
regulation of response to stress GO:0080134 200 0.055
regulation of meiosis GO:0040020 3 0.054
tube morphogenesis GO:0035239 191 0.054
cytoplasmic transport GO:0016482 130 0.054
positive regulation of cellular protein metabolic process GO:0032270 118 0.052
muscle structure development GO:0061061 224 0.052
nuclear import GO:0051170 51 0.051
chromatin modification GO:0016568 147 0.049
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.048
negative regulation of growth GO:0045926 84 0.048
rna splicing GO:0008380 83 0.048
positive regulation of programmed cell death GO:0043068 62 0.046
regulation of cell division GO:0051302 72 0.045
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.045
taxis GO:0042330 304 0.045
regulation of intracellular signal transduction GO:1902531 236 0.042
enzyme linked receptor protein signaling pathway GO:0007167 179 0.041
cell division GO:0051301 248 0.041
meiosis i GO:0007127 59 0.041
hematopoietic or lymphoid organ development GO:0048534 57 0.040
negative regulation of cell cycle process GO:0010948 109 0.039
digestive tract development GO:0048565 149 0.039
spinal cord development GO:0021510 1 0.039
cell death GO:0008219 279 0.039
protein acetylation GO:0006473 39 0.038
cardiovascular system development GO:0072358 82 0.037
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.036
mitotic cell cycle phase transition GO:0044772 138 0.035
positive regulation of protein modification process GO:0031401 58 0.035
response to oxidative stress GO:0006979 86 0.035
regulation of mitotic sister chromatid segregation GO:0033047 28 0.035
protein localization GO:0008104 284 0.035
regulation of organelle organization GO:0033043 196 0.034
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.034
tube development GO:0035295 244 0.034
positive regulation of signaling GO:0023056 243 0.033
camera type eye morphogenesis GO:0048593 2 0.033
chromatin remodeling GO:0006338 72 0.033
regulation of mitotic sister chromatid separation GO:0010965 28 0.033
larval development GO:0002164 104 0.032
regulation of protein modification process GO:0031399 112 0.032
regulation of transport GO:0051049 181 0.032
negative regulation of nucleic acid templated transcription GO:1903507 240 0.032
regulation of mitosis GO:0007088 56 0.031
negative regulation of transcription dna templated GO:0045892 237 0.031
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.030
central nervous system development GO:0007417 201 0.029
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.029
cellular macromolecular complex assembly GO:0034622 153 0.029
negative regulation of organelle organization GO:0010639 56 0.029
positive regulation of cellular component organization GO:0051130 156 0.028
regulation of nuclear division GO:0051783 58 0.028
single organism nuclear import GO:1902593 51 0.027
negative regulation of cellular protein metabolic process GO:0032269 85 0.027
regulation of cellular response to stress GO:0080135 89 0.027
mitotic nuclear division GO:0007067 213 0.027
nuclear export GO:0051168 24 0.026
response to organic substance GO:0010033 284 0.026
single organism intracellular transport GO:1902582 207 0.025
posttranscriptional regulation of gene expression GO:0010608 145 0.025
regulation of mitotic cell cycle GO:0007346 190 0.025
cell cycle arrest GO:0007050 4 0.024
mitotic g2 dna damage checkpoint GO:0007095 69 0.024
positive regulation of cell death GO:0010942 69 0.024
response to endogenous stimulus GO:0009719 119 0.023
head development GO:0060322 135 0.022
body morphogenesis GO:0010171 2 0.022
negative regulation of response to stimulus GO:0048585 258 0.022
regulation of catalytic activity GO:0050790 185 0.021
embryo development ending in birth or egg hatching GO:0009792 152 0.021
cellular ketone metabolic process GO:0042180 24 0.020
formation of a compartment boundary GO:0060288 4 0.020
dna damage checkpoint GO:0000077 78 0.020
protein complex biogenesis GO:0070271 201 0.020
positive regulation of rho protein signal transduction GO:0035025 4 0.020
response to oxygen containing compound GO:1901700 200 0.019
regulation of protein localization GO:0032880 76 0.019
protein localization to nucleus GO:0034504 55 0.019
positive regulation of phosphorus metabolic process GO:0010562 139 0.019
rna processing GO:0006396 147 0.019
regulation of gene expression epigenetic GO:0040029 128 0.019
positive regulation of cell communication GO:0010647 250 0.018
tissue morphogenesis GO:0048729 297 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.018
mitotic sister chromatid separation GO:0051306 30 0.018
regulation of multicellular organismal development GO:2000026 414 0.018
positive regulation of signal transduction GO:0009967 223 0.018
regulation of intracellular protein transport GO:0033157 46 0.018
dna metabolic process GO:0006259 227 0.017
cell proliferation GO:0008283 299 0.017
positive regulation of proteolysis GO:0045862 52 0.017
positive regulation of protein metabolic process GO:0051247 128 0.017
negative regulation of mitotic cell cycle GO:0045930 109 0.017
digestive tract morphogenesis GO:0048546 127 0.017
catabolic process GO:0009056 409 0.017
epithelial tube morphogenesis GO:0060562 88 0.017
dorsal ventral pattern formation GO:0009953 133 0.016
dendrite morphogenesis GO:0048813 199 0.016
peptidyl amino acid modification GO:0018193 105 0.016
signal transduction in response to dna damage GO:0042770 3 0.016
regulation of chromatin organization GO:1902275 32 0.016
digestive system development GO:0055123 149 0.016
single organism catabolic process GO:0044712 228 0.015
cell recognition GO:0008037 102 0.015
cell chemotaxis involved in malpighian tubule morphogenesis GO:0061352 3 0.015
regulation of cell death GO:0010941 173 0.015
regulation of cell proliferation GO:0042127 163 0.015
epithelial cell development GO:0002064 274 0.015
protein dna complex assembly GO:0065004 63 0.015
positive regulation of phosphate metabolic process GO:0045937 139 0.015
protein targeting to nucleus GO:0044744 51 0.015
negative regulation of protein metabolic process GO:0051248 85 0.015
regulation of chromosome segregation GO:0051983 32 0.014
mitotic dna damage checkpoint GO:0044773 74 0.014
sensory organ morphogenesis GO:0090596 260 0.014
protein complex assembly GO:0006461 200 0.014
response to light stimulus GO:0009416 124 0.014
regulation of immune system process GO:0002682 176 0.014
regulation of histone modification GO:0031056 20 0.014
positive regulation of catalytic activity GO:0043085 118 0.014
cellular macromolecule localization GO:0070727 220 0.014
negative regulation of intrinsic apoptotic signaling pathway GO:2001243 1 0.014
regulation of programmed cell death GO:0043067 152 0.013
regulation of cytoplasmic transport GO:1903649 47 0.013
eye development GO:0001654 323 0.013
negative regulation of purine nucleotide metabolic process GO:1900543 4 0.013
mrna splice site selection GO:0006376 1 0.013
cellular amine metabolic process GO:0044106 12 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.013
mitotic sister chromatid segregation GO:0000070 87 0.013
positive regulation of apoptotic process GO:0043065 47 0.013
stem cell division GO:0017145 69 0.013
mrna splicing via spliceosome GO:0000398 73 0.012
microtubule polymerization or depolymerization GO:0031109 39 0.012
chitin based larval cuticle pattern formation GO:0035293 11 0.012
regulation of apoptotic process GO:0042981 130 0.012
positive regulation of neuron projection regeneration GO:0070572 3 0.012
organelle assembly GO:0070925 198 0.012
cell cell signaling involved in cell fate commitment GO:0045168 210 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.012
retina morphogenesis in camera type eye GO:0060042 2 0.012
immune system process GO:0002376 347 0.012
establishment or maintenance of cell polarity GO:0007163 167 0.012
protein import GO:0017038 55 0.012
histone acetylation GO:0016573 38 0.012
regulation of phosphorylation GO:0042325 147 0.012
negative regulation of signaling GO:0023057 219 0.011
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.011
mitochondrial membrane organization GO:0007006 3 0.011
immune system development GO:0002520 57 0.011
negative regulation of protein secretion GO:0050709 2 0.011
regulation of cellular amine metabolic process GO:0033238 3 0.011
sister chromatid segregation GO:0000819 92 0.011
protein modification by small protein conjugation GO:0032446 79 0.011
spliceosomal complex assembly GO:0000245 1 0.011
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.011
post embryonic appendage morphogenesis GO:0035120 385 0.011
regulation of multi organism process GO:0043900 131 0.011
apoptotic process GO:0006915 159 0.010
regulation of cell differentiation GO:0045595 302 0.010
negative regulation of nucleotide catabolic process GO:0030812 1 0.010
maternal determination of dorsal ventral axis ovarian follicular epithelium germ line encoded GO:0008070 2 0.010

kuk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.018
disease of anatomical entity DOID:7 0 0.017
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.012