Drosophila melanogaster

75 known processes

scf (Dmel_CG9148)

supercoiling factor

(Aliases: SCF,anon-EST:Posey14,CK02682,DCB-45,Dmel\CG9148,CG9148,BEST:CK02682)

scf biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular catabolic process GO:0044248 372 0.265
establishment of localization in cell GO:0051649 402 0.249
multi organism behavior GO:0051705 175 0.237
gland development GO:0048732 191 0.160
peptidyl proline hydroxylation GO:0019511 1 0.116
intracellular transport GO:0046907 228 0.110
vesicle mediated transport GO:0016192 381 0.100
response to organic substance GO:0010033 284 0.095
Rat
regionalization GO:0003002 416 0.092
tube morphogenesis GO:0035239 191 0.090
protein modification process GO:0036211 438 0.089
digestive system development GO:0055123 149 0.084
protein localization GO:0008104 284 0.082
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.082
membrane organization GO:0061024 112 0.080
catabolic process GO:0009056 409 0.077
protein hydroxylation GO:0018126 1 0.075
digestive tract morphogenesis GO:0048546 127 0.074
peptidyl amino acid modification GO:0018193 105 0.068
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.067
salivary gland morphogenesis GO:0007435 145 0.066
regulation of multicellular organismal development GO:2000026 414 0.066
secondary metabolic process GO:0019748 75 0.064
digestive tract development GO:0048565 149 0.062
imaginal disc derived appendage development GO:0048737 399 0.058
post embryonic appendage morphogenesis GO:0035120 385 0.055
gland morphogenesis GO:0022612 145 0.053
wing disc morphogenesis GO:0007472 344 0.053
peptidyl proline modification GO:0018208 3 0.052
spermatogenesis GO:0007283 200 0.052
spermatid differentiation GO:0048515 114 0.051
cell migration GO:0016477 238 0.051
exocrine system development GO:0035272 162 0.051
transcription from rna polymerase ii promoter GO:0006366 368 0.050
intracellular signal transduction GO:0035556 300 0.050
regulation of anatomical structure size GO:0090066 163 0.049
cell motility GO:0048870 251 0.049
response to abiotic stimulus GO:0009628 341 0.048
cellular protein modification process GO:0006464 438 0.048
positive regulation of cellular biosynthetic process GO:0031328 316 0.047
single organism behavior GO:0044708 391 0.046
regulation of anatomical structure morphogenesis GO:0022603 242 0.046
cellular response to chemical stimulus GO:0070887 199 0.045
localization of cell GO:0051674 257 0.044
appendage morphogenesis GO:0035107 397 0.043
imaginal disc derived appendage morphogenesis GO:0035114 395 0.042
endocytosis GO:0006897 310 0.041
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.041
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.041
lipid storage GO:0019915 38 0.040
embryonic morphogenesis GO:0048598 206 0.039
regulation of intracellular signal transduction GO:1902531 236 0.038
male gamete generation GO:0048232 201 0.038
positive regulation of rna metabolic process GO:0051254 271 0.037
axon development GO:0061564 297 0.037
Rat
phenol containing compound metabolic process GO:0018958 57 0.037
regulation of localization GO:0032879 275 0.036
central nervous system development GO:0007417 201 0.036
positive regulation of rna biosynthetic process GO:1902680 266 0.036
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.035
biological adhesion GO:0022610 138 0.034
nephron development GO:0072006 3 0.034
positive regulation of biosynthetic process GO:0009891 316 0.033
response to bacterium GO:0009617 198 0.033
striated muscle cell differentiation GO:0051146 90 0.033
organic substance catabolic process GO:1901575 308 0.033
positive regulation of macromolecule metabolic process GO:0010604 405 0.033
regulation of cell development GO:0060284 215 0.033
multi organism reproductive behavior GO:0044705 121 0.033
growth GO:0040007 359 0.032
muscle organ development GO:0007517 127 0.031
salivary gland development GO:0007431 162 0.031
larval development GO:0002164 104 0.031
cellular amine metabolic process GO:0044106 12 0.031
positive regulation of gene expression GO:0010628 290 0.030
lateral inhibition GO:0046331 206 0.030
positive regulation of response to stimulus GO:0048584 323 0.030
response to biotic stimulus GO:0009607 294 0.030
amine metabolic process GO:0009308 12 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.029
reproductive behavior GO:0019098 122 0.029
multi multicellular organism process GO:0044706 123 0.029
single organism intracellular transport GO:1902582 207 0.029
cell death GO:0008219 279 0.028
mating behavior GO:0007617 106 0.028
cytoplasmic transport GO:0016482 130 0.028
mating GO:0007618 120 0.028
single organism membrane organization GO:0044802 93 0.028
embryo development ending in birth or egg hatching GO:0009792 152 0.028
Mouse
anatomical structure homeostasis GO:0060249 97 0.027
kidney development GO:0001822 3 0.027
phagocytosis GO:0006909 215 0.027
regulation of multivesicular body size involved in endosome transport GO:0010797 2 0.027
appendage development GO:0048736 401 0.027
tube development GO:0035295 244 0.027
programmed cell death GO:0012501 257 0.026
androgen metabolic process GO:0008209 1 0.026
urogenital system development GO:0001655 72 0.026
regulation of growth GO:0040008 233 0.026
establishment of protein localization GO:0045184 163 0.025
immune system process GO:0002376 347 0.025
organic substance transport GO:0071702 257 0.025
regulation of nervous system development GO:0051960 248 0.025
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.025
response to inorganic substance GO:0010035 44 0.025
developmental programmed cell death GO:0010623 138 0.025
cellular ketone metabolic process GO:0042180 24 0.024
body morphogenesis GO:0010171 2 0.024
forebrain development GO:0030900 2 0.024
wing disc pattern formation GO:0035222 66 0.024
gonad development GO:0008406 50 0.023
multicellular organismal reproductive behavior GO:0033057 110 0.023
secretion by cell GO:0032940 101 0.023
death GO:0016265 284 0.023
compound eye development GO:0048749 307 0.023
ras protein signal transduction GO:0007265 88 0.023
cell adhesion GO:0007155 136 0.023
eye morphogenesis GO:0048592 260 0.023
muscle structure development GO:0061061 224 0.023
neurological system process GO:0050877 358 0.023
morphogenesis of an epithelium GO:0002009 276 0.023
camera type eye development GO:0043010 4 0.022
Mouse
negative regulation of multicellular organismal process GO:0051241 142 0.022
brain development GO:0007420 120 0.022
cell cell signaling involved in cell fate commitment GO:0045168 210 0.022
regulation of molecular function GO:0065009 217 0.022
Rat
carbohydrate derivative metabolic process GO:1901135 217 0.021
protein transport GO:0015031 155 0.021
cellular protein localization GO:0034613 160 0.021
response to oxygen containing compound GO:1901700 200 0.021
response to other organism GO:0051707 293 0.021
segmentation GO:0035282 207 0.021
positive regulation of signaling GO:0023056 243 0.021
immune response GO:0006955 246 0.021
regulation of protein metabolic process GO:0051246 256 0.021
organic cyclic compound catabolic process GO:1901361 168 0.021
small molecule metabolic process GO:0044281 305 0.021
regulation of response to stress GO:0080134 200 0.021
chemosensory behavior GO:0007635 106 0.021
negative regulation of signaling GO:0023057 219 0.021
regulation of transport GO:0051049 181 0.020
taxis GO:0042330 304 0.020
negative regulation of cellular metabolic process GO:0031324 382 0.020
regulation of cellular protein metabolic process GO:0032268 243 0.020
regulation of catalytic activity GO:0050790 185 0.020
Rat
oocyte differentiation GO:0009994 145 0.020
chemotaxis GO:0006935 249 0.020
steroid catabolic process GO:0006706 1 0.020
carboxylic acid metabolic process GO:0019752 92 0.019
positive regulation of developmental process GO:0051094 143 0.019
alpha amino acid metabolic process GO:1901605 20 0.019
maintenance of cell polarity GO:0030011 18 0.019
regulation of organelle organization GO:0033043 196 0.019
defense response to bacterium GO:0042742 178 0.019
defense response GO:0006952 300 0.019
regulation of multi organism process GO:0043900 131 0.019
compound eye morphogenesis GO:0001745 249 0.019
regulation of cell morphogenesis GO:0022604 163 0.019
organonitrogen compound metabolic process GO:1901564 318 0.019
axis specification GO:0009798 167 0.019
encapsulation of foreign target GO:0035010 38 0.019
heterocycle catabolic process GO:0046700 166 0.019
response to lipopolysaccharide GO:0032496 4 0.019
ubiquitin dependent protein catabolic process GO:0006511 78 0.018
regulation of cellular component size GO:0032535 98 0.018
positive regulation of signal transduction GO:0009967 223 0.018
secretion GO:0046903 109 0.018
regulation of cellular ketone metabolic process GO:0010565 3 0.018
meiotic cell cycle GO:0051321 171 0.018
cellular response to organic substance GO:0071310 132 0.018
locomotory behavior GO:0007626 176 0.018
regulation of cell death GO:0010941 173 0.018
tissue morphogenesis GO:0048729 297 0.018
extracellular structure organization GO:0043062 46 0.018
imaginal disc pattern formation GO:0007447 91 0.018
epithelial cell differentiation GO:0030855 322 0.017
organic acid metabolic process GO:0006082 103 0.017
regulation of small gtpase mediated signal transduction GO:0051056 93 0.017
regulation of phosphorus metabolic process GO:0051174 210 0.017
positive regulation of transcription dna templated GO:0045893 266 0.017
hormone catabolic process GO:0042447 3 0.017
imaginal disc derived wing morphogenesis GO:0007476 337 0.017
small gtpase mediated signal transduction GO:0007264 88 0.017
negative regulation of signal transduction GO:0009968 206 0.017
embryonic pattern specification GO:0009880 174 0.017
developmental growth GO:0048589 280 0.017
cell proliferation GO:0008283 299 0.017
positive regulation of cell migration GO:0030335 2 0.017
notch signaling pathway GO:0007219 120 0.017
negative regulation of cell development GO:0010721 62 0.017
regulation of mitotic cell cycle GO:0007346 190 0.017
positive regulation of cell communication GO:0010647 250 0.017
regulation of cellular amine metabolic process GO:0033238 3 0.016
protein complex biogenesis GO:0070271 201 0.016
protein secretion GO:0009306 45 0.016
regulation of catabolic process GO:0009894 170 0.016
negative regulation of developmental process GO:0051093 201 0.016
single organism carbohydrate metabolic process GO:0044723 72 0.016
inter male aggressive behavior GO:0002121 60 0.016
response to organophosphorus GO:0046683 2 0.016
ethanolamine containing compound metabolic process GO:0042439 4 0.016
positive regulation of cellular component organization GO:0051130 156 0.016
cellular macromolecule catabolic process GO:0044265 136 0.016
regulation of organ morphogenesis GO:2000027 78 0.016
membrane fusion GO:0061025 42 0.016
positive regulation of cell motility GO:2000147 3 0.016
regulation of cell differentiation GO:0045595 302 0.016
oxoacid metabolic process GO:0043436 103 0.015
anterior posterior pattern specification GO:0009952 136 0.015
negative regulation of cell communication GO:0010648 223 0.015
cellular response to oxygen containing compound GO:1901701 79 0.015
negative regulation of gene expression GO:0010629 387 0.015
dna metabolic process GO:0006259 227 0.015
negative regulation of rna metabolic process GO:0051253 251 0.015
regulation of programmed cell death GO:0043067 152 0.015
xenobiotic catabolic process GO:0042178 1 0.015
response to ketone GO:1901654 34 0.015
basement membrane organization GO:0071711 10 0.015
regulation of epithelial cell proliferation GO:0050678 4 0.015
anterior posterior axis specification embryo GO:0008595 103 0.015
regulation of notch signaling pathway GO:0008593 100 0.015
regulation of ras protein signal transduction GO:0046578 93 0.015
sensory organ morphogenesis GO:0090596 260 0.014
melanization defense response GO:0035006 45 0.014
leg disc morphogenesis GO:0007478 80 0.014
regulation of cellular localization GO:0060341 136 0.014
response to organic cyclic compound GO:0014070 89 0.014
Rat
phosphorylation GO:0016310 294 0.014
developmental maturation GO:0021700 172 0.014
regulation of cell proliferation GO:0042127 163 0.014
cellular macromolecule localization GO:0070727 220 0.014
regulation of protein secretion GO:0050708 13 0.014
spermatid development GO:0007286 98 0.014
oocyte development GO:0048599 124 0.014
asymmetric protein localization GO:0008105 33 0.014
neuromuscular junction development GO:0007528 149 0.014
negative regulation of nervous system development GO:0051961 92 0.014
positive regulation of multicellular organismal process GO:0051240 143 0.014
homeostatic process GO:0042592 199 0.014
carbohydrate derivative catabolic process GO:1901136 118 0.014
eye development GO:0001654 323 0.013
Mouse
response to external biotic stimulus GO:0043207 293 0.013
blastoderm segmentation GO:0007350 159 0.013
negative regulation of response to stimulus GO:0048585 258 0.013
positive regulation of intracellular signal transduction GO:1902533 116 0.013
extracellular matrix organization GO:0030198 32 0.013
cellular amino acid metabolic process GO:0006520 61 0.013
cellular homeostasis GO:0019725 80 0.013
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.013
cellular protein catabolic process GO:0044257 83 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
cell maturation GO:0048469 144 0.013
cell cycle arrest GO:0007050 4 0.013
positive regulation of molecular function GO:0044093 136 0.013
ion transport GO:0006811 145 0.013
macromolecule catabolic process GO:0009057 161 0.013
tripartite regional subdivision GO:0007351 103 0.013
response to oxidative stress GO:0006979 86 0.013
organelle fission GO:0048285 340 0.013
mesenchymal cell differentiation GO:0048762 1 0.013
negative regulation of rna biosynthetic process GO:1902679 240 0.013
apoptotic process GO:0006915 159 0.013
telencephalon development GO:0021537 2 0.013
wing disc dorsal ventral pattern formation GO:0048190 47 0.012
pigment metabolic process GO:0042440 84 0.012
negative regulation of biosynthetic process GO:0009890 277 0.012
regulation of phosphate metabolic process GO:0019220 210 0.012
axon guidance GO:0007411 233 0.012
regulation of embryonic development GO:0045995 68 0.012
salivary gland histolysis GO:0035070 88 0.012
negative regulation of cell cycle GO:0045786 116 0.012
head development GO:0060322 135 0.012
axonogenesis GO:0007409 290 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
posttranscriptional regulation of gene expression GO:0010608 145 0.012
nephron morphogenesis GO:0072028 3 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012
innate immune response GO:0045087 144 0.012
male mating behavior GO:0060179 70 0.012
negative regulation of cell differentiation GO:0045596 143 0.012
neuron projection guidance GO:0097485 241 0.012
protein n linked glycosylation GO:0006487 9 0.012
endomembrane system organization GO:0010256 119 0.012
Fly
regulation of cell shape GO:0008360 113 0.012
respiratory system development GO:0060541 213 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
jak stat cascade GO:0007259 49 0.012
defense response to other organism GO:0098542 225 0.012
maintenance of location GO:0051235 73 0.011
dendrite morphogenesis GO:0048813 199 0.011
substrate adhesion dependent cell spreading GO:0034446 2 0.011
single organism cellular localization GO:1902580 180 0.011
negative regulation of cell cycle phase transition GO:1901988 103 0.011
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.011
negative regulation of cellular protein metabolic process GO:0032269 85 0.011
regulation of phosphorylation GO:0042325 147 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
aggressive behavior GO:0002118 63 0.011
regulation of cellular response to stress GO:0080135 89 0.011
hindgut morphogenesis GO:0007442 58 0.011
modification dependent macromolecule catabolic process GO:0043632 79 0.011
dendrite development GO:0016358 204 0.011
modification dependent protein catabolic process GO:0019941 78 0.011
oocyte construction GO:0007308 112 0.011
courtship behavior GO:0007619 68 0.011
macromolecular complex assembly GO:0065003 256 0.011
embryonic axis specification GO:0000578 107 0.011
cell growth GO:0016049 108 0.011
positive regulation of response to external stimulus GO:0032103 44 0.011
mitotic cell cycle phase transition GO:0044772 138 0.011
positive regulation of catalytic activity GO:0043085 118 0.011
cellular nitrogen compound catabolic process GO:0044270 165 0.011
protein localization to organelle GO:0033365 82 0.011
negative regulation of cellular biosynthetic process GO:0031327 277 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
organic hydroxy compound metabolic process GO:1901615 83 0.011
regulation of hydrolase activity GO:0051336 97 0.011
positive regulation of nucleic acid templated transcription GO:1903508 266 0.011
tissue death GO:0016271 102 0.011
protein phosphorylation GO:0006468 169 0.011
single organism catabolic process GO:0044712 228 0.011
lymph gland development GO:0048542 28 0.011
regulation of response to external stimulus GO:0032101 115 0.011
positive regulation of phosphate metabolic process GO:0045937 139 0.010
response to endogenous stimulus GO:0009719 119 0.010
dorsal ventral pattern formation GO:0009953 133 0.010
reproductive system development GO:0061458 74 0.010
lipid metabolic process GO:0006629 121 0.010
response to extracellular stimulus GO:0009991 116 0.010
regulation of cellular component biogenesis GO:0044087 201 0.010
protein complex assembly GO:0006461 200 0.010
midgut development GO:0007494 23 0.010
mesenchymal cell development GO:0014031 1 0.010
proteasomal protein catabolic process GO:0010498 59 0.010
autophagic cell death GO:0048102 83 0.010
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.010
regulation of cellular catabolic process GO:0031329 157 0.010
positive regulation of growth GO:0045927 75 0.010
response to calcium ion GO:0051592 1 0.010
autophagy GO:0006914 108 0.010
nucleoside phosphate catabolic process GO:1901292 110 0.010
retina development in camera type eye GO:0060041 4 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
establishment of organelle localization GO:0051656 122 0.010
nuclear division GO:0000280 332 0.010
immune effector process GO:0002252 98 0.010
gastrulation GO:0007369 70 0.010
regulation of cell cycle GO:0051726 291 0.010
synaptic transmission GO:0007268 288 0.010

scf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.041
cardiovascular system disease DOID:1287 0 0.017
disease of cellular proliferation DOID:14566 0 0.016
cancer DOID:162 0 0.015
musculoskeletal system disease DOID:17 0 0.013
organ system cancer DOID:0050686 0 0.012