Drosophila melanogaster

125 known processes

Rgl (Dmel_CG8865)

Ral guanine nucleotide exchange factor

(Aliases: Dmel\CG8865,RalGDS,CG8865,DRgl,rgl,dRGL)

Rgl biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell proliferation GO:0008283 299 0.517
response to abiotic stimulus GO:0009628 341 0.431
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.416
actin cytoskeleton organization GO:0030036 206 0.376
catabolic process GO:0009056 409 0.358
immune response regulating signaling pathway GO:0002764 2 0.325
positive regulation of macromolecule metabolic process GO:0010604 405 0.275
organic substance catabolic process GO:1901575 308 0.264
cellular catabolic process GO:0044248 372 0.237
single organism behavior GO:0044708 391 0.235
regulation of intracellular signal transduction GO:1902531 236 0.218
long term memory GO:0007616 62 0.200
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.200
regulation of notch signaling pathway GO:0008593 100 0.194
locomotory behavior GO:0007626 176 0.178
organic cyclic compound catabolic process GO:1901361 168 0.170
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.161
positive regulation of rna metabolic process GO:0051254 271 0.161
cellular response to organic substance GO:0071310 132 0.155
wing disc morphogenesis GO:0007472 344 0.146
intracellular signal transduction GO:0035556 300 0.143
negative regulation of response to stimulus GO:0048585 258 0.142
cognition GO:0050890 141 0.141
chromosome segregation GO:0007059 157 0.132
taxis GO:0042330 304 0.131
negative regulation of signal transduction GO:0009968 206 0.130
imaginal disc derived appendage morphogenesis GO:0035114 395 0.130
regionalization GO:0003002 416 0.128
stem cell differentiation GO:0048863 117 0.127
positive regulation of response to stimulus GO:0048584 323 0.123
organonitrogen compound metabolic process GO:1901564 318 0.117
establishment of localization in cell GO:0051649 402 0.117
urogenital system development GO:0001655 72 0.116
chemosensory behavior GO:0007635 106 0.114
transcription from rna polymerase ii promoter GO:0006366 368 0.114
positive regulation of biosynthetic process GO:0009891 316 0.111
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.107
regulation of molecular function GO:0065009 217 0.107
learning or memory GO:0007611 141 0.106
homeostatic process GO:0042592 199 0.105
positive regulation of rna biosynthetic process GO:1902680 266 0.104
actin filament organization GO:0007015 126 0.103
establishment or maintenance of cell polarity GO:0007163 167 0.102
protein localization GO:0008104 284 0.101
small gtpase mediated signal transduction GO:0007264 88 0.100
regulation of multicellular organismal development GO:2000026 414 0.098
Worm
regulation of phosphorus metabolic process GO:0051174 210 0.098
imaginal disc derived appendage development GO:0048737 399 0.097
nucleobase containing compound catabolic process GO:0034655 165 0.096
imaginal disc derived wing morphogenesis GO:0007476 337 0.096
regulation of cellular catabolic process GO:0031329 157 0.094
negative regulation of rna metabolic process GO:0051253 251 0.093
forebrain development GO:0030900 2 0.090
axonogenesis GO:0007409 290 0.089
negative regulation of developmental process GO:0051093 201 0.087
negative regulation of signaling GO:0023057 219 0.086
dorsal closure GO:0007391 79 0.084
intracellular transport GO:0046907 228 0.084
embryo development ending in birth or egg hatching GO:0009792 152 0.083
negative regulation of cellular metabolic process GO:0031324 382 0.083
immune response activating signal transduction GO:0002757 2 0.082
epithelial cell differentiation GO:0030855 322 0.080
embryonic development via the syncytial blastoderm GO:0001700 148 0.080
adult behavior GO:0030534 137 0.080
signal transduction by phosphorylation GO:0023014 107 0.079
positive regulation of nucleic acid templated transcription GO:1903508 266 0.078
heterocycle catabolic process GO:0046700 166 0.078
regulation of neurogenesis GO:0050767 158 0.076
cellular protein modification process GO:0006464 438 0.076
protein phosphorylation GO:0006468 169 0.075
olfactory behavior GO:0042048 97 0.074
purine ribonucleoside catabolic process GO:0046130 112 0.073
carbohydrate derivative metabolic process GO:1901135 217 0.072
positive regulation of gene expression GO:0010628 290 0.071
appendage development GO:0048736 401 0.070
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.069
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.068
positive regulation of transport GO:0051050 92 0.068
memory GO:0007613 94 0.066
meiotic chromosome segregation GO:0045132 59 0.064
regulation of immune effector process GO:0002697 52 0.063
negative regulation of multicellular organismal process GO:0051241 142 0.062
positive regulation of signaling GO:0023056 243 0.062
cellular amino acid metabolic process GO:0006520 61 0.061
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.058
cellular response to chemical stimulus GO:0070887 199 0.058
positive regulation of transcription dna templated GO:0045893 266 0.057
positive regulation of molecular function GO:0044093 136 0.057
immune system process GO:0002376 347 0.057
positive regulation of catabolic process GO:0009896 105 0.057
regulation of cell differentiation GO:0045595 302 0.055
posttranscriptional gene silencing by rna GO:0035194 45 0.055
mapk cascade GO:0000165 107 0.054
endocytosis GO:0006897 310 0.053
regulation of cytoskeleton organization GO:0051493 89 0.052
morphogenesis of embryonic epithelium GO:0016331 94 0.051
positive regulation of developmental process GO:0051094 143 0.050
Worm
renal system development GO:0072001 72 0.050
regulation of response to stress GO:0080134 200 0.049
ras protein signal transduction GO:0007265 88 0.049
chaeta development GO:0022416 97 0.049
response to organic substance GO:0010033 284 0.048
actin filament based process GO:0030029 220 0.048
ribonucleoside metabolic process GO:0009119 127 0.048
aromatic compound catabolic process GO:0019439 166 0.048
positive regulation of catalytic activity GO:0043085 118 0.048
response to external biotic stimulus GO:0043207 293 0.047
positive regulation of signal transduction GO:0009967 223 0.047
negative regulation of cellular biosynthetic process GO:0031327 277 0.046
vesicle mediated transport GO:0016192 381 0.046
post embryonic appendage morphogenesis GO:0035120 385 0.046
posttranscriptional gene silencing GO:0016441 46 0.045
regulation of protein metabolic process GO:0051246 256 0.045
protein modification process GO:0036211 438 0.044
positive regulation of cellular biosynthetic process GO:0031328 316 0.044
regulation of ras protein signal transduction GO:0046578 93 0.044
death GO:0016265 284 0.043
nucleoside triphosphate metabolic process GO:0009141 120 0.043
cortical actin cytoskeleton organization GO:0030866 24 0.043
gtp metabolic process GO:0046039 72 0.043
posttranscriptional regulation of gene expression GO:0010608 145 0.042
protein catabolic process GO:0030163 101 0.041
programmed cell death GO:0012501 257 0.041
notch signaling pathway GO:0007219 120 0.041
mitotic spindle organization GO:0007052 220 0.041
negative regulation of gene expression GO:0010629 387 0.041
appendage morphogenesis GO:0035107 397 0.040
dendrite development GO:0016358 204 0.040
protein transport GO:0015031 155 0.040
regulation of mapk cascade GO:0043408 92 0.040
axon development GO:0061564 297 0.039
macromolecule catabolic process GO:0009057 161 0.039
neural precursor cell proliferation GO:0061351 75 0.038
enzyme linked receptor protein signaling pathway GO:0007167 179 0.037
Worm
phagocytosis GO:0006909 215 0.037
purine nucleoside metabolic process GO:0042278 127 0.037
regulation of cell projection organization GO:0031344 92 0.037
regulation of protein modification process GO:0031399 112 0.037
positive regulation of multicellular organismal process GO:0051240 143 0.037
Worm
morphogenesis of follicular epithelium GO:0016333 36 0.036
regulation of catalytic activity GO:0050790 185 0.036
meiotic cell cycle process GO:1903046 132 0.035
positive regulation of phosphorus metabolic process GO:0010562 139 0.035
r7 cell differentiation GO:0045466 43 0.035
positive regulation of cell development GO:0010720 61 0.035
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.035
regulation of localization GO:0032879 275 0.034
wnt signaling pathway GO:0016055 98 0.034
positive regulation of phosphate metabolic process GO:0045937 139 0.034
glycosyl compound catabolic process GO:1901658 112 0.033
negative regulation of cell communication GO:0010648 223 0.033
regulation of cell development GO:0060284 215 0.032
segmentation GO:0035282 207 0.031
cell death GO:0008219 279 0.031
negative regulation of erk1 and erk2 cascade GO:0070373 3 0.031
response to nutrient levels GO:0031667 114 0.030
positive regulation of protein metabolic process GO:0051247 128 0.030
chemotaxis GO:0006935 249 0.029
growth GO:0040007 359 0.029
immune response GO:0006955 246 0.029
asymmetric neuroblast division GO:0055059 33 0.029
stem cell proliferation GO:0072089 88 0.029
small molecule metabolic process GO:0044281 305 0.029
cellular component disassembly GO:0022411 46 0.028
larval development GO:0002164 104 0.027
Worm
ameboidal type cell migration GO:0001667 151 0.027
cellular nitrogen compound catabolic process GO:0044270 165 0.027
head development GO:0060322 135 0.027
regulation of synaptic transmission GO:0050804 69 0.027
regulation of phosphate metabolic process GO:0019220 210 0.027
neuroblast proliferation GO:0007405 74 0.027
regulation of nervous system development GO:0051960 248 0.026
embryonic pattern specification GO:0009880 174 0.026
cell migration GO:0016477 238 0.026
regulation of immune response GO:0050776 118 0.026
guanosine containing compound catabolic process GO:1901069 74 0.025
nucleotide metabolic process GO:0009117 161 0.025
antimicrobial humoral response GO:0019730 99 0.025
positive regulation of immune response GO:0050778 63 0.025
nucleoside catabolic process GO:0009164 112 0.024
organelle localization GO:0051640 148 0.024
nucleoside phosphate metabolic process GO:0006753 162 0.024
positive regulation of nuclear transcribed mrna catabolic process deadenylation dependent decay GO:1900153 4 0.024
positive regulation of cell communication GO:0010647 250 0.024
single organism catabolic process GO:0044712 228 0.024
negative regulation of rna biosynthetic process GO:1902679 240 0.024
epithelium migration GO:0090132 148 0.023
purine nucleoside triphosphate metabolic process GO:0009144 119 0.023
tissue migration GO:0090130 155 0.023
response to virus GO:0009615 28 0.023
defense response to other organism GO:0098542 225 0.023
immune system development GO:0002520 57 0.023
cell division GO:0051301 248 0.023
ensheathment of neurons GO:0007272 10 0.023
organic acid metabolic process GO:0006082 103 0.023
apoptotic signaling pathway GO:0097190 27 0.023
developmental growth GO:0048589 280 0.022
negative regulation of transcription dna templated GO:0045892 237 0.022
negative regulation of neurogenesis GO:0050768 53 0.021
purine containing compound catabolic process GO:0072523 112 0.021
cellular macromolecule catabolic process GO:0044265 136 0.021
regulation of cell proliferation GO:0042127 163 0.021
establishment of protein localization GO:0045184 163 0.021
biological adhesion GO:0022610 138 0.021
secretion GO:0046903 109 0.020
nucleobase containing small molecule metabolic process GO:0055086 174 0.020
compound eye morphogenesis GO:0001745 249 0.020
response to other organism GO:0051707 293 0.020
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.020
regulation of phosphorylation GO:0042325 147 0.020
negative regulation of intracellular signal transduction GO:1902532 57 0.020
cuticle development GO:0042335 86 0.020
proteolysis GO:0006508 192 0.020
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.019
cell adhesion GO:0007155 136 0.019
regulation of purine nucleotide catabolic process GO:0033121 48 0.019
single organism carbohydrate metabolic process GO:0044723 72 0.019
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.019
oxoacid metabolic process GO:0043436 103 0.019
ribonucleoside catabolic process GO:0042454 112 0.019
regulation of nucleotide metabolic process GO:0006140 62 0.019
ribonucleoside triphosphate metabolic process GO:0009199 119 0.019
body morphogenesis GO:0010171 2 0.019
regulation of mrna processing GO:0050684 71 0.019
cellular protein localization GO:0034613 160 0.019
maintenance of location GO:0051235 73 0.018
regulation of organelle organization GO:0033043 196 0.018
negative regulation of cell differentiation GO:0045596 143 0.018
rhythmic behavior GO:0007622 76 0.018
neuronal stem cell division GO:0036445 35 0.018
positive regulation of hydrolase activity GO:0051345 78 0.018
gene silencing by rna GO:0031047 57 0.018
rna catabolic process GO:0006401 37 0.018
adult locomotory behavior GO:0008344 76 0.018
negative regulation of biosynthetic process GO:0009890 277 0.018
organophosphate metabolic process GO:0019637 195 0.018
limb development GO:0060173 1 0.018
dorsal ventral pattern formation GO:0009953 133 0.018
regulation of gtpase activity GO:0043087 44 0.018
cytoplasmic transport GO:0016482 130 0.018
organonitrogen compound catabolic process GO:1901565 128 0.017
purine nucleotide metabolic process GO:0006163 146 0.017
regulation of cellular protein metabolic process GO:0032268 243 0.017
sensory organ morphogenesis GO:0090596 260 0.017
mesenchymal cell differentiation GO:0048762 1 0.017
cell motility GO:0048870 251 0.017
secretion by cell GO:0032940 101 0.017
phosphorylation GO:0016310 294 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
cortical cytoskeleton organization GO:0030865 29 0.017
stem cell division GO:0017145 69 0.017
chromatin remodeling GO:0006338 72 0.016
organic substance transport GO:0071702 257 0.016
cellular response to dna damage stimulus GO:0006974 223 0.016
negative regulation of cell proliferation GO:0008285 69 0.016
regulation of jnk cascade GO:0046328 40 0.016
regulation of immune system process GO:0002682 176 0.016
positive regulation of neurogenesis GO:0050769 41 0.016
cellular macromolecule localization GO:0070727 220 0.016
compound eye photoreceptor cell differentiation GO:0001751 140 0.016
establishment of spindle localization GO:0051293 22 0.016
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.016
regulation of cellular ketone metabolic process GO:0010565 3 0.015
regulation of membrane depolarization GO:0003254 1 0.015
regulation of multi organism process GO:0043900 131 0.015
protein localization to organelle GO:0033365 82 0.015
positive regulation of nervous system development GO:0051962 69 0.015
response to endogenous stimulus GO:0009719 119 0.015
spindle organization GO:0007051 253 0.015
regulation of vesicle mediated transport GO:0060627 59 0.015
protein targeting GO:0006605 64 0.015
regulation of cellular response to stress GO:0080135 89 0.015
positive regulation of cellular component organization GO:0051130 156 0.015
regulation of nucleotide catabolic process GO:0030811 48 0.015
muscle structure development GO:0061061 224 0.015
mrna splicing via spliceosome GO:0000398 73 0.014
peripheral nervous system development GO:0007422 52 0.014
cellular response to endogenous stimulus GO:0071495 80 0.014
synaptic transmission GO:0007268 288 0.014
morphogenesis of an epithelium GO:0002009 276 0.014
single organism cellular localization GO:1902580 180 0.014
cytoplasmic transport nurse cell to oocyte GO:0007303 12 0.014
response to oxygen containing compound GO:1901700 200 0.014
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.014
somatic stem cell division GO:0048103 37 0.014
stress activated protein kinase signaling cascade GO:0031098 55 0.014
response to radiation GO:0009314 155 0.014
neuroblast division GO:0055057 35 0.014
nucleotide catabolic process GO:0009166 109 0.014
negative regulation of protein metabolic process GO:0051248 85 0.014
regulation of stress activated mapk cascade GO:0032872 41 0.014
regulation of lipid transport GO:0032368 3 0.014
positive regulation of cell migration GO:0030335 2 0.014
blastoderm segmentation GO:0007350 159 0.014
negative regulation of epithelial cell migration GO:0010633 1 0.014
cholesterol transport GO:0030301 2 0.014
reproductive system development GO:0061458 74 0.014
morphogenesis of a polarized epithelium GO:0001738 93 0.014
epithelial cell migration GO:0010631 148 0.014
mrna processing GO:0006397 104 0.014
central nervous system development GO:0007417 201 0.013
organophosphate catabolic process GO:0046434 112 0.013
carbohydrate metabolic process GO:0005975 82 0.013
ribose phosphate metabolic process GO:0019693 145 0.013
amine metabolic process GO:0009308 12 0.013
regulation of small gtpase mediated signal transduction GO:0051056 93 0.013
purine ribonucleotide metabolic process GO:0009150 145 0.013
cellular component assembly involved in morphogenesis GO:0010927 151 0.013
negative regulation of nucleic acid templated transcription GO:1903507 240 0.013
positive regulation of nucleoside metabolic process GO:0045979 47 0.013
imaginal disc pattern formation GO:0007447 91 0.013
regulation of hydrolase activity GO:0051336 97 0.013
cell fate determination GO:0001709 91 0.013
purine nucleotide catabolic process GO:0006195 109 0.013
dendrite morphogenesis GO:0048813 199 0.013
male meiosis chromosome segregation GO:0007060 10 0.012
protein complex assembly GO:0006461 200 0.012
cell growth GO:0016049 108 0.012
epithelial cell development GO:0002064 274 0.012
regulation of cellular amine metabolic process GO:0033238 3 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
positive regulation of programmed cell death GO:0043068 62 0.012
positive regulation of cell death GO:0010942 69 0.012
axon guidance GO:0007411 233 0.012
positive regulation of apoptotic process GO:0043065 47 0.012
protein complex disassembly GO:0043241 36 0.012
immune effector process GO:0002252 98 0.012
open tracheal system development GO:0007424 204 0.012
single organismal cell cell adhesion GO:0016337 45 0.012
limb morphogenesis GO:0035108 1 0.012
regulation of erbb signaling pathway GO:1901184 42 0.012
ncrna metabolic process GO:0034660 43 0.012
mitotic sister chromatid segregation GO:0000070 87 0.012
regulation of gtp catabolic process GO:0033124 44 0.012
positive regulation of protein kinase activity GO:0045860 25 0.012
response to biotic stimulus GO:0009607 294 0.012
regulation of purine nucleotide metabolic process GO:1900542 62 0.012
positive regulation of gtpase activity GO:0043547 43 0.012
nephrocyte differentiation GO:0061319 12 0.012
instar larval development GO:0002168 55 0.012
stem cell development GO:0048864 79 0.011
positive regulation of immune system process GO:0002684 68 0.011
innate immune response activating signal transduction GO:0002758 2 0.011
rna processing GO:0006396 147 0.011
rna splicing via transesterification reactions GO:0000375 73 0.011
regulation of anatomical structure size GO:0090066 163 0.011
imaginal disc derived wing vein specification GO:0007474 48 0.011
cell cell signaling involved in cell fate commitment GO:0045168 210 0.011
regulation of cell shape GO:0008360 113 0.011
regulation of actin filament based process GO:0032970 42 0.011
positive regulation of mrna 3 end processing GO:0031442 4 0.011
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.011
inter male aggressive behavior GO:0002121 60 0.011
sex differentiation GO:0007548 81 0.011
regulation of mrna metabolic process GO:1903311 72 0.011
regulation of catabolic process GO:0009894 170 0.011
chitin based cuticle development GO:0040003 49 0.010
cellular amine metabolic process GO:0044106 12 0.010
mesenchymal cell development GO:0014031 1 0.010
head involution GO:0008258 35 0.010
purine containing compound metabolic process GO:0072521 155 0.010
regulation of membrane potential GO:0042391 35 0.010
telencephalon development GO:0021537 2 0.010
tube morphogenesis GO:0035239 191 0.010

Rgl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.020
disease of cellular proliferation DOID:14566 0 0.020
disease of anatomical entity DOID:7 0 0.019