Drosophila melanogaster

7 known processes

Nep4 (Dmel_CG4058)

Neprilysin 4

(Aliases: DmeNEP4,Dmel\CG4058,dNEP4,CG4058)

Nep4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to biotic stimulus GO:0009607 294 0.060
immune system process GO:0002376 347 0.057
response to external biotic stimulus GO:0043207 293 0.048
defense response GO:0006952 300 0.046
lipid metabolic process GO:0006629 121 0.041
appendage morphogenesis GO:0035107 397 0.039
regulation of multicellular organismal development GO:2000026 414 0.038
response to other organism GO:0051707 293 0.038
defense response to other organism GO:0098542 225 0.037
muscle structure development GO:0061061 224 0.036
single organism behavior GO:0044708 391 0.035
oxoacid metabolic process GO:0043436 103 0.035
mrna metabolic process GO:0016071 124 0.034
protein modification process GO:0036211 438 0.033
vesicle mediated transport GO:0016192 381 0.033
somatic muscle development GO:0007525 66 0.033
positive regulation of response to stimulus GO:0048584 323 0.033
small molecule metabolic process GO:0044281 305 0.032
regulation of rna splicing GO:0043484 69 0.032
positive regulation of macromolecule metabolic process GO:0010604 405 0.029
regionalization GO:0003002 416 0.029
regulation of phosphate metabolic process GO:0019220 210 0.029
camera type eye development GO:0043010 4 0.029
regulation of growth GO:0040008 233 0.029
rna processing GO:0006396 147 0.029
spindle organization GO:0007051 253 0.028
regulation of phosphorus metabolic process GO:0051174 210 0.028
negative regulation of signal transduction GO:0009968 206 0.027
negative regulation of cellular component organization GO:0051129 108 0.027
response to bacterium GO:0009617 198 0.027
adult behavior GO:0030534 137 0.027
cellular lipid metabolic process GO:0044255 83 0.026
negative regulation of multicellular organismal process GO:0051241 142 0.025
regulation of immune response GO:0050776 118 0.025
body morphogenesis GO:0010171 2 0.025
regulation of catalytic activity GO:0050790 185 0.025
immune response GO:0006955 246 0.025
cellular amine metabolic process GO:0044106 12 0.025
regulation of cellular amine metabolic process GO:0033238 3 0.025
single organism biosynthetic process GO:0044711 206 0.024
limb development GO:0060173 1 0.024
macromolecular complex assembly GO:0065003 256 0.024
sensory perception GO:0007600 196 0.024
cellular catabolic process GO:0044248 372 0.024
positive regulation of cellular biosynthetic process GO:0031328 316 0.024
organic acid metabolic process GO:0006082 103 0.023
organic substance catabolic process GO:1901575 308 0.023
phosphorylation GO:0016310 294 0.023
organic substance transport GO:0071702 257 0.023
catabolic process GO:0009056 409 0.023
regulation of immune system process GO:0002682 176 0.023
protein complex biogenesis GO:0070271 201 0.022
intracellular signal transduction GO:0035556 300 0.022
regulation of response to stress GO:0080134 200 0.022
protein localization GO:0008104 284 0.022
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.022
embryonic morphogenesis GO:0048598 206 0.022
amine metabolic process GO:0009308 12 0.021
kidney development GO:0001822 3 0.021
actin filament based process GO:0030029 220 0.021
mrna processing GO:0006397 104 0.021
positive regulation of signal transduction GO:0009967 223 0.021
response to abiotic stimulus GO:0009628 341 0.021
regulation of cellular amino acid metabolic process GO:0006521 0 0.021
cellular protein modification process GO:0006464 438 0.021
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.021
phagocytosis GO:0006909 215 0.021
neuromuscular junction development GO:0007528 149 0.021
organelle fission GO:0048285 340 0.021
imaginal disc derived appendage development GO:0048737 399 0.021
axonogenesis GO:0007409 290 0.021
negative regulation of cellular metabolic process GO:0031324 382 0.021
defense response to bacterium GO:0042742 178 0.020
ethanolamine containing compound metabolic process GO:0042439 4 0.020
regulation of developmental growth GO:0048638 174 0.020
protein complex assembly GO:0006461 200 0.020
tube morphogenesis GO:0035239 191 0.020
spermatogenesis GO:0007283 200 0.020
eye development GO:0001654 323 0.020
Fly
negative regulation of gene expression GO:0010629 387 0.020
anion homeostasis GO:0055081 3 0.020
chemotaxis GO:0006935 249 0.020
positive regulation of cell communication GO:0010647 250 0.020
camera type eye morphogenesis GO:0048593 2 0.020
innate immune response GO:0045087 144 0.020
regulation of defense response GO:0031347 102 0.020
retina development in camera type eye GO:0060041 4 0.020
cranial nerve development GO:0021545 1 0.020
cellular nitrogen compound catabolic process GO:0044270 165 0.019
axon development GO:0061564 297 0.019
developmental maturation GO:0021700 172 0.019
regulation of cellular protein metabolic process GO:0032268 243 0.019
regulation of mrna splicing via spliceosome GO:0048024 64 0.019
wing disc morphogenesis GO:0007472 344 0.019
positive regulation of signaling GO:0023056 243 0.019
organic cyclic compound catabolic process GO:1901361 168 0.019
carboxylic acid metabolic process GO:0019752 92 0.019
synaptic growth at neuromuscular junction GO:0051124 119 0.018
cellular ketone metabolic process GO:0042180 24 0.018
negative regulation of developmental process GO:0051093 201 0.018
regulation of nervous system development GO:0051960 248 0.018
ion transport GO:0006811 145 0.018
forebrain development GO:0030900 2 0.018
response to temperature stimulus GO:0009266 106 0.018
synaptic transmission GO:0007268 288 0.018
neurological system process GO:0050877 358 0.018
single organism catabolic process GO:0044712 228 0.018
organonitrogen compound metabolic process GO:1901564 318 0.018
Rat
appendage development GO:0048736 401 0.018
post embryonic appendage morphogenesis GO:0035120 385 0.018
negative regulation of nervous system development GO:0051961 92 0.018
ras protein signal transduction GO:0007265 88 0.018
chromosome organization GO:0051276 360 0.018
endocytosis GO:0006897 310 0.017
single organism intracellular transport GO:1902582 207 0.017
negative regulation of cell communication GO:0010648 223 0.017
protein ubiquitination GO:0016567 70 0.017
sensory perception of chemical stimulus GO:0007606 116 0.017
regulation of phosphorylation GO:0042325 147 0.017
establishment of localization in cell GO:0051649 402 0.017
regulation of multi organism process GO:0043900 131 0.017
nuclear division GO:0000280 332 0.017
positive regulation of gene expression GO:0010628 290 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.017
regulation of response to external stimulus GO:0032101 115 0.016
innate immune response activating signal transduction GO:0002758 2 0.016
male gamete generation GO:0048232 201 0.016
organic hydroxy compound metabolic process GO:1901615 83 0.016
death GO:0016265 284 0.016
organonitrogen compound catabolic process GO:1901565 128 0.016
heterocycle catabolic process GO:0046700 166 0.016
imaginal disc derived wing morphogenesis GO:0007476 337 0.016
regulation of intracellular signal transduction GO:1902531 236 0.016
taxis GO:0042330 304 0.016
nucleobase containing small molecule metabolic process GO:0055086 174 0.016
acid secretion GO:0046717 1 0.016
cell maturation GO:0048469 144 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.016
intracellular transport GO:0046907 228 0.016
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.016
regulation of mrna metabolic process GO:1903311 72 0.016
nucleoside catabolic process GO:0009164 112 0.016
nucleobase containing compound catabolic process GO:0034655 165 0.015
negative regulation of response to stimulus GO:0048585 258 0.015
positive regulation of molecular function GO:0044093 136 0.015
positive regulation of developmental process GO:0051094 143 0.015
alternative mrna splicing via spliceosome GO:0000380 60 0.015
signal transduction by phosphorylation GO:0023014 107 0.015
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.015
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.015
response to lipopolysaccharide GO:0032496 4 0.015
regulation of cell development GO:0060284 215 0.015
oocyte differentiation GO:0009994 145 0.015
programmed cell death GO:0012501 257 0.015
protein modification by small protein conjugation or removal GO:0070647 106 0.015
cellular amino acid metabolic process GO:0006520 61 0.015
rna splicing via transesterification reactions GO:0000375 73 0.015
epithelial cell development GO:0002064 274 0.015
developmental growth GO:0048589 280 0.015
single organism cellular localization GO:1902580 180 0.014
regulation of innate immune response GO:0045088 71 0.014
limb morphogenesis GO:0035108 1 0.014
immune effector process GO:0002252 98 0.014
homeostatic process GO:0042592 199 0.014
regulation of molecular function GO:0065009 217 0.014
mitotic spindle organization GO:0007052 220 0.014
regulation of mitotic cell cycle GO:0007346 190 0.014
cellular macromolecule localization GO:0070727 220 0.014
purine containing compound metabolic process GO:0072521 155 0.014
nucleotide catabolic process GO:0009166 109 0.014
nucleotide metabolic process GO:0009117 161 0.014
negative regulation of growth GO:0045926 84 0.014
immune response regulating signaling pathway GO:0002764 2 0.014
neuron recognition GO:0008038 101 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
photoreceptor cell differentiation GO:0046530 170 0.014
regulation of protein metabolic process GO:0051246 256 0.014
maintenance of location GO:0051235 73 0.014
defense response to gram negative bacterium GO:0050829 94 0.014
oocyte construction GO:0007308 112 0.014
mesoderm development GO:0007498 78 0.014
mitotic nuclear division GO:0007067 213 0.014
actin cytoskeleton organization GO:0030036 206 0.014
cellularization GO:0007349 90 0.014
extrinsic apoptotic signaling pathway GO:0097191 1 0.013
regulation of cellular component biogenesis GO:0044087 201 0.013
response to organic substance GO:0010033 284 0.013
mapk cascade GO:0000165 107 0.013
regulation of localization GO:0032879 275 0.013
regulation of cell cycle GO:0051726 291 0.013
cellular component assembly involved in morphogenesis GO:0010927 151 0.013
negative regulation of cellular biosynthetic process GO:0031327 277 0.013
developmental pigmentation GO:0048066 68 0.013
cellular protein localization GO:0034613 160 0.013
regulation of mapk cascade GO:0043408 92 0.013
regulation of programmed cell death GO:0043067 152 0.013
actin filament organization GO:0007015 126 0.013
pigmentation GO:0043473 75 0.013
pigment metabolic process involved in developmental pigmentation GO:0043324 33 0.013
response to endogenous stimulus GO:0009719 119 0.013
aromatic compound catabolic process GO:0019439 166 0.013
proteolysis GO:0006508 192 0.013
mrna splicing via spliceosome GO:0000398 73 0.013
positive regulation of phosphorus metabolic process GO:0010562 139 0.013
axon guidance GO:0007411 233 0.013
positive regulation of nucleic acid templated transcription GO:1903508 266 0.013
positive regulation of multicellular organismal process GO:0051240 143 0.013
segmentation GO:0035282 207 0.013
neutral lipid biosynthetic process GO:0046460 2 0.013
regulation of cellular ketone metabolic process GO:0010565 3 0.013
small gtpase mediated signal transduction GO:0007264 88 0.013
cellular homeostasis GO:0019725 80 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
organophosphate metabolic process GO:0019637 195 0.013
eye pigmentation GO:0048069 43 0.013
regulation of synapse structure and activity GO:0050803 128 0.013
regulation of synapse assembly GO:0051963 94 0.013
lipid modification GO:0030258 24 0.013
negative regulation of developmental growth GO:0048640 64 0.013
membrane organization GO:0061024 112 0.013
positive regulation of immune response GO:0050778 63 0.012
protein heterooligomerization GO:0051291 4 0.012
biological adhesion GO:0022610 138 0.012
oocyte development GO:0048599 124 0.012
transcription from rna polymerase ii promoter GO:0006366 368 0.012
response to copper ion GO:0046688 4 0.012
tissue morphogenesis GO:0048729 297 0.012
kidney epithelium development GO:0072073 3 0.012
phosphatidylethanolamine metabolic process GO:0046337 1 0.012
regulation of cell death GO:0010941 173 0.012
epithelial cell differentiation GO:0030855 322 0.012
positive regulation of rna metabolic process GO:0051254 271 0.012
digestive system development GO:0055123 149 0.012
gland development GO:0048732 191 0.012
negative regulation of programmed cell death GO:0043069 72 0.012
multicellular organismal aging GO:0010259 140 0.012
cognition GO:0050890 141 0.012
lipid biosynthetic process GO:0008610 46 0.012
blastoderm segmentation GO:0007350 159 0.012
positive regulation of catalytic activity GO:0043085 118 0.012
feeding behavior GO:0007631 50 0.012
embryonic pattern specification GO:0009880 174 0.012
regulation of cellular catabolic process GO:0031329 157 0.012
imaginal disc derived appendage morphogenesis GO:0035114 395 0.012
positive regulation of transcription dna templated GO:0045893 266 0.012
positive regulation of phosphate metabolic process GO:0045937 139 0.012
positive regulation of rna biosynthetic process GO:1902680 266 0.012
neural retina development GO:0003407 4 0.012
nucleoside phosphate metabolic process GO:0006753 162 0.012
eye morphogenesis GO:0048592 260 0.012
Fly
response to virus GO:0009615 28 0.012
glycosyl compound catabolic process GO:1901658 112 0.012
protein phosphorylation GO:0006468 169 0.012
protein transport GO:0015031 155 0.012
organelle localization GO:0051640 148 0.012
negative regulation of nucleic acid templated transcription GO:1903507 240 0.012
positive regulation of protein metabolic process GO:0051247 128 0.012
organonitrogen compound biosynthetic process GO:1901566 117 0.012
acetate ester metabolic process GO:1900619 2 0.012
compound eye photoreceptor cell differentiation GO:0001751 140 0.012
regulation of hydrolase activity GO:0051336 97 0.012
cell motility GO:0048870 251 0.012
defense response to virus GO:0051607 23 0.012
connective tissue development GO:0061448 3 0.012
larval development GO:0002164 104 0.012
positive regulation of defense response GO:0031349 59 0.011
cell recognition GO:0008037 102 0.011
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.011
growth GO:0040007 359 0.011
purine nucleoside catabolic process GO:0006152 112 0.011
protein modification by small protein conjugation GO:0032446 79 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
vitamin biosynthetic process GO:0009110 1 0.011
nucleoside metabolic process GO:0009116 127 0.011
mesenchymal cell differentiation GO:0048762 1 0.011
positive regulation of i kappab kinase nf kappab signaling GO:0043123 1 0.011
embryonic development via the syncytial blastoderm GO:0001700 148 0.011
mesenchymal cell development GO:0014031 1 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
embryonic axis specification GO:0000578 107 0.011
dendrite development GO:0016358 204 0.011
pattern recognition receptor signaling pathway GO:0002221 2 0.011
cellular response to heat GO:0034605 24 0.011
endomembrane system organization GO:0010256 119 0.011
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.011
rna splicing GO:0008380 83 0.011
regulation of anatomical structure morphogenesis GO:0022603 242 0.011
purine ribonucleoside metabolic process GO:0046128 127 0.011
sensory organ morphogenesis GO:0090596 260 0.011
Fly
ribonucleotide catabolic process GO:0009261 109 0.011
single organism membrane organization GO:0044802 93 0.011
sterol homeostasis GO:0055092 4 0.011
open tracheal system development GO:0007424 204 0.011
positive regulation of biosynthetic process GO:0009891 316 0.011
monocarboxylic acid transport GO:0015718 3 0.011
carbohydrate derivative catabolic process GO:1901136 118 0.011
phosphatidylcholine metabolic process GO:0046470 3 0.011
macromolecule catabolic process GO:0009057 161 0.011
cellular response to radiation GO:0071478 52 0.011
locomotory behavior GO:0007626 176 0.011
rna localization GO:0006403 115 0.011
notch signaling pathway GO:0007219 120 0.011
glycosyl compound metabolic process GO:1901657 127 0.011
morphogenesis of an epithelium GO:0002009 276 0.011
organelle assembly GO:0070925 198 0.011
compound eye development GO:0048749 307 0.011
Fly
salivary gland morphogenesis GO:0007435 145 0.011
neuromuscular synaptic transmission GO:0007274 67 0.011
response to organophosphorus GO:0046683 2 0.011
negative regulation of defense response GO:0031348 35 0.011
cellular macromolecule catabolic process GO:0044265 136 0.010
negative regulation of apoptotic process GO:0043066 63 0.010
negative regulation of cell death GO:0060548 81 0.010
regulation of protein modification process GO:0031399 112 0.010
digestive tract development GO:0048565 149 0.010
eye pigment metabolic process GO:0042441 33 0.010
stem cell differentiation GO:0048863 117 0.010
regulation of cell cycle process GO:0010564 181 0.010
immune response activating signal transduction GO:0002757 2 0.010
pigment metabolic process GO:0042440 84 0.010
regulation of apoptotic process GO:0042981 130 0.010
cell growth GO:0016049 108 0.010
purine nucleoside triphosphate catabolic process GO:0009146 108 0.010
regulation of cell differentiation GO:0045595 302 0.010
positive regulation of cellular catabolic process GO:0031331 95 0.010
organophosphate catabolic process GO:0046434 112 0.010
regulation of immune effector process GO:0002697 52 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
hindbrain development GO:0030902 2 0.010
anatomical structure homeostasis GO:0060249 97 0.010
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.010
dendrite morphogenesis GO:0048813 199 0.010
ribonucleoside metabolic process GO:0009119 127 0.010
protein polymerization GO:0051258 42 0.010
regulation of proteolysis GO:0030162 87 0.010
regulation of response to biotic stimulus GO:0002831 63 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.010
positive regulation of catabolic process GO:0009896 105 0.010

Nep4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.056
nervous system disease DOID:863 0 0.030
cardiovascular system disease DOID:1287 0 0.020
musculoskeletal system disease DOID:17 0 0.019
sensory system disease DOID:0050155 0 0.019
eye and adnexa disease DOID:1492 0 0.019
eye disease DOID:5614 0 0.019
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
organ system cancer DOID:0050686 0 0.018
disease of metabolism DOID:0014667 0 0.015
Human
diabetes mellitus DOID:9351 0 0.014
type 2 diabetes mellitus DOID:9352 0 0.014
carbohydrate metabolism disease DOID:0050013 0 0.014
glucose metabolism disease DOID:4194 0 0.014
acquired metabolic disease DOID:0060158 0 0.014
central nervous system disease DOID:331 0 0.011
neurodegenerative disease DOID:1289 0 0.011
hypertension DOID:10763 0 0.010
artery disease DOID:0050828 0 0.010
vascular disease DOID:178 0 0.010