Drosophila melanogaster

65 known processes

HPS4 (Dmel_CG4966)

Hermansky-Pudlak Syndrome 4 ortholog

(Aliases: Dmel\CG4966,dHPS4,CG4966)

HPS4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of response to stimulus GO:0048584 323 0.107
phosphorylation GO:0016310 294 0.079
positive regulation of cell communication GO:0010647 250 0.070
ion transmembrane transport GO:0034220 122 0.061
positive regulation of signaling GO:0023056 243 0.061
positive regulation of signal transduction GO:0009967 223 0.058
cellular protein modification process GO:0006464 438 0.056
proteolysis GO:0006508 192 0.052
cellular catabolic process GO:0044248 372 0.052
intracellular signal transduction GO:0035556 300 0.051
regulation of intracellular signal transduction GO:1902531 236 0.050
neurological system process GO:0050877 358 0.048
organic substance catabolic process GO:1901575 308 0.047
organic substance transport GO:0071702 257 0.046
chromosome organization GO:0051276 360 0.041
macromolecule catabolic process GO:0009057 161 0.041
cellular macromolecule catabolic process GO:0044265 136 0.040
ion transport GO:0006811 145 0.040
establishment of localization in cell GO:0051649 402 0.040
regulation of phosphorus metabolic process GO:0051174 210 0.039
body morphogenesis GO:0010171 2 0.038
monocarboxylic acid transport GO:0015718 3 0.038
cellular response to dna damage stimulus GO:0006974 223 0.037
cellular protein catabolic process GO:0044257 83 0.037
catabolic process GO:0009056 409 0.037
single organism intracellular transport GO:1902582 207 0.036
positive regulation of intracellular signal transduction GO:1902533 116 0.036
protein modification process GO:0036211 438 0.036
vesicle mediated transport GO:0016192 381 0.034
regulation of localization GO:0032879 275 0.033
positive regulation of macromolecule metabolic process GO:0010604 405 0.033
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.032
small molecule metabolic process GO:0044281 305 0.030
immune response regulating signaling pathway GO:0002764 2 0.030
protein modification by small protein conjugation or removal GO:0070647 106 0.030
chromatin organization GO:0006325 207 0.029
positive regulation of phosphorus metabolic process GO:0010562 139 0.029
organonitrogen compound metabolic process GO:1901564 318 0.029
imaginal disc derived appendage morphogenesis GO:0035114 395 0.028
positive regulation of phosphate metabolic process GO:0045937 139 0.028
single organism catabolic process GO:0044712 228 0.028
regulation of phosphorylation GO:0042325 147 0.028
cellular nitrogen compound catabolic process GO:0044270 165 0.027
positive regulation of transport GO:0051050 92 0.027
response to glucose GO:0009749 2 0.027
regulation of phosphate metabolic process GO:0019220 210 0.026
heterocycle catabolic process GO:0046700 166 0.025
regulation of transport GO:0051049 181 0.025
cell migration GO:0016477 238 0.025
organophosphate metabolic process GO:0019637 195 0.025
response to monosaccharide GO:0034284 4 0.024
positive regulation of multicellular organismal process GO:0051240 143 0.024
nucleobase containing compound catabolic process GO:0034655 165 0.023
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.023
response to hexose GO:0009746 3 0.023
ocellus pigment metabolic process GO:0046158 19 0.023
modification dependent protein catabolic process GO:0019941 78 0.023
immune response activating signal transduction GO:0002757 2 0.023
regulation of cell cycle GO:0051726 291 0.022
positive regulation of phosphorylation GO:0042327 87 0.022
appendage development GO:0048736 401 0.022
secondary metabolite biosynthetic process GO:0044550 24 0.022
response to abiotic stimulus GO:0009628 341 0.022
regulation of mapk cascade GO:0043408 92 0.021
ommochrome biosynthetic process GO:0006727 19 0.021
central nervous system development GO:0007417 201 0.021
localization of cell GO:0051674 257 0.021
organic cyclic compound catabolic process GO:1901361 168 0.021
imaginal disc derived appendage development GO:0048737 399 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.020
ubiquitin dependent protein catabolic process GO:0006511 78 0.020
mapk cascade GO:0000165 107 0.020
modification dependent macromolecule catabolic process GO:0043632 79 0.020
positive regulation of cell migration GO:0030335 2 0.020
negative regulation of cell communication GO:0010648 223 0.020
regulation of protein metabolic process GO:0051246 256 0.019
organic acid metabolic process GO:0006082 103 0.019
forebrain development GO:0030900 2 0.019
negative regulation of signal transduction GO:0009968 206 0.019
protein catabolic process GO:0030163 101 0.019
ribonucleotide catabolic process GO:0009261 109 0.019
regulation of response to stress GO:0080134 200 0.019
inorganic ion transmembrane transport GO:0098660 73 0.019
kidney development GO:0001822 3 0.019
chromatin modification GO:0016568 147 0.019
carboxylic acid metabolic process GO:0019752 92 0.019
aromatic compound catabolic process GO:0019439 166 0.019
signal transduction by phosphorylation GO:0023014 107 0.019
regulation of epithelial cell proliferation GO:0050678 4 0.019
regulation of cellular ketone metabolic process GO:0010565 3 0.019
pigment metabolic process involved in developmental pigmentation GO:0043324 33 0.018
cellular amino acid metabolic process GO:0006520 61 0.018
positive regulation of cellular protein metabolic process GO:0032270 118 0.018
single organism behavior GO:0044708 391 0.018
response to organic substance GO:0010033 284 0.018
response to biotic stimulus GO:0009607 294 0.018
axon cargo transport GO:0008088 29 0.018
secretion by cell GO:0032940 101 0.018
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.018
nucleobase containing small molecule metabolic process GO:0055086 174 0.017
small gtpase mediated signal transduction GO:0007264 88 0.017
actin filament based process GO:0030029 220 0.017
protein ubiquitination GO:0016567 70 0.017
nucleoside phosphate metabolic process GO:0006753 162 0.017
microtubule based transport GO:0010970 42 0.017
ommochrome metabolic process GO:0046152 19 0.017
innate immune response activating signal transduction GO:0002758 2 0.017
positive regulation of cell motility GO:2000147 3 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
phosphatidylethanolamine metabolic process GO:0046337 1 0.017
protein modification by small protein removal GO:0070646 28 0.016
regulation of cellular catabolic process GO:0031329 157 0.016
actin cytoskeleton organization GO:0030036 206 0.016
intracellular transport GO:0046907 228 0.016
protein transport GO:0015031 155 0.016
single organism biosynthetic process GO:0044711 206 0.016
cellular homeostasis GO:0019725 80 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
cell fate determination GO:0001709 91 0.016
positive regulation of cellular biosynthetic process GO:0031328 316 0.016
cellular response to hexose stimulus GO:0071331 1 0.016
regulation of nervous system development GO:0051960 248 0.016
protein phosphorylation GO:0006468 169 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
cellular response to chemical stimulus GO:0070887 199 0.016
regulation of cell differentiation GO:0045595 302 0.016
purine containing compound metabolic process GO:0072521 155 0.016
mitotic nuclear division GO:0007067 213 0.016
metal ion transport GO:0030001 74 0.016
transcription from rna polymerase ii promoter GO:0006366 368 0.016
regulation of immune system process GO:0002682 176 0.016
mesenchymal cell differentiation GO:0048762 1 0.016
epithelial cell development GO:0002064 274 0.015
regulation of mitotic cell cycle GO:0007346 190 0.015
carbohydrate derivative catabolic process GO:1901136 118 0.015
axis specification GO:0009798 167 0.015
transmembrane transport GO:0055085 139 0.015
response to radiation GO:0009314 155 0.015
regulation of multicellular organismal development GO:2000026 414 0.015
nucleotide catabolic process GO:0009166 109 0.015
germarium derived egg chamber formation GO:0007293 101 0.015
regulation of cellular component biogenesis GO:0044087 201 0.015
posttranscriptional regulation of gene expression GO:0010608 145 0.015
protein localization GO:0008104 284 0.015
organonitrogen compound catabolic process GO:1901565 128 0.015
segmentation GO:0035282 207 0.015
negative regulation of immune system process GO:0002683 50 0.015
cell death GO:0008219 279 0.015
salivary gland development GO:0007431 162 0.015
response to lipopolysaccharide GO:0032496 4 0.015
regulation of molecular function GO:0065009 217 0.015
regionalization GO:0003002 416 0.015
nucleotide metabolic process GO:0009117 161 0.015
regulation of neurogenesis GO:0050767 158 0.015
limb development GO:0060173 1 0.015
endosomal transport GO:0016197 44 0.015
cation transmembrane transport GO:0098655 88 0.015
establishment of protein localization GO:0045184 163 0.015
cytoplasmic transport GO:0016482 130 0.014
positive regulation of biosynthetic process GO:0009891 316 0.014
positive regulation of catabolic process GO:0009896 105 0.014
regulation of ras protein signal transduction GO:0046578 93 0.014
regulation of cell cycle process GO:0010564 181 0.014
cytoskeleton dependent intracellular transport GO:0030705 44 0.014
cation transport GO:0006812 110 0.014
spermatogenesis GO:0007283 200 0.014
programmed cell death GO:0012501 257 0.014
endocytosis GO:0006897 310 0.014
phagocytosis GO:0006909 215 0.014
regulation of lipid transport GO:0032368 3 0.014
rna processing GO:0006396 147 0.014
positive regulation of molecular function GO:0044093 136 0.014
negative regulation of developmental process GO:0051093 201 0.014
wing disc morphogenesis GO:0007472 344 0.014
somatic muscle development GO:0007525 66 0.014
regulation of synapse organization GO:0050807 110 0.014
regulation of immune response GO:0050776 118 0.014
cell division GO:0051301 248 0.014
regulation of anatomical structure morphogenesis GO:0022603 242 0.014
purine ribonucleotide catabolic process GO:0009154 109 0.013
stem cell differentiation GO:0048863 117 0.013
proteasomal protein catabolic process GO:0010498 59 0.013
pigment biosynthetic process GO:0046148 36 0.013
homeostatic process GO:0042592 199 0.013
jak stat cascade GO:0007259 49 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
histone modification GO:0016570 106 0.013
response to external biotic stimulus GO:0043207 293 0.013
regulation of cell death GO:0010941 173 0.013
adult behavior GO:0030534 137 0.013
digestive system development GO:0055123 149 0.013
immune system process GO:0002376 347 0.013
organophosphate catabolic process GO:0046434 112 0.013
telencephalon development GO:0021537 2 0.013
regulation of cellular protein metabolic process GO:0032268 243 0.013
epithelial cell differentiation GO:0030855 322 0.013
compound eye development GO:0048749 307 0.013
negative regulation of signaling GO:0023057 219 0.013
purine nucleoside catabolic process GO:0006152 112 0.013
long chain fatty acid metabolic process GO:0001676 3 0.012
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.012
cellular response to carbohydrate stimulus GO:0071322 4 0.012
spindle organization GO:0007051 253 0.012
ocellus pigmentation GO:0033060 19 0.012
synapse organization GO:0050808 196 0.012
positive regulation of hydrolase activity GO:0051345 78 0.012
nitrogen compound transport GO:0071705 85 0.012
ribonucleoside triphosphate catabolic process GO:0009203 108 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
axon development GO:0061564 297 0.012
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.012
camera type eye development GO:0043010 4 0.012
oxoacid metabolic process GO:0043436 103 0.012
mesenchymal cell development GO:0014031 1 0.012
intracellular protein transport GO:0006886 104 0.012
purine ribonucleoside catabolic process GO:0046130 112 0.012
nucleocytoplasmic transport GO:0006913 72 0.012
response to other organism GO:0051707 293 0.012
exocrine system development GO:0035272 162 0.012
organelle fission GO:0048285 340 0.012
response to oxygen containing compound GO:1901700 200 0.012
ras protein signal transduction GO:0007265 88 0.012
negative regulation of response to stimulus GO:0048585 258 0.012
covalent chromatin modification GO:0016569 106 0.012
purine ribonucleoside metabolic process GO:0046128 127 0.012
cell motility GO:0048870 251 0.012
regulation of protein transport GO:0051223 57 0.012
cellular response to biotic stimulus GO:0071216 4 0.011
regulation of cell development GO:0060284 215 0.011
positive regulation of cell death GO:0010942 69 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
taxis GO:0042330 304 0.011
protein complex biogenesis GO:0070271 201 0.011
imaginal disc derived wing morphogenesis GO:0007476 337 0.011
cellularization GO:0007349 90 0.011
regulation of protein localization GO:0032880 76 0.011
organelle assembly GO:0070925 198 0.011
mitotic spindle organization GO:0007052 220 0.011
salivary gland morphogenesis GO:0007435 145 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
regulation of cellular localization GO:0060341 136 0.011
developmental programmed cell death GO:0010623 138 0.011
nucleoside catabolic process GO:0009164 112 0.011
death GO:0016265 284 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
microtubule based movement GO:0007018 51 0.011
cellular ketone metabolic process GO:0042180 24 0.011
post embryonic appendage morphogenesis GO:0035120 385 0.011
purine containing compound catabolic process GO:0072523 112 0.011
response to extracellular stimulus GO:0009991 116 0.011
peptidyl threonine phosphorylation GO:0018107 2 0.011
ribonucleoside triphosphate metabolic process GO:0009199 119 0.011
positive regulation of protein metabolic process GO:0051247 128 0.011
neuroblast proliferation GO:0007405 74 0.011
positive regulation of mapk cascade GO:0043410 63 0.011
cellular response to monosaccharide stimulus GO:0071326 2 0.011
regulation of vesicle mediated transport GO:0060627 59 0.011
ribonucleoside metabolic process GO:0009119 127 0.011
stem cell proliferation GO:0072089 88 0.011
germ line stem cell maintenance GO:0030718 50 0.011
regulation of catabolic process GO:0009894 170 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
nucleoside triphosphate catabolic process GO:0009143 108 0.011
developmental maturation GO:0021700 172 0.011
regulation of catalytic activity GO:0050790 185 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
muscle structure development GO:0061061 224 0.010
cellular response to organic substance GO:0071310 132 0.010
sulfur compound metabolic process GO:0006790 59 0.010
regulation of proteolysis GO:0030162 87 0.010
organic acid transport GO:0015849 18 0.010
stem cell maintenance GO:0019827 67 0.010
cytokinesis GO:0000910 90 0.010
protein complex assembly GO:0006461 200 0.010
purine nucleoside metabolic process GO:0042278 127 0.010
embryonic pattern specification GO:0009880 174 0.010
hormone catabolic process GO:0042447 3 0.010
regulation of response to external stimulus GO:0032101 115 0.010
regulation of synapse structure and activity GO:0050803 128 0.010
inorganic cation transmembrane transport GO:0098662 61 0.010
positive regulation of lipid metabolic process GO:0045834 4 0.010
synaptic vesicle localization GO:0097479 53 0.010
regulation of protein modification process GO:0031399 112 0.010
tripartite regional subdivision GO:0007351 103 0.010
purine nucleotide catabolic process GO:0006195 109 0.010
compound eye morphogenesis GO:0001745 249 0.010
erk1 and erk2 cascade GO:0070371 39 0.010
positive regulation of jun kinase activity GO:0043507 4 0.010
dna metabolic process GO:0006259 227 0.010
appendage morphogenesis GO:0035107 397 0.010
pigment metabolic process involved in pigmentation GO:0043474 33 0.010
organelle localization GO:0051640 148 0.010
negative regulation of nervous system development GO:0051961 92 0.010

HPS4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
nervous system disease DOID:863 0 0.037
disease of metabolism DOID:0014667 0 0.018
central nervous system disease DOID:331 0 0.016
inherited metabolic disorder DOID:655 0 0.013
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013
eye disease DOID:5614 0 0.013
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
neurodegenerative disease DOID:1289 0 0.010