Drosophila melanogaster

122 known processes

HLHm7 (Dmel_CG8361)

E(spl) region transcript m7

(Aliases: E(spl)-M7,En(spl)m7,HLH-m7,ESPL,E(spl)-m7,E(SPL)m7,E(spl)m7,E(spl)M7,m7,M7,bHLHb35,E(spl) m7,Dmel\CG8361,CG8361)

HLHm7 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sensory organ precursor cell fate determination GO:0016360 19 1.000
Fly
neuron fate determination GO:0048664 1 1.000
Mouse
cell fate determination involved in pattern specification GO:0060582 19 0.999
Fly
glial cell fate commitment GO:0021781 3 0.999
Mouse
formation of organ boundary GO:0010160 30 0.999
Fly
regulation of timing of cell differentiation GO:0048505 1 0.999
Mouse
cell fate determination GO:0001709 91 0.998
Mouse Fly
cell fate specification GO:0001708 71 0.996
Worm
sensory organ morphogenesis GO:0090596 260 0.996
Fly
r7 cell differentiation GO:0045466 43 0.995
Fly
cell fate commitment involved in pattern specification GO:0060581 31 0.994
Fly
eye morphogenesis GO:0048592 260 0.991
Fly
r1 r6 cell differentiation GO:0048052 4 0.991
Fly
positive regulation of bmp signaling pathway GO:0030513 5 0.990
Mouse
stem cell maintenance GO:0019827 67 0.988
Human Mouse Rat
neural precursor cell proliferation GO:0061351 75 0.987
Fly
formation of anatomical boundary GO:0048859 37 0.985
Fly
nephron epithelium morphogenesis GO:0072088 3 0.981
Mouse
negative regulation of transcription dna templated GO:0045892 237 0.981
photoreceptor cell differentiation GO:0046530 170 0.979
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.976
nerve development GO:0021675 6 0.976
Mouse
notch signaling pathway GO:0007219 120 0.974
Human Zebrafish Mouse Fly
sensory organ boundary specification GO:0008052 22 0.973
Fly
neuroblast proliferation GO:0007405 74 0.972
Fly
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.971
Rat
nephron tubule morphogenesis GO:0072078 3 0.967
Mouse
primary sex determination soma GO:0007539 2 0.966
Fly
compound eye development GO:0048749 307 0.964
Fly
organ formation GO:0048645 39 0.963
Fly
positive regulation of rna biosynthetic process GO:1902680 266 0.962
Mouse
regionalization GO:0003002 416 0.961
Zebrafish Mouse Worm Fly
sex determination GO:0007530 18 0.960
Fly
hindbrain development GO:0030902 2 0.957
Mouse
negative regulation of cellular metabolic process GO:0031324 382 0.956
eye photoreceptor cell differentiation GO:0001754 145 0.956
Fly
regulation of cell development GO:0060284 215 0.955
Zebrafish Mouse Rat Fly
sex determination establishment of x a ratio GO:0007540 1 0.955
Fly
forebrain development GO:0030900 2 0.955
Mouse Rat
somatic sex determination GO:0018993 2 0.952
Fly
axon ensheathment in central nervous system GO:0032291 3 0.950
Mouse
biological adhesion GO:0022610 138 0.947
Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.941
Mouse
neuronal stem cell maintenance GO:0097150 4 0.939
Human Mouse Rat
regulation of glial cell differentiation GO:0045685 1 0.939
Mouse
regulation of cell differentiation GO:0045595 302 0.936
Human Zebrafish Mouse Rat Fly
negative regulation of gliogenesis GO:0014014 6 0.935
Mouse
positive regulation of transcription dna templated GO:0045893 266 0.934
Mouse
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.933
positive regulation of developmental process GO:0051094 143 0.933
Fly
negative regulation of biosynthetic process GO:0009890 277 0.932
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.932
hair cell differentiation GO:0035315 47 0.930
Mouse
tube morphogenesis GO:0035239 191 0.926
Mouse Fly
kidney epithelium development GO:0072073 3 0.925
Mouse
eye development GO:0001654 323 0.922
Zebrafish Mouse Fly
compound eye morphogenesis GO:0001745 249 0.917
Fly
nephron tubule formation GO:0072079 3 0.916
Mouse
nephron morphogenesis GO:0072028 3 0.914
Mouse
mesoderm development GO:0007498 78 0.913
Fly
axonogenesis GO:0007409 290 0.910
Zebrafish
epithelial tube morphogenesis GO:0060562 88 0.910
Mouse
positive regulation of multicellular organismal process GO:0051240 143 0.905
Fly
dosage compensation GO:0007549 16 0.905
Fly
positive regulation of nervous system development GO:0051962 69 0.904
Fly
malpighian tubule morphogenesis GO:0007443 44 0.904
stem cell proliferation GO:0072089 88 0.904
Fly
positive regulation of macromolecule metabolic process GO:0010604 405 0.899
Zebrafish Mouse
compound eye photoreceptor cell differentiation GO:0001751 140 0.897
Fly
regulation of neural precursor cell proliferation GO:2000177 35 0.894
Fly
embryonic morphogenesis GO:0048598 206 0.890
Zebrafish Mouse
gliogenesis GO:0042063 80 0.886
Zebrafish Mouse Rat
regulation of neuroblast proliferation GO:1902692 34 0.884
Fly
negative regulation of rna biosynthetic process GO:1902679 240 0.881
telencephalon development GO:0021537 2 0.880
Mouse
peripheral nervous system neuron development GO:0048935 8 0.879
Zebrafish
glial cell development GO:0021782 27 0.875
Mouse
cranial nerve development GO:0021545 1 0.865
Mouse
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.861
Mouse
nephron development GO:0072006 3 0.856
Mouse
dendrite morphogenesis GO:0048813 199 0.856
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.850
dorsal ventral pattern formation GO:0009953 133 0.850
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.848
Mouse
regulation of notch signaling pathway GO:0008593 100 0.847
Mouse
tyrosine phosphorylation of stat protein GO:0007260 1 0.843
Mouse
renal tubule morphogenesis GO:0061333 44 0.842
Mouse
camera type eye development GO:0043010 4 0.837
Mouse
bmp signaling pathway GO:0030509 27 0.833
Mouse
regulation of cell cycle GO:0051726 291 0.832
Zebrafish Fly
cellular response to dna damage stimulus GO:0006974 223 0.832
stem cell development GO:0048864 79 0.831
Human Mouse Rat
transcription from rna polymerase ii promoter GO:0006366 368 0.828
embryonic epithelial tube formation GO:0001838 6 0.817
Mouse
negative regulation of rna metabolic process GO:0051253 251 0.814
negative regulation of cellular biosynthetic process GO:0031327 277 0.804
negative regulation of stem cell differentiation GO:2000737 8 0.804
Human
immune system process GO:0002376 347 0.799
Rat
kidney morphogenesis GO:0060993 3 0.797
Mouse
neuron fate specification GO:0048665 12 0.792
neuron fate commitment GO:0048663 50 0.791
Mouse
neuroblast fate specification GO:0014018 2 0.791
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.791
Mouse
positive regulation of nucleic acid templated transcription GO:1903508 266 0.788
Mouse
regulation of neuron differentiation GO:0045664 103 0.785
Mouse Rat
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.774
peripheral nervous system development GO:0007422 52 0.773
Zebrafish
regulation of peptidyl tyrosine phosphorylation GO:0050730 10 0.771
Mouse
nephron tubule development GO:0072080 3 0.766
Mouse
stem cell fate specification GO:0048866 2 0.763
regulation of bmp signaling pathway GO:0030510 23 0.762
Mouse
central nervous system development GO:0007417 201 0.760
nephron epithelium development GO:0072009 3 0.755
Mouse
epithelial tube formation GO:0072175 7 0.752
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.751
epidermal cell differentiation GO:0009913 51 0.745
Mouse Worm
epithelial cell proliferation involved in malpighian tubule morphogenesis GO:0061331 11 0.744
renal system development GO:0072001 72 0.744
Mouse
positive regulation of gene expression GO:0010628 290 0.742
Mouse
morphogenesis of an epithelium GO:0002009 276 0.742
Mouse
connective tissue development GO:0061448 3 0.740
Human Mouse
regulation of cell cycle process GO:0010564 181 0.737
Fly
rhythmic process GO:0048511 106 0.732
Mouse
regulation of mitotic cell cycle GO:0007346 190 0.720
Fly
stem cell fate commitment GO:0048865 25 0.719
tube formation GO:0035148 21 0.718
Mouse
regulation of nervous system development GO:0051960 248 0.717
Zebrafish Mouse Rat Fly
positive regulation of cellular amine metabolic process GO:0033240 0 0.713
regulation of mitosis GO:0007088 56 0.712
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.708
open tracheal system development GO:0007424 204 0.706
Fly
regulation of cell morphogenesis GO:0022604 163 0.703
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.701
Mouse
adult behavior GO:0030534 137 0.700
Fly
regulation of stem cell proliferation GO:0072091 40 0.696
Fly
embryonic hindgut morphogenesis GO:0048619 48 0.693
tube development GO:0035295 244 0.686
Zebrafish Mouse Fly
startle response GO:0001964 16 0.680
cell adhesion GO:0007155 136 0.677
Mouse
urogenital system development GO:0001655 72 0.676
Mouse
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.670
Zebrafish
tissue morphogenesis GO:0048729 297 0.662
Mouse
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.648
Mouse
regulation of gliogenesis GO:0014013 11 0.645
Mouse
protein complex assembly GO:0006461 200 0.641
Mouse
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.631
regulation of neurogenesis GO:0050767 158 0.629
Zebrafish Mouse Rat Fly
phosphorylation GO:0016310 294 0.629
Zebrafish Mouse
salivary gland morphogenesis GO:0007435 145 0.628
Fly
positive regulation of neural precursor cell proliferation GO:2000179 8 0.626
Fly
spinal cord dorsal ventral patterning GO:0021513 1 0.625
glial cell differentiation GO:0010001 35 0.621
Mouse Rat
spinal cord patterning GO:0021511 1 0.618
respiratory system development GO:0060541 213 0.617
Fly
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.617
Mouse
negative regulation of gene expression GO:0010629 387 0.614
negative regulation of nervous system development GO:0051961 92 0.610
Zebrafish Mouse Rat
regulation of multicellular organismal development GO:2000026 414 0.602
Zebrafish Mouse Rat Fly
positive regulation of biosynthetic process GO:0009891 316 0.602
Mouse
positive regulation of rna metabolic process GO:0051254 271 0.601
Mouse
axon development GO:0061564 297 0.595
Zebrafish
cellular amine metabolic process GO:0044106 12 0.592
regulation of cellular amine metabolic process GO:0033238 3 0.575
negative regulation of cell differentiation GO:0045596 143 0.568
Human Zebrafish Mouse Rat
single organism behavior GO:0044708 391 0.567
Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.564
Mouse
positive regulation of signal transduction GO:0009967 223 0.562
Mouse
brain development GO:0007420 120 0.557
kidney development GO:0001822 3 0.553
Mouse
response to abiotic stimulus GO:0009628 341 0.548
Fly
epidermis development GO:0008544 65 0.537
Mouse Worm
cell division GO:0051301 248 0.533
Fly
taxis GO:0042330 304 0.532
regulation of protein metabolic process GO:0051246 256 0.529
Zebrafish Mouse
mitotic nuclear division GO:0007067 213 0.529
Fly
positive regulation of notch signaling pathway GO:0045747 34 0.527
Mouse
negative regulation of nucleic acid templated transcription GO:1903507 240 0.527
negative regulation of notch signaling pathway GO:0045746 41 0.512
neuronal action potential GO:0019228 10 0.511
Mouse
bolwig s organ development GO:0055034 8 0.499
smoothened signaling pathway GO:0007224 49 0.498
Mouse
cell maturation GO:0048469 144 0.498
Mouse
regulation of organelle organization GO:0033043 196 0.491
Fly
intracellular signal transduction GO:0035556 300 0.478
Mouse
neuron projection guidance GO:0097485 241 0.478
macromolecular complex assembly GO:0065003 256 0.477
Mouse
organonitrogen compound metabolic process GO:1901564 318 0.476
epithelial cell proliferation involved in renal tubule morphogenesis GO:2001013 11 0.475
segment specification GO:0007379 33 0.474
Zebrafish Mouse
positive regulation of stem cell proliferation GO:2000648 8 0.474
Fly
regulation of axonogenesis GO:0050770 32 0.464
peptidyl tyrosine modification GO:0018212 24 0.459
Mouse
epithelial cell differentiation GO:0030855 322 0.457
Mouse Worm
gland development GO:0048732 191 0.456
Fly
organelle fission GO:0048285 340 0.449
Fly
regulation of axon extension GO:0030516 8 0.446
negative regulation of cell development GO:0010721 62 0.438
Zebrafish Mouse Rat
enzyme linked receptor protein signaling pathway GO:0007167 179 0.435
Mouse
positive regulation of molecular function GO:0044093 136 0.434
Zebrafish
imaginal disc pattern formation GO:0007447 91 0.433
Fly
regulation of axon extension involved in axon guidance GO:0048841 4 0.433
spinal cord development GO:0021510 1 0.432
head development GO:0060322 135 0.432
regulation of epithelial cell differentiation GO:0030856 4 0.432
salivary gland development GO:0007431 162 0.426
Fly
regulation of phosphorylation GO:0042325 147 0.423
Zebrafish Mouse
stem cell differentiation GO:0048863 117 0.417
Human Mouse Rat
regulation of intracellular signal transduction GO:1902531 236 0.417
Mouse
chaeta development GO:0022416 97 0.414
appendage development GO:0048736 401 0.407
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.404
nuclear division GO:0000280 332 0.400
Fly
axon extension involved in axon guidance GO:0048846 10 0.397
negative regulation of cell cycle process GO:0010948 109 0.393
regulation of molecular function GO:0065009 217 0.376
Zebrafish
regulation of protein phosphorylation GO:0001932 64 0.372
Zebrafish Mouse
dendrite development GO:0016358 204 0.371
positive regulation of response to stimulus GO:0048584 323 0.369
Mouse
morphogenesis of embryonic epithelium GO:0016331 94 0.362
Mouse
regulation of gene expression epigenetic GO:0040029 128 0.362
Fly
renal tubule development GO:0061326 64 0.359
Mouse
skin development GO:0043588 65 0.353
Mouse Worm
proximal distal pattern formation GO:0009954 15 0.350
Mouse
regulation of cell size GO:0008361 63 0.348
regulation of neuron projection development GO:0010975 69 0.344
protein phosphorylation GO:0006468 169 0.340
Zebrafish Mouse
gland morphogenesis GO:0022612 145 0.338
Fly
protein complex biogenesis GO:0070271 201 0.336
Mouse
negative regulation of neurogenesis GO:0050768 53 0.335
Zebrafish Mouse Rat
imaginal disc derived appendage morphogenesis GO:0035114 395 0.333
positive regulation of cell communication GO:0010647 250 0.329
Mouse
peripheral nervous system neuron differentiation GO:0048934 8 0.328
Zebrafish
amine metabolic process GO:0009308 12 0.324
embryonic organ development GO:0048568 50 0.315
Zebrafish
larval behavior GO:0030537 42 0.314
Fly
positive regulation of neurogenesis GO:0050769 41 0.311
Fly
positive regulation of cell development GO:0010720 61 0.309
Fly
larval development GO:0002164 104 0.307
wing disc pattern formation GO:0035222 66 0.305
Fly
regulation of cell proliferation GO:0042127 163 0.304
Human Fly
positive regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090100 9 0.297
Mouse
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.297
Mouse
regulation of phosphate metabolic process GO:0019220 210 0.296
Zebrafish Mouse
ensheathment of neurons GO:0007272 10 0.294
Mouse
regulation of cell death GO:0010941 173 0.294
immune response GO:0006955 246 0.289
positive regulation of phosphorus metabolic process GO:0010562 139 0.289
Zebrafish Mouse
positive regulation of mitotic cell cycle GO:0045931 34 0.287
Fly
positive regulation of phosphorylation GO:0042327 87 0.276
Zebrafish Mouse
positive regulation of cell differentiation GO:0045597 64 0.275
Fly
central nervous system neuron differentiation GO:0021953 8 0.274
Rat
positive regulation of catalytic activity GO:0043085 118 0.273
Zebrafish
cellular ketone metabolic process GO:0042180 24 0.272
regulation of cellular protein metabolic process GO:0032268 243 0.272
Zebrafish Mouse
regulation of response to dna damage stimulus GO:2001020 23 0.272
larval locomotory behavior GO:0008345 27 0.270
Fly
protein modification process GO:0036211 438 0.270
Zebrafish Mouse
cell proliferation GO:0008283 299 0.268
Human Fly
hindgut morphogenesis GO:0007442 58 0.268
regulation of protein modification process GO:0031399 112 0.266
Zebrafish Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.265
neuron projection extension GO:1990138 32 0.263
peptidyl amino acid modification GO:0018193 105 0.261
Mouse
positive regulation of phosphate metabolic process GO:0045937 139 0.245
Zebrafish Mouse
imaginal disc derived appendage development GO:0048737 399 0.244
neuroepithelial cell differentiation GO:0060563 6 0.244
regulation of axon guidance GO:1902667 10 0.244
regulation of transferase activity GO:0051338 58 0.242
Zebrafish
cellular protein modification process GO:0006464 438 0.241
Zebrafish Mouse
negative regulation of glial cell proliferation GO:0060253 6 0.241
adult locomotory behavior GO:0008344 76 0.236
Fly
regulation of protein serine threonine kinase activity GO:0071900 25 0.235
Zebrafish
digestive tract morphogenesis GO:0048546 127 0.232
positive regulation of neuroblast proliferation GO:0002052 7 0.227
Fly
humoral immune response GO:0006959 117 0.227
brain morphogenesis GO:0048854 16 0.226
response to hypoxia GO:0001666 53 0.226
Fly
appendage morphogenesis GO:0035107 397 0.224
ommatidial rotation GO:0016318 20 0.224
anterior posterior pattern specification GO:0009952 136 0.222
Zebrafish Mouse Worm
stem cell fate determination GO:0048867 15 0.221
regulation of phosphorus metabolic process GO:0051174 210 0.218
Zebrafish Mouse
regulation of protein kinase activity GO:0045859 51 0.215
Zebrafish
regulation of response to stress GO:0080134 200 0.215
negative regulation of developmental process GO:0051093 201 0.213
Human Zebrafish Mouse Rat
malpighian tubule development GO:0072002 64 0.212
regulation of cell division GO:0051302 72 0.208
Fly
negative regulation of immune system process GO:0002683 50 0.205
Rat
regulation of kinase activity GO:0043549 53 0.203
Zebrafish
positive regulation of cell cycle GO:0045787 43 0.201
Zebrafish Fly
developmental cell growth GO:0048588 52 0.199
response to external biotic stimulus GO:0043207 293 0.198
regulation of glial cell proliferation GO:0060251 11 0.198
axon extension GO:0048675 32 0.196
response to decreased oxygen levels GO:0036293 58 0.194
Fly
regulation of catalytic activity GO:0050790 185 0.192
Zebrafish
segmentation GO:0035282 207 0.191
Zebrafish Mouse
neuroblast fate commitment GO:0014017 19 0.189
regulation of nuclear division GO:0051783 58 0.188
Fly
lateral inhibition GO:0046331 206 0.185
regulation of immune system process GO:0002682 176 0.183
Rat
endoderm development GO:0007492 6 0.182
Zebrafish
axon guidance GO:0007411 233 0.180
imaginal disc derived wing vein specification GO:0007474 48 0.178
locomotory behavior GO:0007626 176 0.177
regulation of cellular ketone metabolic process GO:0010565 3 0.177
positive regulation of signaling GO:0023056 243 0.175
Mouse
cell death GO:0008219 279 0.164
medulla oblongata development GO:0021550 2 0.163
jak stat cascade GO:0007259 49 0.162
Mouse
hematopoietic or lymphoid organ development GO:0048534 57 0.158
Rat
regulation of cellular response to stress GO:0080135 89 0.158
regulation of cellular component size GO:0032535 98 0.157
organic acid metabolic process GO:0006082 103 0.156
neuroblast fate determination GO:0007400 12 0.152
positive regulation of protein metabolic process GO:0051247 128 0.152
Zebrafish Mouse
glandular epithelial cell differentiation GO:0002067 1 0.152
transmission of nerve impulse GO:0019226 12 0.150
Mouse
immune system development GO:0002520 57 0.143
Rat
positive regulation of cellular protein metabolic process GO:0032270 118 0.140
Zebrafish Mouse
gastrulation involving germ band extension GO:0010004 36 0.138
wing disc dorsal ventral pattern formation GO:0048190 47 0.137
Fly
glial cell proliferation GO:0014009 13 0.132
positive regulation of cell proliferation GO:0008284 47 0.131
Human Fly
cellular amino acid metabolic process GO:0006520 61 0.131
developmental maturation GO:0021700 172 0.130
Mouse
negative regulation of signal transduction GO:0009968 206 0.129
carboxylic acid metabolic process GO:0019752 92 0.129
response to oxygen levels GO:0070482 59 0.125
Fly
exocrine system development GO:0035272 162 0.123
Fly
antennal development GO:0007469 25 0.121
positive regulation of neuron differentiation GO:0045666 26 0.120
positive regulation of organelle organization GO:0010638 65 0.119
Fly
dorsal ventral pattern formation imaginal disc GO:0007450 51 0.118
Fly
negative regulation of cell cycle GO:0045786 116 0.116
regulation of programmed cell death GO:0043067 152 0.116
negative regulation of cell death GO:0060548 81 0.116
axon ensheathment GO:0008366 10 0.113
Mouse
regulation of stem cell differentiation GO:2000736 14 0.112
Human
peptidyl tyrosine phosphorylation GO:0018108 24 0.110
Mouse
negative regulation of programmed cell death GO:0043069 72 0.109
eye photoreceptor cell fate commitment GO:0042706 37 0.109
body morphogenesis GO:0010171 2 0.107
oenocyte development GO:0007438 8 0.106
apoptotic process GO:0006915 159 0.103
regulation of cell projection organization GO:0031344 92 0.103
positive regulation of intracellular signal transduction GO:1902533 116 0.103
Mouse
programmed cell death GO:0012501 257 0.102
bolwig s organ morphogenesis GO:0001746 8 0.102
organonitrogen compound biosynthetic process GO:1901566 117 0.097
neural retina development GO:0003407 4 0.097
neurological system process GO:0050877 358 0.096
neuroblast differentiation GO:0014016 29 0.095
positive regulation of protein kinase activity GO:0045860 25 0.094
Zebrafish
cell cell signaling involved in cell fate commitment GO:0045168 210 0.091
malpighian tubule tip cell differentiation GO:0061382 9 0.090
regulation of membrane potential GO:0042391 35 0.090
Mouse
gastrulation with mouth forming first GO:0001703 36 0.090
oxoacid metabolic process GO:0043436 103 0.089
compound eye photoreceptor fate commitment GO:0001752 36 0.089
hemopoiesis GO:0030097 46 0.087
Rat
developmental growth GO:0048589 280 0.087
small molecule metabolic process GO:0044281 305 0.086
dedifferentiation GO:0043696 2 0.086
defense response GO:0006952 300 0.085
negative regulation of cellular component organization GO:0051129 108 0.084
neuron projection extension involved in neuron projection guidance GO:1902284 10 0.084
positive regulation of cell cycle process GO:0090068 28 0.083
Fly
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.080
Zebrafish
central nervous system neuron development GO:0021954 8 0.080
chaeta morphogenesis GO:0008407 42 0.080
neuromuscular process GO:0050905 21 0.079
negative regulation of apoptotic process GO:0043066 63 0.079
hematopoietic progenitor cell differentiation GO:0002244 1 0.077
Rat
wound healing GO:0042060 75 0.076
regulation of immune response GO:0050776 118 0.074
multi organism behavior GO:0051705 175 0.072
regulation of response to external stimulus GO:0032101 115 0.069
regulation of anatomical structure morphogenesis GO:0022603 242 0.068
Mouse
negative regulation of cell communication GO:0010648 223 0.067
regulation of cellular amide metabolic process GO:0034248 39 0.067
regulation of behavior GO:0050795 75 0.067
positive regulation of histone deacetylation GO:0031065 2 0.067
positive regulation of cellular component organization GO:0051130 156 0.066
Fly
immune effector process GO:0002252 98 0.066
negative regulation of multicellular organismal process GO:0051241 142 0.066
Zebrafish Mouse Rat
negative regulation of neuron differentiation GO:0045665 16 0.065
Mouse Rat
regulation of histone deacetylation GO:0031063 2 0.065
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.062
imaginal disc derived wing morphogenesis GO:0007476 337 0.061
multicellular organismal signaling GO:0035637 12 0.061
Mouse
cell growth GO:0016049 108 0.060
positive regulation of transferase activity GO:0051347 26 0.057
Zebrafish
action potential GO:0001508 13 0.057
Mouse
regulation of humoral immune response GO:0002920 51 0.053
digestive system development GO:0055123 149 0.053
positive regulation of kinase activity GO:0033674 25 0.051
Zebrafish
positive regulation of protein phosphorylation GO:0001934 34 0.051
Zebrafish Mouse
locomotor rhythm GO:0045475 56 0.050
negative regulation of mitotic cell cycle GO:0045930 109 0.050
regulation of localization GO:0032879 275 0.050
developmental growth involved in morphogenesis GO:0060560 65 0.049
response to oxygen containing compound GO:1901700 200 0.048
epithelial cell development GO:0002064 274 0.048
regulation of growth GO:0040008 233 0.046
positive regulation of protein modification process GO:0031401 58 0.046
Zebrafish Mouse
wing disc morphogenesis GO:0007472 344 0.046
negative regulation of signaling GO:0023057 219 0.045
negative regulation of organelle organization GO:0010639 56 0.043
digestive tract development GO:0048565 149 0.043
regulation of immune effector process GO:0002697 52 0.042
regulation of extent of cell growth GO:0061387 8 0.041
positive regulation of programmed cell death GO:0043068 62 0.041
asymmetric cell division GO:0008356 37 0.040
multi organism reproductive behavior GO:0044705 121 0.039
gastrulation GO:0007369 70 0.039
antennal joint development GO:0048098 5 0.038
positive regulation of neuron apoptotic process GO:0043525 1 0.038
death GO:0016265 284 0.037
covalent chromatin modification GO:0016569 106 0.036
regulation of protein deacetylation GO:0090311 2 0.036
intracellular protein transport GO:0006886 104 0.035
regulation of cell growth GO:0001558 43 0.035
post embryonic appendage morphogenesis GO:0035120 385 0.034
defense response to other organism GO:0098542 225 0.034
apoptotic process involved in morphogenesis GO:0060561 3 0.034
positive regulation of growth GO:0045927 75 0.034
response to organic substance GO:0010033 284 0.034
response to other organism GO:0051707 293 0.033
protein transport GO:0015031 155 0.033
organic substance transport GO:0071702 257 0.033
positive regulation of protein deacetylation GO:0090312 2 0.032
response to biotic stimulus GO:0009607 294 0.032
regulation of growth rate GO:0040009 3 0.031
chromosome organization GO:0051276 360 0.031
response to wounding GO:0009611 94 0.030
somatic stem cell maintenance GO:0035019 14 0.030
rhythmic behavior GO:0007622 76 0.030
camera type eye photoreceptor cell differentiation GO:0060219 2 0.030
antimicrobial humoral response GO:0019730 99 0.030
compound eye retinal cell programmed cell death GO:0046667 23 0.029
single organismal cell cell adhesion GO:0016337 45 0.029
photoreceptor cell fate commitment GO:0046552 41 0.029
proteolysis GO:0006508 192 0.029
regulation of developmental growth GO:0048638 174 0.028
localization of cell GO:0051674 257 0.028
neuron recognition GO:0008038 101 0.028
response to fibroblast growth factor GO:0071774 10 0.027
single organism cell adhesion GO:0098602 47 0.027
neuron death GO:0070997 27 0.027
chemotaxis GO:0006935 249 0.026
muscle cell development GO:0055001 50 0.026
muscle structure development GO:0061061 224 0.026
regulation of production of molecular mediator of immune response GO:0002700 44 0.026
camera type eye morphogenesis GO:0048593 2 0.025
imaginal disc derived leg morphogenesis GO:0007480 80 0.025
retina morphogenesis in camera type eye GO:0060042 2 0.025
regulation of antimicrobial peptide production GO:0002784 44 0.025
oenocyte differentiation GO:0001742 8 0.024
negative regulation of nuclear division GO:0051784 17 0.024
antimicrobial peptide production GO:0002775 46 0.024
regulation of anatomical structure size GO:0090066 163 0.023
oviposition GO:0018991 19 0.023
embryonic organ morphogenesis GO:0048562 5 0.023
Zebrafish
regulation of developmental pigmentation GO:0048070 24 0.023
neuron apoptotic process GO:0051402 17 0.023
negative regulation of response to stimulus GO:0048585 258 0.023
wnt signaling pathway GO:0016055 98 0.023
regulation of reproductive process GO:2000241 54 0.022
limb development GO:0060173 1 0.022
hindgut development GO:0061525 58 0.020
peptide biosynthetic process GO:0043043 42 0.020
growth GO:0040007 359 0.019
compound eye pigmentation GO:0048072 17 0.019
negative regulation of cell division GO:0051782 17 0.019
sensory perception of sound GO:0007605 56 0.019
r8 cell fate commitment GO:0007460 6 0.019
cell type specific apoptotic process GO:0097285 38 0.019
compound eye cone cell differentiation GO:0042675 13 0.018
retina development in camera type eye GO:0060041 4 0.018
regulation of apoptotic process GO:0042981 130 0.018
cellular response to ionizing radiation GO:0071479 15 0.018
regulation of response to biotic stimulus GO:0002831 63 0.018
retinal cone cell differentiation GO:0042670 2 0.018
regulation of multi organism process GO:0043900 131 0.017
antimicrobial peptide biosynthetic process GO:0002777 38 0.017
regulation of neuron death GO:1901214 26 0.017
positive regulation of cell division GO:0051781 16 0.017
Fly
formation of primary germ layer GO:0001704 24 0.017
muscle organ development GO:0007517 127 0.016
reproductive behavior GO:0019098 122 0.016
positive regulation of retinal cell programmed cell death GO:0046670 9 0.016

HLHm7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
bone development disease DOID:0080006 0 0.959
Human
bone disease DOID:0080001 0 0.959
Human
disease of anatomical entity DOID:7 0 0.959
Human
musculoskeletal system disease DOID:17 0 0.959
Human
connective tissue disease DOID:65 0 0.959
Human
dysostosis DOID:1934 0 0.939
Human
spondylocostal dysostosis DOID:0050568 0 0.768
Human