Drosophila melanogaster

355 known processes

foxo (Dmel_CG3143)

forkhead box, sub-group O

(Aliases: dFoxo,Q95V55,FoxO,FOXO,DmQ95V5,Dfoxo,anon-WO0118547.374,dfoxo,cg3143,dFOXO,dFoxO,Foxo,3143,Afx,Dmel\CG3143,fd88A,CG3143,FKHR)

foxo biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
feeding behavior GO:0007631 50 0.999
circadian rhythm GO:0007623 105 0.999
syncytium formation by plasma membrane fusion GO:0000768 43 0.994
response to nutrient levels GO:0031667 114 0.982
positive regulation of macromolecule metabolic process GO:0010604 405 0.980
syncytium formation GO:0006949 43 0.966
response to organic substance GO:0010033 284 0.965
response to nitrogen compound GO:1901698 90 0.964
response to extracellular stimulus GO:0009991 116 0.961
circadian behavior GO:0048512 76 0.955
regulation of response to external stimulus GO:0032101 115 0.955
negative regulation of biosynthetic process GO:0009890 277 0.954
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.943
regulation of growth GO:0040008 233 0.929
response to starvation GO:0042594 97 0.920
locomotory behavior GO:0007626 176 0.914
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.907
striated muscle cell differentiation GO:0051146 90 0.900
cellular response to extracellular stimulus GO:0031668 64 0.893
regulation of cell development GO:0060284 215 0.887
growth GO:0040007 359 0.884
negative regulation of cell communication GO:0010648 223 0.877
positive regulation of biosynthetic process GO:0009891 316 0.877
g protein coupled receptor signaling pathway GO:0007186 136 0.876
regulation of multicellular organismal development GO:2000026 414 0.863
Human Zebrafish
immune system process GO:0002376 347 0.859
dendrite development GO:0016358 204 0.857
single organism behavior GO:0044708 391 0.852
myoblast fusion GO:0007520 43 0.845
positive regulation of rna metabolic process GO:0051254 271 0.845
cognition GO:0050890 141 0.844
regulation of cell proliferation GO:0042127 163 0.843
myotube differentiation GO:0014902 46 0.836
sleep GO:0030431 49 0.832
positive regulation of gene expression GO:0010628 290 0.805
actin filament based process GO:0030029 220 0.793
defense response to bacterium GO:0042742 178 0.792
Worm
positive regulation of transcription dna templated GO:0045893 266 0.790
determination of adult lifespan GO:0008340 137 0.788
mating behavior GO:0007617 106 0.784
appendage development GO:0048736 401 0.783
memory GO:0007613 94 0.782
dendrite morphogenesis GO:0048813 199 0.774
locomotor rhythm GO:0045475 56 0.766
cellular response to nutrient levels GO:0031669 62 0.764
rhythmic behavior GO:0007622 76 0.747
open tracheal system development GO:0007424 204 0.741
regulation of intracellular signal transduction GO:1902531 236 0.735
Human
intracellular signal transduction GO:0035556 300 0.734
Human Mouse
phenol containing compound metabolic process GO:0018958 57 0.734
regulation of cell differentiation GO:0045595 302 0.732
signal transduction by phosphorylation GO:0023014 107 0.726
Human
negative regulation of response to stimulus GO:0048585 258 0.693
cyclic purine nucleotide metabolic process GO:0052652 25 0.692
cellular response to chemical stimulus GO:0070887 199 0.675
regulation of cell death GO:0010941 173 0.672
Human Zebrafish Worm
epithelial tube morphogenesis GO:0060562 88 0.669
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.662
positive regulation of response to stimulus GO:0048584 323 0.661
negative regulation of cellular metabolic process GO:0031324 382 0.650
negative regulation of transcription dna templated GO:0045892 237 0.647
tube morphogenesis GO:0035239 191 0.645
positive regulation of growth GO:0045927 75 0.644
rhythmic process GO:0048511 106 0.642
negative regulation of cellular biosynthetic process GO:0031327 277 0.631
synaptic transmission GO:0007268 288 0.627
actin cytoskeleton organization GO:0030036 206 0.626
negative regulation of multicellular organismal process GO:0051241 142 0.616
response to organonitrogen compound GO:0010243 75 0.612
positive regulation of developmental process GO:0051094 143 0.610
Human
response to endogenous stimulus GO:0009719 119 0.609
sensory organ morphogenesis GO:0090596 260 0.598
multicellular organismal aging GO:0010259 140 0.590
cell motility GO:0048870 251 0.587
regulation of anatomical structure morphogenesis GO:0022603 242 0.583
positive regulation of cellular component organization GO:0051130 156 0.583
positive regulation of developmental growth GO:0048639 62 0.582
defense response GO:0006952 300 0.581
Worm
axon guidance GO:0007411 233 0.581
reproductive behavior GO:0019098 122 0.577
positive regulation of cell differentiation GO:0045597 64 0.574
Human
regulation of phosphate metabolic process GO:0019220 210 0.570
Human
response to other organism GO:0051707 293 0.565
male gamete generation GO:0048232 201 0.562
regulation of insulin receptor signaling pathway GO:0046626 17 0.547
localization of cell GO:0051674 257 0.543
compound eye morphogenesis GO:0001745 249 0.535
post embryonic appendage morphogenesis GO:0035120 385 0.532
cell maturation GO:0048469 144 0.522
Mouse
positive regulation of multicellular organismal process GO:0051240 143 0.520
Human
forebrain development GO:0030900 2 0.512
cell death GO:0008219 279 0.511
Human Zebrafish Mouse Worm
muscle structure development GO:0061061 224 0.509
immune response GO:0006955 246 0.505
Worm
multi organism reproductive behavior GO:0044705 121 0.504
regulation of immune system process GO:0002682 176 0.500
imaginal disc derived wing morphogenesis GO:0007476 337 0.493
mating GO:0007618 120 0.488
regulation of protein metabolic process GO:0051246 256 0.485
Human
aging GO:0007568 143 0.448
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.448
single organism cellular localization GO:1902580 180 0.422
regulation of response to extracellular stimulus GO:0032104 18 0.422
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.411
regulation of cell size GO:0008361 63 0.409
apoptotic process GO:0006915 159 0.408
Human Zebrafish Mouse Worm
regulation of cellular component biogenesis GO:0044087 201 0.399
muscle cell differentiation GO:0042692 103 0.397
neurological system process GO:0050877 358 0.387
cell migration GO:0016477 238 0.382
phosphorylation GO:0016310 294 0.379
Human
regulation of anatomical structure size GO:0090066 163 0.379
regulation of neurogenesis GO:0050767 158 0.378
transcription from rna polymerase ii promoter GO:0006366 368 0.377
cellular response to organonitrogen compound GO:0071417 36 0.376
stem cell differentiation GO:0048863 117 0.370
regulation of cellular protein metabolic process GO:0032268 243 0.369
Human
positive regulation of cell communication GO:0010647 250 0.364
response to abiotic stimulus GO:0009628 341 0.362
Human Worm
cell fate determination GO:0001709 91 0.346
cell growth GO:0016049 108 0.345
stress activated mapk cascade GO:0051403 52 0.345
Human
regulation of defense response GO:0031347 102 0.341
cellular response to external stimulus GO:0071496 66 0.340
regulation of response to stress GO:0080134 200 0.339
negative regulation of rna biosynthetic process GO:1902679 240 0.339
cellular response to starvation GO:0009267 61 0.338
regulation of dendrite morphogenesis GO:0048814 28 0.337
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.336
single organism intracellular transport GO:1902582 207 0.335
small molecule metabolic process GO:0044281 305 0.332
larval feeding behavior GO:0030536 15 0.328
regulation of cellular component size GO:0032535 98 0.326
male courtship behavior GO:0008049 63 0.322
response to bacterium GO:0009617 198 0.318
appendage morphogenesis GO:0035107 397 0.318
cellular response to oxygen containing compound GO:1901701 79 0.313
protein phosphorylation GO:0006468 169 0.312
cellular response to hormone stimulus GO:0032870 44 0.312
positive regulation of rna biosynthetic process GO:1902680 266 0.308
regulation of multicellular organism growth GO:0040014 40 0.303
cellular response to organic substance GO:0071310 132 0.303
spermatogenesis GO:0007283 200 0.302
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.299
Human Mouse
regulation of cell cycle GO:0051726 291 0.298
Mouse Worm
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.297
enzyme linked receptor protein signaling pathway GO:0007167 179 0.297
multi organism behavior GO:0051705 175 0.296
regulation of phosphorylation GO:0042325 147 0.296
Human
cellular catabolic process GO:0044248 372 0.294
response to alkaloid GO:0043279 26 0.294
synaptic growth at neuromuscular junction GO:0051124 119 0.289
synapse organization GO:0050808 196 0.283
positive regulation of cellular response to insulin stimulus GO:1900078 4 0.277
regulation of catalytic activity GO:0050790 185 0.276
negative regulation of programmed cell death GO:0043069 72 0.275
Human
nucleobase containing small molecule metabolic process GO:0055086 174 0.264
oxoacid metabolic process GO:0043436 103 0.262
negative regulation of cell differentiation GO:0045596 143 0.261
homeostatic process GO:0042592 199 0.256
regulation of photoreceptor cell differentiation GO:0046532 34 0.255
negative regulation of signaling GO:0023057 219 0.253
developmental growth GO:0048589 280 0.252
immune response regulating signaling pathway GO:0002764 2 0.247
regionalization GO:0003002 416 0.243
programmed cell death GO:0012501 257 0.242
Human Zebrafish Mouse Worm
regulation of phosphorus metabolic process GO:0051174 210 0.242
Human
wing disc morphogenesis GO:0007472 344 0.241
positive regulation of signal transduction GO:0009967 223 0.237
negative regulation of immune system process GO:0002683 50 0.234
positive regulation of cell migration GO:0030335 2 0.233
immune response activating signal transduction GO:0002757 2 0.232
regulation of circadian sleep wake cycle sleep GO:0045187 21 0.231
multi multicellular organism process GO:0044706 123 0.228
regulation of cellular response to stress GO:0080135 89 0.224
response to oxidative stress GO:0006979 86 0.222
organic acid metabolic process GO:0006082 103 0.220
multicellular organism growth GO:0035264 46 0.217
developmental maturation GO:0021700 172 0.214
Mouse
histone modification GO:0016570 106 0.211
negative regulation of developmental process GO:0051093 201 0.210
positive regulation of multicellular organism growth GO:0040018 21 0.208
regulation of cell fate specification GO:0042659 27 0.207
positive regulation of cell size GO:0045793 21 0.206
regulation of nervous system development GO:0051960 248 0.206
Zebrafish
cellular protein modification process GO:0006464 438 0.205
chromosome organization GO:0051276 360 0.203
regulation of programmed cell death GO:0043067 152 0.203
Human Zebrafish Worm
long term memory GO:0007616 62 0.202
regulation of lipid metabolic process GO:0019216 15 0.201
negative regulation of response to external stimulus GO:0032102 22 0.199
response to temperature stimulus GO:0009266 106 0.198
Worm
negative regulation of cell proliferation GO:0008285 69 0.198
negative regulation of gene expression GO:0010629 387 0.197
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.194
catabolic process GO:0009056 409 0.193
cell proliferation GO:0008283 299 0.193
establishment of organelle localization GO:0051656 122 0.192
positive regulation of nucleic acid templated transcription GO:1903508 266 0.190
imaginal disc derived appendage morphogenesis GO:0035114 395 0.190
multicellular organismal reproductive behavior GO:0033057 110 0.189
regulation of localization GO:0032879 275 0.187
protein modification process GO:0036211 438 0.186
antimicrobial humoral response GO:0019730 99 0.185
response to reactive oxygen species GO:0000302 24 0.184
Mouse
autophagic vacuole assembly GO:0000045 2 0.184
imaginal disc derived appendage development GO:0048737 399 0.182
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.181
carbohydrate derivative metabolic process GO:1901135 217 0.180
larval behavior GO:0030537 42 0.180
defense response to other organism GO:0098542 225 0.180
Worm
carboxylic acid metabolic process GO:0019752 92 0.179
gland morphogenesis GO:0022612 145 0.177
positive regulation of cell development GO:0010720 61 0.176
epithelial cell development GO:0002064 274 0.176
negative regulation of rna metabolic process GO:0051253 251 0.175
positive regulation of cellular biosynthetic process GO:0031328 316 0.174
response to oxygen containing compound GO:1901700 200 0.174
response to osmotic stress GO:0006970 14 0.172
embryonic morphogenesis GO:0048598 206 0.169
death GO:0016265 284 0.168
Human Zebrafish Mouse Worm
regulation of epithelial cell proliferation GO:0050678 4 0.166
cellular amine metabolic process GO:0044106 12 0.163
organonitrogen compound metabolic process GO:1901564 318 0.162
negative regulation of protein metabolic process GO:0051248 85 0.161
organic hydroxy compound metabolic process GO:1901615 83 0.158
connective tissue development GO:0061448 3 0.158
autophagy GO:0006914 108 0.156
chromatin organization GO:0006325 207 0.156
negative regulation of immune response GO:0050777 39 0.156
cellular ketone metabolic process GO:0042180 24 0.155
Mouse
heart development GO:0007507 82 0.155
purine containing compound metabolic process GO:0072521 155 0.151
cell cell signaling involved in cell fate commitment GO:0045168 210 0.150
carbohydrate derivative catabolic process GO:1901136 118 0.147
establishment of localization in cell GO:0051649 402 0.146
amine metabolic process GO:0009308 12 0.146
somatic muscle development GO:0007525 66 0.144
adult locomotory behavior GO:0008344 76 0.143
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.142
mucosal immune response GO:0002385 10 0.141
regulation of protein phosphorylation GO:0001932 64 0.140
cell adhesion GO:0007155 136 0.140
regulation of cell morphogenesis GO:0022604 163 0.140
cellular response to endogenous stimulus GO:0071495 80 0.138
organophosphate biosynthetic process GO:0090407 46 0.138
positive regulation of cell motility GO:2000147 3 0.138
regulation of cell growth GO:0001558 43 0.136
organophosphate metabolic process GO:0019637 195 0.136
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.133
purine ribonucleotide biosynthetic process GO:0009152 28 0.130
respiratory system development GO:0060541 213 0.128
purine nucleotide metabolic process GO:0006163 146 0.127
negative regulation of growth GO:0045926 84 0.126
embryonic organ development GO:0048568 50 0.126
positive regulation of organelle organization GO:0010638 65 0.126
regulation of myotube differentiation GO:0010830 6 0.125
regulation of proteolysis GO:0030162 87 0.124
negative regulation of insulin secretion GO:0046676 1 0.124
compound eye development GO:0048749 307 0.124
regulation of protein kinase activity GO:0045859 51 0.121
taxis GO:0042330 304 0.121
negative regulation of catalytic activity GO:0043086 42 0.121
innate immune response GO:0045087 144 0.120
Worm
organelle localization GO:0051640 148 0.120
lateral inhibition GO:0046331 206 0.120
regulation of myoblast fusion GO:1901739 6 0.119
endocytosis GO:0006897 310 0.118
negative regulation of signal transduction GO:0009968 206 0.118
organic substance transport GO:0071702 257 0.116
regulation of dendrite development GO:0050773 37 0.115
tube development GO:0035295 244 0.115
regulation of protein transport GO:0051223 57 0.113
chorion containing eggshell formation GO:0007304 105 0.113
vesicle mediated transport GO:0016192 381 0.113
regulation of macroautophagy GO:0016241 15 0.112
regulation of behavior GO:0050795 75 0.112
neurotransmitter secretion GO:0007269 35 0.112
purine ribonucleotide metabolic process GO:0009150 145 0.111
positive regulation of cellular component biogenesis GO:0044089 80 0.111
response to insulin GO:0032868 29 0.111
negative regulation of defense response GO:0031348 35 0.110
circadian sleep wake cycle sleep GO:0050802 23 0.110
regulation of developmental growth GO:0048638 174 0.110
positive regulation of phosphorus metabolic process GO:0010562 139 0.109
regulation of cellular amine metabolic process GO:0033238 3 0.109
skeletal muscle organ development GO:0060538 48 0.109
neuron projection guidance GO:0097485 241 0.109
response to external biotic stimulus GO:0043207 293 0.108
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.108
Human
circadian sleep wake cycle process GO:0022410 24 0.108
regulation of molecular function GO:0065009 217 0.107
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.107
Human
regulation of syncytium formation by plasma membrane fusion GO:0060142 6 0.106
jnk cascade GO:0007254 50 0.104
columnar cuboidal epithelial cell development GO:0002066 249 0.104
negative regulation of phosphate metabolic process GO:0045936 45 0.104
Human
negative regulation of cell death GO:0060548 81 0.104
Human
detection of chemical stimulus GO:0009593 93 0.103
regulation of organelle organization GO:0033043 196 0.102
male mating behavior GO:0060179 70 0.101
cellular amide metabolic process GO:0043603 80 0.100
eye morphogenesis GO:0048592 260 0.100
nuclear transport GO:0051169 72 0.100
mapk cascade GO:0000165 107 0.099
Human
positive regulation of signaling GO:0023056 243 0.098
regulation of circadian rhythm GO:0042752 49 0.097
cellular protein localization GO:0034613 160 0.096
macroautophagy GO:0016236 42 0.096
regulation of cell motility GO:2000145 23 0.095
regulation of cell migration GO:0030334 22 0.093
negative regulation of cellular protein metabolic process GO:0032269 85 0.093
single organism catabolic process GO:0044712 228 0.093
positive regulation of protein metabolic process GO:0051247 128 0.092
Human
regulation of peptidase activity GO:0052547 39 0.091
regulation of cellular localization GO:0060341 136 0.091
regulation of neuron differentiation GO:0045664 103 0.091
single organism cell adhesion GO:0098602 47 0.091
peptidyl amino acid modification GO:0018193 105 0.091
eye development GO:0001654 323 0.090
axonogenesis GO:0007409 290 0.090
response to biotic stimulus GO:0009607 294 0.089
branching morphogenesis of an epithelial tube GO:0048754 45 0.089
chemotaxis GO:0006935 249 0.088
response to superoxide GO:0000303 3 0.087
oocyte development GO:0048599 124 0.086
Mouse
epithelium migration GO:0090132 148 0.085
negative regulation of transforming growth factor beta receptor signaling pathway GO:0030512 4 0.085
biological adhesion GO:0022610 138 0.085
positive regulation of cell proliferation GO:0008284 47 0.085
regulation of response to oxidative stress GO:1902882 4 0.085
negative regulation of cell fate specification GO:0009996 15 0.084
response to lipopolysaccharide GO:0032496 4 0.084
regulation of adult chitin containing cuticle pigmentation GO:0048082 13 0.083
negative regulation of phosphorus metabolic process GO:0010563 45 0.083
Human
regulation of innate immune response GO:0045088 71 0.083
cellular response to growth factor stimulus GO:0071363 30 0.082
response to heat GO:0009408 63 0.081
Worm
adult feeding behavior GO:0008343 13 0.081
response to oxygen radical GO:0000305 3 0.081
insulin like growth factor receptor signaling pathway GO:0048009 5 0.080
negative regulation of phosphorylation GO:0042326 35 0.080
Human
ameboidal type cell migration GO:0001667 151 0.078
intracellular protein transport GO:0006886 104 0.077
tissue morphogenesis GO:0048729 297 0.076
myotube cell development GO:0014904 3 0.075
protein localization to organelle GO:0033365 82 0.075
positive regulation of cellular protein metabolic process GO:0032270 118 0.075
positive regulation of lipid catabolic process GO:0050996 1 0.074
protein heterooligomerization GO:0051291 4 0.074
epithelial cell differentiation GO:0030855 322 0.074
larval development GO:0002164 104 0.074
Worm
regulation of apoptotic process GO:0042981 130 0.073
Human Zebrafish Worm
nucleotide metabolic process GO:0009117 161 0.073
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.073
gland development GO:0048732 191 0.072
camera type eye development GO:0043010 4 0.070
response to peptide GO:1901652 29 0.070
cellular response to peptide GO:1901653 28 0.070
positive regulation of cell growth GO:0030307 19 0.069
generation of precursor metabolites and energy GO:0006091 42 0.069
learning or memory GO:0007611 141 0.069
regulation of cellular catabolic process GO:0031329 157 0.069
response to inorganic substance GO:0010035 44 0.068
Mouse
regulation of cellular component movement GO:0051270 42 0.067
regulation of transforming growth factor beta receptor signaling pathway GO:0017015 6 0.067
cellular response to peptide hormone stimulus GO:0071375 28 0.067
eggshell formation GO:0030703 105 0.066
visceral muscle development GO:0007522 14 0.066
cytoplasmic transport GO:0016482 130 0.065
positive regulation of protein modification process GO:0031401 58 0.065
regulation of nucleocytoplasmic transport GO:0046822 35 0.064
macromolecular complex assembly GO:0065003 256 0.063
regulation of organ morphogenesis GO:2000027 78 0.063
positive regulation of intracellular signal transduction GO:1902533 116 0.062
defense response to gram negative bacterium GO:0050829 94 0.062
Worm
mitotic nuclear division GO:0007067 213 0.062
ribose phosphate metabolic process GO:0019693 145 0.062
cellular response to lipopolysaccharide GO:0071222 3 0.061
positive regulation of response to external stimulus GO:0032103 44 0.061
humoral immune response GO:0006959 117 0.061
single organism biosynthetic process GO:0044711 206 0.060
learning GO:0007612 75 0.059
establishment or maintenance of cytoskeleton polarity GO:0030952 44 0.059
synapse assembly GO:0007416 143 0.059
regulation of cellular response to insulin stimulus GO:1900076 17 0.058
response to hormone GO:0009725 45 0.058
positive regulation of cell cycle GO:0045787 43 0.058
insulin receptor signaling pathway GO:0008286 25 0.058
cellular amino acid metabolic process GO:0006520 61 0.057
nuclear import GO:0051170 51 0.057
maintenance of location GO:0051235 73 0.057
tissue migration GO:0090130 155 0.057
cuticle development GO:0042335 86 0.056
segmentation GO:0035282 207 0.056
regulation of cellular amino acid metabolic process GO:0006521 0 0.055
nucleoside phosphate biosynthetic process GO:1901293 34 0.055
regulation of autophagy GO:0010506 62 0.055
circadian sleep wake cycle GO:0042745 28 0.054
positive regulation of catabolic process GO:0009896 105 0.054
Human
regulation of secretion GO:0051046 44 0.053
response to growth factor GO:0070848 31 0.052
chromosome segregation GO:0007059 157 0.052
positive regulation of transport GO:0051050 92 0.052
regulation of carbohydrate metabolic process GO:0006109 10 0.052
Mouse
cellular response to biotic stimulus GO:0071216 4 0.051
regulation of mitotic cell cycle GO:0007346 190 0.051
Mouse
muscle cell development GO:0055001 50 0.050
carbohydrate metabolic process GO:0005975 82 0.050
stem cell proliferation GO:0072089 88 0.050
regulation of kinase activity GO:0043549 53 0.050
negative regulation of protein phosphorylation GO:0001933 17 0.049
morphogenesis of a branching epithelium GO:0061138 45 0.049
regulation of multi organism process GO:0043900 131 0.049
innate immune response activating signal transduction GO:0002758 2 0.049
cellular macromolecule localization GO:0070727 220 0.049
nucleobase containing compound catabolic process GO:0034655 165 0.049
cellular response to oxidative stress GO:0034599 28 0.048
regulation of intracellular protein transport GO:0033157 46 0.048
immune effector process GO:0002252 98 0.048
positive regulation of cellular catabolic process GO:0031331 95 0.048
Human
regulation of protein modification process GO:0031399 112 0.048
carbohydrate biosynthetic process GO:0016051 17 0.048
Mouse
nucleocytoplasmic transport GO:0006913 72 0.048
adult behavior GO:0030534 137 0.047
protein targeting to nucleus GO:0044744 51 0.046
neuromuscular junction development GO:0007528 149 0.046
positive regulation of mitotic cell cycle GO:0045931 34 0.046
heart process GO:0003015 37 0.046
stress activated protein kinase signaling cascade GO:0031098 55 0.046
Human
regulation of steroid metabolic process GO:0019218 2 0.046
cellular response to dna damage stimulus GO:0006974 223 0.046
erk1 and erk2 cascade GO:0070371 39 0.045
positive regulation of multi organism process GO:0043902 40 0.045
regulation of cell adhesion GO:0030155 27 0.045
spermatid differentiation GO:0048515 114 0.045
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.045
response to axon injury GO:0048678 12 0.045
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.044
regulation of antimicrobial humoral response GO:0002759 50 0.044
cell type specific apoptotic process GO:0097285 38 0.044
Human Zebrafish
anatomical structure homeostasis GO:0060249 97 0.044
regulation of reactive oxygen species metabolic process GO:2000377 8 0.043
Mouse
negative regulation of developmental growth GO:0048640 64 0.043
oxidation reduction process GO:0055114 123 0.043
energy derivation by oxidation of organic compounds GO:0015980 32 0.043
regulation of humoral immune response GO:0002920 51 0.043
phosphatidylinositol mediated signaling GO:0048015 4 0.043
nucleoside catabolic process GO:0009164 112 0.043
regulation of protein complex assembly GO:0043254 42 0.043
leg disc morphogenesis GO:0007478 80 0.043
translation GO:0006412 69 0.042
Human
skeletal muscle fiber development GO:0048741 3 0.042
transmembrane transport GO:0055085 139 0.042
embryonic pattern specification GO:0009880 174 0.042
positive regulation of catalytic activity GO:0043085 118 0.042
monocarboxylic acid metabolic process GO:0032787 29 0.042
positive regulation of locomotion GO:0040017 8 0.042
regulation of translation GO:0006417 56 0.041
Human
lipid modification GO:0030258 24 0.041
response to peptide hormone GO:0043434 29 0.041
pattern recognition receptor signaling pathway GO:0002221 2 0.041
spermatid development GO:0007286 98 0.040
positive regulation of cellular amine metabolic process GO:0033240 0 0.040
peripheral nervous system development GO:0007422 52 0.040
ribonucleotide metabolic process GO:0009259 145 0.040
melanin metabolic process GO:0006582 47 0.040
molting cycle chitin based cuticle GO:0007591 56 0.040
protein localization GO:0008104 284 0.039
mesenchymal cell differentiation GO:0048762 1 0.039
production of molecular mediator of immune response GO:0002440 46 0.039
response to glucose GO:0009749 2 0.039
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.039
morphogenesis of an epithelium GO:0002009 276 0.038
semaphorin plexin signaling pathway GO:0071526 4 0.038
positive regulation of phosphorylation GO:0042327 87 0.038
dna damage checkpoint GO:0000077 78 0.038
Mouse
regulation of neural precursor cell proliferation GO:2000177 35 0.038
Mouse
regulation of neuronal synaptic plasticity GO:0048168 8 0.038
response to ethanol GO:0045471 59 0.038
regulation of response to nutrient levels GO:0032107 18 0.038
protein localization to nucleus GO:0034504 55 0.037
activation of mapk activity GO:0000187 9 0.037
neuron projection extension GO:1990138 32 0.037
cellular response to molecule of bacterial origin GO:0071219 3 0.037
stem cell development GO:0048864 79 0.037
intracellular transport GO:0046907 228 0.037
developmental cell growth GO:0048588 52 0.037
visual learning GO:0008542 4 0.037
negative regulation of autophagy GO:0010507 16 0.037
peptidyl threonine phosphorylation GO:0018107 2 0.037
negative regulation of mapk cascade GO:0043409 23 0.036
Human
regulation of r7 cell differentiation GO:0045676 15 0.036
regulation of cellular ketone metabolic process GO:0010565 3 0.036
Mouse
regulation of embryonic development GO:0045995 68 0.036

foxo disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.121
Human
disease of cellular proliferation DOID:14566 0 0.121
Human
disease of anatomical entity DOID:7 0 0.039
nervous system disease DOID:863 0 0.039