Drosophila melanogaster

120 known processes

Psc (Dmel_CG3886)

Posterior sex combs

(Aliases: l(2)vr14,l(2)Psc,D-Bmi,Dmel\CG3886,PSC,Psc1,l(2)49Ea,Su(z)2-C,dPSC,CG3886,psc,49Ea,vr14)

Psc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.538
chromatin silencing GO:0006342 76 0.441
negative regulation of rna biosynthetic process GO:1902679 240 0.397
negative regulation of transcription dna templated GO:0045892 237 0.363
negative regulation of gene expression GO:0010629 387 0.345
negative regulation of rna metabolic process GO:0051253 251 0.321
transcription from rna polymerase ii promoter GO:0006366 368 0.262
Human Mouse
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.243
negative regulation of cellular biosynthetic process GO:0031327 277 0.229
imaginal disc derived appendage morphogenesis GO:0035114 395 0.224
gene silencing GO:0016458 138 0.218
negative regulation of nucleic acid templated transcription GO:1903507 240 0.199
intracellular signal transduction GO:0035556 300 0.197
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.194
meiotic cell cycle GO:0051321 171 0.188
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.176
regulation of multicellular organismal development GO:2000026 414 0.168
Mouse
imaginal disc derived appendage development GO:0048737 399 0.167
regulation of gene silencing GO:0060968 63 0.166
death GO:0016265 284 0.163
Mouse
regulation of chromatin silencing GO:0031935 36 0.163
cellular protein modification process GO:0006464 438 0.162
Human Mouse
positive regulation of macromolecule metabolic process GO:0010604 405 0.157
Human
regulation of mitotic cell cycle GO:0007346 190 0.151
regulation of gene expression epigenetic GO:0040029 128 0.148
regionalization GO:0003002 416 0.143
Mouse
positive regulation of cellular biosynthetic process GO:0031328 316 0.133
morphogenesis of an epithelium GO:0002009 276 0.132
organelle fission GO:0048285 340 0.121
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.120
eye development GO:0001654 323 0.116
axonogenesis GO:0007409 290 0.114
regulation of anatomical structure morphogenesis GO:0022603 242 0.105
eye photoreceptor cell development GO:0042462 81 0.102
axon development GO:0061564 297 0.101
vesicle mediated transport GO:0016192 381 0.096
compound eye morphogenesis GO:0001745 249 0.094
positive regulation of rna biosynthetic process GO:1902680 266 0.091
regulation of cell development GO:0060284 215 0.090
macromolecular complex assembly GO:0065003 256 0.088
morphogenesis of a polarized epithelium GO:0001738 93 0.080
chromosome organization GO:0051276 360 0.079
regulation of intracellular signal transduction GO:1902531 236 0.078
post embryonic appendage morphogenesis GO:0035120 385 0.077
mitotic spindle organization GO:0007052 220 0.076
positive regulation of gene expression GO:0010628 290 0.075
ribonucleoside metabolic process GO:0009119 127 0.074
nuclear division GO:0000280 332 0.073
compound eye photoreceptor cell differentiation GO:0001751 140 0.072
response to other organism GO:0051707 293 0.072
regulation of cell differentiation GO:0045595 302 0.071
Mouse
purine ribonucleoside metabolic process GO:0046128 127 0.071
photoreceptor cell differentiation GO:0046530 170 0.070
peptidyl lysine acetylation GO:0018394 39 0.070
Mouse
regulation of cellular catabolic process GO:0031329 157 0.069
positive regulation of nucleic acid templated transcription GO:1903508 266 0.069
embryonic development via the syncytial blastoderm GO:0001700 148 0.069
regulation of organ morphogenesis GO:2000027 78 0.069
tissue morphogenesis GO:0048729 297 0.069
small gtpase mediated signal transduction GO:0007264 88 0.069
multi organism behavior GO:0051705 175 0.067
dendrite morphogenesis GO:0048813 199 0.066
cellular response to dna damage stimulus GO:0006974 223 0.066
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.065
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.065
exocrine system development GO:0035272 162 0.065
positive regulation of transcription dna templated GO:0045893 266 0.064
negative regulation of cellular metabolic process GO:0031324 382 0.064
compound eye development GO:0048749 307 0.064
positive regulation of rna metabolic process GO:0051254 271 0.064
cell division GO:0051301 248 0.063
Mouse
embryonic morphogenesis GO:0048598 206 0.062
Mouse
appendage morphogenesis GO:0035107 397 0.062
imaginal disc derived wing vein morphogenesis GO:0008586 44 0.061
spindle organization GO:0007051 253 0.059
cellular catabolic process GO:0044248 372 0.058
eye morphogenesis GO:0048592 260 0.058
reproductive behavior GO:0019098 122 0.058
negative regulation of gene expression epigenetic GO:0045814 77 0.057
gland development GO:0048732 191 0.057
response to gravity GO:0009629 26 0.057
regulation of phosphate metabolic process GO:0019220 210 0.056
dendrite development GO:0016358 204 0.056
camera type eye development GO:0043010 4 0.056
actin cytoskeleton organization GO:0030036 206 0.055
lateral inhibition GO:0046331 206 0.049
taxis GO:0042330 304 0.049
sister chromatid segregation GO:0000819 92 0.048
actin filament based process GO:0030029 220 0.047
phosphorylation GO:0016310 294 0.047
covalent chromatin modification GO:0016569 106 0.046
Mouse
apoptotic process GO:0006915 159 0.045
Mouse
body morphogenesis GO:0010171 2 0.045
protein dna complex assembly GO:0065004 63 0.045
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.045
Human Mouse
cell cycle checkpoint GO:0000075 95 0.044
regulation of phosphorus metabolic process GO:0051174 210 0.044
regulation of cell morphogenesis GO:0022604 163 0.044
negative regulation of cell cycle GO:0045786 116 0.044
regulation of small gtpase mediated signal transduction GO:0051056 93 0.043
regulation of cellular component biogenesis GO:0044087 201 0.043
embryo development ending in birth or egg hatching GO:0009792 152 0.043
Mouse
regulation of cell shape GO:0008360 113 0.043
internal protein amino acid acetylation GO:0006475 38 0.043
Mouse
regulation of tube size open tracheal system GO:0035151 43 0.043
appendage development GO:0048736 401 0.043
chromosome segregation GO:0007059 157 0.042
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.042
protein acylation GO:0043543 42 0.041
Mouse
chromatin organization GO:0006325 207 0.041
axis specification GO:0009798 167 0.041
establishment of localization in cell GO:0051649 402 0.040
pigmentation GO:0043473 75 0.040
positive regulation of catabolic process GO:0009896 105 0.040
single organism catabolic process GO:0044712 228 0.039
single organism behavior GO:0044708 391 0.039
meiotic nuclear division GO:0007126 151 0.039
chemotaxis GO:0006935 249 0.039
organic substance transport GO:0071702 257 0.038
purine containing compound metabolic process GO:0072521 155 0.038
negative regulation of cell cycle process GO:0010948 109 0.038
positive regulation of phosphorus metabolic process GO:0010562 139 0.038
mitotic sister chromatid segregation GO:0000070 87 0.037
negative regulation of cell communication GO:0010648 223 0.037
Mouse
negative regulation of biosynthetic process GO:0009890 277 0.037
molting cycle process GO:0022404 29 0.036
establishment or maintenance of cell polarity GO:0007163 167 0.036
wing disc morphogenesis GO:0007472 344 0.036
chromatin modification GO:0016568 147 0.036
regulation of programmed cell death GO:0043067 152 0.036
Mouse
immune system process GO:0002376 347 0.035
Human Zebrafish Mouse
regulation of catabolic process GO:0009894 170 0.034
phagocytosis GO:0006909 215 0.034
negative regulation of cell proliferation GO:0008285 69 0.033
multi organism reproductive behavior GO:0044705 121 0.033
muscle structure development GO:0061061 224 0.033
response to abiotic stimulus GO:0009628 341 0.033
small molecule metabolic process GO:0044281 305 0.033
sensory organ morphogenesis GO:0090596 260 0.033
imaginal disc derived wing morphogenesis GO:0007476 337 0.032
regulation of chromosome organization GO:0033044 64 0.032
ribonucleoprotein complex assembly GO:0022618 23 0.032
positive regulation of biosynthetic process GO:0009891 316 0.032
mitotic cell cycle phase transition GO:0044772 138 0.031
eye photoreceptor cell differentiation GO:0001754 145 0.031
establishment of tissue polarity GO:0007164 87 0.031
respiratory system development GO:0060541 213 0.031
establishment of ommatidial planar polarity GO:0042067 49 0.030
programmed cell death GO:0012501 257 0.029
Mouse
digestive system development GO:0055123 149 0.029
tube development GO:0035295 244 0.029
Mouse
developmental pigmentation GO:0048066 68 0.029
single organism intracellular transport GO:1902582 207 0.028
positive regulation of intracellular signal transduction GO:1902533 116 0.028
regulation of mapk cascade GO:0043408 92 0.028
positive regulation of signal transduction GO:0009967 223 0.027
r3 r4 cell differentiation GO:0048056 12 0.027
peptidyl amino acid modification GO:0018193 105 0.027
Mouse
positive regulation of cellular component biogenesis GO:0044089 80 0.027
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.027
Human Mouse
nucleoside triphosphate catabolic process GO:0009143 108 0.027
photoreceptor cell development GO:0042461 96 0.027
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.027
positive regulation of cellular protein metabolic process GO:0032270 118 0.027
Human
developmental programmed cell death GO:0010623 138 0.027
catabolic process GO:0009056 409 0.027
mitotic cell cycle embryonic GO:0045448 38 0.026
protein modification by small protein conjugation or removal GO:0070647 106 0.026
Human Mouse
ras protein signal transduction GO:0007265 88 0.026
multicellular organismal reproductive behavior GO:0033057 110 0.026
establishment of planar polarity GO:0001736 87 0.026
regulation of cell cycle process GO:0010564 181 0.025
regulation of embryonic development GO:0045995 68 0.025
cellular macromolecular complex assembly GO:0034622 153 0.025
larval development GO:0002164 104 0.025
histone modification GO:0016570 106 0.025
Mouse
multi multicellular organism process GO:0044706 123 0.024
defense response GO:0006952 300 0.024
cell death GO:0008219 279 0.024
Mouse
negative regulation of cell cycle phase transition GO:1901988 103 0.024
heterocycle catabolic process GO:0046700 166 0.024
organonitrogen compound metabolic process GO:1901564 318 0.024
aromatic compound catabolic process GO:0019439 166 0.024
gland morphogenesis GO:0022612 145 0.024
peptidyl lysine modification GO:0018205 57 0.024
Mouse
positive regulation of phosphate metabolic process GO:0045937 139 0.024
protein acetylation GO:0006473 39 0.024
Mouse
regulation of apoptotic process GO:0042981 130 0.023
Mouse
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.023
protein dna complex subunit organization GO:0071824 86 0.023
regulation of neurogenesis GO:0050767 158 0.023
mitotic nuclear division GO:0007067 213 0.023
positive regulation of mapk cascade GO:0043410 63 0.023
regulation of tube architecture open tracheal system GO:0035152 68 0.023
amine metabolic process GO:0009308 12 0.023
biological adhesion GO:0022610 138 0.023
nucleotide catabolic process GO:0009166 109 0.023
regulation of ras protein signal transduction GO:0046578 93 0.023
negative regulation of developmental process GO:0051093 201 0.022
regulation of cellular protein metabolic process GO:0032268 243 0.022
Human
positive regulation of cellular component organization GO:0051130 156 0.021
histone acetylation GO:0016573 38 0.021
Mouse
protein modification process GO:0036211 438 0.021
Human Mouse
regulation of hydrolase activity GO:0051336 97 0.021
molting cycle chitin based cuticle GO:0007591 56 0.020
cellular component assembly involved in morphogenesis GO:0010927 151 0.020
endocytosis GO:0006897 310 0.020
locomotory behavior GO:0007626 176 0.020
regulation of proteolysis GO:0030162 87 0.020
humoral immune response GO:0006959 117 0.019
Mouse
regulation of catalytic activity GO:0050790 185 0.019
Human Mouse
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.019
purine nucleotide catabolic process GO:0006195 109 0.019
mrna splicing via spliceosome GO:0000398 73 0.019
tissue death GO:0016271 102 0.019
muscle organ development GO:0007517 127 0.019
leg disc development GO:0035218 92 0.019
regulation of localization GO:0032879 275 0.019
enzyme linked receptor protein signaling pathway GO:0007167 179 0.019
gene silencing by rna GO:0031047 57 0.019
regulation of cell cycle GO:0051726 291 0.019
purine nucleoside triphosphate metabolic process GO:0009144 119 0.019
response to mechanical stimulus GO:0009612 28 0.018
regulation of molecular function GO:0065009 217 0.018
Human Mouse
salivary gland development GO:0007431 162 0.018
cell adhesion GO:0007155 136 0.018
axon guidance GO:0007411 233 0.018
ocellus pigmentation GO:0033060 19 0.018
camera type eye morphogenesis GO:0048593 2 0.018
response to lipopolysaccharide GO:0032496 4 0.018
gonad development GO:0008406 50 0.018
regulation of mitotic cell cycle phase transition GO:1901990 130 0.018
notch signaling pathway GO:0007219 120 0.018
ribose phosphate metabolic process GO:0019693 145 0.017
positive regulation of response to stimulus GO:0048584 323 0.017
striated muscle cell differentiation GO:0051146 90 0.017
segmentation GO:0035282 207 0.017
positive regulation of cellular catabolic process GO:0031331 95 0.017
neurological system process GO:0050877 358 0.017
regulation of lipid transport GO:0032368 3 0.017
regulation of mitotic sister chromatid separation GO:0010965 28 0.017
sensory perception of mechanical stimulus GO:0050954 72 0.017
negative regulation of organelle organization GO:0010639 56 0.017
response to external biotic stimulus GO:0043207 293 0.017
eye pigment metabolic process GO:0042441 33 0.017
regulation of ras gtpase activity GO:0032318 38 0.017
negative regulation of signaling GO:0023057 219 0.017
Mouse
positive regulation of signaling GO:0023056 243 0.017
salivary gland cell autophagic cell death GO:0035071 83 0.017
actin filament organization GO:0007015 126 0.017
response to biotic stimulus GO:0009607 294 0.017
positive regulation of hydrolase activity GO:0051345 78 0.016
purine ribonucleoside catabolic process GO:0046130 112 0.016
negative regulation of cell death GO:0060548 81 0.016
Mouse
positive regulation of molecular function GO:0044093 136 0.016
Human
positive regulation of catalytic activity GO:0043085 118 0.016
Human
cuticle development GO:0042335 86 0.016
dorsal ventral pattern formation GO:0009953 133 0.015
skeletal muscle organ development GO:0060538 48 0.015
regulation of phosphorylation GO:0042325 147 0.015
purine nucleotide metabolic process GO:0006163 146 0.015
response to oxygen containing compound GO:1901700 200 0.015
Mouse Rat
cellular amine metabolic process GO:0044106 12 0.015
rna transport GO:0050658 46 0.015
mapk cascade GO:0000165 107 0.015
chitin based cuticle development GO:0040003 49 0.015
carboxylic acid metabolic process GO:0019752 92 0.015
protein ubiquitination GO:0016567 70 0.015
Human Mouse
negative regulation of cell differentiation GO:0045596 143 0.015
regulation of meiosis GO:0040020 3 0.014
organophosphate metabolic process GO:0019637 195 0.014
positive regulation of purine nucleotide metabolic process GO:1900544 55 0.014
hematopoietic or lymphoid organ development GO:0048534 57 0.014
Human Zebrafish Mouse
retina development in camera type eye GO:0060041 4 0.014
inter male aggressive behavior GO:0002121 60 0.014
cell cell signaling involved in cell fate commitment GO:0045168 210 0.014
response to organic cyclic compound GO:0014070 89 0.014
Rat
regulation of cell proliferation GO:0042127 163 0.014
Human Mouse
nucleobase containing compound transport GO:0015931 56 0.014
gtp metabolic process GO:0046039 72 0.014
protein phosphorylation GO:0006468 169 0.014
positive regulation of multicellular organismal process GO:0051240 143 0.014
Mouse
cellular nitrogen compound catabolic process GO:0044270 165 0.014
salivary gland morphogenesis GO:0007435 145 0.014
rna localization GO:0006403 115 0.014
nitrogen compound transport GO:0071705 85 0.014
cytoplasmic transport GO:0016482 130 0.014
transcription elongation from rna polymerase ii promoter GO:0006368 18 0.014
cellular response to organic substance GO:0071310 132 0.014
Rat
guanosine containing compound catabolic process GO:1901069 74 0.014
regulation of cytoskeleton organization GO:0051493 89 0.014
proteolysis GO:0006508 192 0.014
response to bacterium GO:0009617 198 0.014
stem cell differentiation GO:0048863 117 0.014
negative regulation of multicellular organismal process GO:0051241 142 0.013
cellular ketone metabolic process GO:0042180 24 0.013
purine nucleoside metabolic process GO:0042278 127 0.013
regulation of immune system process GO:0002682 176 0.013
Mouse
regulation of nervous system development GO:0051960 248 0.013
hematopoietic progenitor cell differentiation GO:0002244 1 0.013
signal transduction in response to dna damage GO:0042770 3 0.013
positive regulation of gtpase activity GO:0043547 43 0.013
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.013
negative regulation of mitotic cell cycle GO:0045930 109 0.013
protein complex biogenesis GO:0070271 201 0.013
glycosyl compound metabolic process GO:1901657 127 0.013
neuron projection guidance GO:0097485 241 0.013
morphogenesis of embryonic epithelium GO:0016331 94 0.013
positive regulation of cell communication GO:0010647 250 0.013
regulation of cell death GO:0010941 173 0.013
Mouse
positive regulation of developmental process GO:0051094 143 0.013
Mouse
eggshell chorion assembly GO:0007306 66 0.013
establishment of rna localization GO:0051236 47 0.013
eggshell formation GO:0030703 105 0.012
regulation of chromosome segregation GO:0051983 32 0.012
negative regulation of apoptotic process GO:0043066 63 0.012
Mouse
regulation of membrane potential GO:0042391 35 0.012
imaginal disc derived leg morphogenesis GO:0007480 80 0.012
ribonucleotide catabolic process GO:0009261 109 0.012
organic substance catabolic process GO:1901575 308 0.012
positive regulation of nucleotide catabolic process GO:0030813 46 0.012
striated muscle cell development GO:0055002 50 0.012
cell motility GO:0048870 251 0.012
Zebrafish
carbohydrate derivative catabolic process GO:1901136 118 0.012
negative regulation of cellular component organization GO:0051129 108 0.012
oocyte axis specification GO:0007309 108 0.012
cellular component disassembly GO:0022411 46 0.012
regulation of cellular protein catabolic process GO:1903362 44 0.012
regulation of response to external stimulus GO:0032101 115 0.012
oxoacid metabolic process GO:0043436 103 0.012
protein complex assembly GO:0006461 200 0.012
single organism biosynthetic process GO:0044711 206 0.012
cell proliferation GO:0008283 299 0.012
Human Mouse
nucleoside triphosphate metabolic process GO:0009141 120 0.012
secondary metabolite biosynthetic process GO:0044550 24 0.012
open tracheal system development GO:0007424 204 0.011
embryonic pattern specification GO:0009880 174 0.011
nucleoside phosphate catabolic process GO:1901292 110 0.011
positive regulation of gene expression epigenetic GO:0045815 16 0.011
ribonucleoprotein complex subunit organization GO:0071826 28 0.011
dorsal appendage formation GO:0046843 47 0.011
regulation of tube length open tracheal system GO:0035159 24 0.011
regulation of nucleoside metabolic process GO:0009118 50 0.011
regulation of cellular ketone metabolic process GO:0010565 3 0.011
muscle cell development GO:0055001 50 0.011
transcription initiation from rna polymerase ii promoter GO:0006367 25 0.011
regulation of response to stress GO:0080134 200 0.011
digestive tract development GO:0048565 149 0.011
dna templated transcription elongation GO:0006354 18 0.011
regulation of protein stability GO:0031647 43 0.011
outflow tract morphogenesis GO:0003151 4 0.011
negative regulation of chromosome organization GO:2001251 19 0.011
regulation of protein metabolic process GO:0051246 256 0.011
Human
protein localization GO:0008104 284 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
female meiotic division GO:0007143 70 0.011
carbohydrate derivative metabolic process GO:1901135 217 0.011
positive regulation of proteolysis GO:0045862 52 0.010
methylation GO:0032259 47 0.010
Mouse
nucleobase containing compound catabolic process GO:0034655 165 0.010
regulation of organelle organization GO:0033043 196 0.010
dna templated transcriptional preinitiation complex assembly GO:0070897 20 0.010
protein maturation GO:0051604 71 0.010
oocyte differentiation GO:0009994 145 0.010
dna metabolic process GO:0006259 227 0.010
Mouse
aging GO:0007568 143 0.010
developmental maturation GO:0021700 172 0.010
neuronal stem cell maintenance GO:0097150 4 0.010

Psc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.023
musculoskeletal system disease DOID:17 0 0.023
nervous system disease DOID:863 0 0.014
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.011