Drosophila melanogaster

143 known processes

pic (Dmel_CG7769)

piccolo

(Aliases: Ddb1,D-DDB1,1258/16,263/16,l(3)87Dh,Dmel\CG7769,1366/03,153636_at,dDdb1,l(3)S136603,0263/16,d-ddb1,DDB1,DDB-1,CG7769)

pic biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
g2 dna damage checkpoint GO:0031572 69 0.984
dna metabolic process GO:0006259 227 0.946
mitotic dna integrity checkpoint GO:0044774 75 0.936
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.934
mitotic dna damage checkpoint GO:0044773 74 0.904
mitotic g2 m transition checkpoint GO:0044818 70 0.880
regulation of cell cycle process GO:0010564 181 0.874
dna integrity checkpoint GO:0031570 81 0.872
regulation of cell cycle phase transition GO:1901987 130 0.847
positive regulation of gene expression GO:0010628 290 0.828
positive regulation of rna metabolic process GO:0051254 271 0.819
mitotic g2 dna damage checkpoint GO:0007095 69 0.807
positive regulation of nucleic acid templated transcription GO:1903508 266 0.782
cell cycle phase transition GO:0044770 140 0.782
dna damage checkpoint GO:0000077 78 0.707
nucleobase containing compound catabolic process GO:0034655 165 0.653
eggshell chorion gene amplification GO:0007307 9 0.645
mitotic cell cycle checkpoint GO:0007093 88 0.607
negative regulation of gene expression GO:0010629 387 0.590
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.564
positive regulation of macromolecule metabolic process GO:0010604 405 0.553
nuclear transport GO:0051169 72 0.539
aromatic compound catabolic process GO:0019439 166 0.508
regulation of gene expression epigenetic GO:0040029 128 0.487
reproductive structure development GO:0048608 74 0.452
dna replication GO:0006260 48 0.440
regulation of cell cycle GO:0051726 291 0.412
regulation of mitotic cell cycle phase transition GO:1901990 130 0.395
positive regulation of transcription dna templated GO:0045893 266 0.387
cellular catabolic process GO:0044248 372 0.382
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.382
mitotic cell cycle phase transition GO:0044772 138 0.368
response to abiotic stimulus GO:0009628 341 0.367
negative regulation of cell cycle process GO:0010948 109 0.362
mrna metabolic process GO:0016071 124 0.359
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.357
small molecule metabolic process GO:0044281 305 0.336
defense response GO:0006952 300 0.334
intracellular transport GO:0046907 228 0.308
heterocycle catabolic process GO:0046700 166 0.306
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.303
organic cyclic compound catabolic process GO:1901361 168 0.302
immune system process GO:0002376 347 0.282
death GO:0016265 284 0.280
cellular macromolecule catabolic process GO:0044265 136 0.280
establishment of localization in cell GO:0051649 402 0.278
chromatin organization GO:0006325 207 0.276
single organism biosynthetic process GO:0044711 206 0.270
rna catabolic process GO:0006401 37 0.264
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.262
protein targeting to nucleus GO:0044744 51 0.255
programmed cell death GO:0012501 257 0.244
positive regulation of cellular biosynthetic process GO:0031328 316 0.243
single organism intracellular transport GO:1902582 207 0.241
developmental programmed cell death GO:0010623 138 0.241
negative regulation of cell cycle phase transition GO:1901988 103 0.226
cellular nitrogen compound catabolic process GO:0044270 165 0.223
chromosome organization GO:0051276 360 0.202
catabolic process GO:0009056 409 0.199
negative regulation of mitotic cell cycle GO:0045930 109 0.189
positive regulation of biosynthetic process GO:0009891 316 0.189
dna endoreduplication GO:0042023 22 0.187
cell cycle dna replication GO:0044786 23 0.186
response to external biotic stimulus GO:0043207 293 0.186
regulation of cell cycle g1 s phase transition GO:1902806 23 0.185
regulation of cellular catabolic process GO:0031329 157 0.185
smad protein import into nucleus GO:0007184 11 0.184
dna biosynthetic process GO:0071897 24 0.183
protein complex assembly GO:0006461 200 0.169
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.168
negative regulation of cellular metabolic process GO:0031324 382 0.164
development of primary sexual characteristics GO:0045137 50 0.164
organic substance catabolic process GO:1901575 308 0.159
response to radiation GO:0009314 155 0.155
cell death GO:0008219 279 0.154
negative regulation of cell cycle GO:0045786 116 0.149
organophosphate metabolic process GO:0019637 195 0.145
transcription from rna polymerase ii promoter GO:0006366 368 0.145
positive regulation of cell proliferation GO:0008284 47 0.144
hemopoiesis GO:0030097 46 0.142
regulation of mitotic cell cycle GO:0007346 190 0.141
nucleotide metabolic process GO:0009117 161 0.141
immune response GO:0006955 246 0.141
regulation of multicellular organismal development GO:2000026 414 0.141
regulation of programmed cell death GO:0043067 152 0.139
cell proliferation GO:0008283 299 0.129
nucleocytoplasmic transport GO:0006913 72 0.127
nucleotide excision repair GO:0006289 8 0.122
mrna catabolic process GO:0006402 33 0.120
organic acid metabolic process GO:0006082 103 0.118
nucleobase containing small molecule metabolic process GO:0055086 174 0.117
cell cycle checkpoint GO:0000075 95 0.116
regulation of cell proliferation GO:0042127 163 0.114
histone acetylation GO:0016573 38 0.112
negative regulation of neuron death GO:1901215 18 0.109
multi organism behavior GO:0051705 175 0.109
negative regulation of nucleic acid templated transcription GO:1903507 240 0.107
regulation of developmental growth GO:0048638 174 0.107
regulation of growth GO:0040008 233 0.106
organonitrogen compound metabolic process GO:1901564 318 0.105
mitotic nuclear division GO:0007067 213 0.104
cellular response to extracellular stimulus GO:0031668 64 0.103
negative regulation of cell differentiation GO:0045596 143 0.102
negative regulation of apoptotic process GO:0043066 63 0.102
body morphogenesis GO:0010171 2 0.099
anatomical structure homeostasis GO:0060249 97 0.097
protein import into nucleus GO:0006606 51 0.096
positive regulation of rna biosynthetic process GO:1902680 266 0.095
negative regulation of rna biosynthetic process GO:1902679 240 0.091
negative regulation of transcription dna templated GO:0045892 237 0.090
chromatin modification GO:0016568 147 0.089
nucleoside triphosphate metabolic process GO:0009141 120 0.089
regulation of cellular response to stress GO:0080135 89 0.088
positive regulation of growth GO:0045927 75 0.087
protein modification process GO:0036211 438 0.087
embryo development ending in birth or egg hatching GO:0009792 152 0.086
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.085
negative regulation of biosynthetic process GO:0009890 277 0.085
single organism catabolic process GO:0044712 228 0.082
chromatin remodeling GO:0006338 72 0.081
ribonucleoside catabolic process GO:0042454 112 0.080
negative regulation of rna metabolic process GO:0051253 251 0.079
histone modification GO:0016570 106 0.078
single organism nuclear import GO:1902593 51 0.074
cellular response to dna damage stimulus GO:0006974 223 0.073
atp metabolic process GO:0046034 49 0.072
organic substance transport GO:0071702 257 0.071
regulation of dna metabolic process GO:0051052 34 0.068
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.068
regulation of apoptotic process GO:0042981 130 0.068
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.066
immune system development GO:0002520 57 0.066
protein transport GO:0015031 155 0.066
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.066
regulation of protein metabolic process GO:0051246 256 0.064
posttranscriptional gene silencing by rna GO:0035194 45 0.064
cellular macromolecule localization GO:0070727 220 0.062
negative regulation of multicellular organismal process GO:0051241 142 0.061
dna amplification GO:0006277 11 0.059
sex differentiation GO:0007548 81 0.059
nuclear export GO:0051168 24 0.059
regulation of cell differentiation GO:0045595 302 0.057
ribonucleotide metabolic process GO:0009259 145 0.052
oxidation reduction process GO:0055114 123 0.052
cytoplasmic transport GO:0016482 130 0.051
protein localization to nucleus GO:0034504 55 0.051
intracellular protein transport GO:0006886 104 0.051
purine nucleoside metabolic process GO:0042278 127 0.051
purine nucleotide metabolic process GO:0006163 146 0.051
nitrogen compound transport GO:0071705 85 0.051
nuclear division GO:0000280 332 0.050
cellular response to abiotic stimulus GO:0071214 58 0.050
gene silencing by rna GO:0031047 57 0.049
purine nucleoside triphosphate metabolic process GO:0009144 119 0.049
ribose phosphate metabolic process GO:0019693 145 0.048
nuclear import GO:0051170 51 0.048
response to endogenous stimulus GO:0009719 119 0.048
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.047
positive regulation of cellular catabolic process GO:0031331 95 0.047
generation of precursor metabolites and energy GO:0006091 42 0.046
reproductive system development GO:0061458 74 0.045
positive regulation of response to stimulus GO:0048584 323 0.045
positive regulation of cellular amine metabolic process GO:0033240 0 0.045
posttranscriptional gene silencing GO:0016441 46 0.044
gene silencing GO:0016458 138 0.044
intracellular signal transduction GO:0035556 300 0.044
nucleotide catabolic process GO:0009166 109 0.043
single organism cellular localization GO:1902580 180 0.043
spindle organization GO:0007051 253 0.043
regulation of cell death GO:0010941 173 0.043
larval development GO:0002164 104 0.042
negative regulation of cellular biosynthetic process GO:0031327 277 0.041
eye development GO:0001654 323 0.040
genitalia development GO:0048806 26 0.040
carbohydrate derivative metabolic process GO:1901135 217 0.039
macromolecular complex assembly GO:0065003 256 0.038
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.037
immune effector process GO:0002252 98 0.037
regulation of intracellular transport GO:0032386 64 0.037
regulation of execution phase of apoptosis GO:1900117 5 0.036
compound eye development GO:0048749 307 0.036
purine ribonucleoside metabolic process GO:0046128 127 0.036
cell cycle g1 s phase transition GO:0044843 31 0.033
heart development GO:0007507 82 0.033
regulation of protein export from nucleus GO:0046825 3 0.033
g1 s transition of mitotic cell cycle GO:0000082 31 0.033
neurological system process GO:0050877 358 0.033
insulin like growth factor receptor signaling pathway GO:0048009 5 0.033
negative regulation of programmed cell death GO:0043069 72 0.033
response to extracellular stimulus GO:0009991 116 0.033
organonitrogen compound catabolic process GO:1901565 128 0.033
purine ribonucleotide metabolic process GO:0009150 145 0.032
protein localization GO:0008104 284 0.031
nucleoside phosphate metabolic process GO:0006753 162 0.031
ribonucleoside metabolic process GO:0009119 127 0.031
purine containing compound catabolic process GO:0072523 112 0.030
protein import GO:0017038 55 0.030
gonad development GO:0008406 50 0.030
internal peptidyl lysine acetylation GO:0018393 38 0.030
growth GO:0040007 359 0.030
regulation of nuclear division GO:0051783 58 0.030
homeostatic process GO:0042592 199 0.029
oxoacid metabolic process GO:0043436 103 0.029
response to wounding GO:0009611 94 0.029
ribonucleoside triphosphate metabolic process GO:0009199 119 0.029
regulation of hydrolase activity GO:0051336 97 0.028
macromolecule catabolic process GO:0009057 161 0.028
nucleoside phosphate catabolic process GO:1901292 110 0.028
ribonucleoside triphosphate catabolic process GO:0009203 108 0.028
rna processing GO:0006396 147 0.027
protein targeting GO:0006605 64 0.027
ribonucleotide catabolic process GO:0009261 109 0.027
response to other organism GO:0051707 293 0.027
regulation of mrna metabolic process GO:1903311 72 0.026
positive regulation of multicellular organismal process GO:0051240 143 0.026
hematopoietic or lymphoid organ development GO:0048534 57 0.026
negative regulation of immune system process GO:0002683 50 0.026
compound eye photoreceptor development GO:0042051 78 0.026
oocyte microtubule cytoskeleton polarization GO:0008103 22 0.026
positive regulation of catalytic activity GO:0043085 118 0.025
defense response to other organism GO:0098542 225 0.025
cellular ketone metabolic process GO:0042180 24 0.025
regionalization GO:0003002 416 0.025
signal transduction in response to dna damage GO:0042770 3 0.024
response to uv GO:0009411 24 0.024
organelle fission GO:0048285 340 0.024
tissue death GO:0016271 102 0.024
purine containing compound metabolic process GO:0072521 155 0.024
hematopoietic progenitor cell differentiation GO:0002244 1 0.024
negative regulation of lamellocyte differentiation GO:0035204 5 0.024
salivary gland cell autophagic cell death GO:0035071 83 0.024
glycosyl compound catabolic process GO:1901658 112 0.024
aging GO:0007568 143 0.023
meiotic cell cycle GO:0051321 171 0.023
response to organic cyclic compound GO:0014070 89 0.023
stem cell differentiation GO:0048863 117 0.023
intrinsic apoptotic signaling pathway GO:0097193 16 0.023
covalent chromatin modification GO:0016569 106 0.023
cellular response to external stimulus GO:0071496 66 0.022
regulation of intracellular signal transduction GO:1902531 236 0.022
response to biotic stimulus GO:0009607 294 0.022
purine nucleotide catabolic process GO:0006195 109 0.022
purine nucleoside triphosphate catabolic process GO:0009146 108 0.022
oocyte microtubule cytoskeleton organization GO:0016325 35 0.022
cellular ion homeostasis GO:0006873 39 0.022
meiotic nuclear division GO:0007126 151 0.022
regulation of translation GO:0006417 56 0.022
histolysis GO:0007559 102 0.022
compound eye morphogenesis GO:0001745 249 0.021
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.021
innate immune response GO:0045087 144 0.021
regulation of immune system process GO:0002682 176 0.021
response to organic substance GO:0010033 284 0.021
post embryonic hemopoiesis GO:0035166 17 0.021
carboxylic acid metabolic process GO:0019752 92 0.020
rna localization GO:0006403 115 0.020
mitochondrion organization GO:0007005 65 0.020
positive regulation of hydrolase activity GO:0051345 78 0.020
digestive system development GO:0055123 149 0.020
nucleoside catabolic process GO:0009164 112 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
protein localization to organelle GO:0033365 82 0.019
gliogenesis GO:0042063 80 0.019
cellular response to chemical stimulus GO:0070887 199 0.018
establishment of protein localization to organelle GO:0072594 62 0.018
regulation of organelle organization GO:0033043 196 0.018
apoptotic signaling pathway GO:0097190 27 0.018
central nervous system development GO:0007417 201 0.018
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.018
eye photoreceptor cell differentiation GO:0001754 145 0.017
defense response to gram negative bacterium GO:0050829 94 0.017
regulation of response to stress GO:0080134 200 0.017
rna interference GO:0016246 27 0.017
regulation of cell division GO:0051302 72 0.017
ribonucleoside monophosphate metabolic process GO:0009161 51 0.017
endocytosis GO:0006897 310 0.017
carbohydrate derivative catabolic process GO:1901136 118 0.017
positive regulation of phosphate metabolic process GO:0045937 139 0.017
regulation of mitosis GO:0007088 56 0.017
lipid storage GO:0019915 38 0.017
positive regulation of signal transduction GO:0009967 223 0.016
organonitrogen compound biosynthetic process GO:1901566 117 0.016
nucleoside triphosphate catabolic process GO:0009143 108 0.016
cell recognition GO:0008037 102 0.016
neuron apoptotic process GO:0051402 17 0.016
multicellular organismal reproductive behavior GO:0033057 110 0.016
oocyte development GO:0048599 124 0.016
ribonucleoprotein complex biogenesis GO:0022613 31 0.016
enzyme linked receptor protein signaling pathway GO:0007167 179 0.016
lipid biosynthetic process GO:0008610 46 0.016
positive regulation of signaling GO:0023056 243 0.016
protein complex biogenesis GO:0070271 201 0.016
positive regulation of catabolic process GO:0009896 105 0.016
regulation of cytoplasmic transport GO:1903649 47 0.015
salivary gland histolysis GO:0035070 88 0.015
multi multicellular organism process GO:0044706 123 0.015
establishment of protein localization GO:0045184 163 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
positive regulation of developmental process GO:0051094 143 0.015
regulation of nucleocytoplasmic transport GO:0046822 35 0.015
nucleoside metabolic process GO:0009116 127 0.014
dendrite morphogenesis GO:0048813 199 0.014
regulation of mrna processing GO:0050684 71 0.014
energy derivation by oxidation of organic compounds GO:0015980 32 0.014
exocrine system development GO:0035272 162 0.014
positive regulation of cellular protein metabolic process GO:0032270 118 0.013
autophagic cell death GO:0048102 83 0.013
regulation of mrna splicing via spliceosome GO:0048024 64 0.013
positive regulation of mitotic cell cycle phase transition GO:1901992 20 0.013
cellular homeostasis GO:0019725 80 0.013
proteolysis GO:0006508 192 0.013
glycosyl compound metabolic process GO:1901657 127 0.013
purine nucleoside monophosphate metabolic process GO:0009126 50 0.013
regulation of nucleotide catabolic process GO:0030811 48 0.013
positive regulation of nucleotide metabolic process GO:0045981 55 0.013
cell division GO:0051301 248 0.012
positive regulation of cell communication GO:0010647 250 0.012
positive regulation of intracellular signal transduction GO:1902533 116 0.012
cellular macromolecular complex assembly GO:0034622 153 0.012
wing disc pattern formation GO:0035222 66 0.012
regulation of alternative mrna splicing via spliceosome GO:0000381 60 0.012
negative regulation of cell death GO:0060548 81 0.012
cellular chemical homeostasis GO:0055082 40 0.012
lipid metabolic process GO:0006629 121 0.012
regulation of catalytic activity GO:0050790 185 0.012
posttranscriptional regulation of gene expression GO:0010608 145 0.012
positive regulation of cell cycle process GO:0090068 28 0.012
response to light stimulus GO:0009416 124 0.012
induction of programmed cell death by ecdysone GO:0035078 12 0.012
regulation of protein localization GO:0032880 76 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.011
protein dna complex subunit organization GO:0071824 86 0.011
compound eye photoreceptor cell differentiation GO:0001751 140 0.011
nuclear dna replication GO:0033260 1 0.011
wound healing GO:0042060 75 0.011
phagocytosis GO:0006909 215 0.011
nuclear transcribed mrna catabolic process GO:0000956 24 0.011
mrna transport GO:0051028 15 0.011
centrosome cycle GO:0007098 137 0.011
regulation of catabolic process GO:0009894 170 0.011
response to decreased oxygen levels GO:0036293 58 0.010
regulation of response to dna damage stimulus GO:2001020 23 0.010
organophosphate catabolic process GO:0046434 112 0.010
positive regulation of mitotic cell cycle GO:0045931 34 0.010

pic disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
musculoskeletal system cancer DOID:0060100 0 0.025
connective tissue cancer DOID:201 0 0.025
cancer DOID:162 0 0.025
disease of cellular proliferation DOID:14566 0 0.025
organ system cancer DOID:0050686 0 0.025