Drosophila melanogaster

131 known processes

lack (Dmel_CG4943)

lethal with a checkpoint kinase

(Aliases: CG4943,d-smurf,dSmurf,dSmurf1,Lack,D-smurf,DSmurf,Dsmurf,Smurf,Smurf ubiquitin ligase,Dmel\CG4943)

lack biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of cellular biosynthetic process GO:0031328 316 0.192
Yeast
organelle fission GO:0048285 340 0.166
single organism biosynthetic process GO:0044711 206 0.140
Yeast
response to abiotic stimulus GO:0009628 341 0.123
Yeast
post embryonic appendage morphogenesis GO:0035120 385 0.117
Fly
imaginal disc derived wing morphogenesis GO:0007476 337 0.108
Fly
cell migration GO:0016477 238 0.102
localization of cell GO:0051674 257 0.097
regulation of cell differentiation GO:0045595 302 0.093
organic substance transport GO:0071702 257 0.087
Human Yeast
chromosome organization GO:0051276 360 0.087
Yeast
wing disc morphogenesis GO:0007472 344 0.082
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.076
Yeast
mitotic nuclear division GO:0007067 213 0.075
nuclear division GO:0000280 332 0.074
ovarian follicle cell development GO:0030707 248 0.071
appendage morphogenesis GO:0035107 397 0.071
Fly
cell motility GO:0048870 251 0.069
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.069
Yeast
cell death GO:0008219 279 0.066
organic acid metabolic process GO:0006082 103 0.064
Yeast
response to organic substance GO:0010033 284 0.063
death GO:0016265 284 0.063
organelle localization GO:0051640 148 0.061
Yeast
regulation of organelle organization GO:0033043 196 0.058
Yeast
imaginal disc derived appendage morphogenesis GO:0035114 395 0.058
Fly
organonitrogen compound biosynthetic process GO:1901566 117 0.058
positive regulation of biosynthetic process GO:0009891 316 0.056
Yeast
notch signaling pathway GO:0007219 120 0.055
Fly
regulation of mrna processing GO:0050684 71 0.055
nucleocytoplasmic transport GO:0006913 72 0.055
Human Yeast
carboxylic acid metabolic process GO:0019752 92 0.054
Yeast
mitotic spindle organization GO:0007052 220 0.054
synapse organization GO:0050808 196 0.054
establishment of tissue polarity GO:0007164 87 0.051
cellular macromolecule localization GO:0070727 220 0.051
Human
taxis GO:0042330 304 0.050
epithelial cell migration GO:0010631 148 0.049
epithelium migration GO:0090132 148 0.047
immune system process GO:0002376 347 0.045
protein modification by small protein conjugation or removal GO:0070647 106 0.044
epithelial cell development GO:0002064 274 0.044
appendage development GO:0048736 401 0.044
Fly
organelle assembly GO:0070925 198 0.044
chromatin organization GO:0006325 207 0.043
Yeast
exocrine system development GO:0035272 162 0.042
homeostatic process GO:0042592 199 0.041
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.041
Yeast
nucleobase containing small molecule metabolic process GO:0055086 174 0.040
regulation of notch signaling pathway GO:0008593 100 0.040
Fly
spermatid development GO:0007286 98 0.039
cellular macromolecular complex assembly GO:0034622 153 0.039
negative regulation of signal transduction GO:0009968 206 0.039
spermatid differentiation GO:0048515 114 0.038
cellular response to chemical stimulus GO:0070887 199 0.038
positive regulation of cell death GO:0010942 69 0.038
apoptotic process GO:0006915 159 0.038
cellular protein modification process GO:0006464 438 0.038
regulation of cellular component biogenesis GO:0044087 201 0.038
Yeast
hematopoietic or lymphoid organ development GO:0048534 57 0.038
spindle organization GO:0007051 253 0.037
organonitrogen compound metabolic process GO:1901564 318 0.036
imaginal disc derived appendage development GO:0048737 399 0.036
Fly
covalent chromatin modification GO:0016569 106 0.036
eye development GO:0001654 323 0.035
rna processing GO:0006396 147 0.034
Yeast
response to biotic stimulus GO:0009607 294 0.033
establishment of protein localization to organelle GO:0072594 62 0.033
tissue morphogenesis GO:0048729 297 0.033
regulation of multicellular organismal development GO:2000026 414 0.033
response to oxygen containing compound GO:1901700 200 0.033
cellular amino acid metabolic process GO:0006520 61 0.033
programmed cell death GO:0012501 257 0.032
response to radiation GO:0009314 155 0.032
Yeast
response to other organism GO:0051707 293 0.032
organic substance catabolic process GO:1901575 308 0.032
negative regulation of multicellular organismal process GO:0051241 142 0.031
Mouse
vesicle mediated transport GO:0016192 381 0.030
Yeast Fly
cell division GO:0051301 248 0.030
single organism cellular localization GO:1902580 180 0.030
macromolecular complex assembly GO:0065003 256 0.030
lateral inhibition GO:0046331 206 0.030
regulation of cell development GO:0060284 215 0.029
oxoacid metabolic process GO:0043436 103 0.029
Yeast
growth GO:0040007 359 0.028
imaginal disc fusion GO:0046528 19 0.028
regulation of developmental growth GO:0048638 174 0.028
negative regulation of developmental process GO:0051093 201 0.028
cell proliferation GO:0008283 299 0.028
rna splicing via transesterification reactions GO:0000375 73 0.028
establishment of localization in cell GO:0051649 402 0.027
Human Yeast
regulation of cell proliferation GO:0042127 163 0.027
regulation of meiosis GO:0040020 3 0.027
cellular nitrogen compound catabolic process GO:0044270 165 0.027
ribonucleoprotein complex subunit organization GO:0071826 28 0.027
regulation of molecular function GO:0065009 217 0.027
aromatic compound catabolic process GO:0019439 166 0.027
morphogenesis of an epithelium GO:0002009 276 0.027
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.027
columnar cuboidal epithelial cell development GO:0002066 249 0.026
small molecule metabolic process GO:0044281 305 0.026
Yeast
regulation of neurogenesis GO:0050767 158 0.026
cytoplasmic transport GO:0016482 130 0.025
Human Yeast
negative regulation of cell communication GO:0010648 223 0.025
nitrogen compound transport GO:0071705 85 0.025
Yeast
compound eye development GO:0048749 307 0.025
response to temperature stimulus GO:0009266 106 0.025
intracellular protein transport GO:0006886 104 0.024
Human
defense response GO:0006952 300 0.024
positive regulation of signaling GO:0023056 243 0.024
cellular protein localization GO:0034613 160 0.024
Human
nucleoside phosphate metabolic process GO:0006753 162 0.024
cellular amine metabolic process GO:0044106 12 0.024
dna metabolic process GO:0006259 227 0.023
centrosome organization GO:0051297 163 0.023
sex differentiation GO:0007548 81 0.023
positive regulation of gene expression GO:0010628 290 0.023
Yeast
regulation of cell death GO:0010941 173 0.023
mrna metabolic process GO:0016071 124 0.023
reproductive system development GO:0061458 74 0.023
positive regulation of programmed cell death GO:0043068 62 0.023
gonad development GO:0008406 50 0.023
positive regulation of rna metabolic process GO:0051254 271 0.023
Yeast
negative regulation of growth GO:0045926 84 0.022
eye morphogenesis GO:0048592 260 0.022
protein targeting to nucleus GO:0044744 51 0.022
body morphogenesis GO:0010171 2 0.022
establishment or maintenance of cell polarity GO:0007163 167 0.022
protein targeting GO:0006605 64 0.022
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.021
Yeast
salivary gland development GO:0007431 162 0.021
ameboidal type cell migration GO:0001667 151 0.021
establishment of organelle localization GO:0051656 122 0.021
Yeast
positive regulation of transcription dna templated GO:0045893 266 0.020
Yeast
muscle structure development GO:0061061 224 0.020
tissue migration GO:0090130 155 0.020
nucleobase containing compound catabolic process GO:0034655 165 0.020
establishment of protein localization GO:0045184 163 0.020
Human Yeast
amine metabolic process GO:0009308 12 0.020
cellularization GO:0007349 90 0.020
response to external biotic stimulus GO:0043207 293 0.020
protein transport GO:0015031 155 0.020
Human Yeast
regulation of transport GO:0051049 181 0.020
Yeast
cellular response to oxygen containing compound GO:1901701 79 0.019
axon guidance GO:0007411 233 0.019
embryonic morphogenesis GO:0048598 206 0.019
carbohydrate derivative metabolic process GO:1901135 217 0.019
regulation of cell cycle GO:0051726 291 0.019
meiotic cell cycle GO:0051321 171 0.019
ovarian follicle cell migration GO:0007297 121 0.019
mrna splicing via spliceosome GO:0000398 73 0.019
cellular response to organic substance GO:0071310 132 0.019
regulation of vesicle mediated transport GO:0060627 59 0.019
Yeast
stem cell differentiation GO:0048863 117 0.019
spermatogenesis GO:0007283 200 0.018
histone modification GO:0016570 106 0.018
negative regulation of response to stimulus GO:0048585 258 0.018
response to extracellular stimulus GO:0009991 116 0.018
positive regulation of signal transduction GO:0009967 223 0.018
compound eye morphogenesis GO:0001745 249 0.018
embryo development ending in birth or egg hatching GO:0009792 152 0.018
neuron projection guidance GO:0097485 241 0.018
transcription from rna polymerase ii promoter GO:0006366 368 0.018
Human Yeast
actin filament based process GO:0030029 220 0.018
Yeast
regulation of apoptotic process GO:0042981 130 0.018
mrna processing GO:0006397 104 0.017
immune effector process GO:0002252 98 0.017
endocytosis GO:0006897 310 0.017
Yeast Fly
ribonucleoprotein complex biogenesis GO:0022613 31 0.017
Yeast
regulation of mrna metabolic process GO:1903311 72 0.017
protein localization to nucleus GO:0034504 55 0.017
cell cell signaling involved in cell fate commitment GO:0045168 210 0.017
positive regulation of catalytic activity GO:0043085 118 0.017
phagocytosis GO:0006909 215 0.016
nuclear import GO:0051170 51 0.016
chromatin modification GO:0016568 147 0.016
regulation of cell morphogenesis GO:0022604 163 0.016
Yeast
cellular response to biotic stimulus GO:0071216 4 0.016
purine containing compound metabolic process GO:0072521 155 0.016
ribonucleotide metabolic process GO:0009259 145 0.016
regulation of localization GO:0032879 275 0.016
Yeast Fly
developmental growth GO:0048589 280 0.016
tube morphogenesis GO:0035239 191 0.016
response to lipopolysaccharide GO:0032496 4 0.016
regulation of growth GO:0040008 233 0.016
determination of adult lifespan GO:0008340 137 0.015
positive regulation of rna biosynthetic process GO:1902680 266 0.015
Yeast
regulation of nervous system development GO:0051960 248 0.015
intracellular signal transduction GO:0035556 300 0.015
morphogenesis of embryonic epithelium GO:0016331 94 0.015
immune system development GO:0002520 57 0.015
positive regulation of proteolysis GO:0045862 52 0.015
Yeast
single organism catabolic process GO:0044712 228 0.015
regulation of cellular localization GO:0060341 136 0.015
Yeast
positive regulation of cell communication GO:0010647 250 0.014
protein import into nucleus GO:0006606 51 0.014
response to nutrient levels GO:0031667 114 0.014
regulation of programmed cell death GO:0043067 152 0.014
positive regulation of macromolecule metabolic process GO:0010604 405 0.014
Yeast
heterocycle catabolic process GO:0046700 166 0.014
positive regulation of apoptotic process GO:0043065 47 0.014
protein localization GO:0008104 284 0.014
Human Yeast Fly
multicellular organismal aging GO:0010259 140 0.014
salivary gland morphogenesis GO:0007435 145 0.014
axon development GO:0061564 297 0.014
regulation of nuclear division GO:0051783 58 0.014
pigment metabolic process involved in pigmentation GO:0043474 33 0.014
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.014
protein modification by small protein conjugation GO:0032446 79 0.014
aging GO:0007568 143 0.014
regulation of intracellular signal transduction GO:1902531 236 0.014
organonitrogen compound catabolic process GO:1901565 128 0.013
connective tissue development GO:0061448 3 0.013
tetraterpenoid metabolic process GO:0016108 1 0.013
dendrite morphogenesis GO:0048813 199 0.013
cellular ketone metabolic process GO:0042180 24 0.013
Yeast
establishment of rna localization GO:0051236 47 0.013
Yeast
single organism intracellular transport GO:1902582 207 0.013
Human Yeast
epithelial cell differentiation GO:0030855 322 0.013
protein ubiquitination GO:0016567 70 0.013
blastoderm segmentation GO:0007350 159 0.013
compound eye photoreceptor cell differentiation GO:0001751 140 0.013
nucleobase containing compound transport GO:0015931 56 0.013
Yeast
macromolecule catabolic process GO:0009057 161 0.013
protein maturation GO:0051604 71 0.013
regulation of anatomical structure size GO:0090066 163 0.013
Yeast
developmental growth involved in morphogenesis GO:0060560 65 0.012
purine containing compound catabolic process GO:0072523 112 0.012
single organism behavior GO:0044708 391 0.012
mesenchymal cell differentiation GO:0048762 1 0.012
germline ring canal formation GO:0030725 13 0.012
regionalization GO:0003002 416 0.012
Fly
phosphorylation GO:0016310 294 0.012
positive regulation of peptidase activity GO:0010952 29 0.012
developmental programmed cell death GO:0010623 138 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
Yeast
regulation of cellular amine metabolic process GO:0033238 3 0.012
cellular response to uv GO:0034644 12 0.012
Yeast
morphogenesis of a polarized epithelium GO:0001738 93 0.012
protein localization to organelle GO:0033365 82 0.012
positive regulation of cellular component organization GO:0051130 156 0.012
Yeast
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.011
ribonucleoprotein complex assembly GO:0022618 23 0.011
regulation of immune effector process GO:0002697 52 0.011
positive regulation of cellular protein metabolic process GO:0032270 118 0.011
Yeast
negative regulation of cell differentiation GO:0045596 143 0.011
regulation of neuron differentiation GO:0045664 103 0.011
purine nucleotide metabolic process GO:0006163 146 0.011
nuclear transport GO:0051169 72 0.011
Human Yeast
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.011
regulation of cell cycle process GO:0010564 181 0.011
neurological system process GO:0050877 358 0.011
cellular response to molecule of bacterial origin GO:0071219 3 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
positive regulation of hydrolase activity GO:0051345 78 0.011
cellular protein complex assembly GO:0043623 71 0.011
histone ubiquitination GO:0016574 4 0.011
regulation of intracellular transport GO:0032386 64 0.010
Yeast
regulation of peptidase activity GO:0052547 39 0.010
cellular modified amino acid metabolic process GO:0006575 45 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
reproductive structure development GO:0048608 74 0.010
tube development GO:0035295 244 0.010
regulation of rna splicing GO:0043484 69 0.010
chemotaxis GO:0006935 249 0.010
skin development GO:0043588 65 0.010
organophosphate metabolic process GO:0019637 195 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.010
purine nucleoside metabolic process GO:0042278 127 0.010
intracellular transport GO:0046907 228 0.010
Human Yeast
peptidyl amino acid modification GO:0018193 105 0.010
negative regulation of notch signaling pathway GO:0045746 41 0.010
Fly
reproductive behavior GO:0019098 122 0.010
synapse assembly GO:0007416 143 0.010

lack disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015