Drosophila melanogaster

170 known processes

S6k (Dmel_CG10539)

RPS6-p70-protein kinase

(Aliases: p70[S6 kinase],fs(3)07084,p70 S6K,10539,p70s6K,dp70s6k,DS6K,Dmel\CG10539,S6K,p70S6K,dS6K,p70[S6kinase],Dp70[s6k],p70[S6K],s6k11,p70/S6K,dp70[S6k],S6K1,dS6k,Dp70s6k,p70[S6k],l(3)07084,s6k,7084,dps6k,CG10539,ds6k,Dp70S6k)

S6k biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
growth GO:0040007 359 1.000
regulation of growth GO:0040008 233 0.999
Rat
regulation of cell growth GO:0001558 43 0.997
response to organic substance GO:0010033 284 0.995
Human Rat
regulation of anatomical structure size GO:0090066 163 0.993
myoblast fusion GO:0007520 43 0.989
regulation of intracellular signal transduction GO:1902531 236 0.976
Fly
regulation of cellular component size GO:0032535 98 0.974
striated muscle tissue development GO:0014706 27 0.961
Rat
cell growth GO:0016049 108 0.952
regulation of developmental growth GO:0048638 174 0.952
Rat
response to abiotic stimulus GO:0009628 341 0.952
Rat Worm
syncytium formation by plasma membrane fusion GO:0000768 43 0.951
myotube differentiation GO:0014902 46 0.951
developmental growth GO:0048589 280 0.940
homeostatic process GO:0042592 199 0.938
Fly
negative regulation of growth GO:0045926 84 0.937
muscle structure development GO:0061061 224 0.935
response to oxygen containing compound GO:1901700 200 0.932
Human Rat
cellular response to chemical stimulus GO:0070887 199 0.926
Human Rat
tor signaling GO:0031929 32 0.918
Human
positive regulation of response to stimulus GO:0048584 323 0.916
cell proliferation GO:0008283 299 0.909
Rat
negative regulation of signaling GO:0023057 219 0.906
Human Mouse Rat Fly
respiratory system development GO:0060541 213 0.903
cellular response to dna damage stimulus GO:0006974 223 0.897
apoptotic process GO:0006915 159 0.895
Human Mouse
axon development GO:0061564 297 0.891
regulation of phosphatidylinositol 3 kinase activity GO:0043551 2 0.887
syncytium formation GO:0006949 43 0.879
cell death GO:0008219 279 0.879
Human Mouse
muscle organ development GO:0007517 127 0.877
Rat
determination of adult lifespan GO:0008340 137 0.875
neuron projection guidance GO:0097485 241 0.870
positive regulation of cellular response to insulin stimulus GO:1900078 4 0.859
regulation of multicellular organism growth GO:0040014 40 0.858
establishment of localization in cell GO:0051649 402 0.842
Fly
positive regulation of autophagy GO:0010508 21 0.839
actin cytoskeleton organization GO:0030036 206 0.835
cell migration GO:0016477 238 0.835
Rat
regulation of protein metabolic process GO:0051246 256 0.834
Human
response to nutrient levels GO:0031667 114 0.830
cellular response to starvation GO:0009267 61 0.815
positive regulation of cell growth GO:0030307 19 0.811
somatic muscle development GO:0007525 66 0.811
organ growth GO:0035265 56 0.807
columnar cuboidal epithelial cell development GO:0002066 249 0.789
negative regulation of cellular metabolic process GO:0031324 382 0.788
Fly
negative regulation of signal transduction GO:0009968 206 0.784
Human Mouse Rat Fly
axonogenesis GO:0007409 290 0.781
immune system process GO:0002376 347 0.781
multicellular organism growth GO:0035264 46 0.778
positive regulation of developmental process GO:0051094 143 0.775
Rat
cellular component disassembly GO:0022411 46 0.762
aging GO:0007568 143 0.759
regulation of cell death GO:0010941 173 0.758
Human Mouse
cellular response to external stimulus GO:0071496 66 0.757
actin filament organization GO:0007015 126 0.754
circulatory system development GO:0072359 82 0.749
negative regulation of gene expression GO:0010629 387 0.739
Fly
regulation of nervous system development GO:0051960 248 0.736
Fly
chemotaxis GO:0006935 249 0.736
protein complex assembly GO:0006461 200 0.708
regulation of cell differentiation GO:0045595 302 0.708
Fly
positive regulation of growth GO:0045927 75 0.703
Rat
epithelial cell development GO:0002064 274 0.697
cellular response to organonitrogen compound GO:0071417 36 0.689
Human Rat
striated muscle cell differentiation GO:0051146 90 0.687
regulation of synapse organization GO:0050807 110 0.683
entry into diapause GO:0055115 1 0.681
dendrite morphogenesis GO:0048813 199 0.680
cellular response to insulin stimulus GO:0032869 28 0.671
Human Rat
ovarian follicle cell development GO:0030707 248 0.670
intracellular signal transduction GO:0035556 300 0.660
Human Mouse Fly
lateral inhibition GO:0046331 206 0.658
chemical homeostasis GO:0048878 92 0.657
single organism behavior GO:0044708 391 0.654
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.651
Fly
positive regulation of lipid catabolic process GO:0050996 1 0.650
cellular protein modification process GO:0006464 438 0.647
phosphorylation GO:0016310 294 0.637
translation GO:0006412 69 0.636
Human Worm
regulation of autophagy GO:0010506 62 0.635
regulation of cell proliferation GO:0042127 163 0.635
Rat
neuromuscular junction development GO:0007528 149 0.635
establishment or maintenance of cell polarity GO:0007163 167 0.624
death GO:0016265 284 0.623
Human Mouse
cellular response to extracellular stimulus GO:0031668 64 0.620
cellular catabolic process GO:0044248 372 0.618
regulation of multicellular organismal development GO:2000026 414 0.603
Rat Fly
regulation of macroautophagy GO:0016241 15 0.598
negative regulation of response to stimulus GO:0048585 258 0.596
Human Mouse Rat Fly
positive regulation of cell size GO:0045793 21 0.592
eye development GO:0001654 323 0.591
Fly
programmed cell death GO:0012501 257 0.585
Human Mouse
muscle tissue development GO:0060537 30 0.582
Rat
enzyme linked receptor protein signaling pathway GO:0007167 179 0.579
Human Rat
cell type specific apoptotic process GO:0097285 38 0.573
autophagy GO:0006914 108 0.572
wing disc morphogenesis GO:0007472 344 0.572
Fly
response to starvation GO:0042594 97 0.572
regulation of transport GO:0051049 181 0.569
Rat Fly
regulation of cellular protein metabolic process GO:0032268 243 0.568
Human
synapse organization GO:0050808 196 0.568
cellular response to organic substance GO:0071310 132 0.551
Human Rat
response to nitrogen compound GO:1901698 90 0.549
Human Rat
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.542
Human Rat
actin filament based process GO:0030029 220 0.538
regulation of apoptotic process GO:0042981 130 0.536
Human Mouse
negative regulation of phosphatidylinositol 3 kinase signaling GO:0014067 4 0.534
regulation of programmed cell death GO:0043067 152 0.531
Human Mouse
response to extracellular stimulus GO:0009991 116 0.527
compound eye development GO:0048749 307 0.526
Fly
negative regulation of cell communication GO:0010648 223 0.520
Human Mouse Rat Fly
regulation of phosphorylation GO:0042325 147 0.519
nucleobase containing small molecule metabolic process GO:0055086 174 0.510
regulation of response to nutrient levels GO:0032107 18 0.508
response to endogenous stimulus GO:0009719 119 0.508
Human Rat
response to hexose GO:0009746 3 0.507
Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.504
regulation of organ growth GO:0046620 42 0.502
protein phosphorylation GO:0006468 169 0.502
reactive oxygen species metabolic process GO:0072593 22 0.498
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.498
nucleoside triphosphate catabolic process GO:0009143 108 0.493
cellular response to peptide GO:1901653 28 0.490
Human Rat
epithelial cell migration GO:0010631 148 0.485
regulation of response to external stimulus GO:0032101 115 0.482
chorion containing eggshell formation GO:0007304 105 0.481
positive regulation of cell proliferation GO:0008284 47 0.477
Rat
macromolecular complex assembly GO:0065003 256 0.476
positive regulation of protein metabolic process GO:0051247 128 0.475
Human
regulation of dendrite development GO:0050773 37 0.472
axon guidance GO:0007411 233 0.464
ameboidal type cell migration GO:0001667 151 0.462
dendrite development GO:0016358 204 0.461
appendage development GO:0048736 401 0.458
Fly
regulation of system process GO:0044057 36 0.455
Rat
response to alcohol GO:0097305 95 0.453
Rat
muscle cell differentiation GO:0042692 103 0.450
wnt signaling pathway GO:0016055 98 0.450
ion homeostasis GO:0050801 55 0.444
regulation of neuron differentiation GO:0045664 103 0.444
Fly
cation transport GO:0006812 110 0.440
embryonic ectodermal digestive tract morphogenesis GO:0048613 4 0.440
positive regulation of cellular protein metabolic process GO:0032270 118 0.438
Human
cellular response to nutrient levels GO:0031669 62 0.427
endocytosis GO:0006897 310 0.427
response to insulin GO:0032868 29 0.425
Human Rat
negative regulation of cell proliferation GO:0008285 69 0.424
larval midgut histolysis GO:0035069 22 0.423
insulin receptor signaling pathway GO:0008286 25 0.417
Human Rat
regulation of dendrite morphogenesis GO:0048814 28 0.415
regulation of membrane potential GO:0042391 35 0.413
macroautophagy GO:0016236 42 0.410
ovarian follicle cell migration GO:0007297 121 0.410
border follicle cell migration GO:0007298 113 0.407
negative regulation of developmental growth GO:0048640 64 0.406
embryonic morphogenesis GO:0048598 206 0.404
transmembrane transport GO:0055085 139 0.400
positive regulation of programmed cell death GO:0043068 62 0.400
small molecule metabolic process GO:0044281 305 0.399
cellular response to oxygen containing compound GO:1901701 79 0.394
Human Rat
catabolic process GO:0009056 409 0.392
regulation of immune system process GO:0002682 176 0.389
regulation of actin filament polymerization GO:0030833 25 0.386
purine containing compound metabolic process GO:0072521 155 0.386
purine containing compound catabolic process GO:0072523 112 0.386
rho protein signal transduction GO:0007266 14 0.385
germarium derived female germ line cyst formation GO:0030727 42 0.385
transcription from rna polymerase ii promoter GO:0006366 368 0.384
cellular nitrogen compound catabolic process GO:0044270 165 0.381
regulation of actin filament length GO:0030832 27 0.371
positive regulation of multicellular organismal process GO:0051240 143 0.367
Rat
regulation of actin polymerization or depolymerization GO:0008064 27 0.360
regulation of anatomical structure morphogenesis GO:0022603 242 0.359
Fly
regulation of reactive oxygen species metabolic process GO:2000377 8 0.348
purine nucleotide catabolic process GO:0006195 109 0.347
regulation of phosphorus metabolic process GO:0051174 210 0.343
imaginal disc derived appendage development GO:0048737 399 0.341
Fly
positive regulation of rna biosynthetic process GO:1902680 266 0.340
Fly
response to monosaccharide GO:0034284 4 0.337
Rat
regulation of cellular catabolic process GO:0031329 157 0.330
negative regulation of programmed cell death GO:0043069 72 0.327
Human Mouse
apoptotic signaling pathway GO:0097190 27 0.316
Mouse
response to organonitrogen compound GO:0010243 75 0.316
Human Rat
positive regulation of apoptotic process GO:0043065 47 0.315
cellular response to endogenous stimulus GO:0071495 80 0.315
Human Rat
eye morphogenesis GO:0048592 260 0.313
Fly
positive regulation of immune system process GO:0002684 68 0.310
regulation of catalytic activity GO:0050790 185 0.307
open tracheal system development GO:0007424 204 0.305
carbohydrate homeostasis GO:0033500 12 0.301
regulation of tube size GO:0035150 46 0.299
skeletal muscle organ development GO:0060538 48 0.295
Rat
negative regulation of transcription dna templated GO:0045892 237 0.295
Fly
metal ion transport GO:0030001 74 0.293
positive regulation of macromolecule metabolic process GO:0010604 405 0.292
Human Fly
organelle localization GO:0051640 148 0.290
regulation of translation GO:0006417 56 0.283
Human
female germ line cyst formation GO:0048135 42 0.281
morphogenesis of a polarized epithelium GO:0001738 93 0.276
ribonucleotide metabolic process GO:0009259 145 0.276
positive regulation of cellular biosynthetic process GO:0031328 316 0.274
Human Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.273
negative regulation of intracellular signal transduction GO:1902532 57 0.265
Fly
tissue morphogenesis GO:0048729 297 0.264
positive regulation of cell migration GO:0030335 2 0.260
Rat
learning or memory GO:0007611 141 0.258
Rat Fly
single organism biosynthetic process GO:0044711 206 0.257
guanosine containing compound catabolic process GO:1901069 74 0.256
negative regulation of autophagy GO:0010507 16 0.255
positive regulation of actin filament polymerization GO:0030838 11 0.251
cellular response to nitrogen compound GO:1901699 51 0.249
Human Rat
feeding behavior GO:0007631 50 0.248
synaptic growth at neuromuscular junction GO:0051124 119 0.248
regulation of response to oxidative stress GO:1902882 4 0.243
regulation of localization GO:0032879 275 0.243
Rat Fly
positive regulation of cell cycle GO:0045787 43 0.241
Human
cell competition in a multicellular organism GO:0035212 10 0.240
germ band shortening GO:0007390 19 0.239
actin polymerization or depolymerization GO:0008154 31 0.238
regulation of response to stress GO:0080134 200 0.238
response to carbohydrate GO:0009743 15 0.236
Rat
digestive tract development GO:0048565 149 0.236
regulation of catabolic process GO:0009894 170 0.235
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.234
Fly
tissue migration GO:0090130 155 0.234
regulation of cytoskeleton organization GO:0051493 89 0.233
positive regulation of catabolic process GO:0009896 105 0.232
mitochondrion organization GO:0007005 65 0.231
regulation of intracellular transport GO:0032386 64 0.230
Fly
embryo development ending in birth or egg hatching GO:0009792 152 0.229
positive regulation of cell differentiation GO:0045597 64 0.227
post embryonic appendage morphogenesis GO:0035120 385 0.226
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.225
Fly
peptidyl amino acid modification GO:0018193 105 0.225
Fly
regulation of ion transport GO:0043269 39 0.225
taxis GO:0042330 304 0.224
regulation of actin filament based process GO:0032970 42 0.223
multicellular organismal aging GO:0010259 140 0.223
eggshell chorion assembly GO:0007306 66 0.220
ion transmembrane transport GO:0034220 122 0.217
regulation of cellular localization GO:0060341 136 0.216
Fly
regulation of phosphate metabolic process GO:0019220 210 0.215
negative regulation of rna metabolic process GO:0051253 251 0.215
Fly
response to mechanical stimulus GO:0009612 28 0.212
Rat
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.212
neuron death GO:0070997 27 0.210
immune response GO:0006955 246 0.209
ribonucleoside metabolic process GO:0009119 127 0.206
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.204
regulation of cell size GO:0008361 63 0.204
small gtpase mediated signal transduction GO:0007264 88 0.202
Fly
negative regulation of cell cycle GO:0045786 116 0.201
carbohydrate derivative catabolic process GO:1901136 118 0.201
negative regulation of biosynthetic process GO:0009890 277 0.200
Fly
negative regulation of organ growth GO:0046621 15 0.199
organic acid metabolic process GO:0006082 103 0.199
urogenital system development GO:0001655 72 0.199
anterior midgut ectodermal morphogenesis GO:0007441 4 0.198
negative regulation of cell death GO:0060548 81 0.198
Human Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.196
Human Fly
single organism catabolic process GO:0044712 228 0.195
positive regulation of molecular function GO:0044093 136 0.192
mapk cascade GO:0000165 107 0.187
r8 cell fate specification GO:0045464 5 0.181
carboxylic acid transport GO:0046942 18 0.181
initiation of dorsal closure GO:0007392 12 0.180
cognition GO:0050890 141 0.178
Rat Fly
larval midgut cell programmed cell death GO:0035096 19 0.178
skeletal muscle tissue development GO:0007519 13 0.177
Rat
response to peptide hormone GO:0043434 29 0.176
Human Rat
protein heterooligomerization GO:0051291 4 0.173
positive regulation of signal transduction GO:0009967 223 0.172
positive regulation of lipid metabolic process GO:0045834 4 0.169
cellular response to arsenic containing substance GO:0071243 6 0.169
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.167
response to oxygen levels GO:0070482 59 0.166
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.165
Fly
regulation of protein polymerization GO:0032271 28 0.165
signal transduction by phosphorylation GO:0023014 107 0.163
positive regulation of signaling GO:0023056 243 0.161
regulation of lipid kinase activity GO:0043550 2 0.161
cardiovascular system development GO:0072358 82 0.161
ion transport GO:0006811 145 0.161
positive regulation of transcription dna templated GO:0045893 266 0.159
Fly
photoreceptor cell differentiation GO:0046530 170 0.159
Fly
lamellipodium assembly GO:0030032 21 0.158
positive regulation of multicellular organism growth GO:0040018 21 0.158
metal ion homeostasis GO:0055065 44 0.158
maintenance of location GO:0051235 73 0.155
positive regulation of tor signaling GO:0032008 13 0.154
dorsal appendage formation GO:0046843 47 0.153
nucleoside phosphate catabolic process GO:1901292 110 0.149
activation of mapk activity GO:0000187 9 0.149
regulation of peptidase activity GO:0052547 39 0.149
positive regulation of transport GO:0051050 92 0.148
epithelial cell differentiation GO:0030855 322 0.148
response to peptide GO:1901652 29 0.148
Human Rat
biological adhesion GO:0022610 138 0.147
positive regulation of intracellular signal transduction GO:1902533 116 0.147
peripheral nervous system development GO:0007422 52 0.145
hemocyte differentiation GO:0042386 38 0.145
regulation of molecular function GO:0065009 217 0.144
ectodermal digestive tract morphogenesis GO:0048567 7 0.143
purine nucleoside metabolic process GO:0042278 127 0.142
gene silencing GO:0016458 138 0.142
Fly
tube development GO:0035295 244 0.141
regulation of organelle organization GO:0033043 196 0.141
Worm
cuticle pigmentation GO:0048067 22 0.140
stress activated mapk cascade GO:0051403 52 0.140
positive regulation of cell communication GO:0010647 250 0.140
regulation of hemocyte differentiation GO:0045610 22 0.140
inositol lipid mediated signaling GO:0048017 4 0.138
positive regulation of phosphorylation GO:0042327 87 0.137
single organism cellular localization GO:1902580 180 0.136
Fly
regulation of cellular response to insulin stimulus GO:1900076 17 0.135
Human Rat
negative regulation of developmental process GO:0051093 201 0.135
Fly
immune system development GO:0002520 57 0.135
cellular response to peptide hormone stimulus GO:0071375 28 0.134
Human Rat
organonitrogen compound metabolic process GO:1901564 318 0.133
positive regulation of cell death GO:0010942 69 0.133
regulation of cell development GO:0060284 215 0.131
Fly
negative regulation of cell size GO:0045792 19 0.130
negative regulation of rna biosynthetic process GO:1902679 240 0.129
Fly
phosphatidylinositol mediated signaling GO:0048015 4 0.128
negative regulation of hippo signaling GO:0035331 5 0.126
response to hormone GO:0009725 45 0.125
Human Rat
germ line cyst formation GO:0048134 44 0.125
axon regeneration GO:0031103 8 0.125
imaginal disc derived wing morphogenesis GO:0007476 337 0.125
Fly
localization of cell GO:0051674 257 0.123
Rat
actin filament bundle organization GO:0061572 28 0.123
developmental maturation GO:0021700 172 0.121
glucose homeostasis GO:0042593 6 0.121
spermatogenesis GO:0007283 200 0.121
regulation of mitochondrion organization GO:0010821 12 0.119
organic substance transport GO:0071702 257 0.118
Rat Fly
oxoacid metabolic process GO:0043436 103 0.118
establishment of organelle localization GO:0051656 122 0.118
gtp catabolic process GO:0006184 72 0.117
regulation of cell shape GO:0008360 113 0.117
positive regulation of gene expression GO:0010628 290 0.117
Human Fly
micropyle formation GO:0046844 4 0.117
regulation of cellular component movement GO:0051270 42 0.116
Rat
regulation of neuron projection development GO:0010975 69 0.115
protein modification process GO:0036211 438 0.115
cellular macromolecular complex assembly GO:0034622 153 0.115
larval development GO:0002164 104 0.114
Worm
positive regulation of axon regeneration GO:0048680 3 0.113
positive regulation of protein phosphorylation GO:0001934 34 0.111
ras protein signal transduction GO:0007265 88 0.111
Fly
cell cycle phase transition GO:0044770 140 0.110
Human
positive regulation of protein localization to plasma membrane GO:1903078 3 0.109
execution phase of apoptosis GO:0097194 7 0.108
nucleotide catabolic process GO:0009166 109 0.107
intracellular transport GO:0046907 228 0.106
Fly
regulation of metal ion transport GO:0010959 15 0.105
embryonic development via the syncytial blastoderm GO:0001700 148 0.105
regulation of cell cycle GO:0051726 291 0.104
Human
establishment of planar polarity GO:0001736 87 0.104
eggshell formation GO:0030703 105 0.103
positive regulation of cellular amine metabolic process GO:0033240 0 0.103
negative regulation of apoptotic process GO:0043066 63 0.103
Human Mouse
positive regulation of cellular catabolic process GO:0031331 95 0.103
cellular metal ion homeostasis GO:0006875 31 0.103
defense response to bacterium GO:0042742 178 0.102
establishment of protein localization GO:0045184 163 0.101
Fly
purine nucleoside triphosphate metabolic process GO:0009144 119 0.101
nucleobase containing compound catabolic process GO:0034655 165 0.101
imaginal disc eversion GO:0007561 4 0.100
positive regulation of glycogen biosynthetic process GO:0045725 1 0.099
response to bacterium GO:0009617 198 0.099
Rat
purine ribonucleotide catabolic process GO:0009154 109 0.098
regulation of protein phosphorylation GO:0001932 64 0.098
cellular ketone metabolic process GO:0042180 24 0.098
regulation of ras protein signal transduction GO:0046578 93 0.097
Fly
positive regulation of developmental growth GO:0048639 62 0.096
Rat
regulation of mapk cascade GO:0043408 92 0.095
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.095
response to decreased oxygen levels GO:0036293 58 0.094
nucleoside triphosphate metabolic process GO:0009141 120 0.094
negative regulation of cellular component organization GO:0051129 108 0.093
regulation of protein localization GO:0032880 76 0.093
Fly
negative regulation of organelle organization GO:0010639 56 0.092
ribose phosphate metabolic process GO:0019693 145 0.092
negative regulation of nervous system development GO:0051961 92 0.092
Fly
asymmetric stem cell division GO:0098722 49 0.092
guanosine containing compound metabolic process GO:1901068 74 0.091
response to alkaloid GO:0043279 26 0.091
morphogenesis of an epithelium GO:0002009 276 0.090
camera type eye development GO:0043010 4 0.090
cellular protein complex assembly GO:0043623 71 0.089
regulation of proteolysis GO:0030162 87 0.089
organelle fission GO:0048285 340 0.089
Fly
regulation of insulin receptor signaling pathway GO:0046626 17 0.088
Human Rat
regulation of neural precursor cell proliferation GO:2000177 35 0.087
ribonucleotide catabolic process GO:0009261 109 0.087
purine ribonucleotide metabolic process GO:0009150 145 0.086
membrane organization GO:0061024 112 0.086
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.086
cellular homeostasis GO:0019725 80 0.086
purine ribonucleoside metabolic process GO:0046128 127 0.085
actin filament polymerization GO:0030041 27 0.085
myotube cell development GO:0014904 3 0.084
positive regulation of protein serine threonine kinase activity GO:0071902 15 0.084
posttranscriptional regulation of gene expression GO:0010608 145 0.083
Human
negative regulation of mitotic cell cycle GO:0045930 109 0.083
regulation of protein complex assembly GO:0043254 42 0.083
regulation of epithelial cell proliferation GO:0050678 4 0.083
response to light stimulus GO:0009416 124 0.083
ribonucleoside catabolic process GO:0042454 112 0.083
heart development GO:0007507 82 0.082
autophagic vacuole assembly GO:0000045 2 0.082
Worm
oxidation reduction process GO:0055114 123 0.082
neuromuscular synaptic transmission GO:0007274 67 0.081
cell division GO:0051301 248 0.081
establishment of tissue polarity GO:0007164 87 0.081
activation of protein kinase activity GO:0032147 12 0.080
cytoplasmic transport GO:0016482 130 0.080
Fly
protein targeting GO:0006605 64 0.080
Fly
regulation of glial cell proliferation GO:0060251 11 0.079
lipid storage GO:0019915 38 0.079
regulation of nurse cell apoptotic process GO:0045477 9 0.078
positive regulation of cytoskeleton organization GO:0051495 21 0.078
regulation of mitosis GO:0007088 56 0.077
organophosphate metabolic process GO:0019637 195 0.077
carbohydrate derivative metabolic process GO:1901135 217 0.076
regulation of stress activated mapk cascade GO:0032872 41 0.076
imaginal disc derived wing hair outgrowth GO:0035318 1 0.076
protein localization to organelle GO:0033365 82 0.076
Fly
melanization defense response GO:0035006 45 0.075
cellular response to hormone stimulus GO:0032870 44 0.075
Human Rat
regulation of nuclear transcribed mrna poly a tail shortening GO:0060211 4 0.074
lamellipodium organization GO:0097581 21 0.074
nucleoside catabolic process GO:0009164 112 0.074
regulation of embryonic development GO:0045995 68 0.073
lipid localization GO:0010876 54 0.073
protein catabolic process GO:0030163 101 0.072
developmental cell growth GO:0048588 52 0.072
gliogenesis GO:0042063 80 0.072
aromatic compound catabolic process GO:0019439 166 0.071
proteolysis GO:0006508 192 0.071
single organism intracellular transport GO:1902582 207 0.071
Fly
negative regulation of cellular protein metabolic process GO:0032269 85 0.071
appendage morphogenesis GO:0035107 397 0.070
Fly
response to glucose GO:0009749 2 0.070
Rat
purine ribonucleoside catabolic process GO:0046130 112 0.069
regulation of cellular amine metabolic process GO:0033238 3 0.069
digestive system development GO:0055123 149 0.069
nucleotide metabolic process GO:0009117 161 0.069
stress activated protein kinase signaling cascade GO:0031098 55 0.069
hematopoietic or lymphoid organ development GO:0048534 57 0.069
nucleoside metabolic process GO:0009116 127 0.068
positive regulation of protein complex assembly GO:0031334 22 0.068
cellular ion homeostasis GO:0006873 39 0.068
carboxylic acid metabolic process GO:0019752 92 0.068
glycosyl compound catabolic process GO:1901658 112 0.068
regulation of cysteine type endopeptidase activity GO:2000116 27 0.067
purine nucleotide metabolic process GO:0006163 146 0.067
heterocycle catabolic process GO:0046700 166 0.067
regulation of tor signaling GO:0032006 21 0.067
regulation of cellular ketone metabolic process GO:0010565 3 0.066
cellular carbohydrate biosynthetic process GO:0034637 7 0.066
regulation of nitric oxide biosynthetic process GO:0045428 1 0.065
cardiac muscle tissue development GO:0048738 9 0.065
positive regulation of r7 cell differentiation GO:0045678 7 0.065
hemopoiesis GO:0030097 46 0.065
defense response GO:0006952 300 0.065
regulation of secretion GO:0051046 44 0.065
positive regulation of protein kinase activity GO:0045860 25 0.065
positive regulation of rna metabolic process GO:0051254 271 0.065
Fly
response to wounding GO:0009611 94 0.064
Rat
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.064
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.064
epithelium migration GO:0090132 148 0.063
regulation of hydrolase activity GO:0051336 97 0.063
positive regulation of nitric oxide biosynthetic process GO:0045429 1 0.062
response to acid chemical GO:0001101 25 0.062
Rat
cellular component assembly involved in morphogenesis GO:0010927 151 0.062
organic substance catabolic process GO:1901575 308 0.062
dna metabolic process GO:0006259 227 0.062
Fly
glycosyl compound metabolic process GO:1901657 127 0.062

S6k disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
thoracic cancer DOID:5093 0 0.309
cancer DOID:162 0 0.309
disease of cellular proliferation DOID:14566 0 0.309
organ system cancer DOID:0050686 0 0.309
disease of metabolism DOID:0014667 0 0.161
acquired metabolic disease DOID:0060158 0 0.161
carbohydrate metabolism disease DOID:0050013 0 0.104
glucose metabolism disease DOID:4194 0 0.104
disease of anatomical entity DOID:7 0 0.088
cardiovascular system disease DOID:1287 0 0.088
diabetes mellitus DOID:9351 0 0.063