Drosophila melanogaster

174 known processes

lz (Dmel_CG1689)

lozenge

(Aliases: fs(1)A1569,spe,amx,Dmel\CG1689,CG1689,Lz,fs(1)M69)

lz biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
eye development GO:0001654 323 0.918
sensory perception GO:0007600 196 0.884
regionalization GO:0003002 416 0.830
Zebrafish
tissue morphogenesis GO:0048729 297 0.790
Mouse
axonogenesis GO:0007409 290 0.775
Fly
hair cell differentiation GO:0035315 47 0.772
epithelial cell differentiation GO:0030855 322 0.760
positive regulation of biosynthetic process GO:0009891 316 0.752
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.719
skin development GO:0043588 65 0.652
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.648
eye antennal disc development GO:0035214 60 0.628
appendage development GO:0048736 401 0.595
Mouse
negative regulation of rna biosynthetic process GO:1902679 240 0.583
eye morphogenesis GO:0048592 260 0.559
post embryonic appendage morphogenesis GO:0035120 385 0.547
neurological system process GO:0050877 358 0.521
compound eye morphogenesis GO:0001745 249 0.495
positive regulation of macromolecule metabolic process GO:0010604 405 0.484
stem cell development GO:0048864 79 0.467
positive regulation of transcription dna templated GO:0045893 266 0.456
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.451
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.433
regulation of multicellular organismal development GO:2000026 414 0.424
sensory perception of sound GO:0007605 56 0.421
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.409
epidermal cell differentiation GO:0009913 51 0.400
sensory organ morphogenesis GO:0090596 260 0.398
negative regulation of gene expression GO:0010629 387 0.396
positive regulation of gene expression GO:0010628 290 0.393
positive regulation of rna metabolic process GO:0051254 271 0.390
camera type eye development GO:0043010 4 0.385
r7 cell differentiation GO:0045466 43 0.376
embryonic morphogenesis GO:0048598 206 0.366
Mouse Fly
immune system process GO:0002376 347 0.337
photoreceptor cell fate commitment GO:0046552 41 0.336
appendage morphogenesis GO:0035107 397 0.333
Mouse
cell fate commitment involved in formation of primary germ layer GO:0060795 10 0.323
camera type eye photoreceptor cell differentiation GO:0060219 2 0.321
stem cell differentiation GO:0048863 117 0.305
Mouse
compound eye development GO:0048749 307 0.293
axon guidance GO:0007411 233 0.283
Fly
axon development GO:0061564 297 0.279
Fly
neuron fate specification GO:0048665 12 0.262
positive regulation of nucleic acid templated transcription GO:1903508 266 0.260
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.255
imaginal disc derived wing morphogenesis GO:0007476 337 0.251
branching morphogenesis of an epithelial tube GO:0048754 45 0.250
positive regulation of cellular biosynthetic process GO:0031328 316 0.242
cell death GO:0008219 279 0.231
brain development GO:0007420 120 0.225
localization of cell GO:0051674 257 0.225
cell growth GO:0016049 108 0.219
eye antennal disc morphogenesis GO:0007455 34 0.215
transcription from rna polymerase ii promoter GO:0006366 368 0.213
epithelial cell development GO:0002064 274 0.213
apoptotic process involved in morphogenesis GO:0060561 3 0.206
camera type eye morphogenesis GO:0048593 2 0.206
hindbrain development GO:0030902 2 0.205
cell migration GO:0016477 238 0.204
cell fate specification GO:0001708 71 0.202
imaginal disc derived appendage development GO:0048737 399 0.198
death GO:0016265 284 0.195
regulation of epithelial cell proliferation GO:0050678 4 0.185
kidney morphogenesis GO:0060993 3 0.181
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.177
respiratory system development GO:0060541 213 0.173
retinal cone cell differentiation GO:0042670 2 0.170
neuron fate commitment GO:0048663 50 0.168
gliogenesis GO:0042063 80 0.166
regulation of cell differentiation GO:0045595 302 0.157
antennal development GO:0007469 25 0.156
multicellular organismal reproductive behavior GO:0033057 110 0.155
embryonic pattern specification GO:0009880 174 0.155
apoptotic process GO:0006915 159 0.154
courtship behavior GO:0007619 68 0.150
cell fate determination GO:0001709 91 0.150
epithelial cell proliferation GO:0050673 15 0.146
tube morphogenesis GO:0035239 191 0.145
Fly
epithelial tube morphogenesis GO:0060562 88 0.136
developmental growth involved in morphogenesis GO:0060560 65 0.134
hemopoiesis GO:0030097 46 0.134
nephron development GO:0072006 3 0.129
catabolic process GO:0009056 409 0.127
cell motility GO:0048870 251 0.125
compound eye photoreceptor cell differentiation GO:0001751 140 0.124
sensory perception of chemical stimulus GO:0007606 116 0.124
head development GO:0060322 135 0.120
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.119
imaginal disc derived appendage morphogenesis GO:0035114 395 0.116
developmental growth GO:0048589 280 0.115
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.115
regulation of phosphate metabolic process GO:0019220 210 0.113
notch signaling pathway GO:0007219 120 0.112
motor neuron axon guidance GO:0008045 58 0.107
establishment of ommatidial planar polarity GO:0042067 49 0.104
regulation of immune system process GO:0002682 176 0.102
Human
regulation of protein metabolic process GO:0051246 256 0.102
embryonic organ morphogenesis GO:0048562 5 0.101
Mouse
cranial nerve development GO:0021545 1 0.101
establishment or maintenance of cell polarity GO:0007163 167 0.100
wing disc morphogenesis GO:0007472 344 0.100
male mating behavior GO:0060179 70 0.099
retina morphogenesis in camera type eye GO:0060042 2 0.098
epidermis development GO:0008544 65 0.096
Mouse
tube development GO:0035295 244 0.095
Fly
mating GO:0007618 120 0.095
kidney epithelium development GO:0072073 3 0.092
positive regulation of developmental process GO:0051094 143 0.091
response to other organism GO:0051707 293 0.089
negative regulation of rna metabolic process GO:0051253 251 0.087
positive regulation of response to stimulus GO:0048584 323 0.087
nephron morphogenesis GO:0072028 3 0.084
intracellular signal transduction GO:0035556 300 0.084
immune response GO:0006955 246 0.083
positive regulation of cell death GO:0010942 69 0.082
regulation of heart morphogenesis GO:2000826 3 0.082
columnar cuboidal epithelial cell development GO:0002066 249 0.081
forebrain development GO:0030900 2 0.080
protein localization GO:0008104 284 0.079
visceral muscle development GO:0007522 14 0.078
regulation of nervous system development GO:0051960 248 0.078
cellular amino acid metabolic process GO:0006520 61 0.077
cellular protein modification process GO:0006464 438 0.076
regulation of neuron differentiation GO:0045664 103 0.076
determination of imaginal disc primordium GO:0007445 11 0.076
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.076
Mouse
neuron recognition GO:0008038 101 0.075
multi organism reproductive behavior GO:0044705 121 0.074
regulation of embryonic development GO:0045995 68 0.073
embryonic organ development GO:0048568 50 0.072
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.071
regulation of r7 cell differentiation GO:0045676 15 0.070
cellular response to growth factor stimulus GO:0071363 30 0.066
Mouse
sex differentiation GO:0007548 81 0.065
embryo development ending in birth or egg hatching GO:0009792 152 0.064
Mouse
morphogenesis of an epithelium GO:0002009 276 0.064
Mouse
cytolysis GO:0019835 1 0.064
non sensory hair organization GO:0035316 47 0.062
photoreceptor cell fate specification GO:0043704 9 0.062
organonitrogen compound metabolic process GO:1901564 318 0.062
nephron epithelium development GO:0072009 3 0.062
positive regulation of signaling GO:0023056 243 0.061
regulation of phosphorus metabolic process GO:0051174 210 0.061
developmental programmed cell death GO:0010623 138 0.061
regulation of neurogenesis GO:0050767 158 0.061
organic substance catabolic process GO:1901575 308 0.059
nephron tubule morphogenesis GO:0072078 3 0.057
negative regulation of developmental process GO:0051093 201 0.057
Human
antennal morphogenesis GO:0048800 14 0.056
neuron projection guidance GO:0097485 241 0.056
Fly
developmental cell growth GO:0048588 52 0.054
eye photoreceptor cell fate commitment GO:0042706 37 0.054
positive regulation of retinal cell programmed cell death GO:0046670 9 0.054
positive regulation of rna biosynthetic process GO:1902680 266 0.053
axon extension GO:0048675 32 0.053
photoreceptor cell differentiation GO:0046530 170 0.053
negative regulation of cell differentiation GO:0045596 143 0.052
Human
neural retina development GO:0003407 4 0.051
cellular response to oxygen containing compound GO:1901701 79 0.051
chromatin organization GO:0006325 207 0.050
compound eye photoreceptor fate commitment GO:0001752 36 0.049
mating behavior GO:0007617 106 0.048
regulation of cell fate specification GO:0042659 27 0.048
circulatory system development GO:0072359 82 0.047
Mouse
anterior posterior pattern specification GO:0009952 136 0.047
regulation of cell development GO:0060284 215 0.045
protein modification process GO:0036211 438 0.045
negative regulation of cell death GO:0060548 81 0.045
ovarian follicle cell development GO:0030707 248 0.044
mesenchyme development GO:0060485 9 0.044
mesenchymal cell differentiation GO:0048762 1 0.044
regulation of response to stress GO:0080134 200 0.043
eye photoreceptor cell differentiation GO:0001754 145 0.043
biological adhesion GO:0022610 138 0.043
kidney development GO:0001822 3 0.043
cell proliferation GO:0008283 299 0.043
Mouse
cellular component assembly involved in morphogenesis GO:0010927 151 0.043
negative regulation of cellular metabolic process GO:0031324 382 0.042
negative regulation of multicellular organismal process GO:0051241 142 0.042
Human
dendrite morphogenesis GO:0048813 199 0.041
Fly
sensory perception of mechanical stimulus GO:0050954 72 0.040
sensory perception of smell GO:0007608 80 0.040
spiracle morphogenesis open tracheal system GO:0035277 22 0.040
lipid metabolic process GO:0006629 121 0.040
positive regulation of immune response GO:0050778 63 0.040
cellular response to abiotic stimulus GO:0071214 58 0.039
positive regulation of cell communication GO:0010647 250 0.039
nephron tubule formation GO:0072079 3 0.039
response to abiotic stimulus GO:0009628 341 0.039
organ formation GO:0048645 39 0.038
developmental pigmentation GO:0048066 68 0.038
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.037
multi organism behavior GO:0051705 175 0.036
ras protein signal transduction GO:0007265 88 0.036
striated muscle cell differentiation GO:0051146 90 0.036
reproductive behavior GO:0019098 122 0.035
regulation of epidermal cell differentiation GO:0045604 3 0.035
ameboidal type cell migration GO:0001667 151 0.035
central nervous system development GO:0007417 201 0.035
Mouse
positive regulation of catalytic activity GO:0043085 118 0.034
regulation of epithelial cell differentiation GO:0030856 4 0.034
leg disc development GO:0035218 92 0.034
regulation of intracellular signal transduction GO:1902531 236 0.034
positive regulation of epithelial cell differentiation GO:0030858 1 0.034
segmentation GO:0035282 207 0.034
male courtship behavior GO:0008049 63 0.034
regulation of cell death GO:0010941 173 0.033
cellular ketone metabolic process GO:0042180 24 0.033
response to external biotic stimulus GO:0043207 293 0.033
defense response to other organism GO:0098542 225 0.032
cellular response to chemical stimulus GO:0070887 199 0.032
Mouse
morphogenesis of embryonic epithelium GO:0016331 94 0.032
positive regulation of cell proliferation GO:0008284 47 0.031
Mouse
cell projection assembly GO:0030031 94 0.031
cuticle pattern formation GO:0035017 27 0.031
stem cell maintenance GO:0019827 67 0.030
neuron projection extension GO:1990138 32 0.030
larval development GO:0002164 104 0.030
regulation of hydrolase activity GO:0051336 97 0.029
digestive tract morphogenesis GO:0048546 127 0.029
Fly
regulation of anatomical structure morphogenesis GO:0022603 242 0.028
hematopoietic or lymphoid organ development GO:0048534 57 0.028
imaginal disc derived wing hair organization GO:0035317 45 0.028
ribonucleoprotein complex disassembly GO:0032988 1 0.028
negative regulation of cellular protein metabolic process GO:0032269 85 0.027
mesenchymal cell development GO:0014031 1 0.027
determination of genital disc primordium GO:0035225 10 0.027
positive regulation of cellular catabolic process GO:0031331 95 0.027
retina development in camera type eye GO:0060041 4 0.027
immune effector process GO:0002252 98 0.026
regulation of compound eye cone cell fate specification GO:0042682 4 0.026
organic substance transport GO:0071702 257 0.026
imaginal disc derived leg morphogenesis GO:0007480 80 0.026
muscle fiber development GO:0048747 12 0.025
positive regulation of immune system process GO:0002684 68 0.025
Human
axis elongation GO:0003401 3 0.025
cellular catabolic process GO:0044248 372 0.025
negative regulation of biosynthetic process GO:0009890 277 0.025
enzyme linked receptor protein signaling pathway GO:0007167 179 0.025
Mouse
response to biotic stimulus GO:0009607 294 0.025
compound eye cone cell fate commitment GO:0042676 5 0.025
cell recognition GO:0008037 102 0.024
regulation of cell morphogenesis GO:0022604 163 0.024
chaeta morphogenesis GO:0008407 42 0.024
response to organic substance GO:0010033 284 0.024
Mouse
regulation of molecular function GO:0065009 217 0.024
mitotic cell cycle phase transition GO:0044772 138 0.024
regulation of stem cell proliferation GO:0072091 40 0.024
regulation of catabolic process GO:0009894 170 0.024
cellular response to endogenous stimulus GO:0071495 80 0.024
Mouse
gastrulation GO:0007369 70 0.023
Fly
negative regulation of cellular biosynthetic process GO:0031327 277 0.023
positive regulation of cell differentiation GO:0045597 64 0.023
chaeta development GO:0022416 97 0.022
organic acid metabolic process GO:0006082 103 0.022
striated muscle cell development GO:0055002 50 0.022
regulation of cellular protein metabolic process GO:0032268 243 0.022
post embryonic hemopoiesis GO:0035166 17 0.022
positive regulation of phosphorus metabolic process GO:0010562 139 0.022
regulation of anatomical structure size GO:0090066 163 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.021
programmed cell death GO:0012501 257 0.021
mesodermal cell fate specification GO:0007501 2 0.021
chemotaxis GO:0006935 249 0.021
Fly
regulation of protein modification process GO:0031399 112 0.021
actin cytoskeleton organization GO:0030036 206 0.021
positive regulation of protein metabolic process GO:0051247 128 0.020
carbohydrate derivative metabolic process GO:1901135 217 0.020
spermatogenesis GO:0007283 200 0.020
detection of stimulus involved in sensory perception GO:0050906 92 0.020
regulation of organ formation GO:0003156 3 0.020
negative regulation of transcription dna templated GO:0045892 237 0.020
digestive tract development GO:0048565 149 0.019
Fly
specification of organ identity GO:0010092 3 0.019
retinal cell programmed cell death GO:0046666 25 0.019
morphogenesis of a branching epithelium GO:0061138 45 0.019
positive regulation of phosphate metabolic process GO:0045937 139 0.019
oxoacid metabolic process GO:0043436 103 0.019
negative regulation of neurogenesis GO:0050768 53 0.019
muscle cell differentiation GO:0042692 103 0.019
compound eye retinal cell programmed cell death GO:0046667 23 0.019
nephron epithelium morphogenesis GO:0072088 3 0.019
epithelial cell morphogenesis GO:0003382 25 0.019
proteolysis GO:0006508 192 0.019
regulation of catalytic activity GO:0050790 185 0.018
negative regulation of nervous system development GO:0051961 92 0.018
defense response GO:0006952 300 0.018
body morphogenesis GO:0010171 2 0.018
actin filament based process GO:0030029 220 0.018
larval lymph gland hemopoiesis GO:0035167 17 0.018
mesodermal cell fate commitment GO:0001710 7 0.018
regulation of compound eye retinal cell programmed cell death GO:0046669 18 0.017
regulation of cellular catabolic process GO:0031329 157 0.017
positive regulation of multicellular organismal process GO:0051240 143 0.017
development of primary sexual characteristics GO:0045137 50 0.017
positive regulation of phosphorylation GO:0042327 87 0.017
renal tubule development GO:0061326 64 0.017
positive regulation of signal transduction GO:0009967 223 0.017
single organism biosynthetic process GO:0044711 206 0.016
single organismal cell cell adhesion GO:0016337 45 0.016
apoptotic process involved in development GO:1902742 20 0.016
cell junction organization GO:0034330 57 0.016
protein catabolic process GO:0030163 101 0.015
establishment of mitotic spindle orientation GO:0000132 13 0.015
urogenital system development GO:0001655 72 0.015
organ induction GO:0001759 3 0.015
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.015
cellular protein catabolic process GO:0044257 83 0.015
regulation of protein processing GO:0070613 32 0.015
neuron death GO:0070997 27 0.015
compound eye photoreceptor development GO:0042051 78 0.014
positive regulation of molecular function GO:0044093 136 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
regulation of programmed cell death GO:0043067 152 0.014
ocellus development GO:0008056 4 0.014
formation of anatomical boundary GO:0048859 37 0.014
positive regulation of cellular protein metabolic process GO:0032270 118 0.014
neuron fate determination GO:0048664 1 0.014
imaginal disc pattern formation GO:0007447 91 0.014
cellular response to oxidative stress GO:0034599 28 0.014
nephron tubule development GO:0072080 3 0.014
positive regulation of intracellular signal transduction GO:1902533 116 0.014
regulation of growth GO:0040008 233 0.014
humoral immune response GO:0006959 117 0.014
taxis GO:0042330 304 0.014
Fly
regulation of photoreceptor cell differentiation GO:0046532 34 0.014
single organism cell adhesion GO:0098602 47 0.014
regulation of hemocyte differentiation GO:0045610 22 0.014
synaptic target recognition GO:0008039 45 0.014
regulation of insulin like growth factor receptor signaling pathway GO:0043567 3 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
hematopoietic progenitor cell differentiation GO:0002244 1 0.013
Mouse
cell type specific apoptotic process GO:0097285 38 0.013
pigmentation GO:0043473 75 0.013
small gtpase mediated signal transduction GO:0007264 88 0.013
regulation of apoptotic process GO:0042981 130 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
regulation of developmental growth GO:0048638 174 0.013
purine ribonucleotide metabolic process GO:0009150 145 0.013
brain morphogenesis GO:0048854 16 0.013
glial cell migration GO:0008347 31 0.013
cell adhesion GO:0007155 136 0.013
cardiovascular system development GO:0072358 82 0.013
Mouse
small molecule metabolic process GO:0044281 305 0.013
response to fibroblast growth factor GO:0071774 10 0.012
Mouse
ectodermal placode morphogenesis GO:0071697 4 0.012
smoothened signaling pathway GO:0007224 49 0.012
Mouse
gland development GO:0048732 191 0.012
Mouse
regulation of phosphoprotein phosphatase activity GO:0043666 3 0.012
cellular lipid metabolic process GO:0044255 83 0.012
regulation of immune response GO:0050776 118 0.012
regulation of cell proliferation GO:0042127 163 0.012
Mouse
compound eye cone cell differentiation GO:0042675 13 0.012
positive regulation of compound eye retinal cell programmed cell death GO:0046672 9 0.012
cell maturation GO:0048469 144 0.012
Mouse
myotube differentiation GO:0014902 46 0.012
negative regulation of apoptotic process GO:0043066 63 0.012
eye pigmentation GO:0048069 43 0.012
embryonic development via the syncytial blastoderm GO:0001700 148 0.012
glial cell differentiation GO:0010001 35 0.011
spindle localization GO:0051653 22 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
amine metabolic process GO:0009308 12 0.011
open tracheal system development GO:0007424 204 0.011
morphogenesis of a branching structure GO:0001763 45 0.011
organic cyclic compound catabolic process GO:1901361 168 0.011
germ cell migration GO:0008354 43 0.011
muscle cell fate commitment GO:0042693 14 0.011
regulation of protein phosphorylation GO:0001932 64 0.011
genital disc sexually dimorphic development GO:0035263 4 0.011
mesoderm development GO:0007498 78 0.011
anatomical structure homeostasis GO:0060249 97 0.010
negative regulation of protein metabolic process GO:0051248 85 0.010
heart development GO:0007507 82 0.010
response to endogenous stimulus GO:0009719 119 0.010
Mouse
skeletal muscle organ development GO:0060538 48 0.010
blastoderm segmentation GO:0007350 159 0.010
muscle cell development GO:0055001 50 0.010
regulation of phosphorylation GO:0042325 147 0.010
wing disc pattern formation GO:0035222 66 0.010

lz disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.026
Human
disease of cellular proliferation DOID:14566 0 0.026
Human