Drosophila melanogaster

47 known processes

Ptp99A (Dmel_CG11516)

Protein tyrosine phosphatase 99A

(Aliases: DPTP99A,dptp99A,CG2005,Dmel\CG11516,CT6383,DPTP[[99A]],R-PTP 99A,CG11515,CG11517,CG11516,PTP99A)

Ptp99A biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
axon development GO:0061564 297 0.451
motor neuron axon guidance GO:0008045 58 0.381
axonogenesis GO:0007409 290 0.374
axon guidance GO:0007411 233 0.299
chemotaxis GO:0006935 249 0.228
imaginal disc derived appendage morphogenesis GO:0035114 395 0.186
appendage morphogenesis GO:0035107 397 0.186
taxis GO:0042330 304 0.168
appendage development GO:0048736 401 0.168
imaginal disc derived appendage development GO:0048737 399 0.144
regulation of nervous system development GO:0051960 248 0.144
Fly
sensory organ morphogenesis GO:0090596 260 0.126
Fly
lateral inhibition GO:0046331 206 0.123
neuron projection guidance GO:0097485 241 0.122
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.110
neuron recognition GO:0008038 101 0.104
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.104
tissue morphogenesis GO:0048729 297 0.101
dendrite development GO:0016358 204 0.098
wing disc morphogenesis GO:0007472 344 0.097
regulation of multicellular organismal development GO:2000026 414 0.097
Fly
positive regulation of biosynthetic process GO:0009891 316 0.095
compound eye development GO:0048749 307 0.094
Fly
eye development GO:0001654 323 0.090
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.090
tube morphogenesis GO:0035239 191 0.088
transcription from rna polymerase ii promoter GO:0006366 368 0.085
morphogenesis of an epithelium GO:0002009 276 0.075
regulation of neurogenesis GO:0050767 158 0.075
Fly
connective tissue development GO:0061448 3 0.073
post embryonic appendage morphogenesis GO:0035120 385 0.071
photoreceptor cell axon guidance GO:0072499 23 0.069
imaginal disc derived leg morphogenesis GO:0007480 80 0.066
axonal defasciculation GO:0007414 12 0.065
regionalization GO:0003002 416 0.064
compound eye morphogenesis GO:0001745 249 0.063
Fly
muscle structure development GO:0061061 224 0.059
immune system process GO:0002376 347 0.059
circulatory system development GO:0072359 82 0.058
cell cell signaling involved in cell fate commitment GO:0045168 210 0.058
negative regulation of gene expression GO:0010629 387 0.057
negative regulation of signal transduction GO:0009968 206 0.055
body morphogenesis GO:0010171 2 0.054
negative regulation of nucleic acid templated transcription GO:1903507 240 0.054
tube development GO:0035295 244 0.054
negative regulation of rna biosynthetic process GO:1902679 240 0.052
regulation of behavior GO:0050795 75 0.049
Fly
regulation of cell development GO:0060284 215 0.048
Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.045
single organism behavior GO:0044708 391 0.045
kidney development GO:0001822 3 0.042
cardiovascular system development GO:0072358 82 0.042
imaginal disc derived wing morphogenesis GO:0007476 337 0.042
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.042
negative regulation of cellular metabolic process GO:0031324 382 0.041
striated muscle cell differentiation GO:0051146 90 0.041
regulation of cell differentiation GO:0045595 302 0.040
Fly
cell motility GO:0048870 251 0.039
negative regulation of transcription dna templated GO:0045892 237 0.039
positive regulation of macromolecule metabolic process GO:0010604 405 0.038
homeostatic process GO:0042592 199 0.038
dendrite morphogenesis GO:0048813 199 0.037
positive regulation of rna biosynthetic process GO:1902680 266 0.037
establishment of tissue polarity GO:0007164 87 0.037
cell migration GO:0016477 238 0.037
salivary gland development GO:0007431 162 0.036
eye morphogenesis GO:0048592 260 0.036
Fly
bolwig s organ development GO:0055034 8 0.035
positive regulation of multicellular organismal process GO:0051240 143 0.035
regulation of phosphorylation GO:0042325 147 0.035
spinal cord development GO:0021510 1 0.035
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.034
cell proliferation GO:0008283 299 0.033
negative regulation of biosynthetic process GO:0009890 277 0.033
axon midline choice point recognition GO:0016199 26 0.033
growth GO:0040007 359 0.033
Fly
detection of stimulus GO:0051606 156 0.032
positive regulation of nervous system development GO:0051962 69 0.032
establishment or maintenance of cell polarity GO:0007163 167 0.032
extrinsic apoptotic signaling pathway GO:0097191 1 0.031
cell fate determination GO:0001709 91 0.031
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.031
neurological system process GO:0050877 358 0.031
regulation of cellular protein metabolic process GO:0032268 243 0.031
embryo development ending in birth or egg hatching GO:0009792 152 0.031
compound eye photoreceptor cell differentiation GO:0001751 140 0.030
Fly
negative regulation of cellular biosynthetic process GO:0031327 277 0.030
regulation of wnt signaling pathway GO:0030111 68 0.030
positive regulation of nucleic acid templated transcription GO:1903508 266 0.030
regulation of developmental growth GO:0048638 174 0.030
Fly
apoptotic process GO:0006915 159 0.030
embryonic morphogenesis GO:0048598 206 0.030
negative regulation of rna metabolic process GO:0051253 251 0.029
protein phosphorylation GO:0006468 169 0.029
positive regulation of cellular biosynthetic process GO:0031328 316 0.029
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.029
central nervous system development GO:0007417 201 0.029
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.029
cell recognition GO:0008037 102 0.029
columnar cuboidal epithelial cell development GO:0002066 249 0.028
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 17 0.028
developmental growth GO:0048589 280 0.028
Fly
negative regulation of nervous system development GO:0051961 92 0.028
positive regulation of response to stimulus GO:0048584 323 0.028
catabolic process GO:0009056 409 0.027
response to wounding GO:0009611 94 0.027
regulation of growth GO:0040008 233 0.027
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.027
embryonic axis specification GO:0000578 107 0.027
cell death GO:0008219 279 0.026
negative regulation of multicellular organismal process GO:0051241 142 0.026
cell adhesion GO:0007155 136 0.026
Fly
cell maturation GO:0048469 144 0.026
leg disc development GO:0035218 92 0.026
blastoderm segmentation GO:0007350 159 0.026
regulation of neuron differentiation GO:0045664 103 0.026
Fly
small molecule metabolic process GO:0044281 305 0.025
protein modification process GO:0036211 438 0.025
Fly
positive regulation of transcription dna templated GO:0045893 266 0.025
positive regulation of cell communication GO:0010647 250 0.025
regulation of anatomical structure size GO:0090066 163 0.025
Fly
negative regulation of cell differentiation GO:0045596 143 0.025
epithelial tube morphogenesis GO:0060562 88 0.025
chromosome organization GO:0051276 360 0.025
dorsal ventral pattern formation GO:0009953 133 0.024
endocytosis GO:0006897 310 0.024
response to abiotic stimulus GO:0009628 341 0.024
sex differentiation GO:0007548 81 0.024
positive regulation of phosphorus metabolic process GO:0010562 139 0.024
regulation of transferase activity GO:0051338 58 0.024
negative regulation of response to stimulus GO:0048585 258 0.023
regulation of molecular function GO:0065009 217 0.023
negative regulation of signaling GO:0023057 219 0.022
intracellular signal transduction GO:0035556 300 0.022
heart development GO:0007507 82 0.022
telencephalon development GO:0021537 2 0.022
cellular protein modification process GO:0006464 438 0.022
Fly
positive regulation of signal transduction GO:0009967 223 0.022
respiratory system development GO:0060541 213 0.022
somatic muscle development GO:0007525 66 0.021
positive regulation of gene expression GO:0010628 290 0.021
enzyme linked receptor protein signaling pathway GO:0007167 179 0.021
embryonic organ development GO:0048568 50 0.021
actin cytoskeleton organization GO:0030036 206 0.021
programmed cell death GO:0012501 257 0.021
morphogenesis of a polarized epithelium GO:0001738 93 0.021
genital disc development GO:0035215 44 0.021
eye photoreceptor cell differentiation GO:0001754 145 0.020
Fly
wnt signaling pathway GO:0016055 98 0.020
ras protein signal transduction GO:0007265 88 0.020
positive regulation of rna metabolic process GO:0051254 271 0.020
segmentation GO:0035282 207 0.020
nucleobase containing compound catabolic process GO:0034655 165 0.020
salivary gland morphogenesis GO:0007435 145 0.020
positive regulation of growth GO:0045927 75 0.020
cell cell adhesion GO:0098609 26 0.019
anatomical structure homeostasis GO:0060249 97 0.019
locomotory behavior GO:0007626 176 0.019
organ growth GO:0035265 56 0.019
localization of cell GO:0051674 257 0.019
rho protein signal transduction GO:0007266 14 0.019
regulation of cellular ketone metabolic process GO:0010565 3 0.019
endomembrane system organization GO:0010256 119 0.019
forebrain development GO:0030900 2 0.019
leg disc morphogenesis GO:0007478 80 0.018
exocrine system development GO:0035272 162 0.018
axon choice point recognition GO:0016198 26 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.018
formation of anatomical boundary GO:0048859 37 0.018
immune response GO:0006955 246 0.018
regulation of phosphorus metabolic process GO:0051174 210 0.018
positive regulation of signaling GO:0023056 243 0.018
gene silencing GO:0016458 138 0.018
defense response to other organism GO:0098542 225 0.018
synaptic transmission GO:0007268 288 0.018
establishment of planar polarity GO:0001736 87 0.018
organonitrogen compound metabolic process GO:1901564 318 0.018
vesicle mediated transport GO:0016192 381 0.017
oxoacid metabolic process GO:0043436 103 0.017
detection of external stimulus GO:0009581 66 0.017
regulation of localization GO:0032879 275 0.017
Fly
heterocycle catabolic process GO:0046700 166 0.017
biological adhesion GO:0022610 138 0.017
Fly
regulation of phosphate metabolic process GO:0019220 210 0.017
imaginal disc pattern formation GO:0007447 91 0.017
renal system process GO:0003014 12 0.017
regulation of cell morphogenesis GO:0022604 163 0.017
Fly
regulation of protein modification process GO:0031399 112 0.017
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.017
tripartite regional subdivision GO:0007351 103 0.017
regulation of synapse structure and activity GO:0050803 128 0.017
regulation of neuron projection development GO:0010975 69 0.017
Fly
nephron development GO:0072006 3 0.016
positive regulation of intracellular signal transduction GO:1902533 116 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
digestive tract morphogenesis GO:0048546 127 0.016
posttranscriptional regulation of gene expression GO:0010608 145 0.016
muscle organ development GO:0007517 127 0.016
regulation of axon guidance GO:1902667 10 0.016
Fly
positive regulation of catalytic activity GO:0043085 118 0.016
gland morphogenesis GO:0022612 145 0.016
regulation of cell proliferation GO:0042127 163 0.016
positive regulation of cell differentiation GO:0045597 64 0.016
dendrite guidance GO:0070983 21 0.016
cell growth GO:0016049 108 0.016
Fly
organic substance catabolic process GO:1901575 308 0.016
adult behavior GO:0030534 137 0.016
digestive system development GO:0055123 149 0.016
wound healing GO:0042060 75 0.015
organic acid metabolic process GO:0006082 103 0.015
camera type eye development GO:0043010 4 0.015
olfactory bulb axon guidance GO:0071678 3 0.015
regulation of catalytic activity GO:0050790 185 0.015
cellular catabolic process GO:0044248 372 0.015
chaeta development GO:0022416 97 0.015
epithelial cell differentiation GO:0030855 322 0.015
death GO:0016265 284 0.015
hematopoietic progenitor cell differentiation GO:0002244 1 0.015
regulation of cell projection organization GO:0031344 92 0.015
Fly
synaptic target recognition GO:0008039 45 0.015
developmental growth involved in morphogenesis GO:0060560 65 0.015
Fly
regulation of protein metabolic process GO:0051246 256 0.015
positive regulation of cellular component biogenesis GO:0044089 80 0.015
regulation of organelle organization GO:0033043 196 0.015
positive regulation of cellular component organization GO:0051130 156 0.015
ion transport GO:0006811 145 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.014
regulation of gene expression epigenetic GO:0040029 128 0.014
epithelial cell development GO:0002064 274 0.014
mesenchymal cell development GO:0014031 1 0.014
purine ribonucleotide metabolic process GO:0009150 145 0.014
negative regulation of cell development GO:0010721 62 0.014
neuron fate commitment GO:0048663 50 0.014
carboxylic acid metabolic process GO:0019752 92 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
protein complex biogenesis GO:0070271 201 0.014
anterior posterior axis specification embryo GO:0008595 103 0.014
positive regulation of developmental process GO:0051094 143 0.014
muscle cell development GO:0055001 50 0.014
hair cell differentiation GO:0035315 47 0.014
axis specification GO:0009798 167 0.014
digestive tract development GO:0048565 149 0.014
positive regulation of cell migration GO:0030335 2 0.014
phosphorylation GO:0016310 294 0.014
regulation of intracellular signal transduction GO:1902531 236 0.014
hemocyte differentiation GO:0042386 38 0.014
epidermal growth factor receptor signaling pathway GO:0007173 58 0.014
positive regulation of cell development GO:0010720 61 0.013
regulation of cell size GO:0008361 63 0.013
Fly
urogenital system development GO:0001655 72 0.013
aromatic compound catabolic process GO:0019439 166 0.013
protein complex assembly GO:0006461 200 0.013
sensory perception of chemical stimulus GO:0007606 116 0.013
negative regulation of growth GO:0045926 84 0.013
embryonic pattern specification GO:0009880 174 0.013
branching morphogenesis of an epithelial tube GO:0048754 45 0.013
regulation of axon extension involved in axon guidance GO:0048841 4 0.013
Fly
regulation of protein kinase activity GO:0045859 51 0.013
negative regulation of gene expression epigenetic GO:0045814 77 0.013
positive regulation of phosphate metabolic process GO:0045937 139 0.013
regulation of response to stress GO:0080134 200 0.013
gliogenesis GO:0042063 80 0.013
phagocytosis GO:0006909 215 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
nucleotide metabolic process GO:0009117 161 0.013
regulation of apoptotic process GO:0042981 130 0.012
anterior posterior pattern specification GO:0009952 136 0.012
regulation of cellular component size GO:0032535 98 0.012
Fly
regulation of cell cycle GO:0051726 291 0.012
negative regulation of neurogenesis GO:0050768 53 0.012
macromolecular complex assembly GO:0065003 256 0.012
response to bacterium GO:0009617 198 0.012
chaeta morphogenesis GO:0008407 42 0.012
immune system development GO:0002520 57 0.012
amine metabolic process GO:0009308 12 0.012
gland development GO:0048732 191 0.012
organic cyclic compound catabolic process GO:1901361 168 0.012
negative regulation of developmental process GO:0051093 201 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
hematopoietic or lymphoid organ development GO:0048534 57 0.012
negative regulation of cell communication GO:0010648 223 0.012
response to other organism GO:0051707 293 0.012
response to organic substance GO:0010033 284 0.012
chromatin organization GO:0006325 207 0.012
erbb signaling pathway GO:0038127 58 0.012
reproductive structure development GO:0048608 74 0.012
response to biotic stimulus GO:0009607 294 0.011
nephron morphogenesis GO:0072028 3 0.011
feeding behavior GO:0007631 50 0.011
regulation of mapk cascade GO:0043408 92 0.011
morphogenesis of a branching epithelium GO:0061138 45 0.011
morphogenesis of a branching structure GO:0001763 45 0.011
stem cell division GO:0017145 69 0.011
positive regulation of molecular function GO:0044093 136 0.011
organophosphate metabolic process GO:0019637 195 0.011
response to oxygen containing compound GO:1901700 200 0.011
membrane organization GO:0061024 112 0.011
syncytium formation by plasma membrane fusion GO:0000768 43 0.011
cell division GO:0051301 248 0.011
regulation of response to external stimulus GO:0032101 115 0.011
Fly
single organism membrane organization GO:0044802 93 0.011
response to external biotic stimulus GO:0043207 293 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
regulation of immune system process GO:0002682 176 0.011
detection of mechanical stimulus GO:0050982 6 0.011
ameboidal type cell migration GO:0001667 151 0.011
actin cytoskeleton reorganization GO:0031532 22 0.011
regulation of programmed cell death GO:0043067 152 0.011
regulation of cell cycle process GO:0010564 181 0.011
purine nucleotide metabolic process GO:0006163 146 0.010
regulation of epithelial cell differentiation GO:0030856 4 0.010
photoreceptor cell differentiation GO:0046530 170 0.010
Fly
histolysis GO:0007559 102 0.010
epithelium migration GO:0090132 148 0.010
chemical homeostasis GO:0048878 92 0.010
wing disc pattern formation GO:0035222 66 0.010
positive regulation of protein metabolic process GO:0051247 128 0.010
regulation of canonical wnt signaling pathway GO:0060828 15 0.010
chromatin silencing GO:0006342 76 0.010

Ptp99A disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.060
cardiovascular system disease DOID:1287 0 0.036
urinary system disease DOID:18 0 0.025
musculoskeletal system disease DOID:17 0 0.024
kidney disease DOID:557 0 0.017