Drosophila melanogaster

65 known processes

Drp1 (Dmel_CG3210)

Dynamin related protein 1

(Aliases: drp1,Dnm1/Drp1,DRP1,Drp-1,l(2)ND2,drp-1,frat,Drp,CG3210,l(2)22Fd,l(2)ND3,l(2)22Fc,Dmel\CG3210)

Drp1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mitochondrion morphogenesis GO:0070584 8 0.706
cytoskeleton dependent cytokinesis GO:0061640 81 0.670
establishment of localization in cell GO:0051649 402 0.515
intracellular protein transmembrane transport GO:0065002 4 0.426
intracellular protein transmembrane import GO:0044743 4 0.420
vesicle mediated transport GO:0016192 381 0.355
mitochondrion organization GO:0007005 65 0.310
sperm mitochondrion organization GO:0030382 7 0.301
meiotic cytokinesis GO:0033206 33 0.292
vesicle localization GO:0051648 55 0.267
cellular component disassembly GO:0022411 46 0.257
regulation of cellular component biogenesis GO:0044087 201 0.253
glycosyl compound catabolic process GO:1901658 112 0.240
cellular catabolic process GO:0044248 372 0.238
intracellular transport GO:0046907 228 0.227
male gamete generation GO:0048232 201 0.225
intracellular signal transduction GO:0035556 300 0.220
cellular protein complex disassembly GO:0043624 35 0.174
synapse organization GO:0050808 196 0.174
guanosine containing compound metabolic process GO:1901068 74 0.171
regulation of transport GO:0051049 181 0.170
anterior posterior axis specification GO:0009948 109 0.167
regulation of cellular catabolic process GO:0031329 157 0.166
trna aminoacylation GO:0043039 2 0.166
positive regulation of cellular biosynthetic process GO:0031328 316 0.164
cytokinetic process GO:0032506 27 0.162
protein localization GO:0008104 284 0.148
Mouse
purine nucleotide catabolic process GO:0006195 109 0.144
proteolysis GO:0006508 192 0.144
regulation of protein complex disassembly GO:0043244 29 0.143
cellular macromolecule localization GO:0070727 220 0.140
Mouse
regulation of intracellular signal transduction GO:1902531 236 0.134
protein modification process GO:0036211 438 0.133
response to virus GO:0009615 28 0.130
organelle localization GO:0051640 148 0.129
male meiosis cytokinesis GO:0007112 26 0.128
nucleoside metabolic process GO:0009116 127 0.126
axis specification GO:0009798 167 0.124
regulation of protein metabolic process GO:0051246 256 0.124
cell division GO:0051301 248 0.122
response to external biotic stimulus GO:0043207 293 0.119
protein modification by small protein conjugation or removal GO:0070647 106 0.114
positive regulation of macromolecule metabolic process GO:0010604 405 0.111
single organism biosynthetic process GO:0044711 206 0.110
ribose phosphate metabolic process GO:0019693 145 0.107
negative regulation of cellular metabolic process GO:0031324 382 0.106
macromolecular complex disassembly GO:0032984 37 0.101
endocytosis GO:0006897 310 0.100
axonogenesis GO:0007409 290 0.098
single organism cellular localization GO:1902580 180 0.098
spermatogenesis GO:0007283 200 0.095
nucleobase containing compound catabolic process GO:0034655 165 0.091
death GO:0016265 284 0.090
Mouse
modification dependent macromolecule catabolic process GO:0043632 79 0.088
organelle assembly GO:0070925 198 0.087
establishment of vesicle localization GO:0051650 51 0.086
response to biotic stimulus GO:0009607 294 0.083
establishment of mitochondrion localization GO:0051654 7 0.082
actomyosin structure organization GO:0031032 56 0.082
establishment of protein localization GO:0045184 163 0.079
organic substance catabolic process GO:1901575 308 0.078
regionalization GO:0003002 416 0.078
organic substance transport GO:0071702 257 0.078
regulation of catabolic process GO:0009894 170 0.076
chemotaxis GO:0006935 249 0.075
spermatid development GO:0007286 98 0.074
transcription from rna polymerase ii promoter GO:0006366 368 0.074
synapse assembly GO:0007416 143 0.074
ribonucleoside triphosphate metabolic process GO:0009199 119 0.073
regulation of cell shape GO:0008360 113 0.072
protein modification by small protein removal GO:0070646 28 0.070
purine containing compound metabolic process GO:0072521 155 0.070
purine nucleoside triphosphate catabolic process GO:0009146 108 0.070
nucleoside triphosphate metabolic process GO:0009141 120 0.070
cellular protein catabolic process GO:0044257 83 0.069
small molecule metabolic process GO:0044281 305 0.069
glycosyl compound metabolic process GO:1901657 127 0.069
embryonic axis specification GO:0000578 107 0.068
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.067
regulation of localization GO:0032879 275 0.066
organic cyclic compound catabolic process GO:1901361 168 0.066
cellular protein localization GO:0034613 160 0.066
Mouse
positive regulation of biosynthetic process GO:0009891 316 0.065
cellular protein modification process GO:0006464 438 0.062
nucleoside triphosphate catabolic process GO:0009143 108 0.061
negative regulation of growth GO:0045926 84 0.061
response to other organism GO:0051707 293 0.060
regulation of mitochondrial fusion GO:0010635 5 0.060
protein transmembrane transport GO:0071806 4 0.060
gtp metabolic process GO:0046039 72 0.059
negative regulation of signaling GO:0023057 219 0.059
organophosphate metabolic process GO:0019637 195 0.058
apoptotic process GO:0006915 159 0.057
eye development GO:0001654 323 0.056
organonitrogen compound metabolic process GO:1901564 318 0.054
regulation of oocyte development GO:0060281 27 0.054
establishment of organelle localization GO:0051656 122 0.053
regulation of phosphorus metabolic process GO:0051174 210 0.052
purine containing compound catabolic process GO:0072523 112 0.051
ribonucleotide metabolic process GO:0009259 145 0.051
regulation of molecular function GO:0065009 217 0.050
translation GO:0006412 69 0.049
purine ribonucleotide catabolic process GO:0009154 109 0.049
imaginal disc derived appendage morphogenesis GO:0035114 395 0.049
protein transport GO:0015031 155 0.048
protein complex assembly GO:0006461 200 0.048
imaginal disc derived wing morphogenesis GO:0007476 337 0.047
cytoplasmic transport GO:0016482 130 0.047
carbohydrate derivative catabolic process GO:1901136 118 0.047
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.047
nucleotide catabolic process GO:0009166 109 0.047
embryonic pattern specification GO:0009880 174 0.046
protein complex disassembly GO:0043241 36 0.046
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.046
dorsal ventral pattern formation GO:0009953 133 0.046
cytokinesis GO:0000910 90 0.045
catabolic process GO:0009056 409 0.045
compound eye morphogenesis GO:0001745 249 0.045
nucleoside catabolic process GO:0009164 112 0.044
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.044
regulation of organelle organization GO:0033043 196 0.043
neuromuscular junction development GO:0007528 149 0.041
brain development GO:0007420 120 0.041
eye morphogenesis GO:0048592 260 0.041
positive regulation of cellular catabolic process GO:0031331 95 0.041
purine ribonucleoside catabolic process GO:0046130 112 0.040
homeostatic process GO:0042592 199 0.040
purine nucleoside triphosphate metabolic process GO:0009144 119 0.040
meiotic spindle organization GO:0000212 36 0.040
aging GO:0007568 143 0.040
regulation of cellular protein metabolic process GO:0032268 243 0.039
purine nucleoside metabolic process GO:0042278 127 0.039
multi organism reproductive behavior GO:0044705 121 0.039
establishment of protein localization to organelle GO:0072594 62 0.038
oocyte differentiation GO:0009994 145 0.038
ribonucleoside metabolic process GO:0009119 127 0.038
protein catabolic process GO:0030163 101 0.037
negative regulation of cellular component organization GO:0051129 108 0.037
appendage development GO:0048736 401 0.037
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.037
meiosis ii GO:0007135 23 0.037
regulation of protein depolymerization GO:1901879 27 0.037
cytoplasm organization GO:0007028 64 0.036
wing disc morphogenesis GO:0007472 344 0.036
positive regulation of catabolic process GO:0009896 105 0.036
nuclear transport GO:0051169 72 0.036
transmembrane transport GO:0055085 139 0.036
programmed cell death GO:0012501 257 0.035
Mouse
anterior posterior axis specification embryo GO:0008595 103 0.035
amino acid activation GO:0043038 3 0.034
contractile ring contraction GO:0036213 12 0.034
single organism intracellular transport GO:1902582 207 0.034
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.034
morphogenesis of an epithelium GO:0002009 276 0.033
protein localization to organelle GO:0033365 82 0.033
Mouse
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.033
regulation of cell death GO:0010941 173 0.033
negative regulation of cell communication GO:0010648 223 0.033
protein processing GO:0016485 68 0.033
axon guidance GO:0007411 233 0.032
intracellular protein transport GO:0006886 104 0.032
nucleobase containing small molecule metabolic process GO:0055086 174 0.032
regulation of phosphorylation GO:0042325 147 0.031
sensory organ morphogenesis GO:0090596 260 0.031
positive regulation of cellular protein metabolic process GO:0032270 118 0.031
negative regulation of signal transduction GO:0009968 206 0.030
regulation of multicellular organismal development GO:2000026 414 0.030
nucleotide metabolic process GO:0009117 161 0.030
tripartite regional subdivision GO:0007351 103 0.030
ribonucleoside triphosphate catabolic process GO:0009203 108 0.029
retina development in camera type eye GO:0060041 4 0.029
regulation of cellular amine metabolic process GO:0033238 3 0.029
negative regulation of response to oxidative stress GO:1902883 1 0.029
cell motility GO:0048870 251 0.029
larval development GO:0002164 104 0.029
positive regulation of response to stimulus GO:0048584 323 0.029
regulation of cell proliferation GO:0042127 163 0.028
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.028
carbohydrate derivative metabolic process GO:1901135 217 0.028
sensory perception GO:0007600 196 0.028
appendage morphogenesis GO:0035107 397 0.027
organophosphate catabolic process GO:0046434 112 0.027
central nervous system development GO:0007417 201 0.027
positive regulation of gene expression GO:0010628 290 0.027
negative regulation of protein depolymerization GO:1901880 23 0.027
regulation of meiosis GO:0040020 3 0.027
heterocycle catabolic process GO:0046700 166 0.027
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.026
protein maturation GO:0051604 71 0.026
embryo development ending in birth or egg hatching GO:0009792 152 0.026
forebrain development GO:0030900 2 0.026
spermatid differentiation GO:0048515 114 0.026
axon development GO:0061564 297 0.026
cellular macromolecule catabolic process GO:0044265 136 0.026
purine nucleoside catabolic process GO:0006152 112 0.026
mitochondrial fission GO:0000266 8 0.026
cellular nitrogen compound catabolic process GO:0044270 165 0.026
guanosine containing compound catabolic process GO:1901069 74 0.026
autophagy GO:0006914 108 0.026
negative regulation of organelle organization GO:0010639 56 0.025
post embryonic appendage morphogenesis GO:0035120 385 0.025
imaginal disc derived appendage development GO:0048737 399 0.025
blastoderm segmentation GO:0007350 159 0.025
positive regulation of molecular function GO:0044093 136 0.025
localization of cell GO:0051674 257 0.025
regulation of cell maturation GO:1903429 27 0.025
oocyte anterior posterior axis specification GO:0007314 72 0.025
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.025
extracellular structure organization GO:0043062 46 0.025
tissue morphogenesis GO:0048729 297 0.025
embryonic morphogenesis GO:0048598 206 0.024
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.024
mitochondrion degradation GO:0000422 8 0.024
protein targeting to mitochondrion GO:0006626 1 0.024
nucleoside phosphate metabolic process GO:0006753 162 0.024
cellular amino acid metabolic process GO:0006520 61 0.024
organic acid metabolic process GO:0006082 103 0.023
positive regulation of hydrolase activity GO:0051345 78 0.023
positive regulation of signaling GO:0023056 243 0.023
positive regulation of intracellular signal transduction GO:1902533 116 0.023
dorsal closure GO:0007391 79 0.023
posttranscriptional regulation of gene expression GO:0010608 145 0.023
protein deubiquitination GO:0016579 17 0.023
ubiquitin dependent protein catabolic process GO:0006511 78 0.023
positive regulation of cell communication GO:0010647 250 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.022
positive regulation of cellular component organization GO:0051130 156 0.022
protein depolymerization GO:0051261 31 0.022
cell death GO:0008219 279 0.022
Mouse
positive regulation of cellular protein catabolic process GO:1903364 24 0.022
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.022
positive regulation of rna biosynthetic process GO:1902680 266 0.022
regulation of programmed cell death GO:0043067 152 0.022
segmentation GO:0035282 207 0.021
phosphorylation GO:0016310 294 0.021
neuromuscular synaptic transmission GO:0007274 67 0.021
protein ubiquitination GO:0016567 70 0.021
ribonucleotide catabolic process GO:0009261 109 0.021
ubiquitin homeostasis GO:0010992 1 0.021
positive regulation of phosphate metabolic process GO:0045937 139 0.021
anterior posterior pattern specification GO:0009952 136 0.021
regulation of embryonic pattern specification GO:1902875 27 0.021
regulation of synapse structure and activity GO:0050803 128 0.021
dna metabolic process GO:0006259 227 0.021
positive regulation of nucleotide catabolic process GO:0030813 46 0.020
negative regulation of cellular response to oxidative stress GO:1900408 1 0.020
response to organic substance GO:0010033 284 0.020
positive regulation of transport GO:0051050 92 0.020
peptide metabolic process GO:0006518 80 0.020
protein targeting GO:0006605 64 0.020
cellular response to chemical stimulus GO:0070887 199 0.020
trna aminoacylation for protein translation GO:0006418 2 0.019
maternal determination of anterior posterior axis embryo GO:0008358 74 0.019
protein phosphorylation GO:0006468 169 0.019
mitochondrial fusion GO:0008053 7 0.019
regulation of proteolysis GO:0030162 87 0.019
regulation of cellular response to oxidative stress GO:1900407 4 0.019
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.019
protein localization to mitochondrion GO:0070585 1 0.019
Mouse
retina morphogenesis in camera type eye GO:0060042 2 0.019
developmental growth GO:0048589 280 0.019
body morphogenesis GO:0010171 2 0.018
sperm individualization GO:0007291 48 0.018
growth GO:0040007 359 0.018
negative regulation of catabolic process GO:0009895 36 0.018
positive regulation of protein catabolic process GO:0045732 34 0.018
secretion GO:0046903 109 0.017
regulation of establishment of protein localization to plasma membrane GO:0090003 7 0.017
purine nucleotide metabolic process GO:0006163 146 0.017
camera type eye development GO:0043010 4 0.017
macromolecular complex assembly GO:0065003 256 0.017
regulation of g protein coupled receptor protein signaling pathway GO:0008277 23 0.017
purine ribonucleoside metabolic process GO:0046128 127 0.017
regulation of cellular protein catabolic process GO:1903362 44 0.017
regulation of microtubule based process GO:0032886 49 0.017
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.017
taxis GO:0042330 304 0.017
single organism catabolic process GO:0044712 228 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
regulation of protein catabolic process GO:0042176 55 0.017
photoreceptor cell maintenance GO:0045494 11 0.017
multicellular organismal aging GO:0010259 140 0.016
gtp catabolic process GO:0006184 72 0.016
protein modification by small protein conjugation GO:0032446 79 0.016
mitotic g2 dna damage checkpoint GO:0007095 69 0.016
negative regulation of response to stimulus GO:0048585 258 0.016
meiotic nuclear division GO:0007126 151 0.016
regulation of protein modification process GO:0031399 112 0.016
regulation of mapk cascade GO:0043408 92 0.016
small gtpase mediated signal transduction GO:0007264 88 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
regulation of synapse assembly GO:0051963 94 0.015
golgi to plasma membrane protein transport GO:0043001 8 0.015
ribonucleoside monophosphate metabolic process GO:0009161 51 0.015
regulation of cell development GO:0060284 215 0.015
mating GO:0007618 120 0.015
cellular respiration GO:0045333 26 0.015
regulation of protein phosphorylation GO:0001932 64 0.015
mating behavior GO:0007617 106 0.015
negative regulation of autophagy GO:0010507 16 0.015
cell migration GO:0016477 238 0.015
regulation of small gtpase mediated signal transduction GO:0051056 93 0.015
epithelial cell differentiation GO:0030855 322 0.015
regulation of translation GO:0006417 56 0.015
meiosis i GO:0007127 59 0.015
actomyosin contractile ring contraction GO:0000916 12 0.015
regulation of reproductive process GO:2000241 54 0.014
regulation of catalytic activity GO:0050790 185 0.014
ribonucleoside monophosphate catabolic process GO:0009158 39 0.014
positive regulation of phosphorus metabolic process GO:0010562 139 0.014
positive regulation of cell death GO:0010942 69 0.014
morphogenesis of embryonic epithelium GO:0016331 94 0.014
regulation of protein localization GO:0032880 76 0.014
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.014
intracellular mrna localization involved in pattern specification process GO:0060810 56 0.014
response to dsrna GO:0043331 15 0.014
regulation of vesicle mediated transport GO:0060627 59 0.014
gastrulation involving germ band extension GO:0010004 36 0.014
negative regulation of cytoskeleton organization GO:0051494 30 0.014
compound eye development GO:0048749 307 0.013
regulation of cytoplasmic transport GO:1903649 47 0.013
histone modification GO:0016570 106 0.013
aromatic compound catabolic process GO:0019439 166 0.013
regulation of intracellular transport GO:0032386 64 0.013
negative regulation of cellular catabolic process GO:0031330 34 0.013
pole plasm mrna localization GO:0019094 49 0.013
regulation of microtubule cytoskeleton organization GO:0070507 41 0.013
positive regulation of phosphorylation GO:0042327 87 0.013
oocyte development GO:0048599 124 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
response to temperature stimulus GO:0009266 106 0.013
er associated ubiquitin dependent protein catabolic process GO:0030433 3 0.013
establishment of mitochondrion localization microtubule mediated GO:0034643 6 0.013
single organism nuclear import GO:1902593 51 0.013
purine ribonucleotide metabolic process GO:0009150 145 0.013
anatomical structure homeostasis GO:0060249 97 0.012
positive regulation of mapk cascade GO:0043410 63 0.012
regulation of synapse organization GO:0050807 110 0.012
nephron development GO:0072006 3 0.012
negative regulation of cell death GO:0060548 81 0.012
determination of adult lifespan GO:0008340 137 0.012
protein polymerization GO:0051258 42 0.012
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.012
hemopoiesis GO:0030097 46 0.012
mitotic g2 m transition checkpoint GO:0044818 70 0.012
regulation of mrna 3 end processing GO:0031440 7 0.012
lamellipodium assembly GO:0030032 21 0.012
production of small rna involved in gene silencing by rna GO:0070918 15 0.012
establishment of tissue polarity GO:0007164 87 0.012
synaptic transmission GO:0007268 288 0.011
actin filament organization GO:0007015 126 0.011
neuron death GO:0070997 27 0.011
synaptic vesicle transport GO:0048489 50 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 15 0.011
spindle assembly GO:0051225 80 0.011
regulation of mitotic cell cycle GO:0007346 190 0.011
response to heat GO:0009408 63 0.011
purine ribonucleoside monophosphate metabolic process GO:0009167 50 0.011
regulation of protein polymerization GO:0032271 28 0.011
synaptic vesicle recycling GO:0036465 28 0.011
regulation of intracellular protein transport GO:0033157 46 0.011
detection of light stimulus involved in sensory perception GO:0050962 9 0.011
regulation of cell cycle GO:0051726 291 0.011
cellular response to oxygen containing compound GO:1901701 79 0.011
regulation of protein stability GO:0031647 43 0.011
mapk cascade GO:0000165 107 0.011
regulation of multi organism process GO:0043900 131 0.011
regulation of nucleoside metabolic process GO:0009118 50 0.011
synaptic vesicle localization GO:0097479 53 0.011
negative regulation of protein processing GO:0010955 31 0.011
mitotic nuclear division GO:0007067 213 0.011
metal ion transport GO:0030001 74 0.010
entry into cell of other organism involved in symbiotic interaction GO:0051806 3 0.010
meiotic cell cycle GO:0051321 171 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.010
dna templated transcription elongation GO:0006354 18 0.010
cation transport GO:0006812 110 0.010
tube development GO:0035295 244 0.010
epithelial cell development GO:0002064 274 0.010
positive regulation of signal transduction GO:0009967 223 0.010
regulation of protein processing GO:0070613 32 0.010
purine nucleoside monophosphate metabolic process GO:0009126 50 0.010
male pronucleus assembly GO:0035039 6 0.010
inorganic cation transmembrane transport GO:0098662 61 0.010
mitotic cell cycle phase transition GO:0044772 138 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 25 0.010

Drp1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.016
nervous system disease DOID:863 0 0.014
disease of cellular proliferation DOID:14566 0 0.011