Drosophila melanogaster

98 known processes

Doc1 (Dmel_CG5133)

Dorsocross1

(Aliases: Tb66F2,Ect2,Doc,doc1,CG5133,Dm-DOC1,doc,Dmel\CG5133)

Doc1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of rna metabolic process GO:0051253 251 0.298
Fly
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.250
Fly
regulation of cell differentiation GO:0045595 302 0.245
Fly
negative regulation of cellular metabolic process GO:0031324 382 0.224
Fly
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.220
post embryonic appendage morphogenesis GO:0035120 385 0.216
Fly
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.189
Fly
imaginal disc derived appendage development GO:0048737 399 0.179
Fly
appendage morphogenesis GO:0035107 397 0.178
Fly
imaginal disc derived appendage morphogenesis GO:0035114 395 0.165
Fly
transcription from rna polymerase ii promoter GO:0006366 368 0.156
malpighian tubule development GO:0072002 64 0.156
sensory organ morphogenesis GO:0090596 260 0.141
Fly
negative regulation of transcription dna templated GO:0045892 237 0.137
Fly
regulation of multicellular organismal development GO:2000026 414 0.134
negative regulation of rna biosynthetic process GO:1902679 240 0.133
Fly
columnar cuboidal epithelial cell development GO:0002066 249 0.131
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.131
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.130
Fly
chorion containing eggshell formation GO:0007304 105 0.130
Fly
epithelial cell differentiation GO:0030855 322 0.129
Fly
appendage development GO:0048736 401 0.128
Fly
regionalization GO:0003002 416 0.128
Fly
negative regulation of gene expression GO:0010629 387 0.127
Fly
eye development GO:0001654 323 0.126
Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.123
positive regulation of nucleic acid templated transcription GO:1903508 266 0.111
determination of imaginal disc primordium GO:0007445 11 0.111
malpighian tubule morphogenesis GO:0007443 44 0.110
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.110
negative regulation of nucleic acid templated transcription GO:1903507 240 0.107
Fly
negative regulation of cellular biosynthetic process GO:0031327 277 0.098
Fly
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.091
embryonic morphogenesis GO:0048598 206 0.090
growth GO:0040007 359 0.089
Fly
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.087
Fly
positive regulation of cellular biosynthetic process GO:0031328 316 0.085
positive regulation of macromolecule metabolic process GO:0010604 405 0.082
cardiocyte differentiation GO:0035051 29 0.081
wing disc morphogenesis GO:0007472 344 0.080
Fly
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.079
Fly
epithelial cell development GO:0002064 274 0.078
Fly
positive regulation of rna metabolic process GO:0051254 271 0.075
positive regulation of transcription dna templated GO:0045893 266 0.073
compound eye development GO:0048749 307 0.073
Fly
positive regulation of rna biosynthetic process GO:1902680 266 0.068
eggshell formation GO:0030703 105 0.065
Fly
camera type eye development GO:0043010 4 0.064
positive regulation of gene expression GO:0010628 290 0.064
compound eye morphogenesis GO:0001745 249 0.064
Fly
leg disc development GO:0035218 92 0.063
Fly
immune system process GO:0002376 347 0.058
small molecule metabolic process GO:0044281 305 0.057
cell fate specification GO:0001708 71 0.057
Fly
oxoacid metabolic process GO:0043436 103 0.056
stem cell differentiation GO:0048863 117 0.055
Fly
cell migration GO:0016477 238 0.054
circulatory system development GO:0072359 82 0.053
negative regulation of biosynthetic process GO:0009890 277 0.050
Fly
endocytosis GO:0006897 310 0.049
tube morphogenesis GO:0035239 191 0.049
organonitrogen compound metabolic process GO:1901564 318 0.047
organonitrogen compound biosynthetic process GO:1901566 117 0.047
renal tubule development GO:0061326 64 0.046
heart process GO:0003015 37 0.046
Fly
wing disc pattern formation GO:0035222 66 0.046
Fly
imaginal disc derived wing morphogenesis GO:0007476 337 0.046
Fly
digestive tract development GO:0048565 149 0.045
organelle fission GO:0048285 340 0.044
tissue morphogenesis GO:0048729 297 0.044
organ growth GO:0035265 56 0.044
Fly
negative regulation of developmental process GO:0051093 201 0.043
morphogenesis of an epithelium GO:0002009 276 0.043
hindgut morphogenesis GO:0007442 58 0.043
segmentation GO:0035282 207 0.043
embryo development ending in birth or egg hatching GO:0009792 152 0.042
somatic muscle development GO:0007525 66 0.042
Fly
hindgut development GO:0061525 58 0.041
cell motility GO:0048870 251 0.039
regulation of cell fate specification GO:0042659 27 0.039
Fly
regulation of cell fate commitment GO:0010453 29 0.039
Fly
eye morphogenesis GO:0048592 260 0.039
Fly
cardioblast differentiation GO:0010002 20 0.038
Fly
response to abiotic stimulus GO:0009628 341 0.037
imaginal disc pattern formation GO:0007447 91 0.037
Fly
nucleotide metabolic process GO:0009117 161 0.037
anterior posterior pattern specification GO:0009952 136 0.036
Fly
negative regulation of transcription from rna polymerase ii promoter GO:0000122 119 0.035
Fly
renal system development GO:0072001 72 0.035
cell death GO:0008219 279 0.034
organophosphate metabolic process GO:0019637 195 0.033
embryonic hindgut morphogenesis GO:0048619 48 0.032
chaeta development GO:0022416 97 0.031
muscle structure development GO:0061061 224 0.031
Fly
digestive tract morphogenesis GO:0048546 127 0.031
anterior posterior axis specification embryo GO:0008595 103 0.031
negative regulation of multicellular organismal process GO:0051241 142 0.030
regulation of localization GO:0032879 275 0.030
ovarian follicle cell development GO:0030707 248 0.030
Fly
phagocytosis GO:0006909 215 0.029
sterol homeostasis GO:0055092 4 0.029
carboxylic acid metabolic process GO:0019752 92 0.029
vesicle mediated transport GO:0016192 381 0.029
death GO:0016265 284 0.029
response to oxygen containing compound GO:1901700 200 0.028
digestive system development GO:0055123 149 0.028
nucleobase containing small molecule metabolic process GO:0055086 174 0.028
connective tissue development GO:0061448 3 0.028
developmental maturation GO:0021700 172 0.027
synaptic transmission GO:0007268 288 0.027
nucleoside phosphate metabolic process GO:0006753 162 0.027
regulation of nervous system development GO:0051960 248 0.027
circulatory system process GO:0003013 37 0.027
Fly
kidney development GO:0001822 3 0.027
cardiovascular system development GO:0072358 82 0.027
stem cell proliferation GO:0072089 88 0.027
localization of cell GO:0051674 257 0.026
positive regulation of biosynthetic process GO:0009891 316 0.026
telencephalon development GO:0021537 2 0.025
cell maturation GO:0048469 144 0.025
carbohydrate derivative metabolic process GO:1901135 217 0.025
blastoderm segmentation GO:0007350 159 0.025
regulation of neurogenesis GO:0050767 158 0.024
limb development GO:0060173 1 0.024
developmental growth GO:0048589 280 0.024
axis specification GO:0009798 167 0.024
programmed cell death GO:0012501 257 0.023
cellular response to chemical stimulus GO:0070887 199 0.023
tripartite regional subdivision GO:0007351 103 0.022
oocyte differentiation GO:0009994 145 0.022
embryonic axis specification GO:0000578 107 0.022
organic hydroxy compound metabolic process GO:1901615 83 0.022
positive regulation of signal transduction GO:0009967 223 0.022
protein modification process GO:0036211 438 0.022
kidney epithelium development GO:0072073 3 0.022
regulation of cell death GO:0010941 173 0.022
kidney morphogenesis GO:0060993 3 0.022
single organism biosynthetic process GO:0044711 206 0.021
positive regulation of signaling GO:0023056 243 0.021
negative regulation of programmed cell death GO:0043069 72 0.021
enzyme linked receptor protein signaling pathway GO:0007167 179 0.021
tissue migration GO:0090130 155 0.021
regulation of cell development GO:0060284 215 0.020
dorsal ventral pattern formation GO:0009953 133 0.020
response to organic substance GO:0010033 284 0.020
central nervous system development GO:0007417 201 0.020
regulation of organelle organization GO:0033043 196 0.020
positive regulation of response to stimulus GO:0048584 323 0.020
male gamete generation GO:0048232 201 0.020
positive regulation of cellular component organization GO:0051130 156 0.019
urogenital system development GO:0001655 72 0.019
anterior posterior axis specification GO:0009948 109 0.019
response to external biotic stimulus GO:0043207 293 0.019
response to organophosphorus GO:0046683 2 0.019
spermatid differentiation GO:0048515 114 0.019
epithelial tube morphogenesis GO:0060562 88 0.019
tube development GO:0035295 244 0.019
organic acid metabolic process GO:0006082 103 0.019
regulation of cell proliferation GO:0042127 163 0.019
photoreceptor cell differentiation GO:0046530 170 0.019
cellular protein modification process GO:0006464 438 0.018
response to alcohol GO:0097305 95 0.018
response to biotic stimulus GO:0009607 294 0.018
macromolecular complex assembly GO:0065003 256 0.018
body morphogenesis GO:0010171 2 0.018
establishment of localization in cell GO:0051649 402 0.018
forebrain development GO:0030900 2 0.018
response to other organism GO:0051707 293 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.018
sensory perception GO:0007600 196 0.018
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.017
single organism behavior GO:0044708 391 0.017
apoptotic process GO:0006915 159 0.017
immune response GO:0006955 246 0.017
mitotic nuclear division GO:0007067 213 0.017
heart development GO:0007507 82 0.017
renal tubule morphogenesis GO:0061333 44 0.017
negative regulation of response to stimulus GO:0048585 258 0.017
regulation of catabolic process GO:0009894 170 0.017
catabolic process GO:0009056 409 0.017
response to lipopolysaccharide GO:0032496 4 0.017
regulation of embryonic development GO:0045995 68 0.017
regulation of intracellular signal transduction GO:1902531 236 0.016
lipid metabolic process GO:0006629 121 0.016
regulation of apoptotic process GO:0042981 130 0.016
regulation of growth GO:0040008 233 0.016
purine nucleotide metabolic process GO:0006163 146 0.016
small gtpase mediated signal transduction GO:0007264 88 0.016
embryonic development via the syncytial blastoderm GO:0001700 148 0.016
pyridine nucleotide metabolic process GO:0019362 2 0.016
gland morphogenesis GO:0022612 145 0.016
cellular lipid metabolic process GO:0044255 83 0.016
carbohydrate metabolic process GO:0005975 82 0.016
oocyte development GO:0048599 124 0.016
regulation of developmental growth GO:0048638 174 0.016
ras protein signal transduction GO:0007265 88 0.016
regulation of programmed cell death GO:0043067 152 0.016
proteolysis GO:0006508 192 0.015
neurological system process GO:0050877 358 0.015
regulation of epithelial cell differentiation GO:0030856 4 0.015
taxis GO:0042330 304 0.015
regulation of cell morphogenesis involved in differentiation GO:0010769 61 0.015
ameboidal type cell migration GO:0001667 151 0.015
positive regulation of hydrolase activity GO:0051345 78 0.015
cellular catabolic process GO:0044248 372 0.015
pharynx development GO:0060465 1 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
single organism carbohydrate metabolic process GO:0044723 72 0.015
chemotaxis GO:0006935 249 0.015
negative regulation of signal transduction GO:0009968 206 0.015
oxidoreduction coenzyme metabolic process GO:0006733 2 0.015
retina development in camera type eye GO:0060041 4 0.015
oxidation reduction process GO:0055114 123 0.015
positive regulation of multicellular organismal process GO:0051240 143 0.015
regulation of anatomical structure morphogenesis GO:0022603 242 0.015
regulation of immune system process GO:0002682 176 0.015
cellular amine metabolic process GO:0044106 12 0.014
purine containing compound metabolic process GO:0072521 155 0.014
single organism catabolic process GO:0044712 228 0.014
regulation of response to stress GO:0080134 200 0.014
regulation of molecular function GO:0065009 217 0.014
morphogenesis of embryonic epithelium GO:0016331 94 0.014
nucleoside triphosphate metabolic process GO:0009141 120 0.014
regulation of transport GO:0051049 181 0.014
leg disc morphogenesis GO:0007478 80 0.014
positive regulation of cell communication GO:0010647 250 0.014
response to starvation GO:0042594 97 0.014
cell proliferation GO:0008283 299 0.014
cellular response to organic substance GO:0071310 132 0.014
actin filament based process GO:0030029 220 0.014
aging GO:0007568 143 0.014
regulation of cellular ketone metabolic process GO:0010565 3 0.014
limb morphogenesis GO:0035108 1 0.014
eye photoreceptor cell differentiation GO:0001754 145 0.013
ribonucleotide metabolic process GO:0009259 145 0.013
nicotinamide nucleotide metabolic process GO:0046496 2 0.013
nuclear division GO:0000280 332 0.013
detection of stimulus involved in sensory perception GO:0050906 92 0.013
dna metabolic process GO:0006259 227 0.013
oocyte construction GO:0007308 112 0.013
epithelium migration GO:0090132 148 0.013
chromosome organization GO:0051276 360 0.013
wound healing GO:0042060 75 0.013
nephron epithelium development GO:0072009 3 0.013
regulation of response to external stimulus GO:0032101 115 0.013
organelle assembly GO:0070925 198 0.013
regulation of catalytic activity GO:0050790 185 0.013
mitotic spindle organization GO:0007052 220 0.013
positive regulation of nucleoside metabolic process GO:0045979 47 0.013
regulation of epithelial cell proliferation GO:0050678 4 0.013
regulation of neuron differentiation GO:0045664 103 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.013
positive regulation of developmental process GO:0051094 143 0.013
regulation of cellular localization GO:0060341 136 0.013
protein complex biogenesis GO:0070271 201 0.013
negative regulation of cellular component organization GO:0051129 108 0.013
eye antennal disc development GO:0035214 60 0.013
cellular amino acid metabolic process GO:0006520 61 0.013
ribonucleotide catabolic process GO:0009261 109 0.013
regulation of phosphorus metabolic process GO:0051174 210 0.013
regulation of multi organism process GO:0043900 131 0.013
mesenchymal cell differentiation GO:0048762 1 0.012
amine metabolic process GO:0009308 12 0.012
negative regulation of cell communication GO:0010648 223 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
innate immune response GO:0045087 144 0.012
single organism cellular localization GO:1902580 180 0.012
gastrulation GO:0007369 70 0.012
embryonic organ development GO:0048568 50 0.012
Fly
rna localization GO:0006403 115 0.012
cellular response to dna damage stimulus GO:0006974 223 0.012
regulation of phosphate metabolic process GO:0019220 210 0.012
spindle organization GO:0007051 253 0.012
nephron development GO:0072006 3 0.012
salivary gland development GO:0007431 162 0.012
hematopoietic progenitor cell differentiation GO:0002244 1 0.012
immune system development GO:0002520 57 0.012
regulation of cellular component biogenesis GO:0044087 201 0.012
phosphorylation GO:0016310 294 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
wnt signaling pathway GO:0016055 98 0.012
regulation of cell projection organization GO:0031344 92 0.012
purine nucleoside triphosphate metabolic process GO:0009144 119 0.012
antennal development GO:0007469 25 0.012
organic substance catabolic process GO:1901575 308 0.012
spermatid development GO:0007286 98 0.012
regulation of immune response GO:0050776 118 0.012
mesoderm development GO:0007498 78 0.012
purine nucleotide catabolic process GO:0006195 109 0.012
peptide metabolic process GO:0006518 80 0.012
axon development GO:0061564 297 0.011
regulation of neuron projection development GO:0010975 69 0.011
mushroom body development GO:0016319 70 0.011
skeletal muscle fiber development GO:0048741 3 0.011
epithelial cell migration GO:0010631 148 0.011
intracellular signal transduction GO:0035556 300 0.011
determination of adult lifespan GO:0008340 137 0.011
regulation of cell morphogenesis GO:0022604 163 0.011
response to radiation GO:0009314 155 0.011
defense response to other organism GO:0098542 225 0.011
axon guidance GO:0007411 233 0.011
oocyte axis specification GO:0007309 108 0.011
microtubule based movement GO:0007018 51 0.011
detection of chemical stimulus involved in sensory perception GO:0050907 75 0.011
intracellular transport GO:0046907 228 0.011
cellular protein localization GO:0034613 160 0.011
chromosome segregation GO:0007059 157 0.011
regulation of cellular protein metabolic process GO:0032268 243 0.011
positive regulation of catabolic process GO:0009896 105 0.011
midgut development GO:0007494 23 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
purine ribonucleoside catabolic process GO:0046130 112 0.011
response to wounding GO:0009611 94 0.011
gliogenesis GO:0042063 80 0.011
chorion containing eggshell pattern formation GO:0030381 11 0.011
Fly
homeostatic process GO:0042592 199 0.011
response to nutrient levels GO:0031667 114 0.011
respiratory system development GO:0060541 213 0.011
foregut morphogenesis GO:0007440 10 0.011
ribonucleoside triphosphate catabolic process GO:0009203 108 0.010
antimicrobial humoral response GO:0019730 99 0.010
cell division GO:0051301 248 0.010
regulation of protein metabolic process GO:0051246 256 0.010
negative regulation of neurogenesis GO:0050768 53 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
positive regulation of cellular catabolic process GO:0031331 95 0.010
chromatin remodeling GO:0006338 72 0.010
positive regulation of cell migration GO:0030335 2 0.010
posttranscriptional regulation of gene expression GO:0010608 145 0.010
negative regulation of cell differentiation GO:0045596 143 0.010
intracellular mrna localization involved in anterior posterior axis specification GO:0060811 53 0.010
endomembrane system organization GO:0010256 119 0.010
regulation of cell cycle GO:0051726 291 0.010
purine ribonucleotide catabolic process GO:0009154 109 0.010
negative regulation of nervous system development GO:0051961 92 0.010
chemical homeostasis GO:0048878 92 0.010
ribonucleoside triphosphate metabolic process GO:0009199 119 0.010
response to temperature stimulus GO:0009266 106 0.010
positive regulation of growth GO:0045927 75 0.010
purine nucleoside metabolic process GO:0042278 127 0.010
maternal determination of anterior posterior axis embryo GO:0008358 74 0.010
regulation of vesicle mediated transport GO:0060627 59 0.010

Doc1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.036
nervous system disease DOID:863 0 0.021
musculoskeletal system disease DOID:17 0 0.017
sensory system disease DOID:0050155 0 0.010
eye and adnexa disease DOID:1492 0 0.010
eye disease DOID:5614 0 0.010