Drosophila melanogaster

44 known processes

spd-2 (Dmel_CG17286)

spindle defective 2

(Aliases: DSpd-2,Dmel\CG17286,spd2,SPD-2,Spd-2,BcDNA:LD24702,DSPD-2,CG17286-PA,Dspd-2,anon-73Ba,D-Spd2,CG17286,DSpd2)

spd-2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
centrosome separation GO:0051299 20 0.673
organelle localization GO:0051640 148 0.642
single fertilization GO:0007338 24 0.628
organelle assembly GO:0070925 198 0.625
male meiosis GO:0007140 52 0.523
male gamete generation GO:0048232 201 0.487
protein complex assembly GO:0006461 200 0.447
macromolecular complex assembly GO:0065003 256 0.399
centrosome cycle GO:0007098 137 0.380
centrosome organization GO:0051297 163 0.372
nuclear division GO:0000280 332 0.363
spindle organization GO:0007051 253 0.336
centrosome duplication GO:0051298 121 0.324
protein complex biogenesis GO:0070271 201 0.305
fertilization GO:0009566 26 0.295
spindle assembly involved in meiosis GO:0090306 20 0.273
meiotic nuclear division GO:0007126 151 0.263
maintenance of location in cell GO:0051651 28 0.258
cellular protein localization GO:0034613 160 0.225
centriole replication GO:0007099 24 0.210
establishment of organelle localization GO:0051656 122 0.205
single organism cellular localization GO:1902580 180 0.203
centriole assembly GO:0098534 24 0.196
centriole centriole cohesion GO:0010457 5 0.183
spindle assembly GO:0051225 80 0.167
organelle fission GO:0048285 340 0.162
cellular macromolecule localization GO:0070727 220 0.160
spindle assembly involved in mitosis GO:0090307 50 0.159
mitotic spindle stabilization GO:0043148 6 0.151
nucleus organization GO:0006997 45 0.149
spermatogenesis GO:0007283 200 0.139
dna packaging GO:0006323 91 0.123
establishment of localization in cell GO:0051649 402 0.118
spindle midzone assembly GO:0051255 4 0.118
regulation of cytoskeleton organization GO:0051493 89 0.116
spindle elongation GO:0051231 83 0.113
establishment of spindle orientation GO:0051294 18 0.112
microtubule organizing center organization GO:0031023 168 0.107
dna metabolic process GO:0006259 227 0.105
cell death GO:0008219 279 0.105
positive regulation of response to stimulus GO:0048584 323 0.099
mitotic spindle midzone assembly GO:0051256 1 0.099
dna conformation change GO:0071103 105 0.099
regulation of mitotic spindle organization GO:0060236 9 0.091
mitotic cell cycle embryonic GO:0045448 38 0.090
spindle assembly involved in female meiosis GO:0007056 14 0.087
cytokinesis GO:0000910 90 0.086
maintenance of protein location in cell GO:0032507 26 0.086
cellular component assembly involved in morphogenesis GO:0010927 151 0.080
negative regulation of protein depolymerization GO:1901880 23 0.080
asymmetric cell division GO:0008356 37 0.074
mitotic cytokinesis GO:0000281 50 0.074
negative regulation of cellular metabolic process GO:0031324 382 0.073
regulation of protein depolymerization GO:1901879 27 0.070
organophosphate metabolic process GO:0019637 195 0.069
negative regulation of rna metabolic process GO:0051253 251 0.066
catabolic process GO:0009056 409 0.066
mitotic spindle elongation GO:0000022 81 0.065
positive regulation of cellular protein metabolic process GO:0032270 118 0.063
regulation of cell differentiation GO:0045595 302 0.063
protein localization to organelle GO:0033365 82 0.061
negative regulation of gene expression GO:0010629 387 0.061
death GO:0016265 284 0.061
regulation of cellular localization GO:0060341 136 0.060
mitotic spindle organization GO:0007052 220 0.058
regulation of protein complex disassembly GO:0043244 29 0.057
cellular protein complex assembly GO:0043623 71 0.057
chromosome condensation GO:0030261 41 0.057
cytoskeleton dependent cytokinesis GO:0061640 81 0.053
regulation of mitotic cell cycle GO:0007346 190 0.051
protein localization GO:0008104 284 0.051
attachment of spindle microtubules to kinetochore GO:0008608 5 0.050
cellular macromolecular complex assembly GO:0034622 153 0.049
microtubule anchoring GO:0034453 11 0.049
negative regulation of microtubule depolymerization GO:0007026 21 0.049
regulation of microtubule cytoskeleton organization GO:0070507 41 0.047
mitotic centrosome separation GO:0007100 8 0.046
transposition GO:0032196 13 0.045
establishment or maintenance of cell polarity GO:0007163 167 0.045
cell motility GO:0048870 251 0.044
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.044
stem cell division GO:0017145 69 0.044
chromosome organization GO:0051276 360 0.043
cell division GO:0051301 248 0.043
negative regulation of cell death GO:0060548 81 0.042
regulation of cell cycle GO:0051726 291 0.042
cell maturation GO:0048469 144 0.042
cytokinetic process GO:0032506 27 0.041
organonitrogen compound metabolic process GO:1901564 318 0.041
regulation of catalytic activity GO:0050790 185 0.040
negative regulation of response to stimulus GO:0048585 258 0.039
neural precursor cell proliferation GO:0061351 75 0.039
small molecule metabolic process GO:0044281 305 0.039
negative regulation of signaling GO:0023057 219 0.038
regulation of molecular function GO:0065009 217 0.038
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.037
regulation of spindle organization GO:0090224 17 0.037
body morphogenesis GO:0010171 2 0.036
cell migration GO:0016477 238 0.036
cellular nitrogen compound catabolic process GO:0044270 165 0.035
ribonucleoside triphosphate metabolic process GO:0009199 119 0.034
positive regulation of cell communication GO:0010647 250 0.034
microtubule cytoskeleton organization involved in mitosis GO:1902850 52 0.034
cell proliferation GO:0008283 299 0.034
actin filament based process GO:0030029 220 0.034
regulation of microtubule depolymerization GO:0031114 24 0.034
rna 3 end processing GO:0031123 45 0.033
male meiosis cytokinesis GO:0007112 26 0.033
meiotic cell cycle process GO:1903046 132 0.031
somatic stem cell division GO:0048103 37 0.030
small gtpase mediated signal transduction GO:0007264 88 0.030
meiotic cell cycle GO:0051321 171 0.030
localization of cell GO:0051674 257 0.030
oocyte development GO:0048599 124 0.030
protein dna complex assembly GO:0065004 63 0.030
regulation of phosphorus metabolic process GO:0051174 210 0.030
aromatic compound catabolic process GO:0019439 166 0.030
negative regulation of biosynthetic process GO:0009890 277 0.029
protein modification process GO:0036211 438 0.029
organic substance transport GO:0071702 257 0.028
negative regulation of nucleotide metabolic process GO:0045980 4 0.028
regulation of multicellular organismal development GO:2000026 414 0.028
vesicle mediated transport GO:0016192 381 0.028
synaptic transmission GO:0007268 288 0.027
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.027
meiosis i GO:0007127 59 0.027
positive regulation of phosphorus metabolic process GO:0010562 139 0.027
actin cytoskeleton organization GO:0030036 206 0.027
regulation of nervous system development GO:0051960 248 0.027
chromatin organization GO:0006325 207 0.027
positive regulation of cellular component biogenesis GO:0044089 80 0.027
negative regulation of programmed cell death GO:0043069 72 0.027
single organism intracellular transport GO:1902582 207 0.026
negative regulation of cellular component organization GO:0051129 108 0.026
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.026
organic substance catabolic process GO:1901575 308 0.026
positive regulation of phosphate metabolic process GO:0045937 139 0.026
cilium organization GO:0044782 41 0.025
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.025
endomembrane system organization GO:0010256 119 0.025
transcription from rna polymerase ii promoter GO:0006366 368 0.025
intracellular signal transduction GO:0035556 300 0.025
maintenance of location GO:0051235 73 0.024
negative regulation of apoptotic process GO:0043066 63 0.024
protein import into nucleus GO:0006606 51 0.024
programmed cell death GO:0012501 257 0.024
dna geometric change GO:0032392 16 0.024
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.024
embryo development ending in birth or egg hatching GO:0009792 152 0.024
chromatin modification GO:0016568 147 0.023
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.023
establishment of nucleus localization GO:0040023 26 0.023
negative regulation of rna biosynthetic process GO:1902679 240 0.023
cellular amine metabolic process GO:0044106 12 0.023
maintenance of protein location GO:0045185 28 0.023
establishment of protein localization GO:0045184 163 0.022
membrane organization GO:0061024 112 0.022
negative regulation of cytoskeleton organization GO:0051494 30 0.022
ras protein signal transduction GO:0007265 88 0.022
apoptotic process GO:0006915 159 0.022
negative regulation of transcription dna templated GO:0045892 237 0.022
cellular catabolic process GO:0044248 372 0.021
regulation of phosphate metabolic process GO:0019220 210 0.021
regulation of organelle organization GO:0033043 196 0.021
establishment of cell polarity GO:0030010 40 0.021
regulation of programmed cell death GO:0043067 152 0.021
regulation of anatomical structure morphogenesis GO:0022603 242 0.020
spindle stabilization GO:0043146 14 0.020
nucleobase containing small molecule metabolic process GO:0055086 174 0.020
male pronucleus assembly GO:0035039 6 0.020
asymmetric stem cell division GO:0098722 49 0.020
rna processing GO:0006396 147 0.020
positive regulation of cell cycle GO:0045787 43 0.019
regulation of response to stress GO:0080134 200 0.019
purine nucleoside metabolic process GO:0042278 127 0.019
positive regulation of cellular component organization GO:0051130 156 0.019
negative regulation of cellular biosynthetic process GO:0031327 277 0.019
nucleus localization GO:0051647 34 0.019
stem cell proliferation GO:0072089 88 0.019
regulation of neurogenesis GO:0050767 158 0.019
protein dna complex subunit organization GO:0071824 86 0.019
regulation of protein modification process GO:0031399 112 0.019
resolution of meiotic recombination intermediates GO:0000712 6 0.018
regulation of localization GO:0032879 275 0.018
positive regulation of cellular biosynthetic process GO:0031328 316 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.018
cystoblast division GO:0007282 10 0.018
nucleoside triphosphate catabolic process GO:0009143 108 0.018
negative regulation of signal transduction by p53 class mediator GO:1901797 1 0.017
rho protein signal transduction GO:0007266 14 0.017
ribonucleoprotein complex disassembly GO:0032988 1 0.017
regulation of cellular catabolic process GO:0031329 157 0.017
cellular protein modification process GO:0006464 438 0.017
response to other organism GO:0051707 293 0.017
regulation of apoptotic cell clearance GO:2000425 2 0.017
positive regulation of cellular catabolic process GO:0031331 95 0.017
pole cell formation GO:0007279 19 0.017
regulation of microtubule based process GO:0032886 49 0.016
carbohydrate derivative metabolic process GO:1901135 217 0.016
sister chromatid segregation GO:0000819 92 0.016
regulation of cellular component biogenesis GO:0044087 201 0.016
regulation of cell death GO:0010941 173 0.016
proteolysis GO:0006508 192 0.016
protein transport GO:0015031 155 0.016
regulation of g1 s transition of mitotic cell cycle GO:2000045 23 0.016
actomyosin contractile ring contraction GO:0000916 12 0.016
macromolecular complex disassembly GO:0032984 37 0.015
microtubule polymerization or depolymerization GO:0031109 39 0.015
snrna metabolic process GO:0016073 14 0.015
developmental maturation GO:0021700 172 0.015
mitotic nuclear division GO:0007067 213 0.015
intracellular protein transport GO:0006886 104 0.015
protein phosphorylation GO:0006468 169 0.015
positive regulation of catalytic activity GO:0043085 118 0.015
protein import GO:0017038 55 0.015
female meiotic division GO:0007143 70 0.015
developmental growth GO:0048589 280 0.015
regulation of mitotic spindle elongation GO:0032888 1 0.015
intrinsic apoptotic signaling pathway GO:0097193 16 0.015
mrna metabolic process GO:0016071 124 0.015
oocyte maturation GO:0001556 3 0.015
positive regulation of biosynthetic process GO:0009891 316 0.015
negative regulation of gtpase activity GO:0034260 1 0.014
purine nucleoside triphosphate catabolic process GO:0009146 108 0.014
endocytosis GO:0006897 310 0.014
peptidyl amino acid modification GO:0018193 105 0.014
carbohydrate derivative catabolic process GO:1901136 118 0.014
negative regulation of protein complex disassembly GO:0043242 23 0.014
positive regulation of protein modification process GO:0031401 58 0.014
segmentation GO:0035282 207 0.014
single organism membrane organization GO:0044802 93 0.014
regulation of transport GO:0051049 181 0.013
negative regulation of nucleic acid templated transcription GO:1903507 240 0.013
chitin based larval cuticle pattern formation GO:0035293 11 0.013
phosphorylation GO:0016310 294 0.013
negative regulation of signal transduction GO:0009968 206 0.013
nucleotide metabolic process GO:0009117 161 0.013
negative regulation of cell communication GO:0010648 223 0.013
immune response GO:0006955 246 0.013
regulation of protein localization GO:0032880 76 0.013
nucleoside phosphate metabolic process GO:0006753 162 0.013
oocyte dorsal ventral axis specification GO:0007310 34 0.013
positive regulation of molecular function GO:0044093 136 0.013
regulation of multi organism process GO:0043900 131 0.013
regulation of hemocyte proliferation GO:0035206 37 0.012
regulation of cell cycle process GO:0010564 181 0.012
glycosyl compound metabolic process GO:1901657 127 0.012
regulation of dna metabolic process GO:0051052 34 0.012
spermatid differentiation GO:0048515 114 0.012
regulation of neuron differentiation GO:0045664 103 0.012
nucleobase containing compound catabolic process GO:0034655 165 0.012
actin filament organization GO:0007015 126 0.012
regulation of cellular response to stress GO:0080135 89 0.012
negative regulation of gtp catabolic process GO:0033125 1 0.012
pole cell development GO:0007277 26 0.012
response to biotic stimulus GO:0009607 294 0.012
regulation of catabolic process GO:0009894 170 0.012
regulation of ras protein signal transduction GO:0046578 93 0.012
regulation of apoptotic process GO:0042981 130 0.012
camera type eye morphogenesis GO:0048593 2 0.011
snrna processing GO:0016180 14 0.011
synapse assembly GO:0007416 143 0.011
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.011
oocyte axis specification GO:0007309 108 0.011
regulation of cellular ketone metabolic process GO:0010565 3 0.011
negative regulation of gene expression epigenetic GO:0045814 77 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
cellular response to dna damage stimulus GO:0006974 223 0.011
ubiquitin dependent protein catabolic process GO:0006511 78 0.011
response to organic substance GO:0010033 284 0.011
mitotic sister chromatid segregation GO:0000070 87 0.011
organophosphate catabolic process GO:0046434 112 0.011
cell projection assembly GO:0030031 94 0.011
cytokinetic cell separation GO:0000920 1 0.010
cellular macromolecule catabolic process GO:0044265 136 0.010
regulation of intracellular transport GO:0032386 64 0.010
mitotic cell cycle checkpoint GO:0007093 88 0.010
negative regulation of developmental process GO:0051093 201 0.010
aging GO:0007568 143 0.010
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.010

spd-2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.012