Drosophila melanogaster

133 known processes

l(3)mbt (Dmel_CG5954)

lethal (3) malignant brain tumor

(Aliases: MBT,Dmel\CG5954,l(3)malignant braintumor,dl(3)MBT,mbt,L(3)mbt,L(3)MBT/LIN-61,L(3)MBT,CG5954,L3mbt)

l(3)mbt biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell cycle process GO:0010564 181 0.406
Human
blastoderm segmentation GO:0007350 159 0.383
chromosome organization GO:0051276 360 0.296
Human
peptidyl lysine modification GO:0018205 57 0.270
developmental growth GO:0048589 280 0.270
Fly
negative regulation of gene expression GO:0010629 387 0.257
internal peptidyl lysine acetylation GO:0018393 38 0.253
chromatin modification GO:0016568 147 0.228
Human
covalent chromatin modification GO:0016569 106 0.217
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.212
stem cell proliferation GO:0072089 88 0.203
internal protein amino acid acetylation GO:0006475 38 0.190
positive regulation of molecular function GO:0044093 136 0.182
transcription from rna polymerase ii promoter GO:0006366 368 0.180
tube morphogenesis GO:0035239 191 0.178
organelle fission GO:0048285 340 0.175
Human
dna metabolic process GO:0006259 227 0.163
chromosome segregation GO:0007059 157 0.160
regulation of cellular amino acid metabolic process GO:0006521 0 0.160
histone acetylation GO:0016573 38 0.156
protein modification process GO:0036211 438 0.155
embryo development ending in birth or egg hatching GO:0009792 152 0.151
neurological system process GO:0050877 358 0.145
chromatin organization GO:0006325 207 0.140
Human
histone modification GO:0016570 106 0.134
negative regulation of rna metabolic process GO:0051253 251 0.132
dna conformation change GO:0071103 105 0.123
peptidyl amino acid modification GO:0018193 105 0.102
embryonic development via the syncytial blastoderm GO:0001700 148 0.097
protein acylation GO:0043543 42 0.096
protein acetylation GO:0006473 39 0.090
negative regulation of rna biosynthetic process GO:1902679 240 0.088
regulation of cellular amine metabolic process GO:0033238 3 0.085
dendrite morphogenesis GO:0048813 199 0.085
negative regulation of cellular biosynthetic process GO:0031327 277 0.079
cell division GO:0051301 248 0.078
Human
endocytosis GO:0006897 310 0.078
cellular ketone metabolic process GO:0042180 24 0.078
stem cell differentiation GO:0048863 117 0.077
anterior posterior pattern specification GO:0009952 136 0.070
response to abiotic stimulus GO:0009628 341 0.070
response to radiation GO:0009314 155 0.069
negative regulation of cellular metabolic process GO:0031324 382 0.069
immune system development GO:0002520 57 0.068
Human Mouse
protein modification by small protein conjugation or removal GO:0070647 106 0.068
peptidyl lysine acetylation GO:0018394 39 0.065
cell proliferation GO:0008283 299 0.061
negative regulation of gene expression epigenetic GO:0045814 77 0.061
Fly
regulation of organelle organization GO:0033043 196 0.059
Human
positive regulation of catalytic activity GO:0043085 118 0.059
cellular response to dna damage stimulus GO:0006974 223 0.059
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.059
mitotic sister chromatid segregation GO:0000070 87 0.056
positive regulation of biosynthetic process GO:0009891 316 0.056
regulation of developmental pigmentation GO:0048070 24 0.056
response to sterol GO:0036314 34 0.055
determination of adult lifespan GO:0008340 137 0.054
protein ubiquitination GO:0016567 70 0.053
regulation of gene expression epigenetic GO:0040029 128 0.052
Fly
cellular response to abiotic stimulus GO:0071214 58 0.052
central nervous system development GO:0007417 201 0.051
small molecule metabolic process GO:0044281 305 0.051
nuclear dna replication GO:0033260 1 0.049
long term memory GO:0007616 62 0.049
imaginal disc derived appendage development GO:0048737 399 0.049
anterior posterior axis specification GO:0009948 109 0.047
ventral furrow formation GO:0007370 17 0.046
phagocytosis GO:0006909 215 0.046
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.046
carboxylic acid metabolic process GO:0019752 92 0.046
single organism catabolic process GO:0044712 228 0.045
neural precursor cell proliferation GO:0061351 75 0.045
positive regulation of macromolecule metabolic process GO:0010604 405 0.045
appendage morphogenesis GO:0035107 397 0.045
mrna splicing via spliceosome GO:0000398 73 0.044
regulation of cell cycle GO:0051726 291 0.043
regulation of protein metabolic process GO:0051246 256 0.041
immune system process GO:0002376 347 0.040
Human Mouse
regulation of cellular ketone metabolic process GO:0010565 3 0.040
protein modification by small protein conjugation GO:0032446 79 0.040
negative regulation of biosynthetic process GO:0009890 277 0.040
tripartite regional subdivision GO:0007351 103 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.039
regionalization GO:0003002 416 0.037
cellular protein modification process GO:0006464 438 0.037
appendage development GO:0048736 401 0.037
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.037
digestive tract development GO:0048565 149 0.037
positive regulation of cellular biosynthetic process GO:0031328 316 0.037
gene silencing GO:0016458 138 0.036
Fly
regulation of protein modification process GO:0031399 112 0.035
regulation of catalytic activity GO:0050790 185 0.035
negative regulation of nucleic acid templated transcription GO:1903507 240 0.035
mitotic cell cycle phase transition GO:0044772 138 0.035
heart development GO:0007507 82 0.034
imaginal disc derived appendage morphogenesis GO:0035114 395 0.034
regulation of notch signaling pathway GO:0008593 100 0.034
regulation of molecular function GO:0065009 217 0.034
protein catabolic process GO:0030163 101 0.033
histone h4 acetylation GO:0043967 13 0.033
response to organic substance GO:0010033 284 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.033
mesenchymal cell development GO:0014031 1 0.033
dna replication GO:0006260 48 0.032
intracellular signal transduction GO:0035556 300 0.031
cellular catabolic process GO:0044248 372 0.031
stem cell development GO:0048864 79 0.031
proteolysis GO:0006508 192 0.030
post embryonic appendage morphogenesis GO:0035120 385 0.030
cell cycle phase transition GO:0044770 140 0.029
eye photoreceptor cell differentiation GO:0001754 145 0.029
organic acid metabolic process GO:0006082 103 0.029
single organism behavior GO:0044708 391 0.028
female meiosis chromosome segregation GO:0016321 33 0.028
programmed cell death GO:0012501 257 0.028
positive regulation of catabolic process GO:0009896 105 0.027
kidney morphogenesis GO:0060993 3 0.027
chromatin remodeling GO:0006338 72 0.027
hematopoietic or lymphoid organ development GO:0048534 57 0.027
Human Mouse
camera type eye development GO:0043010 4 0.026
organ growth GO:0035265 56 0.026
Fly
mitotic nuclear division GO:0007067 213 0.026
Human
regulation of multicellular organismal development GO:2000026 414 0.026
axis specification GO:0009798 167 0.025
regulation of intracellular signal transduction GO:1902531 236 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.025
vesicle mediated transport GO:0016192 381 0.025
chromatin silencing GO:0006342 76 0.025
Fly
response to biotic stimulus GO:0009607 294 0.025
regulation of nuclear division GO:0051783 58 0.024
Human
regulation of small gtpase mediated signal transduction GO:0051056 93 0.024
multi organism behavior GO:0051705 175 0.024
head development GO:0060322 135 0.023
positive regulation of cellular protein metabolic process GO:0032270 118 0.023
rna interference GO:0016246 27 0.023
developmental maturation GO:0021700 172 0.023
Mouse
nucleoside triphosphate catabolic process GO:0009143 108 0.023
negative regulation of cellular protein metabolic process GO:0032269 85 0.023
mitotic cell cycle embryonic GO:0045448 38 0.023
taxis GO:0042330 304 0.022
lymph gland development GO:0048542 28 0.022
response to light stimulus GO:0009416 124 0.022
organonitrogen compound metabolic process GO:1901564 318 0.022
muscle cell differentiation GO:0042692 103 0.022
tube development GO:0035295 244 0.022
embryonic axis specification GO:0000578 107 0.021
regulation of g2 m transition of mitotic cell cycle GO:0010389 15 0.021
gland development GO:0048732 191 0.021
renal tubule development GO:0061326 64 0.020
respiratory system development GO:0060541 213 0.020
neuronal stem cell maintenance GO:0097150 4 0.020
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.020
cellular response to organic substance GO:0071310 132 0.020
macromolecular complex assembly GO:0065003 256 0.020
cell fate specification GO:0001708 71 0.020
regulation of neural precursor cell proliferation GO:2000177 35 0.020
single organism biosynthetic process GO:0044711 206 0.020
morphogenesis of an epithelium GO:0002009 276 0.020
regulation of cell division GO:0051302 72 0.019
Human
dna packaging GO:0006323 91 0.019
protein phosphorylation GO:0006468 169 0.019
wing disc morphogenesis GO:0007472 344 0.019
segmentation GO:0035282 207 0.019
regulation of circadian rhythm GO:0042752 49 0.019
actomyosin structure organization GO:0031032 56 0.019
positive regulation of rna biosynthetic process GO:1902680 266 0.019
regulation of phosphorus metabolic process GO:0051174 210 0.019
eye development GO:0001654 323 0.018
death GO:0016265 284 0.018
histone mrna metabolic process GO:0008334 8 0.018
chromatin assembly or disassembly GO:0006333 52 0.018
purine ribonucleotide catabolic process GO:0009154 109 0.018
regulation of cellular protein metabolic process GO:0032268 243 0.018
positive regulation of protein metabolic process GO:0051247 128 0.018
cuticle development GO:0042335 86 0.017
response to external biotic stimulus GO:0043207 293 0.017
negative regulation of signal transduction GO:0009968 206 0.017
organelle assembly GO:0070925 198 0.017
negative regulation of g2 m transition of mitotic cell cycle GO:0010972 8 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.017
smoothened signaling pathway GO:0007224 49 0.017
cell fate determination GO:0001709 91 0.016
mrna processing GO:0006397 104 0.016
multi organism reproductive behavior GO:0044705 121 0.016
regulation of histone modification GO:0031056 20 0.016
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 73 0.016
cellular protein catabolic process GO:0044257 83 0.016
cellular response to external stimulus GO:0071496 66 0.016
multicellular organismal aging GO:0010259 140 0.016
outflow tract morphogenesis GO:0003151 4 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.016
macromolecule methylation GO:0043414 45 0.016
ribonucleoprotein complex assembly GO:0022618 23 0.016
dna damage checkpoint GO:0000077 78 0.016
ribonucleoside triphosphate metabolic process GO:0009199 119 0.016
rna splicing GO:0008380 83 0.016
regulation of cell differentiation GO:0045595 302 0.016
Human
spindle organization GO:0007051 253 0.016
purine containing compound catabolic process GO:0072523 112 0.015
urogenital system development GO:0001655 72 0.015
dendrite development GO:0016358 204 0.015
imaginal disc growth GO:0007446 37 0.015
Fly
regulation of embryonic development GO:0045995 68 0.015
learning or memory GO:0007611 141 0.015
nucleoside phosphate catabolic process GO:1901292 110 0.015
imaginal disc derived wing morphogenesis GO:0007476 337 0.015
purine ribonucleoside triphosphate catabolic process GO:0009207 108 0.015
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.015
malpighian tubule development GO:0072002 64 0.015
embryonic pattern specification GO:0009880 174 0.015
catabolic process GO:0009056 409 0.015
chromosome condensation GO:0030261 41 0.015
negative regulation of protein metabolic process GO:0051248 85 0.014
cellular response to nutrient levels GO:0031669 62 0.014
negative regulation of programmed cell death GO:0043069 72 0.014
purine nucleotide metabolic process GO:0006163 146 0.014
positive regulation of response to stimulus GO:0048584 323 0.014
regulation of mitotic cell cycle GO:0007346 190 0.014
mushroom body development GO:0016319 70 0.014
positive regulation of multicellular organismal process GO:0051240 143 0.014
notch signaling pathway GO:0007219 120 0.014
cellular macromolecular complex assembly GO:0034622 153 0.014
dna repair GO:0006281 54 0.014
renal tubule morphogenesis GO:0061333 44 0.014
ubiquitin dependent protein catabolic process GO:0006511 78 0.014
tissue morphogenesis GO:0048729 297 0.014
compound eye development GO:0048749 307 0.014
regulation of programmed cell death GO:0043067 152 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
growth GO:0040007 359 0.013
Fly
digestive tract morphogenesis GO:0048546 127 0.013
negative regulation of multicellular organismal process GO:0051241 142 0.013
Worm
cellular response to extracellular stimulus GO:0031668 64 0.013
forebrain development GO:0030900 2 0.013
regulation of cellular response to stress GO:0080135 89 0.013
organic substance catabolic process GO:1901575 308 0.013
cellular response to chemical stimulus GO:0070887 199 0.013
regulation of nervous system development GO:0051960 248 0.013
actin cytoskeleton organization GO:0030036 206 0.013
regulation of reproductive process GO:2000241 54 0.013
positive regulation of transcription dna templated GO:0045893 266 0.013
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.013
regulation of gtpase activity GO:0043087 44 0.013
imaginal disc derived leg morphogenesis GO:0007480 80 0.013
spinal cord development GO:0021510 1 0.013
mrna metabolic process GO:0016071 124 0.012
chemotaxis GO:0006935 249 0.012
regulation of cell cycle phase transition GO:1901987 130 0.012
nucleosome assembly GO:0006334 35 0.012
regulation of stem cell proliferation GO:0072091 40 0.012
innate immune response GO:0045087 144 0.012
response to nutrient levels GO:0031667 114 0.012
oxoacid metabolic process GO:0043436 103 0.012
male courtship behavior veined wing generated song production GO:0045433 20 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
regulation of gtp catabolic process GO:0033124 44 0.012
nucleoside triphosphate metabolic process GO:0009141 120 0.012
homeostatic process GO:0042592 199 0.012
Mouse
regulation of catabolic process GO:0009894 170 0.012
rna splicing via transesterification reactions GO:0000375 73 0.012
negative regulation of cell death GO:0060548 81 0.012
cellular response to ketone GO:1901655 17 0.012
cytoplasm organization GO:0007028 64 0.012
negative regulation of developmental process GO:0051093 201 0.012
Worm
cell motility GO:0048870 251 0.012
response to starvation GO:0042594 97 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.012
cellular component assembly involved in morphogenesis GO:0010927 151 0.012
modification dependent macromolecule catabolic process GO:0043632 79 0.012
response to other organism GO:0051707 293 0.012
negative regulation of cell cycle GO:0045786 116 0.012
organophosphate catabolic process GO:0046434 112 0.012
positive regulation of mitotic cell cycle GO:0045931 34 0.011
regulation of chromosome segregation GO:0051983 32 0.011
epithelial cell development GO:0002064 274 0.011
karyosome formation GO:0030717 22 0.011
posttranscriptional gene silencing GO:0016441 46 0.011
small gtpase mediated signal transduction GO:0007264 88 0.011
response to oxygen containing compound GO:1901700 200 0.011
macromolecule catabolic process GO:0009057 161 0.011
crystal cell differentiation GO:0042688 7 0.011
brain development GO:0007420 120 0.011
larval locomotory behavior GO:0008345 27 0.011
molting cycle chitin based cuticle GO:0007591 56 0.011
enzyme linked receptor protein signaling pathway GO:0007167 179 0.011
negative regulation of cell differentiation GO:0045596 143 0.011
positive regulation of gene expression GO:0010628 290 0.010
regulation of nucleoside metabolic process GO:0009118 50 0.010
regulation of oocyte development GO:0060281 27 0.010
regulation of multi organism process GO:0043900 131 0.010
regulation of mitotic cell cycle phase transition GO:1901990 130 0.010
pole plasm protein localization GO:0007318 10 0.010
purine containing compound metabolic process GO:0072521 155 0.010
response to ketone GO:1901654 34 0.010
larval development GO:0002164 104 0.010
Worm
nucleotide metabolic process GO:0009117 161 0.010
neuron fate commitment GO:0048663 50 0.010
cell death GO:0008219 279 0.010
regulation of phosphate metabolic process GO:0019220 210 0.010
purine nucleoside triphosphate metabolic process GO:0009144 119 0.010
regulation of sister chromatid segregation GO:0033045 28 0.010
negative regulation of apoptotic process GO:0043066 63 0.010
regulation of purine nucleotide catabolic process GO:0033121 48 0.010
neuroblast differentiation GO:0014016 29 0.010
retina development in camera type eye GO:0060041 4 0.010
spliceosomal snrnp assembly GO:0000387 2 0.010

l(3)mbt disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.015