Drosophila melanogaster

10 known processes

rux (Dmel_CG4336)

roughex

(Aliases: CG4336,Rux,Dmel\CG4336)

rux biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of cell cycle phase transition GO:1901987 130 0.819
meiosis i GO:0007127 59 0.766
regulation of cell cycle process GO:0010564 181 0.765
regionalization GO:0003002 416 0.746
regulation of cell cycle GO:0051726 291 0.724
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.582
negative regulation of cell cycle phase transition GO:1901988 103 0.564
meiotic nuclear division GO:0007126 151 0.554
nuclear division GO:0000280 332 0.528
organelle fission GO:0048285 340 0.478
mitotic cell cycle phase transition GO:0044772 138 0.467
negative regulation of mitotic cell cycle GO:0045930 109 0.438
regulation of mitotic cell cycle GO:0007346 190 0.423
cell division GO:0051301 248 0.416
cell cycle phase transition GO:0044770 140 0.401
dna metabolic process GO:0006259 227 0.334
meiotic cell cycle process GO:1903046 132 0.261
mitotic nuclear division GO:0007067 213 0.256
regulation of mitotic cell cycle phase transition GO:1901990 130 0.249
protein complex assembly GO:0006461 200 0.243
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress GO:0070059 4 0.233
negative regulation of cell cycle GO:0045786 116 0.208
regulation of synapse organization GO:0050807 110 0.194
regulation of cell division GO:0051302 72 0.185
protein complex biogenesis GO:0070271 201 0.178
synaptic growth at neuromuscular junction GO:0051124 119 0.166
regulation of nuclear division GO:0051783 58 0.160
regulation of microtubule cytoskeleton organization GO:0070507 41 0.146
regulation of organelle organization GO:0033043 196 0.139
cystoblast division GO:0007282 10 0.137
imaginal disc derived appendage development GO:0048737 399 0.135
synapse assembly GO:0007416 143 0.135
developmental maturation GO:0021700 172 0.133
cell projection assembly GO:0030031 94 0.132
regulation of synapse structure and activity GO:0050803 128 0.131
negative regulation of cellular component organization GO:0051129 108 0.128
negative regulation of chromosome segregation GO:0051985 14 0.127
regulation of chromosome segregation GO:0051983 32 0.119
post embryonic appendage morphogenesis GO:0035120 385 0.118
vesicle mediated transport GO:0016192 381 0.116
regulation of nervous system development GO:0051960 248 0.106
regulation of synaptic growth at neuromuscular junction GO:0008582 89 0.101
regulation of synapse assembly GO:0051963 94 0.099
regulation of multicellular organismal development GO:2000026 414 0.099
meiotic sister chromatid segregation GO:0045144 6 0.099
ubiquitin dependent protein catabolic process GO:0006511 78 0.097
male gamete generation GO:0048232 201 0.097
negative regulation of cell cycle process GO:0010948 109 0.092
oocyte maturation GO:0001556 3 0.089
embryo development ending in birth or egg hatching GO:0009792 152 0.088
endocytosis GO:0006897 310 0.085
morphogenesis of an epithelium GO:0002009 276 0.085
negative regulation of reactive oxygen species metabolic process GO:2000378 1 0.085
anterior posterior pattern specification GO:0009952 136 0.084
negative regulation of synapse assembly GO:0051964 39 0.083
meiotic cell cycle GO:0051321 171 0.082
oocyte development GO:0048599 124 0.079
regulation of mitosis GO:0007088 56 0.078
negative regulation of nervous system development GO:0051961 92 0.078
cytokinesis GO:0000910 90 0.076
digestive tract development GO:0048565 149 0.075
open tracheal system development GO:0007424 204 0.073
macromolecular complex assembly GO:0065003 256 0.072
spermatid development GO:0007286 98 0.072
positive regulation of biosynthetic process GO:0009891 316 0.070
positive regulation of gene expression GO:0010628 290 0.070
cytoskeleton dependent cytokinesis GO:0061640 81 0.069
negative regulation of cellular catabolic process GO:0031330 34 0.069
developmental growth GO:0048589 280 0.068
regulation of cellular component biogenesis GO:0044087 201 0.067
mitotic cell cycle checkpoint GO:0007093 88 0.066
axis specification GO:0009798 167 0.066
cell maturation GO:0048469 144 0.065
dendrite morphogenesis GO:0048813 199 0.064
female meiotic division GO:0007143 70 0.064
tube morphogenesis GO:0035239 191 0.062
eye development GO:0001654 323 0.060
organelle assembly GO:0070925 198 0.059
spermatogenesis GO:0007283 200 0.057
wing disc morphogenesis GO:0007472 344 0.054
mitotic cell cycle embryonic GO:0045448 38 0.054
segmentation GO:0035282 207 0.053
dendrite development GO:0016358 204 0.052
embryonic pattern specification GO:0009880 174 0.051
regulation of cytoskeleton organization GO:0051493 89 0.051
apoptotic process GO:0006915 159 0.051
cell cycle dna replication GO:0044786 23 0.050
phagocytosis GO:0006909 215 0.050
chromosome separation GO:0051304 42 0.049
positive regulation of nucleic acid templated transcription GO:1903508 266 0.049
mitotic spindle checkpoint GO:0071174 11 0.048
regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032434 37 0.047
embryonic axis specification GO:0000578 107 0.047
negative regulation of proteasomal ubiquitin dependent protein catabolic process GO:0032435 16 0.046
negative regulation of mitotic sister chromatid separation GO:2000816 13 0.046
regulation of growth GO:0040008 233 0.046
asymmetric neuroblast division GO:0055059 33 0.045
pronuclear migration GO:0035046 4 0.045
negative regulation of sister chromatid segregation GO:0033046 13 0.045
g2 m transition of mitotic cell cycle GO:0000086 19 0.045
positive regulation of macromolecule metabolic process GO:0010604 405 0.044
mitotic sister chromatid separation GO:0051306 30 0.044
positive regulation of signal transduction GO:0009967 223 0.044
rna localization GO:0006403 115 0.044
synapse organization GO:0050808 196 0.043
protein catabolic process GO:0030163 101 0.043
regulation of tube architecture open tracheal system GO:0035152 68 0.042
transcription from rna polymerase ii promoter GO:0006366 368 0.042
sensory organ morphogenesis GO:0090596 260 0.042
regulation of cell proliferation GO:0042127 163 0.041
regulation of mitotic metaphase anaphase transition GO:0030071 26 0.040
negative regulation of developmental process GO:0051093 201 0.040
response to light stimulus GO:0009416 124 0.039
negative regulation of proteasomal protein catabolic process GO:1901799 16 0.039
regulation of microtubule based process GO:0032886 49 0.039
regulation of dna replication GO:0006275 13 0.039
neuromuscular junction development GO:0007528 149 0.038
positive regulation of signaling GO:0023056 243 0.038
negative regulation of synaptic growth at neuromuscular junction GO:0045886 39 0.037
positive regulation of cellular component organization GO:0051130 156 0.037
cilium morphogenesis GO:0060271 39 0.037
regulation of mitotic sister chromatid separation GO:0010965 28 0.037
epidermal growth factor receptor signaling pathway GO:0007173 58 0.037
regulation of intracellular signal transduction GO:1902531 236 0.037
mitotic sister chromatid segregation GO:0000070 87 0.037
negative regulation of organelle organization GO:0010639 56 0.037
respiratory system development GO:0060541 213 0.036
cilium assembly GO:0042384 38 0.036
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.035
regulation of cellular catabolic process GO:0031329 157 0.035
anterior posterior axis specification GO:0009948 109 0.035
negative regulation of mitotic sister chromatid segregation GO:0033048 13 0.035
nucleus organization GO:0006997 45 0.034
appendage development GO:0048736 401 0.034
meiotic spindle organization GO:0000212 36 0.034
blastoderm segmentation GO:0007350 159 0.034
determination of adult lifespan GO:0008340 137 0.032
stem cell division GO:0017145 69 0.032
sister chromatid segregation GO:0000819 92 0.032
rhythmic process GO:0048511 106 0.032
anatomical structure homeostasis GO:0060249 97 0.031
cellular nitrogen compound catabolic process GO:0044270 165 0.030
organelle localization GO:0051640 148 0.030
positive regulation of cellular biosynthetic process GO:0031328 316 0.030
tube development GO:0035295 244 0.030
chromosome segregation GO:0007059 157 0.030
appendage morphogenesis GO:0035107 397 0.029
locomotory behavior GO:0007626 176 0.029
negative regulation of growth GO:0045926 84 0.029
imaginal disc derived wing morphogenesis GO:0007476 337 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 83 0.028
cilium organization GO:0044782 41 0.028
embryonic morphogenesis GO:0048598 206 0.028
spindle checkpoint GO:0031577 11 0.027
mitotic cytokinesis GO:0000281 50 0.027
regulation of apoptotic process GO:0042981 130 0.027
regulation of cell development GO:0060284 215 0.027
tripartite regional subdivision GO:0007351 103 0.027
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 54 0.027
response to endogenous stimulus GO:0009719 119 0.027
macromolecule catabolic process GO:0009057 161 0.027
regulation of mitotic sister chromatid segregation GO:0033047 28 0.027
male meiosis GO:0007140 52 0.026
negative regulation of cell division GO:0051782 17 0.026
neuroblast proliferation GO:0007405 74 0.026
chromosome organization GO:0051276 360 0.026
programmed cell death GO:0012501 257 0.026
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.026
nitrogen compound transport GO:0071705 85 0.026
single organism biosynthetic process GO:0044711 206 0.025
digestive tract morphogenesis GO:0048546 127 0.025
imaginal disc derived appendage morphogenesis GO:0035114 395 0.025
microtubule based movement GO:0007018 51 0.025
germ line cyst formation GO:0048134 44 0.025
body morphogenesis GO:0010171 2 0.025
peptidyl threonine phosphorylation GO:0018107 2 0.025
cellular protein modification process GO:0006464 438 0.025
metaphase anaphase transition of cell cycle GO:0044784 28 0.025
protein complex disassembly GO:0043241 36 0.025
regulation of meiosis GO:0040020 3 0.024
modification dependent protein catabolic process GO:0019941 78 0.024
posttranscriptional regulation of gene expression GO:0010608 145 0.024
tissue morphogenesis GO:0048729 297 0.024
regulation of neuron projection development GO:0010975 69 0.024
endomembrane system organization GO:0010256 119 0.024
oocyte differentiation GO:0009994 145 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.023
regulation of sister chromatid segregation GO:0033045 28 0.023
digestive system development GO:0055123 149 0.023
negative regulation of multicellular organismal process GO:0051241 142 0.023
response to organic substance GO:0010033 284 0.023
response to abiotic stimulus GO:0009628 341 0.023
negative regulation of catabolic process GO:0009895 36 0.022
cellular protein catabolic process GO:0044257 83 0.022
meiotic cell cycle phase transition GO:0044771 4 0.022
regulation of translation GO:0006417 56 0.022
meiosis ii GO:0007135 23 0.022
negative regulation of cell development GO:0010721 62 0.022
intracellular signal transduction GO:0035556 300 0.022
regulation of epithelial cell proliferation GO:0050678 4 0.022
protein ubiquitination GO:0016567 70 0.022
mitochondrial fusion GO:0008053 7 0.022
organic cyclic compound catabolic process GO:1901361 168 0.022
establishment or maintenance of bipolar cell polarity GO:0061245 34 0.021
protein k48 linked ubiquitination GO:0070936 3 0.021
metaphase anaphase transition of mitotic cell cycle GO:0007091 28 0.021
positive regulation of response to stimulus GO:0048584 323 0.021
gastrulation with mouth forming first GO:0001703 36 0.021
cellular amine metabolic process GO:0044106 12 0.021
response to radiation GO:0009314 155 0.021
axon guidance GO:0007411 233 0.021
negative regulation of mitotic metaphase anaphase transition GO:0045841 13 0.020
regulation of membrane potential GO:0042391 35 0.020
establishment of localization in cell GO:0051649 402 0.020
regulation of spindle organization GO:0090224 17 0.020
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.020
positive regulation of nurse cell apoptotic process GO:0045850 5 0.020
peptidyl tyrosine phosphorylation GO:0018108 24 0.020
positive regulation of cell communication GO:0010647 250 0.020
regulation of chromosome organization GO:0033044 64 0.020
dna replication GO:0006260 48 0.020
positive regulation of protein metabolic process GO:0051247 128 0.020
regulation of dendrite development GO:0050773 37 0.019
negative regulation of metaphase anaphase transition of cell cycle GO:1902100 13 0.019
germarium derived female germ line cyst formation GO:0030727 42 0.019
meiotic cytokinesis GO:0033206 33 0.019
peripheral nervous system development GO:0007422 52 0.019
synaptic transmission dopaminergic GO:0001963 2 0.019
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 44 0.019
compound eye development GO:0048749 307 0.019
negative regulation of epithelial cell proliferation GO:0050680 4 0.019
syncytial blastoderm mitotic cell cycle GO:0035186 21 0.019
female germ line cyst formation GO:0048135 42 0.019
camera type eye morphogenesis GO:0048593 2 0.018
cell cycle g2 m phase transition GO:0044839 22 0.018
regulation of microtubule depolymerization GO:0031114 24 0.018
centrosome organization GO:0051297 163 0.018
negative regulation of proteolysis involved in cellular protein catabolic process GO:1903051 17 0.018
axonogenesis GO:0007409 290 0.018
response to endoplasmic reticulum stress GO:0034976 28 0.018
positive regulation of developmental process GO:0051094 143 0.018
protein processing GO:0016485 68 0.018
regulation of cell death GO:0010941 173 0.018
positive regulation of cellular protein catabolic process GO:1903364 24 0.018
chromosome organization involved in meiosis GO:0070192 10 0.018
cell cycle g1 s phase transition GO:0044843 31 0.017
response to copper ion GO:0046688 4 0.017
positive regulation of phosphorus metabolic process GO:0010562 139 0.017
sperm individualization GO:0007291 48 0.017
cell cycle checkpoint GO:0000075 95 0.017
negative regulation of mitosis GO:0045839 16 0.017
dorsal ventral axis specification GO:0009950 66 0.016
protein maturation GO:0051604 71 0.016
asymmetric cell division GO:0008356 37 0.016
negative regulation of protein catabolic process GO:0042177 17 0.016
mitotic spindle assembly checkpoint GO:0007094 11 0.016
regulation of dna metabolic process GO:0051052 34 0.016
neuroblast division GO:0055057 35 0.016
social behavior GO:0035176 4 0.016
positive regulation of transcription dna templated GO:0045893 266 0.016
multicellular organismal aging GO:0010259 140 0.016
sex differentiation GO:0007548 81 0.015
regulation of developmental growth GO:0048638 174 0.015
camera type eye development GO:0043010 4 0.015
negative regulation of neurogenesis GO:0050768 53 0.015
regulation of oocyte development GO:0060281 27 0.015
negative regulation of chromosome organization GO:2001251 19 0.015
cellular macromolecule catabolic process GO:0044265 136 0.015
anterograde axon cargo transport GO:0008089 6 0.015
phosphorylation GO:0016310 294 0.015
gliogenesis GO:0042063 80 0.015
cellular response to organic substance GO:0071310 132 0.015
cellular catabolic process GO:0044248 372 0.015
aging GO:0007568 143 0.015
positive regulation of organelle organization GO:0010638 65 0.015
oxoacid metabolic process GO:0043436 103 0.014
cation transport GO:0006812 110 0.014
establishment of organelle localization GO:0051656 122 0.014
organic substance catabolic process GO:1901575 308 0.014
ribonucleoside triphosphate catabolic process GO:0009203 108 0.014
negative regulation of programmed cell death GO:0043069 72 0.014
proteasomal protein catabolic process GO:0010498 59 0.014
cell proliferation GO:0008283 299 0.014
intracellular transport GO:0046907 228 0.014
synaptic transmission GO:0007268 288 0.014
cell aging GO:0007569 2 0.014
spindle assembly GO:0051225 80 0.014
retina development in camera type eye GO:0060041 4 0.014
actin cytoskeleton organization GO:0030036 206 0.014
epithelial structure maintenance GO:0010669 17 0.014
neuron projection guidance GO:0097485 241 0.014
positive regulation of lipid catabolic process GO:0050996 1 0.014
lateral inhibition GO:0046331 206 0.014
positive regulation of proteasomal protein catabolic process GO:1901800 20 0.014
cell death GO:0008219 279 0.013
g1 s transition of mitotic cell cycle GO:0000082 31 0.013
cellular protein complex assembly GO:0043623 71 0.013
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.013
mrna metabolic process GO:0016071 124 0.013
forebrain development GO:0030900 2 0.013
negative regulation of protein metabolic process GO:0051248 85 0.013
intracellular protein transport GO:0006886 104 0.013
regulation of neurogenesis GO:0050767 158 0.013
carboxylic acid metabolic process GO:0019752 92 0.013
dna double strand break processing GO:0000729 3 0.013
response to other organism GO:0051707 293 0.012
anaphase promoting complex dependent proteasomal ubiquitin dependent protein catabolic process GO:0031145 30 0.012
nucleobase containing compound transport GO:0015931 56 0.012
response to oxygen containing compound GO:1901700 200 0.012
eye morphogenesis GO:0048592 260 0.012
nucleobase containing compound catabolic process GO:0034655 165 0.012
covalent chromatin modification GO:0016569 106 0.012
cell cycle comprising mitosis without cytokinesis GO:0033301 25 0.012
regulation of response to stress GO:0080134 200 0.012
positive regulation of rna metabolic process GO:0051254 271 0.012
single organism cellular localization GO:1902580 180 0.012
negative regulation of microtubule polymerization or depolymerization GO:0031111 21 0.012
chemotaxis GO:0006935 249 0.012
regulation of protein depolymerization GO:1901879 27 0.012
growth GO:0040007 359 0.012
endomitotic cell cycle GO:0007113 7 0.012
telomere organization GO:0032200 21 0.012
stem cell differentiation GO:0048863 117 0.012
regulation of proteasomal protein catabolic process GO:0061136 39 0.012
germarium derived egg chamber formation GO:0007293 101 0.011
centrosome separation GO:0051299 20 0.011
ribose phosphate metabolic process GO:0019693 145 0.011
glial cell differentiation GO:0010001 35 0.011
negative regulation of cytoskeleton organization GO:0051494 30 0.011
regulation of metaphase anaphase transition of cell cycle GO:1902099 26 0.011
organic acid metabolic process GO:0006082 103 0.011
regulation of neuron differentiation GO:0045664 103 0.011
cytokinetic process GO:0032506 27 0.011
dna endoreduplication GO:0042023 22 0.011
biological adhesion GO:0022610 138 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
regulation of protein complex assembly GO:0043254 42 0.011
regulation of erbb signaling pathway GO:1901184 42 0.011
death GO:0016265 284 0.011
jak stat cascade GO:0007259 49 0.011
secretion by cell GO:0032940 101 0.011
reproductive system development GO:0061458 74 0.011
cellular response to chemical stimulus GO:0070887 199 0.011
regulation of phosphate metabolic process GO:0019220 210 0.011
catabolic process GO:0009056 409 0.010
negative regulation of gene expression GO:0010629 387 0.010
regulation of protein dephosphorylation GO:0035304 5 0.010
maintenance of location GO:0051235 73 0.010
gland morphogenesis GO:0022612 145 0.010
positive regulation of multicellular organismal process GO:0051240 143 0.010
translation GO:0006412 69 0.010
development of primary sexual characteristics GO:0045137 50 0.010
regulation of catabolic process GO:0009894 170 0.010
cell cycle arrest GO:0007050 4 0.010

rux disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.020
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
organ system cancer DOID:0050686 0 0.019
central nervous system disease DOID:331 0 0.015
neurodegenerative disease DOID:1289 0 0.015