Drosophila melanogaster

83 known processes

PGRP-LF (Dmel_CG4437)

Peptidoglycan recognition protein LF

(Aliases: PGRP-LCa,anon-WO0118547.581,PGRP-like,PGRPLF,Dmel\CG4437,CG4437)

PGRP-LF biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002816 3 0.881
Fly
negative regulation of peptidoglycan recognition protein signaling pathway GO:0061060 3 0.687
Fly
response to peptidoglycan GO:0032494 2 0.604
Fly
immune system process GO:0002376 347 0.548
defense response to other organism GO:0098542 225 0.545
glycosaminoglycan catabolic process GO:0006027 3 0.509
Fly
response to other organism GO:0051707 293 0.501
defense response GO:0006952 300 0.476
innate immune response GO:0045087 144 0.452
Fly
immune response GO:0006955 246 0.443
humoral immune response GO:0006959 117 0.422
regulation of peptidoglycan recognition protein signaling pathway GO:0061058 4 0.421
Fly
regulation of defense response to bacterium GO:1900424 30 0.407
Fly
response to external biotic stimulus GO:0043207 293 0.407
response to bacterium GO:0009617 198 0.405
regulation of defense response GO:0031347 102 0.381
Fly
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.334
Fly
negative regulation of cellular metabolic process GO:0031324 382 0.311
biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0002815 3 0.281
Fly
negative regulation of signal transduction GO:0009968 206 0.278
defense response to gram negative bacterium GO:0050829 94 0.274
Fly
negative regulation of cell communication GO:0010648 223 0.271
peptidoglycan catabolic process GO:0009253 3 0.262
Fly
defense response to bacterium GO:0042742 178 0.250
antibacterial peptide biosynthetic process GO:0002780 22 0.235
Fly
organonitrogen compound biosynthetic process GO:1901566 117 0.225
Fly
melanization defense response GO:0035006 45 0.225
Fly
response to biotic stimulus GO:0009607 294 0.221
aging GO:0007568 143 0.216
negative regulation of immune system process GO:0002683 50 0.202
Fly
antibacterial humoral response GO:0019731 44 0.198
lipopolysaccharide mediated signaling pathway GO:0031663 1 0.188
Fly
negative regulation of signaling GO:0023057 219 0.187
pigment metabolic process GO:0042440 84 0.178
Fly
phosphorylation GO:0016310 294 0.175
activation of innate immune response GO:0002218 4 0.174
Fly
regulation of response to stress GO:0080134 200 0.173
antibacterial peptide production GO:0002778 22 0.172
Fly
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002813 14 0.169
Fly
intracellular signal transduction GO:0035556 300 0.166
regulation of mapk cascade GO:0043408 92 0.166
multicellular organismal aging GO:0010259 140 0.155
determination of adult lifespan GO:0008340 137 0.152
regulation of antimicrobial humoral response GO:0002759 50 0.151
Fly
regulation of immune response GO:0050776 118 0.148
Fly
defense response to gram positive bacterium GO:0050830 41 0.139
Fly
regulation of response to biotic stimulus GO:0002831 63 0.133
Fly
regulation of intracellular signal transduction GO:1902531 236 0.133
regulation of multi organism process GO:0043900 131 0.133
Fly
cellular response to chemical stimulus GO:0070887 199 0.133
Fly
innate immune response activating signal transduction GO:0002758 2 0.131
Fly
amide biosynthetic process GO:0043604 42 0.129
Fly
peptide metabolic process GO:0006518 80 0.127
Fly
organonitrogen compound metabolic process GO:1901564 318 0.119
Fly
negative regulation of response to stimulus GO:0048585 258 0.117
negative regulation of defense response GO:0031348 35 0.117
Fly
regulation of secondary metabolic process GO:0043455 7 0.115
Fly
immune response regulating signaling pathway GO:0002764 2 0.115
Fly
melanin metabolic process GO:0006582 47 0.115
Fly
regulation of innate immune response GO:0045088 71 0.099
Fly
cellular response to molecule of bacterial origin GO:0071219 3 0.098
Fly
aminoglycan catabolic process GO:0006026 6 0.098
Fly
pattern recognition receptor signaling pathway GO:0002221 2 0.090
Fly
kidney development GO:0001822 3 0.088
secondary metabolic process GO:0019748 75 0.086
Fly
cellular response to lipopolysaccharide GO:0071222 3 0.085
Fly
response to organonitrogen compound GO:0010243 75 0.085
Fly
antimicrobial humoral response GO:0019730 99 0.085
regulation of phosphorus metabolic process GO:0051174 210 0.084
regulation of immune system process GO:0002682 176 0.084
Fly
regulation of antibacterial peptide production GO:0002786 22 0.083
Fly
response to endogenous stimulus GO:0009719 119 0.082
Fly
peptide biosynthetic process GO:0043043 42 0.081
Fly
regulation of phosphate metabolic process GO:0019220 210 0.081
regulation of immune effector process GO:0002697 52 0.080
Fly
response to oxygen containing compound GO:1901700 200 0.079
Fly
small molecule metabolic process GO:0044281 305 0.079
response to virus GO:0009615 28 0.078
Fly
immune effector process GO:0002252 98 0.077
Fly
phenol containing compound metabolic process GO:0018958 57 0.077
Fly
negative regulation of defense response to bacterium GO:1900425 7 0.076
Fly
signal transduction by phosphorylation GO:0023014 107 0.076
organonitrogen compound catabolic process GO:1901565 128 0.073
Fly
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.069
Fly
cellular response to dna damage stimulus GO:0006974 223 0.069
defense response to fungus GO:0050832 48 0.067
single organism biosynthetic process GO:0044711 206 0.066
regulation of antimicrobial peptide production GO:0002784 44 0.066
Fly
peptidoglycan recognition protein signaling pathway GO:0061057 16 0.065
defense response to virus GO:0051607 23 0.065
Fly
production of molecular mediator of immune response GO:0002440 46 0.065
Fly
cellular amino acid metabolic process GO:0006520 61 0.065
negative regulation of phosphorylation GO:0042326 35 0.064
oxoacid metabolic process GO:0043436 103 0.064
positive regulation of biosynthetic process GO:0009891 316 0.062
Fly
jnk cascade GO:0007254 50 0.060
negative regulation of phosphorus metabolic process GO:0010563 45 0.059
organic hydroxy compound metabolic process GO:1901615 83 0.059
Fly
negative regulation of gene expression GO:0010629 387 0.058
cellular modified amino acid metabolic process GO:0006575 45 0.058
phagocytosis GO:0006909 215 0.057
positive regulation of antimicrobial humoral response GO:0002760 28 0.057
Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.056
positive regulation of response to stimulus GO:0048584 323 0.056
Fly
regulation of antimicrobial peptide biosynthetic process GO:0002805 38 0.056
Fly
response to organophosphorus GO:0046683 2 0.055
stress activated protein kinase signaling cascade GO:0031098 55 0.055
imaginal disc derived appendage morphogenesis GO:0035114 395 0.055
antimicrobial peptide biosynthetic process GO:0002777 38 0.054
Fly
regulation of response to external stimulus GO:0032101 115 0.054
Fly
l amino acid import GO:0043092 2 0.053
stress activated mapk cascade GO:0051403 52 0.053
carbohydrate derivative metabolic process GO:1901135 217 0.053
Fly
antimicrobial peptide production GO:0002775 46 0.053
Fly
regulation of jnk cascade GO:0046328 40 0.052
ovarian follicle cell development GO:0030707 248 0.052
cellular ketone metabolic process GO:0042180 24 0.052
positive regulation of multi organism process GO:0043902 40 0.052
Fly
regionalization GO:0003002 416 0.052
neuron death GO:0070997 27 0.051
negative regulation of intracellular signal transduction GO:1902532 57 0.050
regulation of phosphorylation GO:0042325 147 0.050
positive regulation of antimicrobial peptide production GO:0002225 28 0.050
Fly
positive regulation of antibacterial peptide biosynthetic process GO:0006963 20 0.049
Fly
positive regulation of defense response to bacterium GO:1900426 23 0.049
Fly
vesicle mediated transport GO:0016192 381 0.049
regulation of anatomical structure morphogenesis GO:0022603 242 0.048
imaginal disc derived appendage development GO:0048737 399 0.048
catabolic process GO:0009056 409 0.048
Fly
response to nitrogen compound GO:1901698 90 0.047
Fly
appendage morphogenesis GO:0035107 397 0.046
columnar cuboidal epithelial cell development GO:0002066 249 0.046
immune response activating signal transduction GO:0002757 2 0.046
Fly
eye development GO:0001654 323 0.045
death GO:0016265 284 0.045
enzyme linked receptor protein signaling pathway GO:0007167 179 0.044
epithelial cell migration GO:0010631 148 0.044
growth GO:0040007 359 0.044
endocytosis GO:0006897 310 0.043
negative regulation of innate immune response GO:0045824 30 0.043
Fly
epithelial cell development GO:0002064 274 0.043
regulation of cellular response to stress GO:0080135 89 0.042
cellular response to organic substance GO:0071310 132 0.042
Fly
imaginal disc derived wing morphogenesis GO:0007476 337 0.042
positive regulation of cell communication GO:0010647 250 0.041
negative regulation of nucleic acid templated transcription GO:1903507 240 0.041
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.041
response to fungus GO:0009620 50 0.040
positive regulation of immune system process GO:0002684 68 0.040
Fly
cell death GO:0008219 279 0.040
regulation of cell cycle GO:0051726 291 0.039
chemotaxis GO:0006935 249 0.039
negative regulation of nitrogen compound metabolic process GO:0051172 265 0.039
appendage development GO:0048736 401 0.038
positive regulation of cellular biosynthetic process GO:0031328 316 0.038
Fly
organic substance catabolic process GO:1901575 308 0.037
Fly
negative regulation of phosphate metabolic process GO:0045936 45 0.037
carboxylic acid metabolic process GO:0019752 92 0.037
post embryonic appendage morphogenesis GO:0035120 385 0.036
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.036
Fly
wing disc morphogenesis GO:0007472 344 0.036
regulation of protein metabolic process GO:0051246 256 0.036
sensory perception GO:0007600 196 0.036
protein complex biogenesis GO:0070271 201 0.036
ion transmembrane transport GO:0034220 122 0.035
response to lipopolysaccharide GO:0032496 4 0.035
Fly
negative regulation of mapk cascade GO:0043409 23 0.035
positive regulation of signaling GO:0023056 243 0.035
wound healing GO:0042060 75 0.035
cellular protein modification process GO:0006464 438 0.034
response to organic substance GO:0010033 284 0.034
Fly
regulation of multicellular organismal development GO:2000026 414 0.034
positive regulation of macromolecule metabolic process GO:0010604 405 0.034
neurological system process GO:0050877 358 0.034
regulation of stress activated protein kinase signaling cascade GO:0070302 42 0.034
organic acid metabolic process GO:0006082 103 0.033
negative regulation of multi organism process GO:0043901 29 0.033
Fly
compound eye development GO:0048749 307 0.033
response to monosaccharide GO:0034284 4 0.033
cation transmembrane transport GO:0098655 88 0.033
macromolecule catabolic process GO:0009057 161 0.032
Fly
response to hexose GO:0009746 3 0.032
transcription from rna polymerase ii promoter GO:0006366 368 0.032
regulation of cell differentiation GO:0045595 302 0.032
positive regulation of signal transduction GO:0009967 223 0.032
positive regulation of phosphorus metabolic process GO:0010562 139 0.032
negative regulation of response to biotic stimulus GO:0002832 12 0.032
Fly
regulation of production of molecular mediator of immune response GO:0002700 44 0.031
Fly
negative regulation of response to external stimulus GO:0032102 22 0.031
Fly
camera type eye development GO:0043010 4 0.031
positive regulation of defense response GO:0031349 59 0.031
Fly
positive regulation of cell migration GO:0030335 2 0.031
negative regulation of rna biosynthetic process GO:1902679 240 0.030
organophosphate metabolic process GO:0019637 195 0.030
response to wounding GO:0009611 94 0.030
regulation of stress activated mapk cascade GO:0032872 41 0.030
cellular amide metabolic process GO:0043603 80 0.030
Fly
negative regulation of biosynthetic process GO:0009890 277 0.030
positive regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0006964 12 0.030
Fly
cellular catabolic process GO:0044248 372 0.030
single organism catabolic process GO:0044712 228 0.029
biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002812 14 0.029
Fly
positive regulation of humoral immune response GO:0002922 28 0.029
Fly
nucleotide metabolic process GO:0009117 161 0.029
response to organic cyclic compound GO:0014070 89 0.028
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 65 0.028
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.028
sensory organ morphogenesis GO:0090596 260 0.028
organic substance transport GO:0071702 257 0.028
Fly
macromolecular complex assembly GO:0065003 256 0.027
response to glucose GO:0009749 2 0.027
negative regulation of transcription dna templated GO:0045892 237 0.027
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 38 0.027
actin filament based process GO:0030029 220 0.027
ameboidal type cell migration GO:0001667 151 0.027
homeostatic process GO:0042592 199 0.027
positive regulation of molecular function GO:0044093 136 0.027
cellular response to mechanical stimulus GO:0071260 2 0.027
nucleobase containing small molecule metabolic process GO:0055086 174 0.026
gene silencing GO:0016458 138 0.026
eye morphogenesis GO:0048592 260 0.026
regulation of programmed cell death GO:0043067 152 0.026
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 116 0.026
regulation of apoptotic process GO:0042981 130 0.026
positive regulation of cell death GO:0010942 69 0.026
mucopolysaccharide metabolic process GO:1903510 5 0.025
regulation of growth GO:0040008 233 0.025
compound eye morphogenesis GO:0001745 249 0.025
axis specification GO:0009798 167 0.025
protein complex assembly GO:0006461 200 0.025
protein modification process GO:0036211 438 0.025
positive regulation of response to external stimulus GO:0032103 44 0.025
Fly
reactive oxygen species metabolic process GO:0072593 22 0.025
positive regulation of immune response GO:0050778 63 0.025
Fly
negative regulation of stress activated protein kinase signaling cascade GO:0070303 20 0.024
regulation of molecular function GO:0065009 217 0.024
positive regulation of phosphate metabolic process GO:0045937 139 0.024
regulation of transmembrane transport GO:0034762 27 0.024
killing of cells of other organism GO:0031640 1 0.024
negative regulation of insulin secretion GO:0046676 1 0.024
regulation of catabolic process GO:0009894 170 0.024
single organism behavior GO:0044708 391 0.023
cell motility GO:0048870 251 0.023
leg disc development GO:0035218 92 0.023
cell adhesion GO:0007155 136 0.023
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.023
positive regulation of biosynthetic process of antibacterial peptides active against gram positive bacteria GO:0006965 3 0.023
Fly
positive regulation of gene expression GO:0010628 290 0.023
potassium ion transport GO:0006813 20 0.023
regulation of cell death GO:0010941 173 0.022
cellular amine metabolic process GO:0044106 12 0.022
positive regulation of rna metabolic process GO:0051254 271 0.022
proteolysis GO:0006508 192 0.022
mapk cascade GO:0000165 107 0.022
negative regulation of rna metabolic process GO:0051253 251 0.022
cell migration GO:0016477 238 0.022
heart process GO:0003015 37 0.022
regulation of mitotic cell cycle GO:0007346 190 0.022
nuclear division GO:0000280 332 0.022
regulation of cellular protein metabolic process GO:0032268 243 0.022
negative regulation of immune response GO:0050777 39 0.022
Fly
cellular response to hexose stimulus GO:0071331 1 0.022
negative regulation of multicellular organismal process GO:0051241 142 0.021
cellular response to oxygen containing compound GO:1901701 79 0.021
Fly
fat soluble vitamin biosynthetic process GO:0042362 1 0.021
metal ion transport GO:0030001 74 0.021
regulation of cellular component biogenesis GO:0044087 201 0.021
leg disc morphogenesis GO:0007478 80 0.021
negative regulation of developmental process GO:0051093 201 0.021
negative regulation of protein metabolic process GO:0051248 85 0.021
cell cell signaling involved in cell fate commitment GO:0045168 210 0.021
ommochrome biosynthetic process GO:0006727 19 0.021
cellular response to endogenous stimulus GO:0071495 80 0.021
lateral inhibition GO:0046331 206 0.021
organelle fission GO:0048285 340 0.021
purine ribonucleoside metabolic process GO:0046128 127 0.021
response to abiotic stimulus GO:0009628 341 0.021
single organism carbohydrate metabolic process GO:0044723 72 0.021
chemical homeostasis GO:0048878 92 0.021
cellular response to monosaccharide stimulus GO:0071326 2 0.021
positive regulation of catalytic activity GO:0043085 118 0.020
response to alkaloid GO:0043279 26 0.020
regulation of i kappab kinase nf kappab signaling GO:0043122 2 0.020
regulation of cellular ketone metabolic process GO:0010565 3 0.020
regulation of catalytic activity GO:0050790 185 0.020
cellular response to external stimulus GO:0071496 66 0.020
extrinsic apoptotic signaling pathway GO:0097191 1 0.020
carbohydrate metabolic process GO:0005975 82 0.020
ribonucleoside metabolic process GO:0009119 127 0.020
regulation of neuron death GO:1901214 26 0.020
developmental growth GO:0048589 280 0.020
establishment of localization in cell GO:0051649 402 0.020
ommochrome metabolic process GO:0046152 19 0.020
rhythmic process GO:0048511 106 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.019
protein processing GO:0016485 68 0.019
border follicle cell migration GO:0007298 113 0.019
digestive tract development GO:0048565 149 0.019
oocyte development GO:0048599 124 0.019
negative regulation of cellular protein metabolic process GO:0032269 85 0.019
locomotory behavior GO:0007626 176 0.019
chorion containing eggshell formation GO:0007304 105 0.019
chromosome segregation GO:0007059 157 0.018
response to lipid GO:0033993 38 0.018
Fly
reproductive behavior GO:0019098 122 0.018
retina development in camera type eye GO:0060041 4 0.018
inorganic ion transmembrane transport GO:0098660 73 0.018
inorganic cation transmembrane transport GO:0098662 61 0.018
programmed cell death GO:0012501 257 0.018
rhythmic behavior GO:0007622 76 0.018
monovalent inorganic cation transport GO:0015672 40 0.018
regulation of nervous system development GO:0051960 248 0.018
localization of cell GO:0051674 257 0.018
cellular response to organonitrogen compound GO:0071417 36 0.018
toxin catabolic process GO:0009407 1 0.018
nucleoside phosphate catabolic process GO:1901292 110 0.018
hemolymph coagulation GO:0042381 10 0.018
cellular response to carbohydrate stimulus GO:0071322 4 0.018
positive regulation of cellular amide metabolic process GO:0034250 26 0.017
Fly
response to molecule of bacterial origin GO:0002237 7 0.017
Fly
cellular response to peptide GO:1901653 28 0.017
ribonucleotide metabolic process GO:0009259 145 0.017
positive regulation of intracellular signal transduction GO:1902533 116 0.017
l glutamate import GO:0051938 1 0.017
male gamete generation GO:0048232 201 0.017
regulation of cellular amide metabolic process GO:0034248 39 0.017
Fly
vitamin biosynthetic process GO:0009110 1 0.017
negative regulation of cell cycle phase transition GO:1901988 103 0.017
embryonic pattern specification GO:0009880 174 0.017
apoptotic process GO:0006915 159 0.017
cellular response to abiotic stimulus GO:0071214 58 0.017
salivary gland morphogenesis GO:0007435 145 0.017
purine ribonucleotide metabolic process GO:0009150 145 0.017
negative regulation of growth GO:0045926 84 0.017
epithelial cell differentiation GO:0030855 322 0.017
tissue morphogenesis GO:0048729 297 0.017
negative regulation of cell cycle GO:0045786 116 0.017
cell cycle checkpoint GO:0000075 95 0.017
developmental maturation GO:0021700 172 0.017
regulation of cell cycle process GO:0010564 181 0.016
anatomical structure homeostasis GO:0060249 97 0.016
single organism cellular localization GO:1902580 180 0.016
tissue migration GO:0090130 155 0.016
amine metabolic process GO:0009308 12 0.016
cellular response to nitrogen compound GO:1901699 51 0.016
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.016
nucleoside phosphate metabolic process GO:0006753 162 0.016
chromosome organization GO:0051276 360 0.016
positive regulation of response to biotic stimulus GO:0002833 31 0.016
Fly
forebrain development GO:0030900 2 0.016
regulation of cell substrate adhesion GO:0010810 2 0.016
establishment of planar polarity GO:0001736 87 0.016
regulation of mitotic cell cycle phase transition GO:1901990 130 0.016
regulation of transport GO:0051049 181 0.016
protein phosphorylation GO:0006468 169 0.016
urogenital system development GO:0001655 72 0.016
positive regulation of programmed cell death GO:0043068 62 0.016
regulation of wnt signaling pathway GO:0030111 68 0.016
cellular response to lipid GO:0071396 20 0.016
Fly
positive regulation of antibacterial peptide production GO:0002803 20 0.016
Fly
negative regulation of cellular biosynthetic process GO:0031327 277 0.016
ovarian follicle cell migration GO:0007297 121 0.016
positive regulation of rna biosynthetic process GO:1902680 266 0.016
positive regulation of phosphorylation GO:0042327 87 0.016
positive regulation of cell motility GO:2000147 3 0.015
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.015
epithelium migration GO:0090132 148 0.015
regulation of cellular amine metabolic process GO:0033238 3 0.015
regulation of localization GO:0032879 275 0.015
organelle assembly GO:0070925 198 0.015
cellular response to starvation GO:0009267 61 0.015
regulation of cellular localization GO:0060341 136 0.015
regulation of gene expression epigenetic GO:0040029 128 0.015
protein import into nucleus GO:0006606 51 0.015
eggshell formation GO:0030703 105 0.015
spindle organization GO:0007051 253 0.015
protein localization GO:0008104 284 0.015
taxis GO:0042330 304 0.015
nucleoside metabolic process GO:0009116 127 0.015
glutathione metabolic process GO:0006749 37 0.015
regulation of developmental growth GO:0048638 174 0.015
regulation of organ morphogenesis GO:2000027 78 0.015
embryonic development via the syncytial blastoderm GO:0001700 148 0.015
response to nutrient levels GO:0031667 114 0.015
biological adhesion GO:0022610 138 0.014
cellular response to biotic stimulus GO:0071216 4 0.014
Fly
posttranscriptional regulation of gene expression GO:0010608 145 0.014
melanotic encapsulation of foreign target GO:0035011 30 0.014
dorsal ventral axis specification GO:0009950 66 0.014
hindgut development GO:0061525 58 0.014
positive regulation of transport GO:0051050 92 0.014
cellular response to ionizing radiation GO:0071479 15 0.014
aromatic compound catabolic process GO:0019439 166 0.014
positive regulation of reactive oxygen species metabolic process GO:2000379 0 0.014
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 18 0.014
purine nucleotide catabolic process GO:0006195 109 0.014
axonogenesis GO:0007409 290 0.014
dorsal ventral pattern formation GO:0009953 133 0.014
cellular nitrogen compound catabolic process GO:0044270 165 0.014
negative regulation of cell differentiation GO:0045596 143 0.014
respiratory system development GO:0060541 213 0.014
sensory perception of chemical stimulus GO:0007606 116 0.014
protein transport GO:0015031 155 0.014
cellular macromolecule localization GO:0070727 220 0.014
morphogenesis of an epithelium GO:0002009 276 0.014
response to alcohol GO:0097305 95 0.014
renal system development GO:0072001 72 0.014
kynurenine metabolic process GO:0070189 3 0.014
organophosphate catabolic process GO:0046434 112 0.014
digestive system development GO:0055123 149 0.014
benzene containing compound metabolic process GO:0042537 3 0.014
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
ribose phosphate metabolic process GO:0019693 145 0.014
positive regulation of hydrolase activity GO:0051345 78 0.014
secretion by cell GO:0032940 101 0.014
positive regulation of antimicrobial peptide biosynthetic process GO:0002807 26 0.014
Fly
chaeta development GO:0022416 97 0.013
negative regulation of cell death GO:0060548 81 0.013
single organism cell adhesion GO:0098602 47 0.013
pigmentation GO:0043473 75 0.013
notch signaling pathway GO:0007219 120 0.013
negative regulation of cell cycle process GO:0010948 109 0.013
regulation of secretion by cell GO:1903530 39 0.013
establishment of tissue polarity GO:0007164 87 0.013
ocellus pigment metabolic process GO:0046158 19 0.013
action potential GO:0001508 13 0.013
glycosaminoglycan metabolic process GO:0030203 11 0.013
Fly
membrane organization GO:0061024 112 0.013
regulation of protein modification process GO:0031399 112 0.013
response to oxidative stress GO:0006979 86 0.013
positive regulation of transcription dna templated GO:0045893 266 0.013
ion transport GO:0006811 145 0.013
regulation of transferase activity GO:0051338 58 0.013
regulation of hydrolase activity GO:0051336 97 0.013
mitotic nuclear division GO:0007067 213 0.013
negative regulation of peptide secretion GO:0002792 1 0.013
body morphogenesis GO:0010171 2 0.013
cranial nerve development GO:0021545 1 0.013
positive regulation of melanization defense response GO:0035008 1 0.013
dna metabolic process GO:0006259 227 0.013
cellular homeostasis GO:0019725 80 0.013
regulation of anatomical structure size GO:0090066 163 0.013
aminoglycan biosynthetic process GO:0006023 11 0.013
circadian behavior GO:0048512 76 0.013
cellular component assembly involved in morphogenesis GO:0010927 151 0.013
positive regulation of lipid metabolic process GO:0045834 4 0.013
tissue homeostasis GO:0001894 36 0.013
regulation of epithelial cell differentiation GO:0030856 4 0.013
dna integrity checkpoint GO:0031570 81 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
gland morphogenesis GO:0022612 145 0.013
secretion GO:0046903 109 0.013
glycosyl compound metabolic process GO:1901657 127 0.013
positive regulation of protein metabolic process GO:0051247 128 0.013
regulation of proteolysis GO:0030162 87 0.013
salivary gland development GO:0007431 162 0.013
positive regulation of apoptotic process GO:0043065 47 0.013
response to ionizing radiation GO:0010212 32 0.013
neuron projection guidance GO:0097485 241 0.013
positive regulation of apoptotic signaling pathway GO:2001235 4 0.012
cellular protein localization GO:0034613 160 0.012
positive regulation of nucleic acid templated transcription GO:1903508 266 0.012
myotube cell development GO:0014904 3 0.012
wnt signaling pathway GO:0016055 98 0.012
regulation of cellular catabolic process GO:0031329 157 0.012
locomotor rhythm GO:0045475 56 0.012
morphogenesis of a polarized epithelium GO:0001738 93 0.012
segmentation GO:0035282 207 0.012
ribonucleoside triphosphate metabolic process GO:0009199 119 0.012
cation transport GO:0006812 110 0.012
regulation of tube size GO:0035150 46 0.012
regulation of synapse structure and activity GO:0050803 128 0.012
open tracheal system development GO:0007424 204 0.012
nucleoside triphosphate metabolic process GO:0009141 120 0.012

PGRP-LF disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.074
cardiovascular system disease DOID:1287 0 0.074
nervous system disease DOID:863 0 0.038
kidney disease DOID:557 0 0.038
urinary system disease DOID:18 0 0.038
disease of metabolism DOID:0014667 0 0.027
acquired metabolic disease DOID:0060158 0 0.027
sensory system disease DOID:0050155 0 0.026
eye and adnexa disease DOID:1492 0 0.026
eye disease DOID:5614 0 0.026
heart conduction disease DOID:10273 0 0.024
renal tubular transport disease DOID:447 0 0.023
inherited metabolic disorder DOID:655 0 0.023
disease of cellular proliferation DOID:14566 0 0.023
diabetes mellitus DOID:9351 0 0.022
carbohydrate metabolism disease DOID:0050013 0 0.022
glucose metabolism disease DOID:4194 0 0.022
type 2 diabetes mellitus DOID:9352 0 0.021
cancer DOID:162 0 0.019
organ system cancer DOID:0050686 0 0.018
bartter disease DOID:445 0 0.012