Drosophila melanogaster

78 known processes

Mlf (Dmel_CG8295)

Myelodysplasia/myeloid leukemia factor

(Aliases: MLF,CG8295,dMLF,Dmel\CG8295,BcDNA:SD18148,dmlf)

Mlf biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein modification by small protein conjugation or removal GO:0070647 106 0.546
cell death GO:0008219 279 0.521
regulation of cell cycle GO:0051726 291 0.473
endocytosis GO:0006897 310 0.411
programmed cell death GO:0012501 257 0.400
death GO:0016265 284 0.376
positive regulation of cellular component organization GO:0051130 156 0.354
protein ubiquitination GO:0016567 70 0.339
positive regulation of rna metabolic process GO:0051254 271 0.252
organic substance catabolic process GO:1901575 308 0.238
vesicle mediated transport GO:0016192 381 0.223
dendrite development GO:0016358 204 0.188
intracellular signal transduction GO:0035556 300 0.176
regulation of cellular component biogenesis GO:0044087 201 0.171
positive regulation of gene expression GO:0010628 290 0.170
embryo development ending in birth or egg hatching GO:0009792 152 0.164
apoptotic process GO:0006915 159 0.160
neuromuscular junction development GO:0007528 149 0.159
heterocycle catabolic process GO:0046700 166 0.157
cellular nitrogen compound catabolic process GO:0044270 165 0.147
cellular macromolecule catabolic process GO:0044265 136 0.144
protein modification by small protein conjugation GO:0032446 79 0.126
negative regulation of apoptotic process GO:0043066 63 0.123
catabolic process GO:0009056 409 0.112
synapse organization GO:0050808 196 0.107
positive regulation of signal transduction GO:0009967 223 0.104
negative regulation of cyclin dependent protein serine threonine kinase activity GO:0045736 1 0.102
negative regulation of cell death GO:0060548 81 0.101
aromatic compound catabolic process GO:0019439 166 0.100
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.098
purine ribonucleotide metabolic process GO:0009150 145 0.093
regulation of localization GO:0032879 275 0.092
negative regulation of rna metabolic process GO:0051253 251 0.091
phosphorylation GO:0016310 294 0.089
nucleobase containing compound catabolic process GO:0034655 165 0.086
macromolecular complex assembly GO:0065003 256 0.084
posttranscriptional regulation of gene expression GO:0010608 145 0.083
cellular catabolic process GO:0044248 372 0.082
positive regulation of cellular biosynthetic process GO:0031328 316 0.081
organonitrogen compound biosynthetic process GO:1901566 117 0.079
establishment of localization in cell GO:0051649 402 0.076
organic acid metabolic process GO:0006082 103 0.075
developmental pigmentation GO:0048066 68 0.069
regulation of cell proliferation GO:0042127 163 0.069
embryonic development via the syncytial blastoderm GO:0001700 148 0.069
negative regulation of cell cycle GO:0045786 116 0.068
gland development GO:0048732 191 0.068
synaptic transmission GO:0007268 288 0.066
regulation of phosphate metabolic process GO:0019220 210 0.066
regulation of apoptotic process GO:0042981 130 0.065
oxoacid metabolic process GO:0043436 103 0.064
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.062
purine ribonucleotide catabolic process GO:0009154 109 0.062
cell proliferation GO:0008283 299 0.060
homeostatic process GO:0042592 199 0.060
negative regulation of programmed cell death GO:0043069 72 0.060
regulation of cell death GO:0010941 173 0.059
positive regulation of phosphate metabolic process GO:0045937 139 0.059
positive regulation of transcription dna templated GO:0045893 266 0.055
regulation of programmed cell death GO:0043067 152 0.055
transcription from rna polymerase ii promoter GO:0006366 368 0.054
cell cycle checkpoint GO:0000075 95 0.051
negative regulation of developmental process GO:0051093 201 0.051
organonitrogen compound metabolic process GO:1901564 318 0.050
regulation of phosphorylation GO:0042325 147 0.050
oocyte microtubule cytoskeleton organization GO:0016325 35 0.050
protein localization to nucleus GO:0034504 55 0.050
regulation of phosphorus metabolic process GO:0051174 210 0.049
positive regulation of catabolic process GO:0009896 105 0.049
small molecule metabolic process GO:0044281 305 0.048
nucleoside phosphate catabolic process GO:1901292 110 0.048
negative regulation of cell differentiation GO:0045596 143 0.048
cellular protein modification process GO:0006464 438 0.047
regulation of synapse structure and activity GO:0050803 128 0.047
phagocytosis GO:0006909 215 0.047
positive regulation of phosphorus metabolic process GO:0010562 139 0.046
cell division GO:0051301 248 0.046
regulation of molecular function GO:0065009 217 0.043
positive regulation of cellular amine metabolic process GO:0033240 0 0.043
membrane organization GO:0061024 112 0.042
negative regulation of cellular macromolecule biosynthetic process GO:2000113 267 0.042
organophosphate metabolic process GO:0019637 195 0.041
protein localization to organelle GO:0033365 82 0.041
response to external biotic stimulus GO:0043207 293 0.040
positive regulation of proteolysis involved in cellular protein catabolic process GO:1903052 24 0.040
pigmentation GO:0043473 75 0.040
cellular response to dna damage stimulus GO:0006974 223 0.040
ribonucleotide catabolic process GO:0009261 109 0.039
protein modification process GO:0036211 438 0.039
regulation of reproductive process GO:2000241 54 0.038
growth GO:0040007 359 0.037
rna processing GO:0006396 147 0.037
immune system development GO:0002520 57 0.036
positive regulation of rna biosynthetic process GO:1902680 266 0.036
regulation of cell development GO:0060284 215 0.035
reproductive system development GO:0061458 74 0.035
regulation of intracellular signal transduction GO:1902531 236 0.035
hemopoiesis GO:0030097 46 0.035
regulation of synaptic transmission GO:0050804 69 0.035
nucleus organization GO:0006997 45 0.035
regulation of transport GO:0051049 181 0.035
positive regulation of programmed cell death GO:0043068 62 0.035
axis specification GO:0009798 167 0.035
cellular protein catabolic process GO:0044257 83 0.034
germ line stem cell maintenance GO:0030718 50 0.033
neurological system process GO:0050877 358 0.032
camera type eye development GO:0043010 4 0.032
regulation of canonical wnt signaling pathway GO:0060828 15 0.032
negative regulation of multicellular organismal process GO:0051241 142 0.032
larval development GO:0002164 104 0.032
positive regulation of cell death GO:0010942 69 0.032
cellular macromolecule localization GO:0070727 220 0.030
macromolecule catabolic process GO:0009057 161 0.030
regulation of mitotic cell cycle GO:0007346 190 0.030
positive regulation of nucleic acid templated transcription GO:1903508 266 0.030
eye morphogenesis GO:0048592 260 0.029
appendage development GO:0048736 401 0.029
purine nucleotide metabolic process GO:0006163 146 0.029
immune system process GO:0002376 347 0.029
positive regulation of macromolecule metabolic process GO:0010604 405 0.028
nucleoside phosphate metabolic process GO:0006753 162 0.028
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.028
ras protein signal transduction GO:0007265 88 0.027
nucleotide metabolic process GO:0009117 161 0.027
connective tissue development GO:0061448 3 0.026
adult behavior GO:0030534 137 0.026
secretion GO:0046903 109 0.026
positive regulation of transport GO:0051050 92 0.026
mapk cascade GO:0000165 107 0.026
stem cell maintenance GO:0019827 67 0.025
cellular protein localization GO:0034613 160 0.025
positive regulation of cell communication GO:0010647 250 0.025
protein targeting to nucleus GO:0044744 51 0.025
regulation of establishment of protein localization GO:0070201 61 0.025
negative regulation of biosynthetic process GO:0009890 277 0.025
positive regulation of response to stimulus GO:0048584 323 0.024
regulation of mrna 3 end processing GO:0031440 7 0.024
purine containing compound catabolic process GO:0072523 112 0.024
negative regulation of cell proliferation GO:0008285 69 0.024
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 3 0.024
regulation of wnt signaling pathway GO:0030111 68 0.024
mitotic dna damage checkpoint GO:0044773 74 0.024
positive regulation of apoptotic signaling pathway GO:2001235 4 0.024
regulation of anatomical structure morphogenesis GO:0022603 242 0.024
chondroitin sulfate biosynthetic process GO:0030206 2 0.024
cellular response to starvation GO:0009267 61 0.023
regulation of catalytic activity GO:0050790 185 0.022
rhythmic process GO:0048511 106 0.022
negative regulation of response to stimulus GO:0048585 258 0.022
taxis GO:0042330 304 0.022
actin filament based process GO:0030029 220 0.022
signal transduction by phosphorylation GO:0023014 107 0.021
positive regulation of transcription from rna polymerase ii promoter GO:0045944 204 0.021
positive regulation of protein transport GO:0051222 37 0.021
regulation of cellular protein metabolic process GO:0032268 243 0.021
intrinsic apoptotic signaling pathway GO:0097193 16 0.021
negative regulation of cellular metabolic process GO:0031324 382 0.020
meiotic cytokinesis GO:0033206 33 0.020
negative regulation of rna biosynthetic process GO:1902679 240 0.020
peptidyl amino acid modification GO:0018193 105 0.020
mitotic g2 m transition checkpoint GO:0044818 70 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.020
negative regulation of cellular protein metabolic process GO:0032269 85 0.019
rna phosphodiester bond hydrolysis GO:0090501 17 0.019
histone modification GO:0016570 106 0.019
reproductive structure development GO:0048608 74 0.019
tissue morphogenesis GO:0048729 297 0.019
small gtpase mediated signal transduction GO:0007264 88 0.019
ribose phosphate metabolic process GO:0019693 145 0.019
purine nucleoside triphosphate metabolic process GO:0009144 119 0.019
apoptotic signaling pathway GO:0097190 27 0.019
erk1 and erk2 cascade GO:0070371 39 0.019
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 4 0.018
mitotic g2 dna damage checkpoint GO:0007095 69 0.018
chromosome organization GO:0051276 360 0.018
regulation of immune response GO:0050776 118 0.018
exocrine system development GO:0035272 162 0.018
axon cargo transport GO:0008088 29 0.018
regulation of vesicle mediated transport GO:0060627 59 0.018
development of primary sexual characteristics GO:0045137 50 0.018
single organism biosynthetic process GO:0044711 206 0.017
regulation of endocytosis GO:0030100 37 0.017
organic cyclic compound catabolic process GO:1901361 168 0.017
intracellular transport GO:0046907 228 0.017
regulation of protein complex assembly GO:0043254 42 0.017
retrograde transport endosome to golgi GO:0042147 3 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
nucleoside triphosphate metabolic process GO:0009141 120 0.017
positive regulation of signaling GO:0023056 243 0.017
regulation of protein stability GO:0031647 43 0.016
purine ribonucleoside catabolic process GO:0046130 112 0.016
positive regulation of molecular function GO:0044093 136 0.016
nucleoside triphosphate catabolic process GO:0009143 108 0.016
modification dependent macromolecule catabolic process GO:0043632 79 0.016
mitotic cell cycle checkpoint GO:0007093 88 0.016
carbohydrate derivative metabolic process GO:1901135 217 0.016
autophagic cell death GO:0048102 83 0.016
response to endogenous stimulus GO:0009719 119 0.016
carbohydrate metabolic process GO:0005975 82 0.016
purine nucleotide catabolic process GO:0006195 109 0.015
dendrite morphogenesis GO:0048813 199 0.015
regulation of nervous system development GO:0051960 248 0.015
chaeta development GO:0022416 97 0.015
negative regulation of cell communication GO:0010648 223 0.015
single organism intracellular transport GO:1902582 207 0.015
cortical cytoskeleton organization GO:0030865 29 0.015
nuclear transcribed mrna poly a tail shortening GO:0000289 12 0.015
photoreceptor cell differentiation GO:0046530 170 0.015
eye pigmentation GO:0048069 43 0.014
histone deubiquitination GO:0016578 8 0.014
single organism nuclear import GO:1902593 51 0.014
negative regulation of gene expression GO:0010629 387 0.014
eye photoreceptor cell development GO:0042462 81 0.014
purine nucleoside metabolic process GO:0042278 127 0.014
actin cytoskeleton organization GO:0030036 206 0.014
hematopoietic progenitor cell differentiation GO:0002244 1 0.013
negative regulation of cell cycle process GO:0010948 109 0.013
regulation of protein metabolic process GO:0051246 256 0.013
receptor mediated endocytosis GO:0006898 21 0.013
regulation of cytoplasmic transport GO:1903649 47 0.013
purine containing compound metabolic process GO:0072521 155 0.013
meiotic cell cycle process GO:1903046 132 0.013
membrane disassembly GO:0030397 4 0.013
synapse assembly GO:0007416 143 0.013
positive regulation of protein catabolic process GO:0045732 34 0.013
cytoplasmic transport GO:0016482 130 0.013
nucleocytoplasmic transport GO:0006913 72 0.013
ribonucleoside metabolic process GO:0009119 127 0.013
regulation of cellular amine metabolic process GO:0033238 3 0.013
ion transport GO:0006811 145 0.013
protein catabolic process GO:0030163 101 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 261 0.013
nucleoside metabolic process GO:0009116 127 0.012
anterior posterior pattern specification GO:0009952 136 0.012
regulation of protein ubiquitination GO:0031396 22 0.012
post embryonic appendage morphogenesis GO:0035120 385 0.012
organelle assembly GO:0070925 198 0.012
rhabdomere development GO:0042052 38 0.012
negative regulation of signal transduction GO:0009968 206 0.012
response to abiotic stimulus GO:0009628 341 0.012
regulation of protein transport GO:0051223 57 0.012
regulation of protein localization GO:0032880 76 0.012
response to biotic stimulus GO:0009607 294 0.012
regulation of protein modification process GO:0031399 112 0.012
cellular homeostasis GO:0019725 80 0.012
dna damage checkpoint GO:0000077 78 0.012
developmental programmed cell death GO:0010623 138 0.012
regulation of gene expression epigenetic GO:0040029 128 0.012
dna templated transcription elongation GO:0006354 18 0.012
negative regulation of nucleic acid templated transcription GO:1903507 240 0.011
vesicle organization GO:0016050 44 0.011
regulation of protein import into nucleus GO:0042306 28 0.011
negative regulation of immune response GO:0050777 39 0.011
stem cell development GO:0048864 79 0.011
dna amplification GO:0006277 11 0.011
regulation of cellular localization GO:0060341 136 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
hematopoietic or lymphoid organ development GO:0048534 57 0.011
muscle organ development GO:0007517 127 0.011
arf protein signal transduction GO:0032011 2 0.011
regulation of multi organism process GO:0043900 131 0.011
regulation of synapse organization GO:0050807 110 0.011
single organism catabolic process GO:0044712 228 0.011
positive regulation of phosphorylation GO:0042327 87 0.011
axon development GO:0061564 297 0.010
establishment or maintenance of microtubule cytoskeleton polarity GO:0030951 41 0.010
synaptic transmission gabaergic GO:0051932 1 0.010
ribonucleoside catabolic process GO:0042454 112 0.010
nucleobase containing small molecule metabolic process GO:0055086 174 0.010
response to other organism GO:0051707 293 0.010
embryonic organ development GO:0048568 50 0.010
regulation of multicellular organismal development GO:2000026 414 0.010

Mlf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
male reproductive organ cancer DOID:3856 0 0.018
reproductive organ cancer DOID:193 0 0.018
cancer DOID:162 0 0.018
organ system cancer DOID:0050686 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
musculoskeletal system disease DOID:17 0 0.011
disease of anatomical entity DOID:7 0 0.011