Drosophila melanogaster

238 known processes

Iap2 (Dmel_CG8293)

Inhibitor of apoptosis 2

(Aliases: Diha,dIAP2,dIAP,dILP,CG8293,IAP2,IAP,DIHA,Dmel\CG8293,D-iap2,Diap,Ilp,D-IAP2,diap2,DIAP2,DIAPII,Diap2,DIAP-2,DIAP)

Iap2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein complex assembly GO:0006461 200 0.391
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 25 0.327
regulation of peptidase activity GO:0052547 39 0.324
regulation of endopeptidase activity GO:0052548 36 0.265
regulation of response to stress GO:0080134 200 0.234
regulation of cellular protein metabolic process GO:0032268 243 0.194
positive regulation of response to stimulus GO:0048584 323 0.186
negative regulation of cellular metabolic process GO:0031324 382 0.169
regulation of protein metabolic process GO:0051246 256 0.147
transmembrane transport GO:0055085 139 0.144
negative regulation of signaling GO:0023057 219 0.137
regulation of programmed cell death GO:0043067 152 0.137
cell death GO:0008219 279 0.120
regulation of hydrolase activity GO:0051336 97 0.099
positive regulation of cellular biosynthetic process GO:0031328 316 0.096
regulation of intracellular signal transduction GO:1902531 236 0.090
positive regulation of nitrogen compound metabolic process GO:0051173 354 0.087
intracellular signal transduction GO:0035556 300 0.086
organic substance catabolic process GO:1901575 308 0.085
peptide metabolic process GO:0006518 80 0.085
positive regulation of peptidase activity GO:0010952 29 0.083
death GO:0016265 284 0.080
positive regulation of multi organism process GO:0043902 40 0.079
apoptotic process GO:0006915 159 0.078
regulation of cell death GO:0010941 173 0.075
regulation of cysteine type endopeptidase activity GO:2000116 27 0.073
positive regulation of biosynthetic process GO:0009891 316 0.071
immune response GO:0006955 246 0.069
purine containing compound metabolic process GO:0072521 155 0.067
establishment of localization in cell GO:0051649 402 0.067
central nervous system development GO:0007417 201 0.067
catabolic process GO:0009056 409 0.064
spermatid differentiation GO:0048515 114 0.063
positive regulation of response to external stimulus GO:0032103 44 0.060
dendrite development GO:0016358 204 0.058
protein localization GO:0008104 284 0.056
positive regulation of endopeptidase activity GO:0010950 26 0.056
programmed cell death GO:0012501 257 0.054
phosphorylation GO:0016310 294 0.054
spermatogenesis GO:0007283 200 0.051
macromolecule catabolic process GO:0009057 161 0.051
centrosome organization GO:0051297 163 0.051
response to bacterium GO:0009617 198 0.050
positive regulation of nucleobase containing compound metabolic process GO:0045935 332 0.049
positive regulation of transport GO:0051050 92 0.049
cellular homeostasis GO:0019725 80 0.049
cellular amide metabolic process GO:0043603 80 0.049
negative regulation of cell death GO:0060548 81 0.049
embryo development ending in birth or egg hatching GO:0009792 152 0.048
posttranscriptional regulation of gene expression GO:0010608 145 0.048
negative regulation of signal transduction GO:0009968 206 0.047
vesicle mediated transport GO:0016192 381 0.045
negative regulation of cell communication GO:0010648 223 0.044
organonitrogen compound biosynthetic process GO:1901566 117 0.043
regulation of defense response GO:0031347 102 0.043
response to biotic stimulus GO:0009607 294 0.042
negative regulation of response to stimulus GO:0048585 258 0.041
positive regulation of macromolecule metabolic process GO:0010604 405 0.041
regulation of cellular response to stress GO:0080135 89 0.041
positive regulation of catalytic activity GO:0043085 118 0.040
positive regulation of signaling GO:0023056 243 0.040
spermatid development GO:0007286 98 0.040
positive regulation of cell communication GO:0010647 250 0.040
regulation of anatomical structure morphogenesis GO:0022603 242 0.039
proteolysis GO:0006508 192 0.039
intracellular transport GO:0046907 228 0.038
single organism membrane organization GO:0044802 93 0.038
body morphogenesis GO:0010171 2 0.038
regulation of molecular function GO:0065009 217 0.038
spindle organization GO:0007051 253 0.038
regulation of proteolysis GO:0030162 87 0.037
positive regulation of proteolysis GO:0045862 52 0.036
cellular component disassembly GO:0022411 46 0.035
cellular catabolic process GO:0044248 372 0.035
positive regulation of signal transduction GO:0009967 223 0.035
positive regulation of defense response to bacterium GO:1900426 23 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 378 0.034
single organism cellular localization GO:1902580 180 0.034
positive regulation of rna metabolic process GO:0051254 271 0.033
aromatic compound catabolic process GO:0019439 166 0.033
organonitrogen compound catabolic process GO:1901565 128 0.032
protein processing GO:0016485 68 0.032
antibacterial humoral response GO:0019731 44 0.032
positive regulation of immune system process GO:0002684 68 0.032
regulation of innate immune response GO:0045088 71 0.032
regulation of phosphorus metabolic process GO:0051174 210 0.032
antibacterial peptide biosynthetic process GO:0002780 22 0.031
melanization defense response GO:0035006 45 0.031
small molecule metabolic process GO:0044281 305 0.031
single organism catabolic process GO:0044712 228 0.031
single organism intracellular transport GO:1902582 207 0.031
regulation of immune response GO:0050776 118 0.031
regulation of cell cycle GO:0051726 291 0.031
intracellular protein transport GO:0006886 104 0.031
guanosine containing compound catabolic process GO:1901069 74 0.031
cellular macromolecule catabolic process GO:0044265 136 0.031
positive regulation of cellular protein metabolic process GO:0032270 118 0.030
cellular nitrogen compound catabolic process GO:0044270 165 0.030
negative regulation of apoptotic process GO:0043066 63 0.029
homeostatic process GO:0042592 199 0.029
antibacterial peptide production GO:0002778 22 0.029
macromolecular complex assembly GO:0065003 256 0.029
positive regulation of cell death GO:0010942 69 0.029
forebrain development GO:0030900 2 0.028
positive regulation of immune response GO:0050778 63 0.028
purine nucleoside metabolic process GO:0042278 127 0.028
protein modification process GO:0036211 438 0.028
microtubule organizing center organization GO:0031023 168 0.028
compound eye development GO:0048749 307 0.027
dendrite morphogenesis GO:0048813 199 0.027
regulation of catalytic activity GO:0050790 185 0.027
chromosome organization GO:0051276 360 0.027
compound eye morphogenesis GO:0001745 249 0.027
cellular protein modification process GO:0006464 438 0.027
jak stat cascade GO:0007259 49 0.026
heterocycle catabolic process GO:0046700 166 0.026
positive regulation of programmed cell death GO:0043068 62 0.026
negative regulation of endopeptidase activity GO:0010951 11 0.026
positive regulation of nucleic acid templated transcription GO:1903508 266 0.025
regulation of immune system process GO:0002682 176 0.025
cell proliferation GO:0008283 299 0.025
single organism behavior GO:0044708 391 0.024
endomembrane system organization GO:0010256 119 0.024
immune system process GO:0002376 347 0.024
regulation of multi organism process GO:0043900 131 0.024
positive regulation of protein metabolic process GO:0051247 128 0.024
mitochondrion organization GO:0007005 65 0.024
positive regulation of apoptotic process GO:0043065 47 0.024
defense response to gram negative bacterium GO:0050829 94 0.023
regulation of apoptotic process GO:0042981 130 0.023
cell migration GO:0016477 238 0.023
nucleoside phosphate metabolic process GO:0006753 162 0.023
enzyme linked receptor protein signaling pathway GO:0007167 179 0.023
male gamete generation GO:0048232 201 0.023
embryonic development via the syncytial blastoderm GO:0001700 148 0.022
positive regulation of intracellular signal transduction GO:1902533 116 0.022
microtubule based transport GO:0010970 42 0.022
defense response to bacterium GO:0042742 178 0.022
purine ribonucleoside metabolic process GO:0046128 127 0.022
regulation of phosphorylation GO:0042325 147 0.021
organic hydroxy compound metabolic process GO:1901615 83 0.021
negative regulation of biosynthetic process GO:0009890 277 0.021
defense response GO:0006952 300 0.021
cellular macromolecular complex assembly GO:0034622 153 0.021
cation transport GO:0006812 110 0.021
actin cytoskeleton organization GO:0030036 206 0.021
response to radiation GO:0009314 155 0.021
ovarian follicle cell development GO:0030707 248 0.021
cell cell signaling involved in cell fate commitment GO:0045168 210 0.020
regulation of mapk cascade GO:0043408 92 0.020
positive regulation of hydrolase activity GO:0051345 78 0.020
negative regulation of gene expression GO:0010629 387 0.020
mapk cascade GO:0000165 107 0.020
ion transport GO:0006811 145 0.020
melanin metabolic process GO:0006582 47 0.020
positive regulation of phosphorus metabolic process GO:0010562 139 0.019
cell division GO:0051301 248 0.019
protein complex biogenesis GO:0070271 201 0.019
macromolecular complex disassembly GO:0032984 37 0.019
endocytosis GO:0006897 310 0.019
nucleobase containing compound catabolic process GO:0034655 165 0.019
regulation of organelle organization GO:0033043 196 0.019
protein catabolic process GO:0030163 101 0.019
positive regulation of multicellular organismal process GO:0051240 143 0.019
ion transmembrane transport GO:0034220 122 0.019
immune system development GO:0002520 57 0.019
chaeta development GO:0022416 97 0.019
positive regulation of developmental process GO:0051094 143 0.019
organic cyclic compound catabolic process GO:1901361 168 0.019
developmental programmed cell death GO:0010623 138 0.019
appendage morphogenesis GO:0035107 397 0.018
intracellular protein transmembrane transport GO:0065002 4 0.018
protein modification by small protein conjugation or removal GO:0070647 106 0.018
establishment of protein localization GO:0045184 163 0.018
metal ion homeostasis GO:0055065 44 0.018
male mating behavior GO:0060179 70 0.018
protein transmembrane transport GO:0071806 4 0.018
positive regulation of macromolecule biosynthetic process GO:0010557 283 0.018
immune effector process GO:0002252 98 0.018
cell motility GO:0048870 251 0.018
protein modification by small protein conjugation GO:0032446 79 0.017
nucleus organization GO:0006997 45 0.017
metal ion transport GO:0030001 74 0.017
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 23 0.017
organonitrogen compound metabolic process GO:1901564 318 0.017
purine ribonucleoside catabolic process GO:0046130 112 0.017
chromatin organization GO:0006325 207 0.017
pigment metabolic process GO:0042440 84 0.017
carboxylic acid metabolic process GO:0019752 92 0.017
regulation of vesicle mediated transport GO:0060627 59 0.016
regulation of cellular amine metabolic process GO:0033238 3 0.016
embryonic morphogenesis GO:0048598 206 0.016
innate immune response GO:0045087 144 0.016
regulation of cell shape GO:0008360 113 0.016
regulation of transport GO:0051049 181 0.016
appendage development GO:0048736 401 0.016
protein localization to organelle GO:0033365 82 0.016
positive regulation of apoptotic signaling pathway GO:2001235 4 0.016
transcription from rna polymerase ii promoter GO:0006366 368 0.016
regulation of catabolic process GO:0009894 170 0.016
peptidyl amino acid modification GO:0018193 105 0.016
regulation of execution phase of apoptosis GO:1900117 5 0.015
establishment of organelle localization GO:0051656 122 0.015
regulation of antibacterial peptide biosynthetic process GO:0002808 22 0.015
brain development GO:0007420 120 0.015
purine nucleoside catabolic process GO:0006152 112 0.015
protein maturation GO:0051604 71 0.015
positive regulation of gene expression GO:0010628 290 0.015
cytoskeleton dependent intracellular transport GO:0030705 44 0.015
amide biosynthetic process GO:0043604 42 0.015
oxoacid metabolic process GO:0043436 103 0.015
negative regulation of intracellular signal transduction GO:1902532 57 0.015
eye morphogenesis GO:0048592 260 0.015
tissue morphogenesis GO:0048729 297 0.014
regulation of protein modification process GO:0031399 112 0.014
translation GO:0006412 69 0.014
microtubule based movement GO:0007018 51 0.014
mitotic cell cycle phase transition GO:0044772 138 0.014
regulation of production of molecular mediator of immune response GO:0002700 44 0.014
centrosome duplication GO:0051298 121 0.014
regulation of immune effector process GO:0002697 52 0.014
response to other organism GO:0051707 293 0.014
mitochondrion morphogenesis GO:0070584 8 0.014
cellular metal ion homeostasis GO:0006875 31 0.014
regulation of protein processing GO:0070613 32 0.014
negative regulation of phosphate metabolic process GO:0045936 45 0.014
regulation of multicellular organismal development GO:2000026 414 0.013
glycosyl compound metabolic process GO:1901657 127 0.013
regulation of phosphate metabolic process GO:0019220 210 0.013
regulation of mitotic cell cycle phase transition GO:1901990 130 0.013
ribose phosphate metabolic process GO:0019693 145 0.013
ameboidal type cell migration GO:0001667 151 0.013
cellular macromolecule localization GO:0070727 220 0.013
organelle fission GO:0048285 340 0.013
nucleoside triphosphate catabolic process GO:0009143 108 0.013
response to abiotic stimulus GO:0009628 341 0.013
reactive oxygen species metabolic process GO:0072593 22 0.013
nucleobase containing small molecule metabolic process GO:0055086 174 0.013
negative regulation of nucleic acid templated transcription GO:1903507 240 0.013
regulation of cellular localization GO:0060341 136 0.013
negative regulation of mitotic cell cycle phase transition GO:1901991 103 0.013
positive regulation of cellular catabolic process GO:0031331 95 0.013
response to organic substance GO:0010033 284 0.013
carbohydrate derivative catabolic process GO:1901136 118 0.012
response to external biotic stimulus GO:0043207 293 0.012
signal transduction by phosphorylation GO:0023014 107 0.012
positive regulation of cysteine type endopeptidase activity GO:2001056 24 0.012
negative regulation of cell cycle phase transition GO:1901988 103 0.012
peptide biosynthetic process GO:0043043 42 0.012
ribonucleoside metabolic process GO:0009119 127 0.012
negative regulation of macromolecule biosynthetic process GO:0010558 270 0.012
negative regulation of proteolysis GO:0045861 31 0.012
determination of adult lifespan GO:0008340 137 0.012
negative regulation of protein metabolic process GO:0051248 85 0.012
nucleoside triphosphate metabolic process GO:0009141 120 0.012
development of primary sexual characteristics GO:0045137 50 0.012
positive regulation of production of molecular mediator of immune response GO:0002702 28 0.012
purine ribonucleotide metabolic process GO:0009150 145 0.012
positive regulation of wnt signaling pathway GO:0030177 25 0.012
positive regulation of defense response GO:0031349 59 0.012
adult behavior GO:0030534 137 0.012
protein acetylation GO:0006473 39 0.012
columnar cuboidal epithelial cell differentiation GO:0002065 256 0.012
antimicrobial humoral response GO:0019730 99 0.012
protein secretion GO:0009306 45 0.012
carbohydrate derivative metabolic process GO:1901135 217 0.011
purine containing compound catabolic process GO:0072523 112 0.011
positive regulation of antibacterial peptide production GO:0002803 20 0.011
salivary gland morphogenesis GO:0007435 145 0.011
regulation of cell proliferation GO:0042127 163 0.011
localization of cell GO:0051674 257 0.011
positive regulation of molecular function GO:0044093 136 0.011
regulation of translation GO:0006417 56 0.011
developmental maturation GO:0021700 172 0.011
epithelium migration GO:0090132 148 0.011
cellular amino acid metabolic process GO:0006520 61 0.011
regulation of biosynthetic process of antibacterial peptides active against gram negative bacteria GO:0002813 14 0.011
negative regulation of molecular function GO:0044092 51 0.011
purine nucleoside triphosphate metabolic process GO:0009144 119 0.011
hematopoietic or lymphoid organ development GO:0048534 57 0.011
mitotic spindle organization GO:0007052 220 0.011
gland development GO:0048732 191 0.011
nucleoside catabolic process GO:0009164 112 0.011
regulation of antibacterial peptide production GO:0002786 22 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
stress activated protein kinase signaling cascade GO:0031098 55 0.011
spindle assembly GO:0051225 80 0.011
protein ubiquitination GO:0016567 70 0.011
antimicrobial peptide biosynthetic process GO:0002777 38 0.011
membrane organization GO:0061024 112 0.011
regulation of cellular catabolic process GO:0031329 157 0.011
negative regulation of mitotic cell cycle GO:0045930 109 0.011
regulation of localization GO:0032879 275 0.011
purine ribonucleoside triphosphate metabolic process GO:0009205 119 0.011
morphogenesis of an epithelium GO:0002009 276 0.011
phagocytosis GO:0006909 215 0.011
chaeta morphogenesis GO:0008407 42 0.011
regulation of organ morphogenesis GO:2000027 78 0.010
protein transport GO:0015031 155 0.010
positive regulation of cellular component organization GO:0051130 156 0.010
negative regulation of phosphorus metabolic process GO:0010563 45 0.010
tissue death GO:0016271 102 0.010
developmental growth GO:0048589 280 0.010
nephron development GO:0072006 3 0.010
gtp metabolic process GO:0046039 72 0.010
translational elongation GO:0006414 4 0.010
protein modification by small protein removal GO:0070646 28 0.010
cell cycle phase transition GO:0044770 140 0.010
negative regulation of cellular protein metabolic process GO:0032269 85 0.010
protein polymerization GO:0051258 42 0.010
positive regulation of rna biosynthetic process GO:1902680 266 0.010

Iap2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in fly and predicted with the fly functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.052
central nervous system disease DOID:331 0 0.028
nervous system disease DOID:863 0 0.028